serin (BioDeep_00000001115)

Main id: BioDeep_00000014494

Secondary id: BioDeep_00000410695

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


DL-Serine, BioReagent, suitable for cell culture, suitable for insect cell culture, >=98\\% (HPLC)

化学式: C3H7NO3 (105.0426)
中文名称: L-丝氨酸, DL-丝氨酸, 丝氨酸, D-丝氨酸(mM/ml), D-丝氨酸
谱图信息: 最多检出来源 Viridiplantae(plant) 100%

分子结构信息

SMILES: C(C(C(=O)O)N)O
InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)

描述信息

Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV)[1].
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV)[1].
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

同义名列表

42 个代谢物同义名

DL-Serine, BioReagent, suitable for cell culture, suitable for insect cell culture, >=98\\% (HPLC); .alpha.-Amino-.beta.-hydroxypropionic acid; DL-Serine, Vetec(TM) reagent grade, 98\\%; (+/-)-2-Amino-3-hydroxypropionic acid; 86DE1CCF-D642-4822-9B51-508B465A7DEC; DL-2-Amino-3-hydroxypropionic Acid; Propanoic acid, 2-amino-3-hydroxy-; 2-Amino-3-hydroxy-propionic acid; 2-Amino-3-hydroxypropanoic acid; DL-Serine, analytical standard; DL-Serine, >=98\\% (TLC); .beta.-Hydroxyalanine; SERINE DL-FORM [MI]; DL-HOCH2CH(NH2)COOH; DL-SERINE [WHO-DD]; L-Serine-2-13c-15N; DL-SERINE (1-13C); 3-Hydroxyalanine; L-SERINE (2-13C); SERINE, L-[3-3H]; UNII-00PAR1C66F; NCIOpen2_000684; DL-Serine, 99\\%; DL-SERINE [FCC]; L-Serine-3,3-d2; Serine DL-form; SERINE, (L); Serine, DL-; H-DL-Ser-OH; 00PAR1C66F; d,l-serine; DL-Serine; D-serine; L-Serine; serin; 2-Amino-3-hydroxypropionic acid; SERINE; (R)-Serine; D-serine; L-Serine; D-Serine; Serine



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

150 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 CAT, DAO, EIF4EBP1, FST, KIF11, KIF2A, MTOR, PRKX, PYGB, RPS6, SMAD2, SMAD4, TOP2A
Peripheral membrane protein 2 DAO, MTOR
Endoplasmic reticulum membrane 3 MTOR, SERP1, SERP2
Nucleus 9 EIF4EBP1, FST, KIF11, MTOR, PRKX, RPS6, SMAD2, SMAD4, TOP2A
cytosol 11 CAT, DAO, EIF4EBP1, KIF11, KIF2A, MTOR, RPS6, SERP1, SMAD2, SMAD4, TDO2
dendrite 2 MTOR, RPS6
nuclear body 1 KIF2A
phagocytic vesicle 1 MTOR
centrosome 2 KIF2A, SMAD4
nucleoplasm 7 KIF2A, MTOR, PRKX, RPS6, SMAD2, SMAD4, TOP2A
RNA polymerase II transcription regulator complex 1 SMAD4
Cell membrane 1 DAO
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 1 RYR2
Golgi apparatus membrane 1 MTOR
Golgi membrane 1 MTOR
lysosomal membrane 2 GAA, MTOR
mitochondrial inner membrane 1 TDH
sarcolemma 1 RYR2
smooth endoplasmic reticulum 1 RYR2
Cytoplasm, cytosol 1 DAO
Lysosome 2 GAA, MTOR
plasma membrane 3 DAO, GAA, RYR2
presynaptic active zone 1 DAO
Membrane 11 CAT, GAA, KIF11, KIF2A, MTOR, PYGB, RPS6, RYR2, SERP1, SERP2, SMAD2
extracellular exosome 4 CAT, DAO, GAA, PYGB
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 3 RPS6, SERP1, SERP2
extracellular space 3 DAO, DCN, FST
lysosomal lumen 2 DCN, GAA
perinuclear region of cytoplasm 1 RPS6
bicellular tight junction 1 DAO
mitochondrion 2 CAT, TDH
protein-containing complex 5 CAT, KIF11, RYR2, SMAD2, TOP2A
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 DAO, DCN, GAA
extracellular region 6 CAT, DAO, DCN, FST, GAA, PYGB
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 2 SERP1, SERP2
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 DAO
transcription regulator complex 2 SMAD2, SMAD4
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 KIF2A
Secreted, extracellular space, extracellular matrix 1 DCN
Z disc 1 RYR2
nucleolus 3 KIF2A, RPS6, TOP2A
Cytoplasm, cytoskeleton 1 KIF2A
Cytoplasm, cytoskeleton, spindle 1 KIF2A
focal adhesion 1 CAT
microtubule 2 KIF11, KIF2A
spindle 2 KIF11, KIF2A
Peroxisome 2 CAT, DAO
sarcoplasmic reticulum 1 RYR2
Peroxisome matrix 2 CAT, DAO
peroxisomal matrix 2 CAT, DAO
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 DCN
chromatin 2 SMAD2, SMAD4
cell projection 1 DAO
mitotic spindle 1 KIF11
centriole 1 KIF2A
cytoplasmic ribonucleoprotein granule 1 RPS6
Secreted, extracellular space 1 DAO
Nucleus, nucleolus 2 RPS6, TOP2A
spindle pole 2 KIF11, KIF2A
Cytoplasm, cytoskeleton, spindle pole 1 KIF11
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Nucleus, nucleoplasm 1 TOP2A
tertiary granule membrane 1 GAA
cell body 1 RPS6
centriolar subdistal appendage 1 KIF2A
kinesin complex 2 KIF11, KIF2A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 DCN
male germ cell nucleus 1 TOP2A
specific granule lumen 1 DAO
azurophil granule membrane 1 GAA
azurophil granule lumen 1 PYGB
small-subunit processome 1 RPS6
Sarcoplasmic reticulum membrane 1 RYR2
chromosome, centromeric region 1 TOP2A
calcium channel complex 1 RYR2
junctional sarcoplasmic reticulum membrane 1 RYR2
ribonucleoprotein complex 2 RPS6, TOP2A
cytoplasmic microtubule 1 SERP1
heteromeric SMAD protein complex 2 SMAD2, SMAD4
SMAD protein complex 2 SMAD2, SMAD4
ficolin-1-rich granule membrane 1 GAA
condensed chromosome 1 TOP2A
Cytoplasmic vesicle, phagosome 1 MTOR
cytosolic ribosome 1 RPS6
activin responsive factor complex 2 SMAD2, SMAD4
ribosome 2 RPS6, SERP1
catalase complex 1 CAT
cytosolic small ribosomal subunit 1 RPS6
autolysosome lumen 1 GAA
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex 1 TOP2A
small ribosomal subunit 1 RPS6
homomeric SMAD protein complex 1 SMAD2


文献列表

  • Qingsheng Liu, Anuradha Singh, Lingyun Liu. Amino acid-based zwitterionic poly(serine methacrylate) as an antifouling material. Biomacromolecules. 2013 Jan; 14(1):226-31. doi: 10.1021/bm301646y. [PMID: 23228182]
  • Fei Geng, Weijia Zhu, Richard A Anderson, Brian Leber, David W Andrews. Multiple post-translational modifications regulate E-cadherin transport during apoptosis. Journal of cell science. 2012 Jun; 125(Pt 11):2615-25. doi: 10.1242/jcs.096735. [PMID: 22375065]
  • D Ehrlich, M Pirchl, C Humpel. Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. Neuroscience. 2012 Mar; 205(?):154-66. doi: 10.1016/j.neuroscience.2011.12.054. [PMID: 22244974]
  • Barbara Nesta, Glen Spraggon, Christopher Alteri, Danilo Gomes Moriel, Roberto Rosini, Daniele Veggi, Sara Smith, Isabella Bertoldi, Ilaria Pastorello, Ilaria Ferlenghi, Maria Rita Fontana, Gad Frankel, Harry L T Mobley, Rino Rappuoli, Mariagrazia Pizza, Laura Serino, Marco Soriani. FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections. mBio. 2012; 3(2):. doi: 10.1128/mbio.00010-12. [PMID: 22496310]
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  • Monica Borgatti, Irene Mancini, Nicoletta Bianchi, Alessandra Guerrini, Ilaria Lampronti, Damiano Rossi, Gianni Sacchetti, Roberto Gambari. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC biochemistry. 2011 Apr; 12(?):15. doi: 10.1186/1471-2091-12-15. [PMID: 21496221]
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  • Judith Buddensiek, Alexander Dressel, Michael Kowalski, Uwe Runge, Henry Schroeder, Andreas Hermann, Matthias Kirsch, Alexander Storch, Michael Sabolek. Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. BMC neuroscience. 2010 Apr; 11(?):48. doi: 10.1186/1471-2202-11-48. [PMID: 20377845]
  • H Bauer, J Zweimueller-Mayer, P Steinbacher, A Lametschwandtner, H C Bauer. The dual role of zonula occludens (ZO) proteins. Journal of biomedicine & biotechnology. 2010; 2010(?):402593. doi: 10.1155/2010/402593. [PMID: 20224657]
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