2-Aminobenzoic acid (BioDeep_00000001194)

 

Secondary id: BioDeep_00000400097, BioDeep_00000400192

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Toxin BioNovoGene_Lab2019


Metabolite Card


Anthranilic acid, calcium (2:1) salt

Formula: C7H7NO2 (137.0476762)
Chinese Names: 邻氨基苯甲酸
Spectrum Hits: Top Source Homo sapiens(blood) 0.01%

Molecular Structure

SMILES: C1=CC=C(C(=C1)C(=O)O)N
InChI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)

Description

2-Aminobenzoic acid, also known as anthranilic acid or O-aminobenzoate, belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety. Within humans, 2-aminobenzoic acid participates in a number of enzymatic reactions. In particular, 2-aminobenzoic acid and formic acid can be biosynthesized from formylanthranilic acid through its interaction with the enzyme kynurenine formamidase. In addition, 2-aminobenzoic acid and L-alanine can be biosynthesized from L-kynurenine through its interaction with the enzyme kynureninase. It is a substrate of enzyme 2-Aminobenzoic acid hydroxylase in benzoate degradation via hydroxylation pathway (KEGG). In humans, 2-aminobenzoic acid is involved in tryptophan metabolism. Outside of the human body, 2-Aminobenzoic acid has been detected, but not quantified in several different foods, such as mamey sapotes, prairie turnips, rowals, natal plums, and hyacinth beans. This could make 2-aminobenzoic acid a potential biomarker for the consumption of these foods. 2-Aminobenzoic acid is a is a tryptophan-derived uremic toxin with multidirectional properties that can affect the hemostatic system. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma.
2-Aminobenzoic acid is an organic compound. It is a substrate of enzyme anthranilate hydroxylase [EC 1.14.13.35] in benzoate degradation via hydroxylation pathway (KEGG). [HMDB]. Anthranilic acid is found in many foods, some of which are butternut squash, sunflower, ginger, and hyssop.
Acquisition and generation of the data is financially supported in part by CREST/JST.
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; INTERNAL_ID 8844
CONFIDENCE standard compound; INTERNAL_ID 8009
CONFIDENCE standard compound; INTERNAL_ID 115
KEIO_ID A010

Synonyms

39 synonym names

Anthranilic acid, calcium (2:1) salt; Anthranilic acid, monolithium salt; Anthranilic acid, monosodium salt; Anthranilic acid, dihydrochloride; Anthranilic acid, hydrochloride; Anthranilic acid, cadmium salt; 1-Amino-2-carboxybenzene; Kyselina O-aminobenzoova; 2-Aminophenylacetic acid; Ortho-aminobenzoic acid; Ortho-amidobenzoic acid; Kyselina anthranilova; 2-Amino-benzoic acid; 2-Aminophenylacetate; O-Amino-benzoic acid; sodium anthranilate; 2-Aminobenzoesaeure; O-Aminobenzoic acid; Ortho-aminobenzoate; O-Aminobenzoesaeure; 2-aminobenzoic acid; Ortho-amidobenzoate; Anthranilic acid GR; O-Anthranilic acid; 2-Carboxyaniline; O-Amino-benzoate; O-Carboxyaniline; Anthranilic acid; 2-Amino-benzoate; O-Aminobenzoate; 2-Aminobenzoate; O-Anthranilate; Carboxyaniline; Anthranic acid; Anthranilate; Anthranate; H-2-Abz-OH; Vitamin L1; Vitamin L



Cross Reference

57 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

346 related biological process reactions.

Reactome(0)

BioCyc(6)

WikiPathways(2)

Plant Reactome(328)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(9)

PharmGKB(0)

15 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



Literature Reference

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