serin (BioDeep_00000001115)

Main id: BioDeep_00000014494

Secondary id: BioDeep_00000410695

PANOMIX_OTCML-2023


代谢物信息卡片


DL-Serine, BioReagent, suitable for cell culture, suitable for insect cell culture, >=98\\% (HPLC)

化学式: C3H7NO3 (105.0425912)
中文名称: DL-丝氨酸, L-丝氨酸, 丝氨酸, D-丝氨酸(mM/ml)
谱图信息: 最多检出来源 Viridiplantae(plant) 92.86%

分子结构信息

SMILES: C(C(C(=O)O)N)O
InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)

描述信息

Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV)[1].
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV)[1].
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

同义名列表

38 个代谢物同义名

DL-Serine, BioReagent, suitable for cell culture, suitable for insect cell culture, >=98\\% (HPLC); .alpha.-Amino-.beta.-hydroxypropionic acid; DL-Serine, Vetec(TM) reagent grade, 98\\%; (+/-)-2-Amino-3-hydroxypropionic acid; 86DE1CCF-D642-4822-9B51-508B465A7DEC; DL-2-Amino-3-hydroxypropionic Acid; Propanoic acid, 2-amino-3-hydroxy-; 2-Amino-3-hydroxy-propionic acid; 2-Amino-3-hydroxypropanoic acid; DL-Serine, analytical standard; DL-Serine, >=98\\% (TLC); .beta.-Hydroxyalanine; SERINE DL-FORM [MI]; DL-HOCH2CH(NH2)COOH; DL-SERINE [WHO-DD]; L-Serine-2-13c-15N; DL-SERINE (1-13C); 3-Hydroxyalanine; L-SERINE (2-13C); SERINE, L-[3-3H]; UNII-00PAR1C66F; NCIOpen2_000684; DL-Serine, 99\\%; DL-SERINE [FCC]; L-Serine-3,3-d2; Serine DL-form; SERINE, (L); Serine, DL-; H-DL-Ser-OH; 00PAR1C66F; d,l-serine; DL-Serine; D-serine; L-Serine; serin; 2-Amino-3-hydroxypropionic acid; SERINE; (R)-Serine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qingsheng Liu, Anuradha Singh, Lingyun Liu. Amino acid-based zwitterionic poly(serine methacrylate) as an antifouling material. Biomacromolecules. 2013 Jan; 14(1):226-31. doi: 10.1021/bm301646y. [PMID: 23228182]
  • Fei Geng, Weijia Zhu, Richard A Anderson, Brian Leber, David W Andrews. Multiple post-translational modifications regulate E-cadherin transport during apoptosis. Journal of cell science. 2012 Jun; 125(Pt 11):2615-25. doi: 10.1242/jcs.096735. [PMID: 22375065]
  • D Ehrlich, M Pirchl, C Humpel. Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. Neuroscience. 2012 Mar; 205(?):154-66. doi: 10.1016/j.neuroscience.2011.12.054. [PMID: 22244974]
  • Barbara Nesta, Glen Spraggon, Christopher Alteri, Danilo Gomes Moriel, Roberto Rosini, Daniele Veggi, Sara Smith, Isabella Bertoldi, Ilaria Pastorello, Ilaria Ferlenghi, Maria Rita Fontana, Gad Frankel, Harry L T Mobley, Rino Rappuoli, Mariagrazia Pizza, Laura Serino, Marco Soriani. FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections. mBio. 2012; 3(2):. doi: 10.1128/mbio.00010-12. [PMID: 22496310]
  • Raquel Rodríguez-González, Tomás Sobrino, Manuel Rodríguez-Yáñez, Mónica Millán, David Brea, Elena Miranda, Octavio Moldes, Juan Pérez, David A Lomas, Rogelio Leira, Antoni Dávalos, José Castillo. Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke. Journal of translational medicine. 2011 May; 9(?):58. doi: 10.1186/1479-5876-9-58. [PMID: 21569344]
  • Monica Borgatti, Irene Mancini, Nicoletta Bianchi, Alessandra Guerrini, Ilaria Lampronti, Damiano Rossi, Gianni Sacchetti, Roberto Gambari. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC biochemistry. 2011 Apr; 12(?):15. doi: 10.1186/1471-2091-12-15. [PMID: 21496221]
  • Weiyan Zhu, Ching-Ju Chen, Christopher E Thomas, James E Anderson, Ann E Jerse, P Frederick Sparling. Vaccines for gonorrhea: can we rise to the challenge?. Frontiers in microbiology. 2011; 2(?):124. doi: 10.3389/fmicb.2011.00124. [PMID: 21687431]
  • David M Maahs, Justyna Siwy, Angel Argilés, Marie Cerna, Christian Delles, Anna F Dominiczak, Nathalie Gayrard, Alexander Iphöfer, Lothar Jänsch, George Jerums, Karel Medek, Harald Mischak, Gerjan J Navis, Johannes M Roob, Kasper Rossing, Peter Rossing, Ivan Rychlík, Eric Schiffer, Roland E Schmieder, Thomas C Wascher, Brigitte M Winklhofer-Roob, Lukas U Zimmerli, Petra Zürbig, Janet K Snell-Bergeon. Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PloS one. 2010 Sep; 5(9):. doi: 10.1371/journal.pone.0013051. [PMID: 20927192]
  • Judith Buddensiek, Alexander Dressel, Michael Kowalski, Uwe Runge, Henry Schroeder, Andreas Hermann, Matthias Kirsch, Alexander Storch, Michael Sabolek. Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. BMC neuroscience. 2010 Apr; 11(?):48. doi: 10.1186/1471-2202-11-48. [PMID: 20377845]
  • H Bauer, J Zweimueller-Mayer, P Steinbacher, A Lametschwandtner, H C Bauer. The dual role of zonula occludens (ZO) proteins. Journal of biomedicine & biotechnology. 2010; 2010(?):402593. doi: 10.1155/2010/402593. [PMID: 20224657]
  • Tohru Ohnuma, Yoshie Sakai, Hitoshi Maeshima, Tokiko Hatano, Ryo Hanzawa, Sawako Abe, Sayaka Kida, Nobuto Shibata, Toshihito Suzuki, Heii Arai. Changes in plasma glycine, L-serine, and D-serine levels in patients with schizophrenia as their clinical symptoms improve: results from the Juntendo University Schizophrenia Projects (JUSP). Progress in neuro-psychopharmacology & biological psychiatry. 2008 Dec; 32(8):1905-12. doi: 10.1016/j.pnpbp.2008.07.022. [PMID: 18835577]
  • Soo Hyun An, Kee Hoon Sohn, Hyong Woo Choi, In Sun Hwang, Sung Chul Lee, Byung Kook Hwang. Pepper pectin methylesterase inhibitor protein CaPMEI1 is required for antifungal activity, basal disease resistance and abiotic stress tolerance. Planta. 2008 Jun; 228(1):61-78. doi: 10.1007/s00425-008-0719-z. [PMID: 18327607]
  • M Prakash, J K Shetty, L Rao, S Sharma, A Rodrigues, R Prabhu. Serum paraoxonase activity and protein thiols in chronic renal failure patients. Indian journal of nephrology. 2008 Jan; 18(1):13-6. doi: 10.4103/0971-4065.41282. [PMID: 20368914]
  • Guillermo López, Jordi Figuerola, Ramón Soriguer. Time of day, age and feeding habits influence coccidian oocyst shedding in wild passerines. International journal for parasitology. 2007 Apr; 37(5):559-64. doi: 10.1016/j.ijpara.2006.12.014. [PMID: 17289051]
  • C Zweifel, S Schumacher, L Beutin, J Blanco, R Stephan. Virulence profiles of Shiga toxin 2e-producing Escherichia coli isolated from healthy pig at slaughter. Veterinary microbiology. 2006 Oct; 117(2-4):328-32. doi: 10.1016/j.vetmic.2006.06.017. [PMID: 16872761]
  • Guzi Li, Michael Hundemer, Sonja Wolfrum, Anthony D Ho, Hartmut Goldschmidt, Mathias Witzens-Harig. Identification and characterization of HLA-class-I-restricted T-cell epitopes in the putative tumor-associated antigens P21-activated serin kinase 2 (PAK2) and cyclin-dependent kinase inhibitor 1A (CDKN1A). Annals of hematology. 2006 Sep; 85(9):583-90. doi: 10.1007/s00277-006-0137-x. [PMID: 16718496]
  • Carsten Rautengarten, Dirk Steinhauser, Dirk Büssis, Annick Stintzi, Andreas Schaller, Joachim Kopka, Thomas Altmann. Inferring hypotheses on functional relationships of genes: Analysis of the Arabidopsis thaliana subtilase gene family. PLoS computational biology. 2005 Sep; 1(4):e40. doi: 10.1371/journal.pcbi.0010040. [PMID: 16193095]
  • Mônica Lopes-Ferreira, José Artur da Silva Emim, Vitor Oliveira, Luciano Puzer, Maria Helena Cezari, Mariana da Silva Araújo, Luiz Juliano, Antônio José Lapa, Caden Souccar, Ana Maria Moura-da-Silva. Kininogenase activity of Thalassophryne nattereri fish venom. Biochemical pharmacology. 2004 Dec; 68(11):2151-7. doi: 10.1016/j.bcp.2004.07.037. [PMID: 15498505]
  • Daisuke Fukuta, Shuji Miyagawa, Tomoko Kubo, Tamiko Kusama, Akio Shirasu, Hiroyuki Hattori, Ryota Shirakura. Only the light chain is sufficient for the serine protease function of the membrane bound form of factor I on a xeno-surface. Transplant immunology. 2004 Jan; 12(2):109-14. doi: 10.1016/j.trim.2003.11.001. [PMID: 14967308]
  • O D Zinkevich, Iu A Glushko, N A Cafina, Iu A Tiurin. [The spectrum and activity of urinary Ig-proteinases as a marker of chronic pyelonephritis]. Terapevticheskii arkhiv. 2004; 76(4):43-5. doi: NULL. [PMID: 15174321]
  • Renaud Villard, Djilali Hammache, Guillaume Delapierre, Frédéric Fotiadu, Gérard Buono, Jacques Fantini. Asymmetric synthesis of water-soluble analogues of galactosylceramide, an HIV-1 receptor: new tools to study virus-glycolipid interactions. Chembiochem : a European journal of chemical biology. 2002 Jun; 3(6):517-25. doi: 10.1002/1439-7633(20020603)3:6<517::aid-cbic517>3.0.co;2-n. [PMID: 12325007]
  • A Hasper, P Soteropoulos, D S Perlin. Modification of the N-terminal polyserine cluster alters stability of the plasma membrane H(+)-ATPase from Saccharomyces cerevisiae. Biochimica et biophysica acta. 1999 Aug; 1420(1-2):214-22. doi: 10.1016/s0005-2736(99)00100-5. [PMID: 10446304]
  • M Nakagawa, M Uchiyama. Effect of organophosphate pesticides on lecithin-cholesterol acyltransferase in human plasma. Biochemical pharmacology. 1974 May; 23(11):1641-5. doi: 10.1016/0006-2952(74)90376-1. [PMID: 4847537]