Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato- (BioDeep_00000172895)
human metabolite blood metabolite
代谢物信息卡片
5-isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acid
化学式: C16H10N2O6S4 (453.9422)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 95.28%
分子结构信息
SMILES: OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S
InChI: InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
描述信息
同义名列表
7 个代谢物同义名
5-isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acid; Benzenesulfonic acid, 2,2-(1,2-ethenediyl)bis[5-isothiocyanato-; 2,2-Ethene-1,2-diylbis(5-isothiocyanatobenzenesulphonic acid); 2,2-Ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonic acid); 2,2-Ethene-1,2-diylbis(5-isothiocyanatobenzenesulphonate); 2,2-Ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonate); DIDS
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cell biology international.
2006 Jan; 30(1):93-100. doi:
10.1016/j.cellbi.2005.10.020. [PMID: 16376114] - Yvonne Neye, Martina Düfer, Gisela Drews, Peter Krippeit-Drews. HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.
The Journal of pharmacology and experimental therapeutics.
2006 Jan; 316(1):106-12. doi:
10.1124/jpet.105.090589. [PMID: 16162820] - Astrid Stumpf, Joana Almaca, Karl Kunzelmann, Kerstin Wenners-Epping, Stephan M Huber, Johannes Haberle, Sabine Falk, Angelika Duebbers, Mike Walte, Hans Oberleithner, Hermann Schillers. IADS, a decomposition product of DIDS activates a cation conductance in Xenopus oocytes and human erythrocytes: new compound for the diagnosis of cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2006; 18(4-5):243-52. doi:
10.1159/000097671. [PMID: 17167229] - Min Xia, Mengjun Hou, Huilian Zhu, Jing Ma, Zhihong Tang, Qing Wang, Yan Li, Dongsheng Chi, Xiaoping Yu, Ting Zhao, Pinghua Han, Xiaodong Xia, Wenhua Ling. Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway.
The Journal of biological chemistry.
2005 Nov; 280(44):36792-801. doi:
10.1074/jbc.m505047200. [PMID: 16107338] - Kimberly Matulef, Merritt Maduke. Side-dependent inhibition of a prokaryotic ClC by DIDS.
Biophysical journal.
2005 Sep; 89(3):1721-30. doi:
10.1529/biophysj.105.066522. [PMID: 15994902] - Sachar Lambert, Johannes Oberwinkler. Characterization of a proton-activated, outwardly rectifying anion channel.
The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
10.1113/jphysiol.2005.089888. [PMID: 15961423] - David Pérez-Morga, Benoit Vanhollebeke, Françoise Paturiaux-Hanocq, Derek P Nolan, Laurence Lins, Fabrice Homblé, Luc Vanhamme, Patricia Tebabi, Annette Pays, Philippe Poelvoorde, Alain Jacquet, Robert Brasseur, Etienne Pays. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.
Science (New York, N.Y.).
2005 Jul; 309(5733):469-72. doi:
10.1126/science.1114566. [PMID: 16020735] - Pauline Cavelier, David Attwell. Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices.
The Journal of physiology.
2005 Apr; 564(Pt 2):397-410. doi:
10.1113/jphysiol.2004.082131. [PMID: 15695241] - Solange Abdulnour-Nakhoul, Nazih L Nakhoul, Scott A Wheeler, Paul Wang, Eric R Swenson, Roy C Orlando. HCO3- secretion in the esophageal submucosal glands.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Apr; 288(4):G736-44. doi:
10.1152/ajpgi.00055.2004. [PMID: 15576627] - Elena Fonfría, M Teresa Vilaró, Zoila Babot, Eduard Rodríguez-Farré, Cristina Suñol. Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells.
Journal of neuroscience research.
2005 Feb; 79(4):545-53. doi:
10.1002/jnr.20375. [PMID: 15635608] - Wen-Zhi Lan, Houria Abbas, Hung D Lam, Anne-Marie Lemay, Ceredwyn E Hill. Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Feb; 288(2):G221-9. doi:
10.1152/ajpgi.00226.2004. [PMID: 15358597] - M Matsuki, S Hashimoto, M Shimono, M Murakami, J Fujita-Yoshigaki, S Furuyama, H Sugiya. Involvement of aquaporin-5 water channel in osmoregulation in parotid secretory granules.
The Journal of membrane biology.
2005 Feb; 203(3):119-26. doi:
10.1007/s00232-005-0736-9. [PMID: 15986091] - Marie Vanková, Vladimir A Snetkov, Greg A Knock, Philip I Aaronson, Jeremy P T Ward. Euhydric hypercapnia increases vasoreactivity of rat pulmonary arteries via HCO3- transport and depolarisation.
Cardiovascular research.
2005 Feb; 65(2):505-12. doi:
10.1016/j.cardiores.2004.10.038. [PMID: 15639490] - Didi Baev, Alberto Rivetta, Slavena Vylkova, Jianing N Sun, Ge-Fei Zeng, Clifford L Slayman, Mira Edgerton. The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.
The Journal of biological chemistry.
2004 Dec; 279(53):55060-72. doi:
10.1074/jbc.m411031200. [PMID: 15485849] - Florian Nolte, Oliver Friedrich, Markus Rojewski, Rainer H A Fink, Hubert Schrezenmeier, Sixten Körper. Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells.
FEBS letters.
2004 Dec; 578(1-2):85-9. doi:
10.1016/j.febslet.2004.10.075. [PMID: 15581621] - Byung-Hyun Park, Young Lee, Marlei Walton, Laurence Duplomb, Roger H Unger. Demonstration of reverse fatty acid transport from rat cardiomyocytes.
Journal of lipid research.
2004 Nov; 45(11):1992-9. doi:
10.1194/jlr.m400237-jlr200. [PMID: 15342682] - Philip A Knauf, Foon-Yee Law, Tze-Wah Vivian Leung, Stephen J Atherton. Relocation of the disulfonic stilbene sites of AE1 (band 3) on the basis of fluorescence energy transfer measurements.
Biochemistry.
2004 Sep; 43(38):11917-31. doi:
10.1021/bi048622a. [PMID: 15379532] - F Savignan, B Ballion, M F Odessa, M Charveron, P Bordat, B Dufy. Mitochondrial membrane potential (DeltaPsi) and Ca(2+)-induced differentiation in HaCaT keratinocytes.
Journal of biomedical science.
2004 Sep; 11(5):671-82. doi:
10.1007/bf02256133. [PMID: 15316143] - J M Kristensen, M Kristensen, C Juel. Expression of Na+/HCO3- co-transporter proteins (NBCs) in rat and human skeletal muscle.
Acta physiologica Scandinavica.
2004 Sep; 182(1):69-76. doi:
10.1111/j.1365-201x.2004.01297.x. [PMID: 15329059] - P Settle, K Mynett, P Speake, E Champion, I M Doughty, C P Sibley, S W D'Souza, J Glazier. Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta.
Placenta.
2004 Jul; 25(6):496-504. doi:
10.1016/j.placenta.2003.11.009. [PMID: 15135232] - Alessandra Picollo, Antonella Liantonio, Maria Paola Didonna, Laura Elia, Diana Conte Camerino, Michael Pusch. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
EMBO reports.
2004 Jun; 5(6):584-9. doi:
10.1038/sj.embor.7400169. [PMID: 15167890] - Xiao-Gai Yang, Xiao-Da Yang, Lan Yuan, Kui Wang, Debbie C Crans. The permeability and cytotoxicity of insulin-mimetic vanadium compounds.
Pharmaceutical research.
2004 Jun; 21(6):1026-33. doi:
10.1023/b:pham.0000029293.89113.d5. [PMID: 15212169] - Ling Wei, Ai Ying Xiao, Chun Jin, Aizhen Yang, Zhong Yang Lu, Shan Ping Yu. Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons.
Pflugers Archiv : European journal of physiology.
2004 Jun; 448(3):325-34. doi:
10.1007/s00424-004-1277-2. [PMID: 15057559] - K M Gilmour, P R Desforges, S F Perry. Buffering limits plasma HCO3- dehydration when red blood cell anion exchange is inhibited.
Respiratory physiology & neurobiology.
2004 May; 140(2):173-87. doi:
10.1016/j.resp.2004.02.001. [PMID: 15134665] - Jeppe Praetorius, Young-Hee Kim, Elena V Bouzinova, Sebastian Frische, Aleksandra Rojek, Christian Aalkjaer, Søren Nielsen. NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts.
American journal of physiology. Renal physiology.
2004 May; 286(5):F903-12. doi:
10.1152/ajprenal.00437.2002. [PMID: 15075186] - Wen-Hao Zhang, N Alan Walker, John W Patrick, Stephen D Tyerman. Pulsing Cl- channels in coat cells of developing bean seeds linked to hypo-osmotic turgor regulation.
Journal of experimental botany.
2004 May; 55(399):993-1001. doi:
10.1093/jxb/erh120. [PMID: 15047765] - Joen Steendahl, Niels-Henrik Holstein-Rathlou, Charlotte Mehlin Sorensen, Max Salomonsson. Effects of chloride channel blockers on rat renal vascular responses to angiotensin II and norepinephrine.
American journal of physiology. Renal physiology.
2004 Feb; 286(2):F323-30. doi:
10.1152/ajprenal.00017.2003. [PMID: 14506073] - Michael F Romero, Christiaan M Fulton, Walter F Boron. The SLC4 family of HCO 3 - transporters.
Pflugers Archiv : European journal of physiology.
2004 Feb; 447(5):495-509. doi:
10.1007/s00424-003-1180-2. [PMID: 14722772] - Ha-Van Nguyen, Alan Stuart-Tilley, Seth L Alper, James E Melvin. Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Feb; 286(2):G312-20. doi:
10.1152/ajpgi.00158.2003. [PMID: 12958022] - Stefan H Boese, Mike A Gray, Nick L Simmons. Volume-dependent and -independent activated anion conductances and their interaction in the renal inner medullary collecting duct (IMCD).
Advances in experimental medicine and biology.
2004; 559(?):109-18. doi:
10.1007/0-387-23752-6_10. [PMID: 18727232] - Antonella Liantonio, Michael Pusch, Alessandra Picollo, Patrizia Guida, Annamaria De Luca, Sabata Pierno, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Diana Conte Camerino. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):13-20. doi:
10.1097/01.asn.0000103226.28798.ea. [PMID: 14694153] - Weiqin Gong, Hongtao Xu, Takahiro Shimizu, Shigeru Morishima, Shigeru Tanabe, Takanori Tachibe, Shinichi Uchida, Sei Sasaki, Yasunobu Okada. ClC-3-independent, PKC-dependent activity of volume-sensitive Cl channel in mouse ventricular cardiomyocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2004; 14(4-6):213-24. doi:
10.1159/000080330. [PMID: 15319524] - Kaname Kubota, Takaharu Ishibashi, Taku Matsubara, Tomoyuki Hori, Kazuyuki Ozaki, Masaru Yamazoe, Junko Yoshida, Matomo Nishio, Yoshifusa Aizawa. Effects of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid (DIDS) and chlorpromazine on NO3- transport via anion exchanger in erythrocytes: inertness of DIDS in whole blood.
Journal of pharmacological sciences.
2003 Dec; 93(4):505-8. doi:
10.1254/jphs.93.505. [PMID: 14737025] - N P Matveyeva, D S Andreyuk, I P Yermakov. Transport of Cl- across the plasma membrane during pollen grain germination in tobacco.
Biochemistry. Biokhimiia.
2003 Nov; 68(11):1247-51. doi:
10.1023/b:biry.0000009140.50032.3d. [PMID: 14640968] - Zheng Dong, Jinzhao Wang, Qiu Zhong. Postmitochondrial regulation of apoptosis by bicarbonate.
Experimental cell research.
2003 Aug; 288(2):301-12. doi:
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