Purine (BioDeep_00000001416)
Secondary id: BioDeep_00000399866
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
{7h-imidazo[4,} 5-D]pyrimidine
化学式: C5H4N4 (120.04359439999999)
中文名称: 嘌呤, 嘌呤
谱图信息:
最多检出来源 Viridiplantae(plant) 0.35%
分子结构信息
SMILES: C12=NC=NC=C1N=CN2
InChI: InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)
描述信息
Purine, also known as purine base or 1H-purine, belongs to the class of organic compounds known as purines and purine derivatives. These are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. Purine exists in all living species, ranging from bacteria to humans. High levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that lack an intrinsic uricase enzyme that can further degrade uric acid. In humans, purine is involved in thioguanine action pathway. Outside of the human body, purine is found, on average, in the highest concentration within cocoa beans. Purine has also been detected, but not quantified in several different foods, such as rapinis, plains prickly pears, blackcurrants, radish, and parsley. This could make purine a potential biomarker for the consumption of these foods. Purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring.
A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature. Purine is found in many foods, some of which are triticale, chickpea, japanese persimmon, and wild carrot.
KEIO_ID P049
Purine is an endogenous metabolite.
Purine is an endogenous metabolite.
同义名列表
34 个代谢物同义名
{7h-imidazo[4,} 5-D]pyrimidine; {6h-imidazo[4,5-D]pyrimidine}; 7H-imidazo(4,5-D)Pyrimidine; 6H-imidazo[4,5-D]Pyrimidine; {Imidazo[4,5-D]pyrimidine}; Propoxyphene Compound 65; imidazo(4,5-D)Pyrimidine; 7-Methyltheophylline; Methyltheobromine; β-Purine; Purine base; beta-Purine; Caffedrine; 7H-Purine; 9H-Purine; 1H-Purine; Isopurine; Durvitan; Coffeine; Mateina; Caffein; Phensal; Koffein; Cafipel; Dexitac; Purine; Diurex; Dasin; Purine; Purine (6CI,8CI); 3,5,7-Triazaindole; 3H-Imidazo[4,5-d]pyrimidine; NSC 753; β-Purine
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:17258
- ChEBI: CHEBI:35584
- ChEBI: CHEBI:35588
- ChEBI: CHEBI:26386
- ChEBI: CHEBI:35586
- ChEBI: CHEBI:35589
- KEGG: C15587
- PubChem: 1044
- HMDB: HMDB0001366
- Metlin: METLIN6193
- ChEMBL: CHEMBL302239
- Wikipedia: Purine
- MetaCyc: PURINE
- foodb: FDB007311
- chemspider: 1015
- CAS: 149297-77-8
- CAS: 51953-03-8
- CAS: 120-73-0
- MoNA: KO003749
- MoNA: KO003748
- MoNA: KO003751
- MoNA: KO003752
- MoNA: KO003750
- PMhub: MS000000474
- PubChem: 17396579
- NIKKAJI: J5.332E
- RefMet: Purine
- medchemexpress: HY-34431
分类词条
相关代谢途径
Reactome(0)
BioCyc(4)
PlantCyc(0)
代谢反应
10 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(10)
- purine nucleobases degradation I (anaerobic):
3,5-dihydro-4H-imidazol-4-one + H2O ⟶ N-formimino-glycine - purine nucleobases degradation I (anaerobic):
ATP + acetate ⟶ ADP + acetyl phosphate - purine nucleotides degradation III (anaerobic):
4-aminoimidazole + H2O ⟶ 4-imidazolone + H+ + ammonia - purine nucleotides degradation III (anaerobic):
acetylphosphate + ammonia + an oxidized thioredoxin ⟶ a reduced thioredoxin + gly + phosphate - purine nucleobases degradation I (anaerobic):
4-ureido-5-imidazole carboxylate + H2O + H+ ⟶ 4-amino-5-imidazole carboxylate + CO2 + ammonia - purine nucleobases degradation I (anaerobic):
ATP + acetate ⟶ ADP + acetyl phosphate - purine nucleobases degradation II (anaerobic):
3,5-dihydro-4H-imidazol-4-one + H2O ⟶ N-formimino-glycine - purine nucleotides degradation IV (anaerobic):
4-aminoimidazole + H2O ⟶ 4-imidazolone + H+ + ammonia - purine nucleotides degradation IV (anaerobic):
ser ⟶ H+ + ammonia + pyruvate - purine nucleobases degradation II (anaerobic):
ser ⟶ H+ + ammonia + pyruvate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 3818 - Arachis hypogaea: -
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-015-0840-5
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoyan Feng, Hongkun Ma, Lina Zou, Yingyao Wang, Yannan Zhang, Yan Wang, Jiaxin Chen, Hongzhi Pan, Shengzhong Rong. Determination of purines in prepackaged food using optimum acid hydrolysis followed by high performance liquid chromatography.
Food chemistry.
2023 Aug; 417(?):135813. doi:
10.1016/j.foodchem.2023.135813. [PMID: 36913870] - Jana Pilátová, Tomáš Pánek, Miroslav Oborník, Ivan Čepička, Peter Mojzeš. Revisiting biocrystallization: purine crystalline inclusions are widespread in eukaryotes.
The ISME journal.
2022 09; 16(9):2290-2294. doi:
10.1038/s41396-022-01264-1. [PMID: 35672454] - Eric M Burton, Benjamin E Gewurz. Epstein-Barr virus oncoprotein-driven B cell metabolism remodeling.
PLoS pathogens.
2022 02; 18(2):e1010254. doi:
10.1371/journal.ppat.1010254. [PMID: 35108325] - Dmitri Svistounov, Marit D Solbu, Trond G Jenssen, Ulla Dorte Mathisen, Terkel Hansen, Katja Benedikte Prestø Elgstøen, Svetlana N Zykova. Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry.
Scandinavian journal of clinical and laboratory investigation.
2022 02; 82(1):37-49. doi:
10.1080/00365513.2021.2015799. [PMID: 35048747] - Aigerim Soltabayeva, Aizat Bekturova, Assylay Kurmanbayeva, Dinara Oshanova, Zhadyrassyn Nurbekova, Sudhakar Srivastava, Dominic Standing, Moshe Sagi. Ureides are accumulated similarly in response to UV-C irradiation and wounding in Arabidopsis leaves but are remobilized differently during recovery.
Journal of experimental botany.
2022 01; 73(3):1016-1032. doi:
10.1093/jxb/erab441. [PMID: 34606608] - Huanhuan Wang, Lingzhu Xie, Xuhong Song, Jing Wang, Xinyan Li, Zhike Lin, Ting Su, Bin Liang, Dongyang Huang. Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.
Frontiers in immunology.
2022; 13(?):773001. doi:
10.3389/fimmu.2022.773001. [PMID: 35154100] - Phuc N Ho, Poramate Klanrit, Yupa Hanboonsong, Umaporn Yordpratum, Manida Suksawat, Thanaporn Kulthawatsiri, Anyarin Jirahiranpat, Suthicha Deewai, Panya Mackawan, Rasana W Sermswan, Nisana Namwat, Watcharin Loilome, Tueanjit Khampitak, Arporn Wangwiwatsin, Jutarop Phetcharaburanin. Bacterial challenge-associated metabolic phenotypes in Hermetia illucens defining nutritional and functional benefits.
Scientific reports.
2021 12; 11(1):23316. doi:
10.1038/s41598-021-02752-8. [PMID: 34857836] - Jayoung Kim, Amanda De Hoedt, Emily Wiggins, Kelsey Haywood, Peng Jin, Bennett Greenwood, Niven R Narain, Vladimir Tolstikov, Valerie Bussberg, Kamil E Barbour, Michael A Kiebish, Stephen J Freedland, Jennifer T Anger. Diagnostic Utility of Serum and Urinary Metabolite Analysis in Patients with Interstitial Cystitis/Painful Bladder Syndrome.
Urology.
2021 11; 157(?):85-92. doi:
10.1016/j.urology.2021.05.005. [PMID: 34010675] - Satoru Suzuki, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka. Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme.
Pharmaceutical research.
2021 Sep; 38(9):1585-1592. doi:
10.1007/s11095-021-03086-w. [PMID: 34435306] - Weibo Wang, Zhixinyi Li, Wei Gao, Xiaoyu Liu, You Lv, Zesheng Hao, Liangfu Tang, Kun Li, Bin Zhao, Zhijin Fan. Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound.
Journal of agricultural and food chemistry.
2021 Aug; 69(32):9461-9471. doi:
10.1021/acs.jafc.1c01651. [PMID: 34355907] - Michael Busche, M Regina Scarpin, Robert Hnasko, Jacob O Brunkard. TOR coordinates nucleotide availability with ribosome biogenesis in plants.
The Plant cell.
2021 07; 33(5):1615-1632. doi:
10.1093/plcell/koab043. [PMID: 33793860] - Bin Zhu, Shannon P Green, Xiuchun Ge, Tanya Puccio, Haider Nadhem, Henry Ge, Liang Bao, Todd Kitten, Ping Xu. Genome-wide identification of Streptococcus sanguinis fitness genes in human serum and discovery of potential selective drug targets.
Molecular microbiology.
2021 04; 115(4):658-671. doi:
10.1111/mmi.14629. [PMID: 33084151] - Barbara Maková, Václav Mik, Barbora Lišková, Gabriel Gonzalez, Dominik Vítek, Martina Medvedíková, Beata Monfort, Veronika Ručilová, Alena Kadlecová, Prashant Khirsariya, Zoila Gándara Barreiro, Libor Havlíček, Marek Zatloukal, Miroslav Soural, Kamil Paruch, Benoit D'Autréaux, Marián Hajdúch, Miroslav Strnad, Jiří Voller. Cytoprotective activities of kinetin purine isosteres.
Bioorganic & medicinal chemistry.
2021 03; 33(?):115993. doi:
10.1016/j.bmc.2021.115993. [PMID: 33497938] - Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz. Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
PloS one.
2021; 16(7):e0253852. doi:
10.1371/journal.pone.0253852. [PMID: 34255797] - Zarazuela Zolkipli-Cunningham, Jane C Naviaux, Tomohiro Nakayama, Charlotte M Hirsch, Jonathan M Monk, Kefeng Li, Lin Wang, Thuy P Le, Simone Meinardi, Donald R Blake, Robert K Naviaux. Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.
PloS one.
2021; 16(3):e0248771. doi:
10.1371/journal.pone.0248771. [PMID: 33735311] - Zhi-Ying Lv, Yong-Qing Yang, Lei-Miao Yin. Role of Purinergic Signaling in Acupuncture Therapeutics.
The American journal of Chinese medicine.
2021; 49(3):645-659. doi:
10.1142/s0192415x21500294. [PMID: 33641652] - Hiroki Nishi, Daisuke Yamanaka, Masato Masuda, Yuki Goda, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi. Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats.
Scientific reports.
2020 12; 10(1):22110. doi:
10.1038/s41598-020-79234-w. [PMID: 33335253] - Tongtong Kong, Xin Ren, Shanmeng Lin, Shengkang Li, Yi Gong. Elucidation of metabolic responses in mud crab Scylla paramamosain challenged to WSSV infection by integration of metabolomics and transcriptomics.
Developmental and comparative immunology.
2020 12; 113(?):103799. doi:
10.1016/j.dci.2020.103799. [PMID: 32738334] - Yajing Lv, Xiaoshuang Wang, Xiaoyu Li, Guangwei Xu, Yuting Bai, Jiayi Wu, Yongjun Piao, Yi Shi, Rong Xiang, Longlong Wang. Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.
PLoS biology.
2020 11; 18(11):e3000872. doi:
10.1371/journal.pbio.3000872. [PMID: 33186350] - Amitchihoué Franck Sessou, Jane W Kahia, Jerome Anani Houngue, Elijah Miinda Ateka, Colombe Dadjo, Corneille Ahanhanzo. In vitro propagation of three mosaic disease resistant cassava cultivars.
BMC biotechnology.
2020 09; 20(1):51. doi:
10.1186/s12896-020-00645-8. [PMID: 32993601] - Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-Wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin, Ayelet Erez. Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.
Nature cancer.
2020 09; 1(9):894-908. doi:
10.1038/s43018-020-0106-7. [PMID: 35121952] - Lijuan Xie, Yiwei Zhao, Jingyi Duan, Simiao Fan, Lexin Shu, Hui Liu, Yuming Wang, Yanyan Xu, Yubo Li. Integrated Proteomics and Metabolomics Reveal the Mechanism of Nephrotoxicity Induced by Triptolide.
Chemical research in toxicology.
2020 07; 33(7):1897-1906. doi:
10.1021/acs.chemrestox.0c00091. [PMID: 32519852] - Giulio R Romeo, Meenu Jain. Purine Metabolite Signatures and Type 2 Diabetes: Innocent Bystanders or Actionable Items?.
Current diabetes reports.
2020 06; 20(8):30. doi:
10.1007/s11892-020-01313-z. [PMID: 32519009] - Lee S Nguyen, Edi Prifti, Farid Ichou, Monique Leban, Christian Funck-Brentano, Philippe Touraine, Joe-Elie Salem, Anne Bachelot. Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis.
Scientific reports.
2020 06; 10(1):8859. doi:
10.1038/s41598-020-65897-y. [PMID: 32483270] - Lei Liu, Bin Wang, Dan Liu, Chunlei Zou, Peiran Wu, Ziyang Wang, Yubo Wang, Caifeng Li. Transcriptomic and metabolomic analyses reveal mechanisms of adaptation to salinity in which carbon and nitrogen metabolism is altered in sugar beet roots.
BMC plant biology.
2020 Apr; 20(1):138. doi:
10.1186/s12870-020-02349-9. [PMID: 32245415] - Wankun Wu, Rong Xu, Yingjun Lv, Endong Bao. Goose astrovirus infection affects uric acid production and excretion in goslings.
Poultry science.
2020 Apr; 99(4):1967-1974. doi:
10.1016/j.psj.2019.11.064. [PMID: 32241477] - Raji Balasubramanian, Nina P Paynter, Franco Giulianini, JoAnn E Manson, Yibai Zhao, Jiu-Chiuan Chen, Mara Z Vitolins, Christine A Albert, Clary Clish, Kathryn M Rexrode. Metabolomic profiles associated with all-cause mortality in the Women's Health Initiative.
International journal of epidemiology.
2020 02; 49(1):289-300. doi:
10.1093/ije/dyz211. [PMID: 31651959] - Izabela Grzegorczyk-Karolak, Katarzyna Hnatuszko-Konka, Mariola Zarzycka, Łukasz Kuźma. The Stimulatory Effect of Purine-Type Cytokinins on Proliferation and Polyphenolic Compound Accumulation in Shoot Culture of Salvia Viridis.
Biomolecules.
2020 01; 10(2):. doi:
10.3390/biom10020178. [PMID: 31991557] - T Ikenaga, H Noguchi, K Kakumoto, N Kohda, H Tsukikawa, K Matsuguma, T Yamamoto. Effect of phytic acid on postprandial serum uric acid level in healthy volunteers: a randomized, double-blind, crossover study.
Nucleosides, nucleotides & nucleic acids.
2020; 39(4):504-517. doi:
10.1080/15257770.2019.1656337. [PMID: 31469027] - Pengyang Li, Xihui Oyang, Xiaocan Xie, Yang Guo, Zhifang Li, Jialin Xi, Dongxue Zhu, Xiao Ma, Bin Liu, Jiuyi Li, Zhiyong Xiao. Perfluorooctanoic acid and perfluorooctane sulfonate co-exposure induced changes of metabolites and defense pathways in lettuce leaves.
Environmental pollution (Barking, Essex : 1987).
2020 Jan; 256(?):113512. doi:
10.1016/j.envpol.2019.113512. [PMID: 31706779] - Claus-Peter Witte, Marco Herde. Nucleotide Metabolism in Plants.
Plant physiology.
2020 01; 182(1):63-78. doi:
10.1104/pp.19.00955. [PMID: 31641078] - Geoffrey Burnstock. Introduction to Purinergic Signaling.
Methods in molecular biology (Clifton, N.J.).
2020; 2041(?):1-15. doi:
10.1007/978-1-4939-9717-6_1. [PMID: 31646477] - Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis.
Theranostics.
2020; 10(23):10665-10679. doi:
10.7150/thno.43528. [PMID: 32929373] - Eyal Grunebaum, Nicholas Campbell, Matilde Leon-Ponte, Xiaobai Xu, Hugo Chapdelaine. Partial Purine Nucleoside Phosphorylase Deficiency Helps Determine Minimal Activity Required for Immune and Neurological Development.
Frontiers in immunology.
2020; 11(?):1257. doi:
10.3389/fimmu.2020.01257. [PMID: 32695102] - Runbin Sun, Jingqiu Huang, Na Yang, Jun He, Xiaoyi Yu, Siqi Feng, Yuan Xie, Guangji Wang, Hui Ye, Jiye Aa. Purine Catabolism Shows a Dampened Circadian Rhythmicity in a High-fat Diet-Induced Mouse Model of Obesity.
Molecules (Basel, Switzerland).
2019 Dec; 24(24):. doi:
10.3390/molecules24244524. [PMID: 31835615] - Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang, Wei Sun. UPLC-MS based urine untargeted metabolomic analyses to differentiate bladder cancer from renal cell carcinoma.
BMC cancer.
2019 Dec; 19(1):1195. doi:
10.1186/s12885-019-6354-1. [PMID: 31805976] - Shunji Oshima, Sachie Shiiya, Yasunori Nakamura. Combined Supplementation with Glycine and Tryptophan Reduces Purine-Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study.
Nutrients.
2019 Oct; 11(11):. doi:
10.3390/nu11112562. [PMID: 31652875] - Sarah Gehrke, Nirmish Shah, Fabia Gamboni, Reed Kamyszek, Amudan J Srinivasan, Alan Gray, Matthew Landrigan, Ian Welsby, Angelo D'Alessandro. Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.
Transfusion.
2019 10; 59(10):3102-3112. doi:
10.1111/trf.15467. [PMID: 31385330] - Kristina Robbers, Edwin Westreicher-Kristen, Arnulf Troescher, Andreas Susenbeth. Effects of abomasally infused amylase and increasing amounts of corn starch on fecal excretion of starch, total and microbial nitrogen, and volatile fatty acids in heifers1.
Journal of animal science.
2019 Sep; 97(9):3984-3993. doi:
10.1093/jas/skz243. [PMID: 31325356] - Jacek Zieliński, Ewa M Slominska, Magdalena Król-Zielińska, Zbigniew Krasiński, Krzysztof Kusy. Purine metabolism in sprint- vs endurance-trained athletes aged 20‒90 years.
Scientific reports.
2019 08; 9(1):12075. doi:
10.1038/s41598-019-48633-z. [PMID: 31427706] - Zhi-Xue Cheng, Chang Guo, Zhuang-Gui Chen, Tian-Ci Yang, Jian-Ying Zhang, Jie Wang, Jia-Xin Zhu, Dan Li, Tian-Tuo Zhang, Hui Li, Bo Peng, Xuan-Xian Peng. Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing.
Nature communications.
2019 07; 10(1):3325. doi:
10.1038/s41467-019-11129-5. [PMID: 31346171] - Hirohide Takemura, Jae-Hoon Choi, Nobuo Matsuzaki, Yuki Taniguchi, Jing Wu, Hirofumi Hirai, Reiko Motohashi, Tomohiro Asakawa, Kazutada Ikeuchi, Makoto Inai, Toshiyuki Kan, Hirokazu Kawagishi. A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice.
Scientific reports.
2019 07; 9(1):9899. doi:
10.1038/s41598-019-46312-7. [PMID: 31289299] - Lina Yang, Yanyan Ru, Xingjia Cai, Ziyi Yin, Xinyu Liu, Yuhan Xiao, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang. MoImd4 mediates crosstalk between MoPdeH-cAMP signalling and purine metabolism to govern growth and pathogenicity in Magnaporthe oryzae.
Molecular plant pathology.
2019 04; 20(4):500-518. doi:
10.1111/mpp.12770. [PMID: 30426699] - Chaevien S Clendinen, David A Gaul, María Eugenia Monge, Rebecca S Arnold, Arthur S Edison, John A Petros, Facundo M Fernández. Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy.
Journal of proteome research.
2019 03; 18(3):1316-1327. doi:
10.1021/acs.jproteome.8b00926. [PMID: 30758971] - Alberto Casartelli, Vanessa J Melino, Ute Baumann, Matteo Riboni, Radoslaw Suchecki, Nirupama S Jayasinghe, Himasha Mendis, Mutsumi Watanabe, Alexander Erban, Ellen Zuther, Rainer Hoefgen, Ute Roessner, Mamoru Okamoto, Sigrid Heuer. Opposite fates of the purine metabolite allantoin under water and nitrogen limitations in bread wheat.
Plant molecular biology.
2019 Mar; 99(4-5):477-497. doi:
10.1007/s11103-019-00831-z. [PMID: 30721380] - M Krijt, O Souckova, V Baresova, V Skopova, M Zikanova. Metabolic Tools for Identification of New Mutations of Enzymes Engaged in Purine Synthesis Leading to Neurological Impairment.
Folia biologica.
2019; 65(3):152-157. doi:
. [PMID: 31638562] - Mamdouh A Abu-Zaied, Samah A Loutfy, Ashraf E Hassan, Galal H Elgemeie. Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models.
Drug design, development and therapy.
2019; 13(?):2437-2457. doi:
10.2147/dddt.s201249. [PMID: 31440030] - Yanjie Yang, Dehui Xu, Ning Ning, Yujing Xu. Analysis of Metabolite Profiling in Human Endothelial Cells after Plasma Jet Treatment.
BioMed research international.
2019; 2019(?):3015150. doi:
10.1155/2019/3015150. [PMID: 31781609] - M Khosravi, Y Rouzbehan, M Rezaei, J Rezaei. Total replacement of corn silage with sorghum silage improves milk fatty acid profile and antioxidant capacity of Holstein dairy cows.
Journal of dairy science.
2018 Dec; 101(12):10953-10961. doi:
10.3168/jds.2017-14350. [PMID: 30316585] - Aigerim Soltabayeva, Sudhakar Srivastava, Assylay Kurmanbayeva, Aizat Bekturova, Robert Fluhr, Moshe Sagi. Early Senescence in Older Leaves of Low Nitrate-Grown Atxdh1 Uncovers a Role for Purine Catabolism in N Supply.
Plant physiology.
2018 11; 178(3):1027-1044. doi:
10.1104/pp.18.00795. [PMID: 30190419] - Jennifer C Yu, Gene Lin, Joshua J Field, Joel Linden. Induction of antiinflammatory purinergic signaling in activated human iNKT cells.
JCI insight.
2018 09; 3(17):. doi:
10.1172/jci.insight.91954. [PMID: 30185656] - Josephine C McGowan, Collin Hill, Alessia Mastrodonato, Christina T LaGamma, Alexander Kitayev, Rebecca A Brachman, Niven R Narain, Michael A Kiebish, Christine A Denny. Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 08; 43(9):1813-1821. doi:
10.1038/s41386-018-0043-7. [PMID: 29599484] - Karolina Kubiasová, Václav Mik, Jaroslav Nisler, Martin Hönig, Alexandra Husičková, Lukáš Spíchal, Zuzana Pěkná, Olga Šamajová, Karel Doležal, Ondřej Plíhal, Eva Benková, Miroslav Strnad, Lucie Plíhalová. Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins.
Phytochemistry.
2018 Jun; 150(?):1-11. doi:
10.1016/j.phytochem.2018.02.015. [PMID: 29524794] - Edwin Westreicher-Kristen, Kristina Robbers, Ralf Blank, Arnulf Tröscher, Uta Dickhoefer, Siegfried Wolffram, Andreas Susenbeth. Postruminal digestion of starch infused into the abomasum of heifers with or without exogenous amylase administration.
Journal of animal science.
2018 May; 96(5):1939-1951. doi:
10.1093/jas/sky082. [PMID: 29617812] - Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, Katsuya Tsuchihara. Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.
Cancer research.
2018 05; 78(9):2179-2190. doi:
10.1158/0008-5472.can-17-2109. [PMID: 29490947] - Feidi Wang, Haijun Zhang, Ningbo Geng, Xiaoqian Ren, Baoqin Zhang, Yufeng Gong, Jiping Chen. A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs).
Environmental pollution (Barking, Essex : 1987).
2018 Mar; 234(?):572-580. doi:
10.1016/j.envpol.2017.11.073. [PMID: 29223814] - Yuhua Huang, Feilong Guo, Yousheng Li, Jian Wang, Jieshou Li. Fecal microbiota signatures of adult patients with different types of short bowel syndrome.
Journal of gastroenterology and hepatology.
2017 Dec; 32(12):1949-1957. doi:
10.1111/jgh.13806. [PMID: 28425133] - Carine F Souza, Matheus D Baldissera, Karen L S Moreira, Maria Izabel U M da Rocha, Marcelo L da Veiga, Roberto C V Santos, Bernardo Baldisserotto. Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide.
Microbial pathogenesis.
2017 Oct; 111(?):1-5. doi:
10.1016/j.micpath.2017.08.010. [PMID: 28804017] - Divya Sahu, Yair Lotan, Bryan Wittmann, Bruce Neri, Donna E Hansel. Metabolomics analysis reveals distinct profiles of nonmuscle-invasive and muscle-invasive bladder cancer.
Cancer medicine.
2017 Sep; 6(9):2106-2120. doi:
10.1002/cam4.1109. [PMID: 28766915] - N S K Gowthaman, Bharathi Sinduja, Rangasamy Karthikeyan, K Rubini, S Abraham John. Fabrication of nitrogen-doped carbon dots for screening the purine metabolic disorder in human fluids.
Biosensors & bioelectronics.
2017 Aug; 94(?):30-38. doi:
10.1016/j.bios.2017.02.034. [PMID: 28249204] - Sofia Balaska, Vassilios Myrianthopoulos, Martha Tselika, Dimitris G Hatzinikolaou, Emmanuel Mikros, George Diallinas. NmeA, a novel efflux transporter specific for nucleobases and nucleosides, contributes to metal resistance in Aspergillus nidulans.
Molecular microbiology.
2017 Aug; 105(3):426-439. doi:
10.1111/mmi.13708. [PMID: 28509393] - Xiao Lian, Bing Yan. Phosphonate MOFs Composite as Off-On Fluorescent Sensor for Detecting Purine Metabolite Uric Acid and Diagnosing Hyperuricuria.
Inorganic chemistry.
2017 Jun; 56(12):6802-6808. doi:
10.1021/acs.inorgchem.6b03009. [PMID: 28358494] - Li Su, Lei Shi, Jian Liu, Lifei Huang, Yi Huang, Xiaomeng Nie. Metabolic profiling of asthma in mice and the interventional effects of SPA using liquid chromatography and Q-TOF mass spectrometry.
Molecular bioSystems.
2017 May; 13(6):1172-1181. doi:
10.1039/c7mb00025a. [PMID: 28463380] - Lieke E J M Scheepers, Annelies Boonen, Wieke Pijnenburg, Jörgen Bierau, Jan A Staessen, Coen D A Stehouwer, Carel Thijs, Ilja C W Arts. Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study.
Journal of hypertension.
2017 05; 35(5):982-993. doi:
10.1097/hjh.0000000000001270. [PMID: 28355168] - Jodi L Westropp, Jennifer A Larsen, Eric G Johnson, Dannika Bannasch, Andrea J Fascetti, Vincent Biourge, Yann Queau. Evaluation of dogs with genetic hyperuricosuria and urate urolithiasis consuming a purine restricted diet: a pilot study.
BMC veterinary research.
2017 Feb; 13(1):45. doi:
10.1186/s12917-017-0958-y. [PMID: 28178975] - J Y Wu, D Wang, J Kong, X X Wang, X J Yu. [Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia].
Fa yi xue za zhi.
2017 Feb; 33(1):11-16. doi:
10.3969/j.issn.1004-5619.2017.01.003. [PMID: 29231001] - Koichiro Ueda, Tomohiro Mitani, Seiji Kondo. Effect of timing and type of supplementary grain on herbage intake, nitrogen utilization and milk production in dairy cows grazed on perennial ryegrass pasture from evening to morning.
Animal science journal = Nihon chikusan Gakkaiho.
2017 Jan; 88(1):107-118. doi:
10.1111/asj.12605. [PMID: 27145745] - Xiaomei Liu, Jun Wang, Linlin Gao, Hao Liu, Caixia Liu. iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(1):185-199. doi:
10.1159/000484626. [PMID: 29130966] - Sebastián Acosta-Jurado, Dulce-Nombre Rodríguez-Navarro, Yasuyuki Kawaharada, Juan Fernández Perea, Antonio Gil-Serrano, Haojie Jin, Qi An, Miguel A Rodríguez-Carvajal, Stig U Andersen, Niels Sandal, Jens Stougaard, José-María Vinardell, José E Ruiz-Sainz. Sinorhizobium fredii HH103 Invades Lotus burttii by Crack Entry in a Nod Factor-and Surface Polysaccharide-Dependent Manner.
Molecular plant-microbe interactions : MPMI.
2016 12; 29(12):925-937. doi:
10.1094/mpmi-09-16-0195-r. [PMID: 27827003] - Fred R Opperdoes, Anzhelika Butenko, Pavel Flegontov, Vyacheslav Yurchenko, Julius Lukeš. Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids.
The Journal of eukaryotic microbiology.
2016 09; 63(5):657-78. doi:
10.1111/jeu.12315. [PMID: 27009761] - Angelo D'Alessandro, Hunter B Moore, Ernest E Moore, Matthew J Wither, Travis Nemkov, Alexander P Morton, Eduardo Gonzalez, Michael P Chapman, Miguel Fragoso, Anne Slaughter, Angela Sauaia, Christopher C Silliman, Kirk C Hansen, Anirban Banerjee. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock.
Shock (Augusta, Ga.).
2016 08; 46(2):173-82. doi:
10.1097/shk.0000000000000588. [PMID: 26863033] - Zhe Wang, Min-Yi Li, Bo Peng, Zhi-Xue Cheng, Hui Li, Xuan-Xian Peng. GC-MS-Based Metabolome and Metabolite Regulation in Serum-Resistant Streptococcus agalactiae.
Journal of proteome research.
2016 07; 15(7):2246-53. doi:
10.1021/acs.jproteome.6b00215. [PMID: 27251450] - U Dickhoefer, S Ahnert, A Susenbeth. Effects of quebracho tannin extract on rumen fermentation and yield and composition of microbial mass in heifers.
Journal of animal science.
2016 Apr; 94(4):1561-75. doi:
10.2527/jas.2015-0061. [PMID: 27136015] - Hiroshi Takagi, Yasuhiro Ishiga, Shunsuke Watanabe, Tomokazu Konishi, Mayumi Egusa, Nobuhiro Akiyoshi, Takakazu Matsuura, Izumi C Mori, Takashi Hirayama, Hironori Kaminaka, Hiroshi Shimada, Atsushi Sakamoto. Allantoin, a stress-related purine metabolite, can activate jasmonate signaling in a MYC2-regulated and abscisic acid-dependent manner.
Journal of experimental botany.
2016 Apr; 67(8):2519-2532. doi:
10.1093/jxb/erw071. [PMID: 26931169] - Yaoyao Wang, Richard Caldwell, David A Cowan, Cristina Legido-Quigley. LC-MS-Based Metabolomics Discovers Purine Endogenous Associations with Low-Dose Salbutamol in Urine Collected for Antidoping Tests.
Analytical chemistry.
2016 Feb; 88(4):2243-9. doi:
10.1021/acs.analchem.5b03927. [PMID: 26760048] - Yumi Kim, In-Seung Lee, Kang-Hoon Kim, Jiyoung Park, Ji-Hyun Lee, Eunjung Bang, Hyeung-Jin Jang, Yun-Cheol Na. Metabolic Profiling of Liver Tissue in Diabetic Mice Treated with Artemisia Capillaris and Alisma Rhizome Using LC-MS and CE-MS.
The American journal of Chinese medicine.
2016; 44(8):1639-1661. doi:
10.1142/s0192415x16500920. [PMID: 27852124] - Iris Del Castillo Velasco-Martínez, Claudia J Hernández-Camacho, Lía C Méndez-Rodríguez, Tania Zenteno-Savín. Purine metabolism in response to hypoxic conditions associated with breath-hold diving and exercise in erythrocytes and plasma from bottlenose dolphins (Tursiops truncatus).
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2016 Jan; 191(?):196-201. doi:
10.1016/j.cbpa.2015.10.021. [PMID: 26506131] - Qin Sun. Urine Purine Metabolite Determination by UPLC-Tandem Mass Spectrometry.
Methods in molecular biology (Clifton, N.J.).
2016; 1378(?):227-35. doi:
10.1007/978-1-4939-3182-8_24. [PMID: 26602134] - Zhipan Yang, Zengzhen Shang, Lei Wang, Qingtao Lu, Xiaogang Wen, Wei Chi, Lixin Zhang, Congming Lu. Purine biosynthetic enzyme ATase2 is involved in the regulation of early chloroplast development and chloroplast gene expression in Arabidopsis.
Photosynthesis research.
2015 Dec; 126(2-3):285-300. doi:
10.1007/s11120-015-0131-z. [PMID: 25837856] - Tippapha Pisithkul, Tyler B Jacobson, Thomas J O'Brien, David M Stevenson, Daniel Amador-Noguez. Phenolic Amides Are Potent Inhibitors of De Novo Nucleotide Biosynthesis.
Applied and environmental microbiology.
2015 Sep; 81(17):5761-72. doi:
10.1128/aem.01324-15. [PMID: 26070680] - Hamako Sasamoto, Yoshiharu Fujii, Hiroshi Ashihara. Effect of purine alkaloids on the proliferation of lettuce cells derived from protoplasts.
Natural product communications.
2015 May; 10(5):751-4. doi:
". [PMID: 26058150] - Yuling Yin, Riko Katahira, Hiroshi Ashihara. Metabolism of purine alkaloids and xanthine in leaves of maté (Ilex paraguariensis).
Natural product communications.
2015 May; 10(5):707-12. doi:
. [PMID: 26058140] - Martial Boutchueng-Djidjou, Gabriel Collard-Simard, Suzanne Fortier, Sébastien S Hébert, Isabelle Kelly, Christian R Landry, Robert L Faure. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.
Molecular & cellular proteomics : MCP.
2015 Apr; 14(4):1079-92. doi:
10.1074/mcp.m114.047159. [PMID: 25687571] - Gloria Fernández-Cureses, Sonia de Castro, María-Luisa Jimeno, Jan Balzarini, María-José Camarasa. Design, synthesis, and biological evaluation of unconventional aminopyrimidine, aminopurine, and amino-1,3,5-triazine methyloxynucleosides.
ChemMedChem.
2015 Feb; 10(2):321-35. doi:
10.1002/cmdc.201402465. [PMID: 25420933] - Dagmara A Jankowska, Anke Trautwein-Schult, Arno Cordes, Rüdiger Bode, Keith Baronian, Gotthard Kunze. A novel enzymatic approach in the production of food with low purine content using Arxula adeninivorans endogenous and recombinant purine degradative enzymes.
Bioengineered.
2015; 6(1):20-5. doi:
10.4161/21655979.2014.991667. [PMID: 25513995] - Ying-Yong Zhao, Dan-Dan Tang, Hua Chen, Jia-Rong Mao, Xu Bai, Xiao-Hong Cheng, Xin-Yue Xiao. Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS.
Bioanalysis.
2015; 7(6):685-700. doi:
10.4155/bio.14.309. [PMID: 25871586] - Gordana Kocic, Dusan Sokolovic, Tatjana Jevtovic, Tatjana Cvetkovic, Andrej Veljkovic, Hristina Kocic, Svetlana Stojanovic, Aneta Jovanovic, Jelena Jovanovic, Petar Zivkovic. Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia.
Journal of dairy science.
2014 Nov; 97(11):6823-7. doi:
10.3168/jds.2014-8556. [PMID: 25218755] - Lina Zou, Yinfeng Li, Shaokui Cao, Baoxian Ye. A new voltammetric sensor for sensitive and selective determination of xanthine based on DNA and polyaniline composite Langmuir-Blodgett film.
Talanta.
2014 Nov; 129(?):346-51. doi:
10.1016/j.talanta.2014.05.057. [PMID: 25127605] - Mariko Forconi, Maria Assunta Biscotti, Marco Barucca, Francesco Buonocore, Gianluca De Moro, Anna Maria Fausto, Marco Gerdol, Alberto Pallavicini, Giuseppe Scapigliati, Manfred Schartl, Ettore Olmo, Adriana Canapa. Characterization of purine catabolic pathway genes in coelacanths.
Journal of experimental zoology. Part B, Molecular and developmental evolution.
2014 Sep; 322(6):334-41. doi:
10.1002/jez.b.22515. [PMID: 23733620] - E R Farmer, H A Tucker, H M Dann, K W Cotanch, C S Mooney, A L Lock, K Yagi, R J Grant. Effect of reducing dietary forage in lower starch diets on performance, ruminal characteristics, and nutrient digestibility in lactating Holstein cows.
Journal of dairy science.
2014 Sep; 97(9):5742-53. doi:
10.3168/jds.2014-7963. [PMID: 24996272] - Flávia Camila Schimpl, Eduardo Kiyota, Juliana Lischka Sampaio Mayer, José Francisco de Carvalho Gonçalves, José Ferreira da Silva, Paulo Mazzafera. Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit.
Phytochemistry.
2014 Sep; 105(?):25-36. doi:
10.1016/j.phytochem.2014.04.018. [PMID: 24856135] - S E Aggrey, J Lee, A B Karnuah, R Rekaya. Transcriptomic analysis of genes in the nitrogen recycling pathway of meat-type chickens divergently selected for feed efficiency.
Animal genetics.
2014 Apr; 45(2):215-22. doi:
10.1111/age.12098. [PMID: 24330162] - Shunsuke Watanabe, Mayumi Matsumoto, Yuki Hakomori, Hiroshi Takagi, Hiroshi Shimada, Atsushi Sakamoto. The purine metabolite allantoin enhances abiotic stress tolerance through synergistic activation of abscisic acid metabolism.
Plant, cell & environment.
2014 Apr; 37(4):1022-36. doi:
10.1111/pce.12218. [PMID: 24182190] - Li Ma, Qian Ma, Xuan Li, Leilei Cheng, Kai Li, Sheng Li. Transcriptomic analysis of differentially expressed genes in the Ras1(CA)-overexpressed and wildtype posterior silk glands.
BMC genomics.
2014 Mar; 15(?):182. doi:
10.1186/1471-2164-15-182. [PMID: 24606580] - Jae-Hoon Choi, Toshiyuki Ohnishi, Yasuhiro Yamakawa, Shogo Takeda, Shuhei Sekiguchi, Waki Maruyama, Kimiko Yamashita, Tomohiro Suzuki, Akio Morita, Takashi Ikka, Reiko Motohashi, Yoshikazu Kiriiwa, Hiroyuki Tobina, Tatsuo Asai, Shinji Tokuyama, Hirofumi Hirai, Nobuhiro Yasuda, Keiichi Noguchi, Tomohiro Asakawa, Shimpei Sugiyama, Toshiyuki Kan, Hirokazu Kawagishi. The source of "fairy rings": 2-azahypoxanthine and its metabolite found in a novel purine metabolic pathway in plants.
Angewandte Chemie (International ed. in English).
2014 Feb; 53(6):1552-5. doi:
10.1002/anie.201308109. [PMID: 24402866] - Yunyun Zhu, Wenjuan Cong, Lan Shen, Hai Wei, Yuan Wang, Lingyi Wang, Kefeng Ruan, Fei Wu, Yi Feng. Fecal metabonomic study of a polysaccharide, MDG-1 from Ophiopogon japonicus on diabetic mice based on gas chromatography/time-of-flight mass spectrometry (GC TOF/MS).
Molecular bioSystems.
2014 Feb; 10(2):304-12. doi:
10.1039/c3mb70392d. [PMID: 24292023] - Anke Trautwein-Schult, Dagmara Jankowska, Arno Cordes, Petra Hoferichter, Christina Klein, Andrea Matros, Hans-Peter Mock, Keith Baronian, Rüdiger Bode, Gotthard Kunze. Arxula adeninivorans recombinant guanine deaminase and its application in the production of food with low purine content.
Journal of molecular microbiology and biotechnology.
2014; 24(2):67-81. doi:
10.1159/000357674. [PMID: 24481069] - Tracey Gerber, Melissa Louise Borg, Alan Hayes, Christos George Stathis. High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling.
European journal of applied physiology.
2014; 114(7):1513-20. doi:
10.1007/s00421-014-2878-x. [PMID: 24748529] - Qingqing Wei, Xiao Xiao, Paul Fogle, Zheng Dong. Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion.
PloS one.
2014; 9(9):e106647. doi:
10.1371/journal.pone.0106647. [PMID: 25191961]