Etodolac (BioDeep_00000001784)
Secondary id: BioDeep_00000397851
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H21NO3 (287.1521356)
中文名称: 依托度酸
谱图信息:
最多检出来源 Homo sapiens(blood) 28.57%
分子结构信息
SMILES: CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O
InChI: InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
描述信息
Etodolac is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Similar to other NSAIDs, the anti-inflammatory effects of etodolac result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5 – 50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
KEIO_ID E034; [MS2] KO008956
KEIO_ID E034
同义名列表
26 个代谢物同义名
(1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid; (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid; (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetate; 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid; (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetate; 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid; 1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid; 2-{1,8-diethyl-1H,3H,4H,9H-pyrano[3,4-b]indol-1-yl}acetic acid; 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetate; 1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetate; 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetate; Etodolac, monosodium salt, (+-) isomer; Etodolac, monosodium salt, (S)-isomer; Etodolac, monosodium salt; Etodolac, (+-)-isomer; Etodolac, (-)-isomer; Etodolac, (S)-isomer; Acid, etodolic; ETODOLIC ACID; Etodolacum; Etodolaco; ETODOLate; Ultradol; etodolac; Ramodar; Lodine
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:4909
- KEGG: C06991
- KEGGdrug: D00315
- PubChem: 3308
- HMDB: HMDB0014887
- Metlin: METLIN2630
- DrugBank: DB00749
- ChEMBL: CHEMBL622
- Wikipedia: Etodolac
- MeSH: Etodolac
- chemspider: 3192
- CAS: 41340-25-4
- CAS: 87226-38-8
- MoNA: KO002865
- MoNA: KO000741
- MoNA: KO000742
- MoNA: KO000739
- MoNA: KO000743
- MoNA: KO008957
- MoNA: KO002868
- MoNA: KO008956
- MoNA: KO002864
- MoNA: KO002867
- MoNA: KO000740
- MoNA: KO002866
- PMhub: MS000001166
- PubChem: 9204
- RefMet: Etodolac
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Poonam Patil, Atul Shirkhedkar. Nanostructured Etodolac Carriers in Transdermal Gel: Optimization and Characterization.
Pharmaceutical nanotechnology.
2023 Jun; 11(3):276-293. doi:
10.2174/2211738511666230111110340
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Molecules (Basel, Switzerland).
2022 Dec; 28(1):. doi:
10.3390/molecules28010235
. [PMID: 36615429] - Marwa Ibrahim Helmy, Samah Sabry Saad, Maha Abdelmonem Hegazy, Ahmed Salah Fayed. Sensitive and selective LC-MS/MS for the determination of tolperisone and etodolac in human plasma and application to a pharmacokinetic study.
Journal of separation science.
2022 May; 45(10):1646-1655. doi:
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2013 Feb; 69(2):161-5. doi:
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2012 Sep; 73(9):1485-90. doi:
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