Griseofulvin (BioDeep_00000001594)

 

Secondary id: BioDeep_00000182534, BioDeep_00000398549

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(2S,6R)-7-chloro-2,4,6-trimethoxy-6-methyl-3H-spiro[1-benzofuran-2,1-cyclohexan]-2-ene-3,4-dione

化学式: C17H17ClO6 (352.0714)
中文名称: 灰黄霉素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 18.44%

分子结构信息

SMILES: CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
InChI: InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3

描述信息

Griseofulvin is only found in individuals that have used or taken this drug. It is an antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. [PubChem]Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
D - Dermatologicals > D01 - Antifungals for dermatological use > D01B - Antifungals for systemic use > D01BA - Antifungals for systemic use
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AA - Antibiotics
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

同义名列表

31 个代谢物同义名

(2S,6R)-7-chloro-2,4,6-trimethoxy-6-methyl-3H-spiro[1-benzofuran-2,1-cyclohexan]-2-ene-3,4-dione; (+)-Griseofulvin; Curling factor; Griseofulvinum; Griseofulvina; Griseofulvine; Fulvicin u F; Griseofulvin; Fulvicin-u-F; V, Grifulvin; Spirofulvin; Grifulvin V; Grisefuline; sporostatin; Grisactin V; FulvicinUF; Grifulvin; Grisactin; Grisovin; Fulvicin; Gris peg; Gris-peg; Amudane; GrisPEG; Lamoryl; Likuden; Poncyl; Fulcin; Grysio; GRE; Griseofulvin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ABCB4, ACE2, ALB, CASP3, CAT, CYP2A6, CYP3A4, DMD, HPGDS, KRT18, KRT8
Peripheral membrane protein 2 DMD, SQLE
Endoplasmic reticulum membrane 3 CYP2A6, CYP3A4, SQLE
Nucleus 4 ALB, CASP3, DMD, KRT8
cytosol 9 ABCB4, ALB, CASP3, CAT, DMD, GPT, HPGDS, KRT18, KRT8
centrosome 1 ALB
nucleoplasm 4 ABCB4, CASP3, HPGDS, KRT8
Cell membrane 4 ABCB1, ABCB4, ACE2, TNF
Cytoplasmic side 1 DMD
Multi-pass membrane protein 2 ABCB1, ABCB4
Synapse 1 DMD
cell surface 5 ABCB1, ACE2, DMD, EPO, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ALB
mitochondrial inner membrane 1 FECH
neuronal cell body 2 CASP3, TNF
sarcolemma 2 DMD, KRT8
plasma membrane 7 ABCB1, ABCB4, ACE2, DMD, IFNLR1, IGHE, TNF
Membrane 9 ABCB1, ABCB4, ACE2, CAT, CYP2A6, CYP3A4, DMD, IFNLR1, SQLE
apical plasma membrane 3 ABCB1, ABCB4, ACE2
extracellular exosome 9 ABCB1, ABCB4, ACE2, ALB, CAT, EPO, GPT, KRT18, KRT8
endoplasmic reticulum 2 ALB, SQLE
extracellular space 5 ACE2, ALB, EPO, IGHE, TNF
perinuclear region of cytoplasm 1 KRT18
adherens junction 1 KRT18
apicolateral plasma membrane 1 KRT8
intercellular canaliculus 1 ABCB4
mitochondrion 2 CAT, FECH
protein-containing complex 3 ALB, CAT, DMD
intracellular membrane-bounded organelle 5 CAT, CYP2A6, CYP3A4, HPGDS, SQLE
Microsome membrane 2 CYP3A4, SQLE
filopodium 1 DMD
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 ACE2, IFNLR1, IGHE
Secreted 3 ACE2, ALB, EPO
extracellular region 6 ACE2, ALB, CAT, EPO, IGHE, TNF
mitochondrial matrix 2 CAT, FECH
anchoring junction 1 ALB
Cell projection, cilium 1 ACE2
centriolar satellite 1 KRT18
external side of plasma membrane 1 TNF
Z disc 2 DMD, KRT8
nucleolus 1 KRT18
cell-cell junction 1 KRT8
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 DMD
Apical cell membrane 3 ABCB1, ABCB4, ACE2
Cell membrane, sarcolemma 1 DMD
Mitochondrion inner membrane 1 FECH
Membrane raft 4 ABCB4, ACE2, DMD, TNF
Cytoplasm, cytoskeleton 1 DMD
focal adhesion 2 ABCB4, CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
intermediate filament 2 KRT18, KRT8
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
ciliary basal body 1 ALB
cilium 1 ACE2
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
cell periphery 1 KRT18
cytoskeleton 2 DMD, KRT18
centriole 1 ALB
brush border membrane 1 ACE2
Nucleus, nucleolus 1 KRT18
spindle pole 1 ALB
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
microtubule organizing center 1 KRT18
Nucleus, nucleoplasm 1 KRT8
cell body 1 EPO
intermediate filament cytoskeleton 1 KRT8
filopodium membrane 1 DMD
clathrin-coated vesicle 1 ABCB4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, EPO
endoplasmic reticulum lumen 2 ACE2, ALB
nuclear matrix 2 KRT18, KRT8
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 ACE2
Cytoplasmic vesicle, clathrin-coated vesicle 1 ABCB4
Single-pass type IV membrane protein 1 DMD
Nucleus matrix 2 KRT18, KRT8
costamere 2 DMD, KRT8
cytoplasmic microtubule 1 CYP2A6
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 2 DMD, KRT8
keratin filament 2 KRT18, KRT8
cell-substrate junction 1 DMD
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

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  • Yanjing Guo, Jingjing Li, Jiale Shi, Liru Mi, Jing Zhang, Su Han, Wei Liu, Dan Cheng, Sheng Qiang, Hazem M Kalaji, Shiguo Chen. Griseofulvin Inhibits Root Growth by Targeting Microtubule-Associated Proteins Rather Tubulins in Arabidopsis. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108692. [PMID: 37240033]
  • Hongke Huang, Dongxue Li, Shilong Jiang, Rui Yang, Yuqing Yang, Zhongqiu Xia, Xinyue Jiang, Yongtian Zhao, Delu Wang, Baoan Song, Zhuo Chen. Integrated Transcriptome and Proteome Analysis Reveals that the Antimicrobial Griseofulvin Targets Didymella segeticola Beta-Tubulin to Control Tea Leaf Spot. Phytopathology. 2023 Feb; ?(?):PHYTO02220061R. doi: 10.1094/phyto-02-22-0061-r. [PMID: 36173282]
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