2,6-Dihydroxybenzoic acid (BioDeep_00000001650)
Secondary id: BioDeep_00000416056, BioDeep_00000614848, BioDeep_00000866237
human metabolite Endogenous blood metabolite PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C7H6O4 (154.0266)
中文名称: 2,6-二羟基苯甲酸
谱图信息:
最多检出来源 Homo sapiens(blood) 10.89%
Last reviewed on 2024-09-13.
Cite this Page
2,6-Dihydroxybenzoic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/2,6-dihydroxybenzoic_acid (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000001650). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1=CC(=C(C(=C1)O)C(=O)O)O
InChI: InChI=1S/C7H6O4/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,8-9H,(H,10,11)
描述信息
2,6-dihydroxybenzoic acid, also known as gamma-resorcylic acid or 6-hydroxysalicylic acid, is a member of the class of compounds known as salicylic acids. Salicylic acids are ortho-hydroxylated benzoic acids. 2,6-dihydroxybenzoic acid is slightly soluble (in water) and a moderately acidic compound (based on its pKa). 2,6-dihydroxybenzoic acid can be found in beer and olive, which makes 2,6-dihydroxybenzoic acid a potential biomarker for the consumption of these food products. 2,6-dihydroxybenzoic acid can be found primarily in blood and urine. 2,6-Dihydroxybenzoic acid (γ-resorcylic acid) is a dihydroxybenzoic acid. It is a very strong acid due to its intramolecular hydrogen bonding .
2,6-dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
同义名列表
17 个代谢物同义名
2,6-Dihydroxybenzoic acid (acd/name 4.0); 2,6-Dihydroxy-benzoic acid; 2,6-DIHYDROXYBENZOIC ACID; 6-Hydroxysalicylic acid; gamma-Resorcylic acid; 2,6-Dihydroxybenzoate; 2,6-Resorcylic acid; 2-Carboxyresorcinol; 6-Hydroxysalicylate; Γ-resorcylic acid; g-Resorcylic acid; gamma-Resorcylate; Γ-resorcylate; g-Resorcylate; Benzoic Acid; benzoate; 2,6-Dihydroxybenzoic acid
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:68465
- KEGG: C21298
- PubChem: 9338
- HMDB: HMDB0013676
- ChEMBL: CHEMBL454808
- Wikipedia: 2,6-Dihydroxybenzoic_acid
- MetaCyc: CPD-8816
- KNApSAcK: C00032618
- foodb: FDB000845
- chemspider: 8974
- CAS: 303-07-1
- PMhub: MS000000916
- PubChem: 318172278
- PDB-CCD: GRE
- RefMet: 2,6-Dihydroxybenzoic acid
- medchemexpress: HY-Y0801
- LOTUS: LTS0046588
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
58 个相关的物种来源信息
- 16896 - Alangium: LTS0046588
- 60116 - Alangium platanifolium: 10.1016/0031-9422(89)80306-1
- 60116 - Alangium platanifolium: LTS0046588
- 2650355 - Alangium platanifolium var. trilobum: 10.1016/0031-9422(89)80306-1
- 128591 - Aniba: LTS0046588
- 4890 - Ascomycota: LTS0046588
- 42219 - Cornaceae: LTS0046588
- 2759 - Eukaryota: LTS0046588
- 76024 - Fallopia: LTS0046588
- 3746 - Fragaria: 10.1016/J.JFF.2014.08.013
- 4751 - Fungi: LTS0046588
- 71598 - Graphidaceae: LTS0046588
- 71599 - Graphis: LTS0046588
- 996888 - Graphis proserpens: 10.1016/J.PHYTOCHEM.2011.04.017
- 996888 - Graphis proserpens: LTS0046588
- 9606 - Homo sapiens: -
- 3433 - Lauraceae: LTS0046588
- 147547 - Lecanoromycetes: LTS0046588
- 3398 - Magnoliopsida: LTS0046588
- 3939 - Oenothera: LTS0046588
- 3942 - Oenothera biennis: 10.5586/ASBP.1995.007
- 3942 - Oenothera biennis: LTS0046588
- 44456 - Oenothera elata: LTS0046588
- 85636 - Oenothera elata subsp. hookeri: 10.5586/ASBP.1995.007
- 85636 - Oenothera elata subsp. hookeri: LTS0046588
- 482428 - Oenothera glazioviana: 10.5586/ASBP.1995.007
- 482428 - Oenothera glazioviana: LTS0046588
- 49455 - Oenothera grandiflora: 10.5586/ASBP.1995.007
- 49455 - Oenothera grandiflora: LTS0046588
- 44479 - Oenothera lamarckiana: 10.5586/ASBP.1995.007
- 44479 - Oenothera lamarckiana: LTS0046588
- 4145 - Olea: LTS0046588
- 4146 - Olea europaea:
- 4146 - Olea europaea: 10.1002/JSSC.200390053
- 4146 - Olea europaea: 10.1002/JSSC.200390054
- 4146 - Olea europaea: LTS0046588
- 4144 - Oleaceae: LTS0046588
- 3934 - Onagraceae: LTS0046588
- 3434 - Persea: LTS0046588
- 3435 - Persea americana: 10.1021/JF00078A018
- 3435 - Persea americana: LTS0046588
- 3318 - Pinaceae: LTS0046588
- 58019 - Pinopsida: LTS0046588
- 3337 - Pinus: LTS0046588
- 28528 - Pinus mugo: 10.5586/ASBP.1985.037
- 28528 - Pinus mugo: LTS0046588
- 3615 - Polygonaceae: LTS0046588
- 83819 - Polygonum cuspidatum Sieb. et Zucc.: -
- 655516 - Reynoutria: LTS0046588
- 488216 - Reynoutria japonica: LTS0046588
- 3618 - Rumex: LTS0046588
- 174651 - Rumex japonicus: 10.1016/J.PHYTOCHEM.2007.05.032
- 174651 - Rumex japonicus: LTS0046588
- 35493 - Streptophyta: LTS0046588
- 58023 - Tracheophyta: LTS0046588
- 33090 - Viridiplantae: LTS0046588
- 29760 - Vitis vinifera: 10.1016/J.DIB.2020.106469
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhiqiang Li, Ludan Zhao, Qiaomei Sun, Na Gan, Qiyi Zhang, Ji Yang, Bin Yi, Xiaoxiang Liao, Donglai Zhu, Hui Li. Study on the interaction between 2,6-dihydroxybenzoic acid nicotine salt and human serum albumin by multi-spectroscopy and molecular dynamics simulation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Apr; 270(?):120868. doi:
10.1016/j.saa.2022.120868. [PMID: 35032760] - Wataru Nabeyama, Kenji Ishihara, Hyun Seung Ban, Hiroshi Wada, Hiroyuki Nakamura. Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
Bioorganic & medicinal chemistry.
2017 05; 25(9):2601-2608. doi:
10.1016/j.bmc.2017.03.024. [PMID: 28341401] - Stéphanie Cottier, Timon Mönig, Zheming Wang, Jiří Svoboda, Wilhelm Boland, Markus Kaiser, Erich Kombrink. The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations.
Frontiers in plant science.
2011; 2(?):101. doi:
10.3389/fpls.2011.00101. [PMID: 22639623] - Susana Tárraga, Purificación Lisón, María Pilar López-Gresa, Cristina Torres, Ismael Rodrigo, José María Bellés, Vicente Conejero. Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid.
Journal of experimental botany.
2010 Oct; 61(15):4325-38. doi:
10.1093/jxb/erq234. [PMID: 20729481] - Wendy R Russell, Lorraine Scobbie, Garry G Duthie, Andrew Chesson. Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.
Bioorganic & medicinal chemistry.
2008 Apr; 16(8):4589-93. doi:
10.1016/j.bmc.2008.02.041. [PMID: 18314336] - Lili Jiang, Shuwei Zhang, Lijiang Xuan. Oxanthrone C-glycosides and epoxynaphthoquinol from the roots of Rumex japonicus.
Phytochemistry.
2007 Oct; 68(19):2444-9. doi:
10.1016/j.phytochem.2007.05.032. [PMID: 17603087] - Maria Stasiuk, Anna Jaromin, Arkadiusz Kozubek. The effect of merulinic acid on biomembranes.
Biochimica et biophysica acta.
2004 Dec; 1667(2):215-21. doi:
10.1016/j.bbamem.2004.10.010. [PMID: 15581858] - M Sakurai, M Ohsako, M Nagano, C Nakamura, O Tsuzuki, M Ichikawa, Y Matsumoto. [Effect of human serum albumin on transport of drugs through human erythrocyte membranes].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1996 Aug; 116(8):630-8. doi:
10.1248/yakushi1947.116.8_630. [PMID: 8831264] - H S Yun-Choi, J H Kim, J R Lee. Potential inhibitors of platelet aggregation from plant sources, III.
Journal of natural products.
1987 Nov; 50(6):1059-64. doi:
10.1021/np50054a008. [PMID: 3127544] - S M Rocha, E L Angerami. [Study of urine pH and density in the rehydration of infants. Introduction to nursing care].
Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau.
1978 Feb; 84(2):146-56. doi:
NULL. [PMID: 24456] - R A Scherrer, S M Howard. Use of distribution coefficients in quantitative structure-activity relationships.
Journal of medicinal chemistry.
1977 Jan; 20(1):53-8. doi:
10.1021/jm00211a010. [PMID: 13215] - H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor.
The Biochemical journal.
1975 Dec; 152(3):601-7. doi:
10.1042/bj1520601. [PMID: 5997]
