Cordycepin (BioDeep_00000000114)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol

化学式: C10H13N5O3 (251.1018)
中文名称: 蛹虫草菌素, 虫草多糖, 虫草素, 冬虫夏草菌素, 3-脱氧腺苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 26.56%

分子结构信息

SMILES: C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
InChI: InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)

描述信息

Cordycepin is a 3-deoxyribonucleoside and a member of adenosines. It has a role as an antimetabolite and a nucleoside antibiotic.
Cordycepin has been used in trials studying the treatment of Leukemia.
Cordycepin is a natural product found in Aspergillus nidulans, Streptomyces sparsogenes, and other organisms with data available.
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase (AMPK) and reduces mammalian target of rapamycin (mTOR) signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D009676 - Noxae > D009153 - Mutagens
D000970 - Antineoplastic Agents
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2].
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2].
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2].

同义名列表

38 个代谢物同义名

(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol; (2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol; (2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol; (2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol; 9H-Purin-6-amine, 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-; 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol; 9-(3-Deoxy-b-D-erythro-pentofuranosyl)-9H-purin-6-amine; 9H-Purine, 6-amino-9-(3-deoxy-beta-D-ribofuranosyl)-; beta-D-erythro-Pentofuranoside, adenine-9 3-deoxy-; 4-26-00-03594 (Beilstein Handbook Reference); 9-(3-DEOXY-.BETA.-D-RIBOFURANOSYL)ADENINE; 9-(beta-D-3-Deoxyribofuranosyl)adenine; Cordycepin, from Cordyceps militaris; 2-Hydroxy-3-deoxyadenosine erythro; Cordycepin, >=98.0\\% (HPLC); 9-Cordyceposidoadenosine; 9-cordyceposidoadenine; Adenine cordyceposide; ADENOSINE, 3-DEOXY-; Cordycepin [WHO-DD]; 2-OH-3-dA erythro; 3-deoxy-adenosine; CORDYCEPIN [INCI]; 3-deoxyadenosine; UNII-GZ8VF4M2J8; CORDYCEPIN [MI]; Cordycepin,(S); PDSP1_001033; PDSP2_001017; cordycepine; cordycepene; Cordycepin; GZ8VF4M2J8; 3AD; NCGC00092360-03_C10H13N5O3_3-Deoxyadenosine; 3-Deoxyadenosine; Cordycepin; 3'-Deoxyadenosine



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ADA, AKT1, CAT, MAPK14, MTOR, NLRP3, PIK3CA, PRKAA2, PTGS2, PTK2, VEGFA
Peripheral membrane protein 4 ADA, MTOR, PTGS2, PTK2
Endoplasmic reticulum membrane 3 HMOX1, MTOR, PTGS2
Nucleus 9 ADK, AKT1, HMOX1, MAPK14, MTOR, NLRP3, PRKAA2, PTK2, VEGFA
cytosol 12 ADA, ADK, AKT1, CAT, HMOX1, MAPK14, MTOR, NLRP3, NT5E, PIK3CA, PRKAA2, PTK2
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 PTK2
nucleoplasm 7 ADK, AKT1, HMOX1, MAPK14, MTOR, NT5E, PRKAA2
Cell membrane 4 ADA, AKT1, NT5E, PTK2
Cytoplasmic side 3 HMOX1, MTOR, PTK2
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 2 MTOR, NLRP3
cell cortex 2 AKT1, PTK2
cell junction 1 ADA
cell surface 3 ADA, NT5E, VEGFA
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 PRKAA2, VEGFA
Golgi membrane 3 INS, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 1 PRKAA2
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NLRP3
Lysosome 2 ADA, MTOR
plasma membrane 6 ADA, ADK, AKT1, NT5E, PIK3CA, PTK2
Membrane 9 ADA, AKT1, CAT, HMOX1, MTOR, NLRP3, NT5E, PRKAA2, VEGFA
axon 1 PRKAA2
caveola 1 PTGS2
extracellular exosome 2 CAT, NT5E
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 HMOX1, NLRP3, PTGS2, VEGFA
extracellular space 8 CCL2, CXCL8, HMOX1, IL10, IL2, IL4, INS, VEGFA
perinuclear region of cytoplasm 3 HMOX1, PIK3CA, PTK2
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 CAT, MAPK14, NLRP3
protein-containing complex 3 AKT1, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, PTK2
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 8 CCL2, CXCL8, IL10, IL2, IL4, INS, NLRP3, VEGFA
extracellular region 10 CAT, CCL2, CXCL8, IL10, IL2, IL4, INS, MAPK14, NLRP3, VEGFA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 HMOX1, MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 2 ADA, PTK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
external side of plasma membrane 2 ADA, NT5E
Secreted, extracellular space, extracellular matrix 1 VEGFA
dendritic spine 1 PTK2
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 PTK2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 2 CAT, PTK2
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, PTK2
cell projection 1 PTK2
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
spindle pole 1 MAPK14
Cytoplasm, cell cortex 1 PTK2
Lipid-anchor, GPI-anchor 1 NT5E
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
side of membrane 1 NT5E
stress fiber 1 PTK2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
[Isoform 2]: Cytoplasm 1 ADK
[Isoform 1]: Nucleus 1 ADK
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
catalase complex 1 CAT
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Kozue Sakao, Cho Sho, Takeshi Miyata, Kensaku Takara, Rio Oda, De-Xing Hou. Verification of In Vitro Anticancer Activity and Bioactive Compounds in Cordyceps Militaris-Infused Sweet Potato Shochu Spirits. Molecules (Basel, Switzerland). 2024 May; 29(9):. doi: 10.3390/molecules29092119. [PMID: 38731610]
  • Ning Wang, Bo Hong, Yingchun Zhao, Chuanbo Ding, Guodong Chai, Yue Wang, Jiali Yang, Lifeng Zhang, Weimin Yu, Yang Lu, Shuang Ma, Shuai Zhang, Xinglong Liu. Dopamine-grafted oxidized hyaluronic acid/gelatin/cordycepin nanofiber membranes modulate the TLR4/NF-kB signaling pathway to promote diabetic wound healing. International journal of biological macromolecules. 2024 Mar; 262(Pt 1):130079. doi: 10.1016/j.ijbiomac.2024.130079. [PMID: 38340939]
  • Huizhen Sun, Shanshan Wei, Yanchun Gong, Kaizhi Ding, Shan Tang, Wei Sun, Chunhua Yuan, Liping Huang, Zhibing Liu, Chong Chen, Lihua Yao. Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons. Cell stress & chaperones. 2024 Jan; ?(?):. doi: 10.1016/j.cstres.2024.01.001. [PMID: 38219840]
  • Rongzhang Chen, Chen Feng, Lujun Chen, Xiao Zheng, Weiwei Fang, Shaoxian Wu, Xinran Gao, Can Chen, Jiayi Yang, Yue Wu, Yuanyuan Chen, Panpan Zheng, Nan Hu, Maoling Yuan, Yuanyuan Fu, Hanjie Ying, Jun Zhou, Jingting Jiang. Single-cell RNA sequencing indicates cordycepin remodels the tumor immune microenvironment to enhance TIGIT blockade's anti-tumor effect in colon cancer. International immunopharmacology. 2024 Jan; 126(?):111268. doi: 10.1016/j.intimp.2023.111268. [PMID: 37992442]
  • H B Zhou, L J Feng, X H Weng, T Wang, H Lu, Y B Bian, Z Y Huang, J L Zhang. Inhibition mechanism of cordycepin and ergosterol from Cordyceps militaris Link. against xanthine oxidase and cyclooxygenase-2. International journal of biological macromolecules. 2023 Dec; 258(Pt 2):128898. doi: 10.1016/j.ijbiomac.2023.128898. [PMID: 38141695]
  • Lujun Chen, Xiao Zheng, Hao Huang, Chen Feng, Shaoxian Wu, Rongzhang Chen, Hongwei Jiang, Maoling Yuan, Yuanyuan Fu, Hanjie Ying, Jun Zhou, Jingting Jiang. Cordycepin synergizes with CTLA-4 blockade to remodel the tumor microenvironment for enhanced cancer immunotherapy. International immunopharmacology. 2023 Aug; 124(Pt A):110786. doi: 10.1016/j.intimp.2023.110786. [PMID: 37611443]
  • P Snega Priya, Raghul Murugan, Bader O Almutairi, Selvaraj Arokiyaraj, P Shanjeev, Jesu Arockiaraj. Delineating the protective action of cordycepin against cadmium induced oxidative stress and gut inflammation through downregulation of NF-κB pathway. Environmental toxicology and pharmacology. 2023 Aug; 102(?):104246. doi: 10.1016/j.etap.2023.104246. [PMID: 37595934]
  • Min Chen, Jiahao Luo, Wenming Jiang, Lijing Chen, Longxing Miao, Chunchao Han. Cordycepin: A review of strategies to improve the bioavailability and efficacy. Phytotherapy research : PTR. 2023 Jun; ?(?):. doi: 10.1002/ptr.7921. [PMID: 37329165]
  • Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao. Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Apr; 163(?):114776. doi: 10.1016/j.biopha.2023.114776. [PMID: 37100012]
  • Xuebing Zhou, Chunyu Yang, Yuan Li, Dan Chen, Tong Wang, Tesi Liu, Wendi Yan, Zhaoxia Su, Bosen Peng, Xiangshan Ren. Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma. Life sciences. 2023 Apr; ?(?):121698. doi: 10.1016/j.lfs.2023.121698. [PMID: 37080351]
  • Jinyan Yu, Min Sun, Xiaoyu Wang, Dongmei Qi, Chunchao Han. Poly-pathways metabolomics for high-yielding cordycepin of Cordyceps militaris. Biomedical chromatography : BMC. 2023 Feb; 37(2):e5551. doi: 10.1002/bmc.5551. [PMID: 36408993]
  • Shenglan Qi, Huida Guan, Yongli Wang, Qinqin Fang, Xuemei Cheng, Ping Liu, Hai Wei, Wei Liu, Changhong Wang. Simultaneous determination of cordycepin and its metabolite 3'-deoxyinosine in rat whole blood by ultra-high-performance liquid chromatography coupled with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry and its application to accurate pharmacokinetic studies. Journal of separation science. 2023 Jan; 46(2):e2200602. doi: 10.1002/jssc.202200602. [PMID: 36377517]
  • Shi-Ru Zhang, Miao Pan, Ying-Bin Gao, Ruo-Yue Fan, Xin-Ni Bin, Si-Tong Qian, Cheng-Lun Tang, Han-Jie Ying, Jia-Qi Wu, Ming-Fang He. Efficacy and mechanism study of cordycepin against brain metastases of small cell lung cancer based on zebrafish. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154613. doi: 10.1016/j.phymed.2022.154613. [PMID: 36610112]
  • Rolf Teschke, Tran Dang Xuan. Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic Steps. Frontiers in bioscience (Landmark edition). 2022 11; 27(11):314. doi: 10.31083/j.fbl2711314. [PMID: 36472117]
  • Abdulmohsin J Alamoudi, Sami A Alessi, Waleed Y Rizg, Abdulmajeed M Jali, Awaji Y Safhi, Fahad Y Sabei, Sameer Alshehri, Khaled M Hosny, Ashraf B Abdel-Naim. Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation. Pharmaceutics. 2022 Aug; 14(8):. doi: 10.3390/pharmaceutics14081652. [PMID: 36015278]
  • Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Ren. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2022 Jun; 38(6):513-521. doi: . [PMID: 35732609]
  • Yuanxi Feng, Qiang Huang. Protective effects of cordycepin against d-galactose-induced aging in rats: A view from the heart. Geriatrics & gerontology international. 2022 May; 22(5):433-440. doi: 10.1111/ggi.14376. [PMID: 35352454]
  • Akalesh Kumar Verma. Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19. Journal of biomolecular structure & dynamics. 2022 05; 40(8):3745-3752. doi: 10.1080/07391102.2020.1850352. [PMID: 33225826]
  • Han Xu, Jing Cheng, Fei He. Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway. Journal of physiology and biochemistry. 2022 May; 78(2):401-413. doi: 10.1007/s13105-021-00816-x. [PMID: 35230668]
  • Ying-Chyi Song, Chuan-Teng Liu, Hui-Ju Lee, Hung-Rong Yen. Cordycepin prevents and ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte infiltration and reducing neuroinflammation. Biochemical pharmacology. 2022 03; 197(?):114918. doi: 10.1016/j.bcp.2022.114918. [PMID: 35063441]
  • Shabana Bibi, Mohammad Mehedi Hasan, Yuan-Bing Wang, Stavros P Papadakos, Hong Yu. Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp). Current medicinal chemistry. 2022; 29(1):152-162. doi: 10.2174/0929867328666210820114025. [PMID: 34420502]
  • Jinxiu Wang, Yanchun Gong, Haoyuan Tan, Wenxi Li, Baiyi Yan, Chunfang Cheng, Juan Wan, Wei Sun, Chunhua Yuan, Li-Hua Yao. Cordycepin suppresses glutamatergic and GABAergic synaptic transmission through activation of A1 adenosine receptor in rat hippocampal CA1 pyramidal neurons. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112446. doi: 10.1016/j.biopha.2021.112446. [PMID: 34808556]
  • Tzu-Yun Chou, Hsiao-Ping Kuo, Sheng-Fa Tsai, Shyue-Tsong Huang, Meei-Ju Yang, Shoei-Sheng Lee, Chia-Chuan Chang. Doubled production of cordycepin analogs in cultured Cordyceps militaris by addition of Andrea droppings. Natural product research. 2021 Dec; 35(23):5459-5464. doi: 10.1080/14786419.2020.1781112. [PMID: 32594773]
  • Shi Qi Zuo, Can Li, Yi Lun Liu, Yue Hao Tan, Xing Wan, Tian Xu, Qiang Li, Li Wang, Yong Li Wu, Feng Mei Deng, Bin Tang. Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway. FEBS open bio. 2021 10; 11(10):2705-2714. doi: 10.1002/2211-5463.13263. [PMID: 34448542]
  • Suthida Panwong, Methi Wathikthinnakon, Thida Kaewkod, Nunghathai Sawasdee, Yingmanee Tragoolpua, Pa-Thai Yenchitsomanus, Aussara Panya. Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26195973. [PMID: 34641520]
  • Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang, Rong-Jane Chen. The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164954. [PMID: 34443541]
  • Tian Lan, Yang Yu, Jing Zhang, Haonan Li, Qiqing Weng, Shuo Jiang, Song Tian, Tonghao Xu, Sha Hu, Guizhi Yang, Yan Zhang, Weixuan Wang, Lexun Wang, Qing Zhu, Xianglu Rong, Jiao Guo. Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway. Hepatology (Baltimore, Md.). 2021 08; 74(2):686-703. doi: 10.1002/hep.31749. [PMID: 33576035]
  • Junyu Zhang, Tongtong Jian, Yu Zhang, Guoying Zhang, Jianya Ling. Dynamic content changes of cordycepin and adenosine and transcriptome in Cordyceps kyushuensis Kob at different fermentation stages. Bioprocess and biosystems engineering. 2021 Aug; 44(8):1793-1803. doi: 10.1007/s00449-021-02561-3. [PMID: 33786675]
  • Aussara Panya, Pucharee Songprakhon, Suthida Panwong, Kanyaluck Jantakee, Thida Kaewkod, Yingmanee Tragoolpua, Nunghathai Sawasdee, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Pa-Thai Yenchitsomanus. Cordycepin Inhibits Virus Replication in Dengue Virus-Infected Vero Cells. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113118. [PMID: 34071102]
  • Xiao-Ling Zhang, Wen-Min Huang, Pei-Chen Tang, Ying Sun, Xin Zhang, Lu Qiu, Bo-Cheng Yu, Xiao-Yan Zhang, Yu-Xin Hong, Yun He, Xiao-Qun Ge. Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission. Neurotoxicology. 2021 05; 84(?):1-13. doi: 10.1016/j.neuro.2021.02.002. [PMID: 33549657]
  • Akalesh Kumar Verma, Rohit Aggarwal. Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm. Chemical biology & drug design. 2021 04; 97(4):836-853. doi: 10.1111/cbdd.13812. [PMID: 33289334]
  • Xiaobao Gong, Tianju Li, Rongzhen Wan, Lin Sha. Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses. International immunopharmacology. 2021 Feb; 91(?):107173. doi: 10.1016/j.intimp.2020.107173. [PMID: 33352441]
  • Chang-Wen Ku, Tsung-Jung Ho, Chih-Yang Huang, Pei-Ming Chu, Hsiu-Chung Ou, Pei-Ling Hsieh. Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway. The American journal of Chinese medicine. 2021; 49(7):1703-1722. doi: 10.1142/s0192415x21500804. [PMID: 34488549]
  • Dabing Li, Xiaoyan Liu, Lianmei Zhang, Jiayue He, Xianmao Chen, Shuguang Liu, Jiewen Fu, Shangyi Fu, Hanchun Chen, Junjiang Fu, Jingliang Cheng. COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2. International journal of biological sciences. 2021; 17(14):3954-3967. doi: 10.7150/ijbs.63072. [PMID: 34671211]
  • Warut Kengkittipat, Somrudee Kaewmalun, Mattaka Khongkow, Tawin Iempridee, Angkana Jantimaporn, Phichaporn Bunwatcharaphansakun, Jakarwan Yostawonkul, Teerapong Yata, Waranyoo Phoolcharoen, Katawut Namdee. Improvement of the multi-performance biocharacteristics of cordycepin using BiloNiosome-core/chitosan-shell hybrid nanocarriers. Colloids and surfaces. B, Biointerfaces. 2021 Jan; 197(?):111369. doi: 10.1016/j.colsurfb.2020.111369. [PMID: 33032178]
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