Isochamaejasmin (BioDeep_00000000920)

 

Secondary id: BioDeep_00001867565

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2S,3R)-3-[(2R,3S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

化学式: C30H22O10 (542.1213)
中文名称: 异狼毒素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.5%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Isochamaejasmin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/isochamaejasmin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000920). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(O)=CC2O[C@H](C3C=CC(O)=CC=3)[C@@]([H])([C@]3([H])C(=O)C4=C(O)C=C(O)C=C4O[C@H]3C3=CC=C(O)C=C3)C(=O)C=2C(O)=C1
InChI: InChI=1S/C30H22O10/c31-15-5-1-13(2-6-15)29-25(27(37)23-19(35)9-17(33)11-21(23)39-29)26-28(38)24-20(36)10-18(34)12-22(24)40-30(26)14-3-7-16(32)8-4-14/h1-12,25-26,29-36H

描述信息

Chamaejasmin is a natural product found in Brackenridgea zanguebarica, Stellera chamaejasme, and other organisms with data available.
Isochamaejasmin is a biflavonoid that consists of two units of 5,7,4-trihydroxyflavanone joined together at position 3 and 3. It has a role as a plant metabolite. It is a biflavonoid and a hydroxyflavone.
Isochamaejasmin is a natural product found in Brackenridgea zanguebarica, Stellera chamaejasme, and Ormocarpum kirkii with data available.

同义名列表

14 个代谢物同义名

Chamaejasmin; 3-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; 3-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-chroman-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one; [3,3-Bi-2H-1-benzopyran]-4,4(3H,3H)-dione, 5,5,7,7-tetrahydroxy-2,2-bis(4-hydroxyphenyl)-; Neochamaejasmine A; Neochamaejasmin A; MEGxp0_001158; ACon1_001326; (2S,3R)-3-[(2R,3S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; (2R,2S,3S,3R)-5,5,7,7-tetrahydroxy-2,2-bis(4-hydroxyphenyl)-2,2,3,3-tetrahydro-4H,4H-[3,3-bi-1-benzopyran]-4,4-dione; 3,3-Binaringenin; Isochamaejasmine; Isochamaejasmin; Isochamaejasmin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AIMP2, ANG, ANXA5, BCL2, BCL2L1, BECN1, CASP3, CASP9, CCNB1, CDK2, MAPK8, MSMP, TP53, VEGFA
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 2 ANXA5, BECN1
Endosome membrane 1 BECN1
Endoplasmic reticulum membrane 2 BCL2, BECN1
Mitochondrion membrane 2 BCL2L1, BECN1
Cytoplasmic vesicle, autophagosome 1 BECN1
Nucleus 13 AIMP2, ANG, BCL2, BECN1, CASP3, CASP9, CCNB1, CDK2, MAPK8, OGG1, PARP1, TP53, VEGFA
autophagosome 1 BECN1
cytosol 14 AIMP2, ANG, ANXA5, BCL2, BCL2L1, BECN1, CASP3, CASP9, CCNB1, CDK2, MAPK8, OGG1, PARP1, TP53
dendrite 1 BECN1
mitochondrial membrane 1 BECN1
nuclear body 2 BECN1, PARP1
phagocytic vesicle 1 BECN1
phosphatidylinositol 3-kinase complex, class III 1 BECN1
trans-Golgi network 1 BECN1
centrosome 4 BCL2L1, CCNB1, CDK2, TP53
nucleoplasm 7 CASP3, CCNB1, CDK2, MAPK8, OGG1, PARP1, TP53
Cytoplasmic side 1 BCL2L1
Synapse 1 MAPK8
cell surface 1 VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 1 VEGFA
growth cone 1 ANG
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 ANG, CASP3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 3 AIMP2, BCL2L1, PARP1
endosome 2 BECN1, CDK2
plasma membrane 1 IGHE
synaptic vesicle membrane 1 BCL2L1
Membrane 7 AIMP2, ANXA5, BCL2, CCNB1, PARP1, TP53, VEGFA
axon 2 CCK, MAPK8
extracellular exosome 1 ANXA5
endoplasmic reticulum 5 BCL2, BCL2L1, BECN1, TP53, VEGFA
extracellular space 6 ANG, CCK, IGHE, IL4, MSMP, VEGFA
adherens junction 1 VEGFA
mitochondrion 6 BCL2, BCL2L1, CASP9, OGG1, PARP1, TP53
protein-containing complex 5 BCL2, CASP9, OGG1, PARP1, TP53
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IGHE
Secreted 5 ANG, CCK, IL4, MSMP, VEGFA
extracellular region 6 ANG, ANXA5, CCK, IGHE, IL4, VEGFA
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 2 BCL2L1, TP53
mitochondrial matrix 4 BCL2L1, CCNB1, OGG1, TP53
transcription regulator complex 3 CDK2, PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 BCL2L1, CDK2, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 3 ANG, PARP1, TP53
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
nuclear speck 1 OGG1
Zymogen granule membrane 1 ANXA5
chromatin 2 PARP1, TP53
IgE immunoglobulin complex 1 IGHE
Chromosome 2 ANG, PARP1
Nucleus, nucleolus 2 ANG, PARP1
spindle pole 1 CCNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 CDK2, PARP1
[Isoform 2]: Cell membrane 1 IGHE
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 CDK2, PARP1
phagophore assembly site 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type I 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type II 1 BECN1
Nucleus, nucleoplasm 1 OGG1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Nucleus speckle 1 OGG1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
nuclear matrix 2 OGG1, TP53
transcription repressor complex 1 TP53
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
Nucleus matrix 1 OGG1
apoptosome 1 CASP9
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
Cajal body 1 CDK2
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
site of DNA damage 1 PARP1
[Isoform 3]: Cell membrane 1 IGHE
cyclin-dependent protein kinase holoenzyme complex 1 CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
angiogenin-PRI complex 1 ANG
cyclin B1-CDK1 complex 1 CCNB1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
cytoplasmic side of mitochondrial outer membrane 1 BECN1
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1


文献列表

  • Yuanhang Ren, Qiang Li, Lidan Lu, Hong Jin, Ke Tao, Taiping Hou. Isochamaejasmin induces toxic effects on Helicoverpa zea via DNA damage and mitochondria-associated apoptosis. Pest management science. 2021 Jan; 77(1):557-567. doi: 10.1002/ps.6055. [PMID: 32815281]
  • Ahmed H H El-Desoky, Keisuke Eguchi, Hikaru Kato, Naoki Kishimoto, Shogo Misumi, Takashi Watanabe, Sachiko Tsukamoto. Chamaejasmins, cytotoxic guaiane sesquiterpenes from the root of Stellera chamaejasme L. Fitoterapia. 2020 Oct; 146(?):104714. doi: 10.1016/j.fitote.2020.104714. [PMID: 32858173]
  • Ludi Wang, Wei Yang, Siyang Wu, Shuyao Wang, Chen Kang, Xiaoli Ma, Yingfei Li, Chuan Li. Simultaneous determination of isochamaejasmin, neochamaejasmin A and aphnoretinin rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study of Stellera chamaejasme L. extract. Biomedical chromatography : BMC. 2018 May; 32(5):e4162. doi: 10.1002/bmc.4162. [PMID: 29235122]
  • Sumin Qian, Meng Li. Chamaejasmine induces apoptosis in HeLa cells through the PI3K/Akt signaling pathway. Anti-cancer drugs. 2017 01; 28(1):40-50. doi: 10.1097/cad.0000000000000424. [PMID: 27557139]
  • Shou-De Zhang, Lei Shan, Wei Li, Hong-Lin Li, Wei-Dong Zhang. Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. Chinese journal of natural medicines. 2015 Sep; 13(9):660-6. doi: 10.1016/s1875-5364(15)30063-7. [PMID: 26412425]
  • Oue-artorn Rajachan, Somdej Kanokmedhakul, Phitak Nasomjai, Kwanjai Kanokmedhakul. Chemical constituents and biological activities from roots of Enkleia siamensis. Natural product research. 2014; 28(4):268-70. doi: 10.1080/14786419.2013.838241. [PMID: 24047498]
  • Li-Yin Chen, Ih-Sheng Chen, Chien-Fang Peng. Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. International journal of molecular sciences. 2012; 13(1):1029-1038. doi: 10.3390/ijms13011029. [PMID: 22312302]
  • Qinghai Tian, Jing Li, Xin Xie, Meiling Sun, Hairong Sang, Caihong Zhou, Tianying An, Lihong Hu, Richard D Ye, Ming-Wei Wang. Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Molecular pharmacology. 2005 Dec; 68(6):1534-42. doi: 10.1124/mol.105.014720. [PMID: 16141313]