Isochamaejasmin (BioDeep_00001867565)

Main id: BioDeep_00000000920

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2S,3R)-3-[(2R,3S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

化学式: C30H22O10 (542.1213)
中文名称: 异狼毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC2O[C@H](C3C=CC(O)=CC=3)[C@@]([H])([C@]3([H])C(=O)C4=C(O)C=C(O)C=C4O[C@H]3C3=CC=C(O)C=C3)C(=O)C=2C(O)=C1
InChI: InChI=1S/C30H22O10/c31-15-5-1-13(2-6-15)29-25(27(37)23-19(35)9-17(33)11-21(23)39-29)26-28(38)24-20(36)10-18(34)12-22(24)40-30(26)14-3-7-16(32)8-4-14/h1-12,25-26,29-36H/t25-,26+,29+,30-

描述信息

Isochamaejasmin is a biflavonoid that consists of two units of 5,7,4-trihydroxyflavanone joined together at position 3 and 3. It has a role as a plant metabolite. It is a biflavonoid and a hydroxyflavone.
Isochamaejasmin is a natural product found in Brackenridgea zanguebarica, Stellera chamaejasme, and Ormocarpum kirkii with data available.
A biflavonoid that consists of two units of 5,7,4-trihydroxyflavanone joined together at position 3 and 3.

同义名列表

6 个代谢物同义名

(2S,3R)-3-[(2R,3S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; (2R,2S,3S,3R)-5,5,7,7-tetrahydroxy-2,2-bis(4-hydroxyphenyl)-2,2,3,3-tetrahydro-4H,4H-[3,3-bi-1-benzopyran]-4,4-dione; 3,3-Binaringenin; Isochamaejasmine; Isochamaejasmin; Isochamaejasmin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AIMP2, BCL2, BCL2L1, CASP3, CASP9, CCND1, CTNNB1, DCTN4, FPR2, HRAS, MAPK3, MAPK9, MCL1, NFKB1, NFKBIA
Endoplasmic reticulum membrane 2 BCL2, HRAS
Mitochondrion membrane 1 BCL2L1
Nucleus 15 AIMP2, BCL2, CASP3, CASP9, CCND1, CTNNB1, DCTN4, GABPA, MAPK3, MAPK9, MCL1, NFKB1, NFKBIA, OGG1, PARP1
cytosol 17 AIMP2, BCL2, BCL2L1, CASP3, CASP9, CCND1, CTNNB1, DCTN4, HRAS, MAPK3, MAPK9, MCL1, NFKB1, NFKBIA, OGG1, PARP1, PRKCQ
nuclear body 1 PARP1
centrosome 4 BCL2L1, CCND1, CTNNB1, DCTN4
nucleoplasm 12 CASP3, CCND1, CTNNB1, GABPA, HRAS, MAPK3, MAPK9, MCL1, NFKB1, NFKBIA, OGG1, PARP1
Cell membrane 3 CTNNB1, FPR2, HRAS
Lipid-anchor 1 HRAS
Cytoplasmic side 2 BCL2L1, HRAS
lamellipodium 1 CTNNB1
Multi-pass membrane protein 1 FPR2
Golgi apparatus membrane 1 HRAS
Synapse 1 CTNNB1
cell cortex 2 CTNNB1, DCTN4
cell junction 1 CTNNB1
glutamatergic synapse 4 CASP3, CTNNB1, HRAS, MAPK3
Golgi apparatus 2 HRAS, MAPK3
Golgi membrane 1 HRAS
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 CASP3
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 3 AIMP2, BCL2L1, PARP1
Lysosome 1 SGSH
plasma membrane 7 CTNNB1, FPR2, HRAS, MAPK3, MAPK9, NFKBIA, PRKCQ
synaptic vesicle membrane 1 BCL2L1
Membrane 7 AIMP2, BCL2, CTNNB1, FPR2, HRAS, MCL1, PARP1
basolateral plasma membrane 1 CTNNB1
caveola 1 MAPK3
extracellular exosome 2 CTNNB1, SGSH
endoplasmic reticulum 2 BCL2, BCL2L1
lysosomal lumen 1 SGSH
perinuclear region of cytoplasm 2 CTNNB1, HRAS
Schaffer collateral - CA1 synapse 2 CTNNB1, MAPK9
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 9 BCL2, BCL2L1, CASP9, MAPK3, MAPK9, MCL1, NFKB1, OGG1, PARP1
protein-containing complex 5 BCL2, CASP9, CTNNB1, OGG1, PARP1
postsynaptic density 1 CASP3
extracellular region 1 NFKB1
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 3 BCL2, BCL2L1, MCL1
mitochondrial outer membrane 3 BCL2, BCL2L1, MCL1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 2 BCL2L1, OGG1
transcription regulator complex 3 CTNNB1, NFKB1, PARP1
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, DCTN4
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 3 BCL2, BCL2L1, MCL1
nuclear membrane 3 BCL2, BCL2L1, CCND1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 PARP1
Wnt signalosome 1 CTNNB1
Early endosome 1 MAPK3
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK3
Cytoplasm, cytoskeleton 2 CTNNB1, DCTN4
focal adhesion 3 CTNNB1, DCTN4, MAPK3
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 MAPK9, OGG1
Cytoplasm, myofibril, sarcomere 1 DCTN4
Late endosome 1 MAPK3
sarcomere 1 DCTN4
chromatin 3 GABPA, NFKB1, PARP1
cell periphery 1 CTNNB1
Chromosome 1 PARP1
cytoskeleton 1 MAPK3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 PARP1
spindle pole 2 CTNNB1, DCTN4
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Cytoplasm, cell cortex 1 DCTN4
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 PARP1
nuclear envelope 2 MAPK3, PARP1
Endomembrane system 2 CTNNB1, HRAS
Membrane, caveola 1 MAPK3
myosin complex 1 MCL1
Nucleus, nucleoplasm 2 MCL1, OGG1
specific granule membrane 1 FPR2
tertiary granule membrane 1 FPR2
Nucleus speckle 1 OGG1
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
pseudopodium 1 MAPK3
stress fiber 1 DCTN4
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 1 MAPK3
nuclear matrix 1 OGG1
transcription repressor complex 1 CCND1
specific granule lumen 1 NFKB1
dynactin complex 1 DCTN4
kinetochore 1 DCTN4
beta-catenin-TCF complex 1 CTNNB1
immunological synapse 1 PRKCQ
cytoplasmic dynein complex 1 DCTN4
aggresome 1 PRKCQ
Nucleus matrix 1 OGG1
apoptosome 1 CASP9
presynaptic active zone cytoplasmic component 1 CTNNB1
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
protein-DNA complex 2 CTNNB1, PARP1
ficolin-1-rich granule membrane 1 FPR2
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
catenin complex 1 CTNNB1
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
GTPase complex 1 HRAS
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
beta-catenin-TCF7L2 complex 1 CTNNB1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 2 NFKB1, NFKBIA
NF-kappaB p50/p65 complex 1 NFKB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Yuanhang Ren, Qiang Li, Lidan Lu, Hong Jin, Ke Tao, Taiping Hou. Isochamaejasmin induces toxic effects on Helicoverpa zea via DNA damage and mitochondria-associated apoptosis. Pest management science. 2021 Jan; 77(1):557-567. doi: 10.1002/ps.6055. [PMID: 32815281]
  • Ludi Wang, Wei Yang, Siyang Wu, Shuyao Wang, Chen Kang, Xiaoli Ma, Yingfei Li, Chuan Li. Simultaneous determination of isochamaejasmin, neochamaejasmin A and aphnoretinin rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study of Stellera chamaejasme L. extract. Biomedical chromatography : BMC. 2018 May; 32(5):e4162. doi: 10.1002/bmc.4162. [PMID: 29235122]
  • Shou-De Zhang, Lei Shan, Wei Li, Hong-Lin Li, Wei-Dong Zhang. Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. Chinese journal of natural medicines. 2015 Sep; 13(9):660-6. doi: 10.1016/s1875-5364(15)30063-7. [PMID: 26412425]
  • Li-Yin Chen, Ih-Sheng Chen, Chien-Fang Peng. Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. International journal of molecular sciences. 2012; 13(1):1029-1038. doi: 10.3390/ijms13011029. [PMID: 22312302]
  • Qinghai Tian, Jing Li, Xin Xie, Meiling Sun, Hairong Sang, Caihong Zhou, Tianying An, Lihong Hu, Richard D Ye, Ming-Wei Wang. Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Molecular pharmacology. 2005 Dec; 68(6):1534-42. doi: 10.1124/mol.105.014720. [PMID: 16141313]