Silibinin (BioDeep_00000001706)

Main id: BioDeep_00000230327

Secondary id: BioDeep_00000396894

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


Silybin B, 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

化学式: C25H22O10 (482.1212912)
中文名称: 水飞蓟提取物, 水飞蓟素, 水飞蓟宾
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COc(c(O)5)cc(cc5)C(O1)C(CO)Oc(c4)c(cc(c4)C(O2)C(O)C(=O)c(c(O)3)c(cc(O)c3)2)1
InChI: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

描述信息

A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
Silibinin is found in coffee and coffee products. Silibinin is isolated from Silybum marianum (milk thistle
D020011 - Protective Agents > D000975 - Antioxidants
[Raw Data] CBA85_Silybin-B_pos_30eV.txt
[Raw Data] CBA85_Silybin-B_neg_30eV.txt
[Raw Data] CBA85_Silybin-B_pos_50eV.txt
[Raw Data] CBA85_Silybin-B_pos_20eV.txt
[Raw Data] CBA85_Silybin-B_pos_40eV.txt
[Raw Data] CBA85_Silybin-B_pos_10eV.txt
[Raw Data] CBA85_Silybin-B_neg_40eV.txt
[Raw Data] CBA85_Silybin-B_neg_10eV.txt
[Raw Data] CBA85_Silybin-B_neg_50eV.txt
[Raw Data] CBA85_Silybin-B_neg_20eV.txt
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

同义名列表

48 个代谢物同义名

Silybin B, 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; (2R,3R)-3,5,7-trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; Milk Thistle Extract; Silybum substance e6; 2,3 Dehydrosilybin; 2,3-dehydrosilybin; Flavobin Spofa; Silibinin, inn; Cefasilymarin; Silybin (7ci); Hepa Merz Sil; Hepa-Merz Sil; legalon forte; durasilymarin; Silymarine I; Alepa-forte; Alepa forte; Silymarin I; Silibinin A; Silibinin B; Silibininum; Hepar-Pasc; Hepa loges; Ardeyhepan; Hepar Pasc; Silibinina; Silibinine; hepa-loges; silybinin; SILYMARIN; HepaBesch; Silibinin; silybin B; Silimarin; silybin A; Silybine; Flavobin; Silliver; Heparsyx; Heplant; Legalon; silibin; silybin; Karsil; Carsil; Lagosa



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fatma M El-Demerdash, Manal M Ahmed, Raghda A El-Sayed, Tarek M Mohemed, Marian N Gerges. Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity. Environmental toxicology. 2024 Jun; 39(6):3746-3759. doi: 10.1002/tox.24223. [PMID: 38546352]
  • J Anupama Sekar, Shiny Velayudhan, M Senthilkumar, P R Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114272. doi: 10.1016/j.ejpb.2024.114272. [PMID: 38537909]
  • Peihai Li, Dexu Wang, Xueliang Yang, Changyu Liu, Xiaobin Li, Xuanming Zhang, Kechun Liu, Yun Zhang, Mengqi Zhang, Changyun Wang, Rongchun Wang. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081901. [PMID: 38675723]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Zoe D. Draelos, Martina Kerscher, Stephen Lynch, Stacy White, Hina Choudhary. A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen. Journal of drugs in dermatology : JDD. 2024 04; 23(4):233-238. doi: 10.36849/jdd.8120. [PMID: 38564394]
  • Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan. Innovative prophylactic and therapeutic approaches in liver cirrhosis. Physiology international. 2024 Mar; 111(1):1-18. doi: 10.1556/2060.2024.00339. [PMID: 38421387]
  • Xiang Zhang, Zhenghao Jiang, Xiaoliang Jin, Qiujun Zhou. Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review. Medicine. 2024 Feb; 103(5):e37052. doi: 10.1097/md.0000000000037052. [PMID: 38306552]
  • Hebatallah Husseini Atteia. A combination of silymarin and garlic extract enhances thyroid hormone activation and body metabolism in orally intoxicated male rats with atrazine: Impact on hepatic iodothyronine deiodinase type 1. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105801. doi: 10.1016/j.pestbp.2024.105801. [PMID: 38458692]
  • Rajeev K Singla, Digvijay Singh, Ravinder Verma, Deepak Kaushik, Javier Echeverría, Vandana Garg, Pankaj Gupta, Mohammad Akhlaquer Rahman, Ajay Sharma, Vineet Mittal, Bairong Shen. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155286. doi: 10.1016/j.phymed.2023.155286. [PMID: 38241906]
  • Xin Zhang, Yuhan Jiang, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao, Yanni Lv. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115816. doi: 10.1016/j.jpba.2023.115816. [PMID: 37976988]
  • Mohammad Reza Karimzadeh, Afsane Masoudi Chelegahi, Shahrzad Shahbazi, Somayeh Reiisi. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Molecular biology reports. 2024 Jan; 51(1):118. doi: 10.1007/s11033-023-09026-8. [PMID: 38227082]
  • Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose, Mohd Kashif Kidwai. Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155142. doi: 10.1016/j.phymed.2023.155142. [PMID: 37913641]
  • Hao-Ran Shen, Zhi-Yu Wang, Zhen Shen, Tong-Tong Liu, Yun-Dan Guo, Tian-Le Gao, Hui-Hui Guo, Yan-Xing Han, Jian-Dong Jiang. Bacterial butyrate mediates the anti-atherosclerotic effect of silybin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115916. doi: 10.1016/j.biopha.2023.115916. [PMID: 38000354]
  • Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. The Journal of steroid biochemistry and molecular biology. 2023 Dec; 238(?):106450. doi: 10.1016/j.jsbmb.2023.106450. [PMID: 38143010]
  • Jialuo Cai, Yilin Zhu, Xiaoping Li, Guiming Deng, Yuanshan Han, Feiyun Yuan, Gangqiang Yi, Xinhua Xia. Liposomal Silybin Improves Glucose and Lipid Metabolisms in Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease via AMPK/TGF-β1/Smad Signaling. The Tohoku journal of experimental medicine. 2023 Dec; 261(4):257-265. doi: 10.1620/tjem.2023.j050. [PMID: 37344419]
  • Ebrahim Salimi-Sabour, Ramazan-Ali Tahri, Amirhossein Asgari, Maryam Ghorbani. The novel hepatoprotective effects of silibinin-loaded nanostructured lipid carriers against diazinon-induced liver injuries in male mice. Pesticide biochemistry and physiology. 2023 Dec; 197(?):105643. doi: 10.1016/j.pestbp.2023.105643. [PMID: 38072518]
  • Helena Pluháčková, Barbora Kudláčková, Lenka Svojanovská, Michal Roth, Marta Bradáčová, Marie Bjelková. Effect of Field Trial on Silymarin Complex Composition and Antioxidant Assessment of Milk Thistle (Silybum marianum L. Gaertner). Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; 78(4):691-697. doi: 10.1007/s11130-023-01101-6. [PMID: 37668769]
  • Zhenzhen Chen, Wenhao Gao, Xianquan Feng, Guizhi Zhou, Minxin Zhang, Lingjun Zeng, Xiaomu Hu, Zhihong Liu, Hongtao Song. A comparative study on the preparation and evaluation of solubilizing systems for silymarin. Drug delivery and translational research. 2023 Nov; ?(?):. doi: 10.1007/s13346-023-01476-8. [PMID: 37964172]
  • Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar. Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02776-z. [PMID: 37847410]
  • Salah A Sheweita, Ahmed Abd El Rafea, Sabah G Elbana. The deleterious effects of cadmium on oxidative stress markers, drug-metabolizing, and antioxidant enzyme activities: Role of Silymarin and Garlic as Antioxidants. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30197-1. [PMID: 37831250]
  • Hanaa S S Gazwi, Osama I A Soltan, Sanaa M Abdel-Hameed. Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30172-w. [PMID: 37815681]
  • Xinyu Wu, Yue Xin, Yeyun Ma, Kaixin Ping, Qiulu Li, Ying Sun, Zunhan Hu, Jingquan Dong. Abamectin induced brain and liver toxicity in carp: The healing potential of silybin and potential molecular mechanisms. Fish & shellfish immunology. 2023 Oct; ?(?):109152. doi: 10.1016/j.fsi.2023.109152. [PMID: 37821005]
  • Pei-Ling Yen, Ting-An Lin, Wei Lin Chuah, Chih-Yi Chang, Yen-Hsueh Tseng, Chia-Yin Huang, Jeng-Chuann Yang, Fu-Lan Hsu, Vivian Hsiu-Chuan Liao. Methanol Extracts from Cirsium japonicum DC. var. australe Kitam. and Their Active Components Reduce Intracellular Oxidative Stress in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196923. [PMID: 37836767]
  • Ahmed H Sherif, Adel E Toulan, Naglaa El-Kalamwi, Enas A H Farag, Abeer E Mahmoud. Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila. Scientific reports. 2023 Sep; 13(1):16235. doi: 10.1038/s41598-023-43270-z. [PMID: 37758826]
  • Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117238. doi: 10.1016/j.jep.2023.117238. [PMID: 37774895]
  • Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity. Journal of ethnopharmacology. 2023 Sep; ?(?):117185. doi: 10.1016/j.jep.2023.117185. [PMID: 37714225]
  • Fatemeh Gheybi, Fatemeh Rajabian, Zahra Tayarani-Najaran, Amir Reza Adibi, Seyedeh Hoda Alavizadeh, Prashant Kesharwani, Amirhossein Sahebkar. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Aug; 80(?):127291. doi: 10.1016/j.jtemb.2023.127291. [PMID: 37672872]
  • Hossein Abbasinia, Masoumeh Heshmati, Mohammad Yousefi, Nabaa Najjar, Hanieh Sadeghi. Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells. ACS applied bio materials. 2023 Aug; ?(?):. doi: 10.1021/acsabm.3c00434. [PMID: 37608575]
  • Iman H Hasan, Amirah Badr, Haneen Almalki, Alanoud Alhindi, Hesham S Mostafa. Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect. Life sciences. 2023 Aug; 330(?):121996. doi: 10.1016/j.lfs.2023.121996. [PMID: 37536613]
  • Panwen Liu, Wenhui Chen, Yu Kang, Chenkang Wang, Xiaoling Wang, Weiwei Liu, Toshihiko Hayashi, Zhiyue Qiu, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Archives of biochemistry and biophysics. 2023 08; 744(?):109691. doi: 10.1016/j.abb.2023.109691. [PMID: 37473980]
  • Hamed Baharara, Sara Rahsepar, Seyyed Ahmad Emami, Sepideh Elyasi, Amir Hooshang Mohammadpour, Vahid Ghavami, Rajkumar Rajendram, Amirhossein Sahebkar, Omid Arasteh. The efficacy of medicinal plant preparations in the alleviation of radiodermatitis in patients with breast cancer: A systematic review of clinical trials. Phytotherapy research : PTR. 2023 Aug; 37(8):3275-3295. doi: 10.1002/ptr.7894. [PMID: 37211432]
  • Ricardo J Ramírez-Carreto, Víctor J Zaldívar-Machorro, Dafne J Pérez-Ramírez, Blanca E Rodríguez-López, Claudia Meza, Esperanza García, Abel Santamaría, Anahí Chavarría. Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03485-7. [PMID: 37480498]
  • Fatemeh Gheybi, Alireza Khooei, Azam Hoseinian, Maham Doagooyan, Kebria Houshangi, Mahmoud Reza Jaafari, Arash Papi, Zahra Khoddamipour, Amirhossein Sahebkar, Seyedeh Hoda Alavizadeh. Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. Biochemical and biophysical research communications. 2023 Jul; 676(?):103-108. doi: 10.1016/j.bbrc.2023.07.045. [PMID: 37506470]
  • A Jabbari, B Alani, A Arjmand, T Mazoochi, N Kheiripour, A Ardjmand. Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence. Journal of chemical neuroanatomy. 2023 Jul; 132(?):102310. doi: 10.1016/j.jchemneu.2023.102310. [PMID: 37429530]
  • Asimah Khalid, Imrana Naseem. Increased therapeutic effect of nanotized silibinin against glycation and diabetes: An in vitro and in silico-based approach. Biochimica et biophysica acta. General subjects. 2023 07; 1867(7):130364. doi: 10.1016/j.bbagen.2023.130364. [PMID: 37088248]
  • Chunqiu Fang, Jingzhou Zhang, Jiajun Han, Yuting Lei, Zhanhong Cao, Jianheng Pan, Zhi Pan, Zhong Zhang, Ning Qu, Haoming Luo, Yan Ma, Dong Han. Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats. Journal of ethnopharmacology. 2023 Jun; 317(?):116838. doi: 10.1016/j.jep.2023.116838. [PMID: 37355081]
  • Huan Gu, Xing Liu, Ping Chen, Mingyi Shi, Liping Chen, Xiaofang Li. Topical treatment of tea saponin stabilized silybin nanocrystal gel reduced oxidative stress in UV-induced skin damage. Biochemical and biophysical research communications. 2023 06; 660(?):82-87. doi: 10.1016/j.bbrc.2023.04.016. [PMID: 37075642]
  • Paolo Bellavite, Serafino Fazio, Flora Affuso. A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention. Molecules (Basel, Switzerland). 2023 Jun; 28(11):. doi: 10.3390/molecules28114491. [PMID: 37298967]
  • Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Amin Haratian, Morteza Kosari-Nasab, Majid Mahdavi. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; 228(?):107127. doi: 10.1016/j.toxicon.2023.107127. [PMID: 37085055]
  • Elnaz Golestaneh, Abolfazl Aslani, Mahmoud Aghaei, Mohammad Hashemnia, Mohammad Hosein Aarabi. Preparation and characterisation of a new form of silymarin as a potential antidiabetic agent in the adult male rat. Archives of physiology and biochemistry. 2023 Jun; 129(3):799-809. doi: 10.1080/13813455.2021.1874018. [PMID: 33529090]
  • Peichen Wang, Ning Yang, Ying Luo, Gan Wang, Shuaizhen Zhou, Shuai Huang, Li Chen, Yiping Zhao. Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti-M1 macrophage polarization and hemocompatibility for blood purification. Journal of biomedical materials research. Part B, Applied biomaterials. 2023 May; ?(?):. doi: 10.1002/jbm.b.35285. [PMID: 37255001]
  • Qingqing Du, Xiaoyun Wu, Kai Ma, Weiwei Liu, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy. Archives of biochemistry and biophysics. 2023 May; ?(?):109644. doi: 10.1016/j.abb.2023.109644. [PMID: 37245586]
  • Doriana Eurosia Angela Tedesco, Alessandro Guerrini. Use of Milk Thistle in Farm and Companion Animals: A Review. Planta medica. 2023 May; 89(6):584-607. doi: 10.1055/a-1969-2440. [PMID: 36302565]
  • Jiang-Pei Shi, Rong-Guang Zhang, Xiao-Yan Gu, Ying-Wei Sun, Nian-Ping Feng, Ying Liu. [Effects of Platycodonis Radix-Curcumae Rhizoma on oral nanoparticle uptake and in vitro inhibition against breast cancer metastasis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 May; 48(9):2419-2425. doi: 10.19540/j.cnki.cjcmm.20230301.301. [PMID: 37282871]
  • Mehran Ebrahimi Shah-Abadi, Armin Ariaei, Fatemeh Moradi, Auob Rustamzadeh, Rastegar Rahmani Tanha, Nader Sadigh, Mohsen Marzban, Mahdi Heydari, Vahid Tavakolian Ferdousie. In Silico Interactions of Natural and Synthetic Compounds with Key Proteins Involved in Alzheimer's Disease: Prospects for Designing New Therapeutics Compound. Neurotoxicity research. 2023 Apr; ?(?):. doi: 10.1007/s12640-023-00648-1. [PMID: 37086338]
  • D Shah, N Mahurkar, D Gadhave, R Nikhate, K Kakad. Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation. Annales pharmaceutiques francaises. 2023 Apr; ?(?):. doi: 10.1016/j.pharma.2023.04.003. [PMID: 37060939]
  • Yingwen Bai, Lulu Wang, TingYang, Lingyun Wang, Weihong Ge. Silymarin ameliorates peritoneal fibrosis by inhibiting the TGF-β/Smad signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02450-4. [PMID: 37052642]
  • Meghanath B Shete, Ashwini S Deshpande, Pravin Shende. Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured lipid carrier in mucoadhesive in-situ gel. International journal of pharmaceutics. 2023 Apr; 636(?):122860. doi: 10.1016/j.ijpharm.2023.122860. [PMID: 36933584]
  • D Jayabal, S Jayanthi, R Thirumalaisamy, R Karthika, Muhammad Nasir Iqbal. Comparative anti-Diabetic potential of phytocompounds from Dr. Duke's phytochemical and ethnobotanical database and standard antidiabetic drugs against diabetes hyperglycemic target proteins: an in silico validation. Journal of biomolecular structure & dynamics. 2023 Apr; ?(?):1-13. doi: 10.1080/07391102.2023.2187231. [PMID: 37011006]
  • Kassahun Dires Ayenew, Yared Wasihun. Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats. BMC complementary medicine and therapies. 2023 Apr; 23(1):99. doi: 10.1186/s12906-023-03931-y. [PMID: 37005601]
  • Arwa A Elsheikh, Sulaiman Mohammed Alnasser, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Noha Ali Abd-Almotaleb, Mohammed Alorini, Fatima A Jaber, Eman El-Sayed Khayal. Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin. Toxicology mechanisms and methods. 2023 Mar; ?(?):1-17. doi: 10.1080/15376516.2023.2191270. [PMID: 36970996]
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