Bovinocidin (BioDeep_00000001089)
human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs
代谢物信息卡片
2-(4-Nitrophenylamino)thiazole-4-carboxylicacid
化学式: C3H5NO4 (119.0219)
中文名称: 3-硝基丙酸
谱图信息:
最多检出来源 Homo sapiens(otcml) 36.09%
分子结构信息
SMILES: C(C[N+](=O)[O-])C(=O)O
InChI: InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
描述信息
3-nitropropionic acid appears as golden crystals (from chloroform). (NTP, 1992)
3-nitropropanoic acid is a C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. It has a role as a neurotoxin, an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor, an antimycobacterial drug and a mycotoxin. It is functionally related to a propionic acid. It is a conjugate acid of a 3-nitropropanoate. It is a tautomer of a 3-aci-nitropropanoic acid.
3-Nitropropionic acid is a natural product found in Indigofera suffruticosa, Coscinoderma, and other organisms with data available.
Bovinocidin is isolated from Aspergillus sp. and moulds contaminating foodBovinocidin belongs to the family of Beta Amino Acids and Derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
Bovinocidin is isolated from Aspergillus sp. and moulds contaminating foo
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Isolated from Aspergillus species and moulds contaminating food.
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM[1][2].
同义名列表
67 个代谢物同义名
2-(4-Nitrophenylamino)thiazole-4-carboxylicacid; 4-02-00-00771 (Beilstein Handbook Reference); 3-Nitropropanoic acid; 3-nitropropanoate; 3-Nitropropionic acid - CAS 504-88-1; BOVINOCIDIN (3-nitropropionic acid); Propanoic acid, 3-nitro- (9CI); 3-Nitropropionic acid, >=97\\%; 3-NITROPROPIONIC ACID [HSDB]; 3-Nitropropionic acid, 97\\%; Nitropropionic acid, .beta.; .beta.-Nitropropionic acid; 3-Nitropropionic acid, 8CI; beta -nitropropionic acid; NITROPROPIONIC ACID, BETA; beta-nitropropionic acid; Propionic acid, 3-nitro-; beta-Nitropropanoic acid; Nitropropionic aci, beta; Propanoic acid, 3-nitro-; Nitropropionic acid, 3-; 3-Nitro-Propanoic acid; propionate 3-nitronate; 3-nitro-propionic acid; 3-Nitropropanoic acid; Β-nitropropanoic acid; b-Nitropropanoic acid; 3-Nitropropionic acid; 3-Nitroporpionic Acid; Β-nitropropionic acid; b-nitropropionic acid; 504-88-1 (FREE acid); 3-nitro-1-propionate; beta-Nitropropionate; beta-Nitropropanoate; Β-nitropropanoate; 3-nitropropionate; b-Nitropropanoate; b-Nitropropionate; Β-nitropropionate; 3-Nitropropanoate; Spectrum4_001119; Spectrum5_001895; Spectrum3_000993; Spectrum2_000876; UNII-QY4L0FOX0D; Hiptagenic acid; DivK1c_006788; Lopac0_000838; KBio1_001732; Tox21_500838; KBio3_001905; Tox21_303007; Tox21_202460; KBio2_007290; KBio2_004722; KBio2_002154; Bovinocidin; WLN: WN2VQ; QY4L0FOX0D; 3-NP acid; NSC 64266; 3-NPA; 3-NP; 3NP; BNP; beta-Nitropropanoate; 3-Nitropropionic acid
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:16348
- KEGG: C05669
- PubChem: 1678
- HMDB: HMDB0034259
- Metlin: METLIN44116
- ChEMBL: CHEMBL451226
- Wikipedia: Beta-Nitropropionic_acid
- MeSH: 3-nitropropionic acid
- ChemIDplus: 0000504881
- KNApSAcK: C00018684
- foodb: FDB012579
- chemspider: 1615
- CAS: 504-88-1
- medchemexpress: HY-W012875
- PMhub: MS000012786
- PubChem: 7977
- PDB-CCD: 3NP
- 3DMET: B00833
- NIKKAJI: J12.998D
- RefMet: Bovinocidin
- KNApSAcK: 16348
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 1162776 - Coscinoderma: 10.1021/NP500156N
- 9606 - Homo sapiens: -
- 100149 - Indigofera suffruticosa: 10.1016/S0305-1978(02)00087-X
- 69764 - Penicillium atrovenetum:
- 1807033 - Phomopsis velata: 10.1016/S0031-9422(00)83157-X
- 53861 - Securigera varia: 10.1007/BF02887073
- 562744 - Synoicum:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fereshteh Badini, Abolfazl Bayrami, Mohammad Ali Mirshekar, Samira Shahraki, Hamed Fanaei. Levothyroxine attenuates behavioral impairment and improves oxidative stress and histological alteration 3-nitropropionic acid induced experimental Huntington's disease in rats.
Behavioural brain research.
2024 Mar; 461(?):114864. doi:
10.1016/j.bbr.2024.114864. [PMID: 38220060] - Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar. Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Oct; ?(?):. doi:
10.1007/s00210-023-02776-z. [PMID: 37847410] - Vishal Kumar, Charan Singh, Arti Singh. Neuroprotective Potential of Hydroalcoholic Extract of Centella asiatica Against 3-Nitropropionic Acid-Induced Huntington's Like Symptoms in Adult Zebrafish.
Rejuvenation research.
2022 Dec; 25(6):260-274. doi:
10.1089/rej.2022.0036. [PMID: 36150031] - Orsolya Takács, Andrea Nagyné Nedves, Imre Boldizsár, Mária Höhn, Szabolcs Béni, Nóra Gampe. Analysis of 3-nitropropionic acid in Fabaceae plants by HPLC-MS/MS.
Phytochemical analysis : PCA.
2022 Dec; 33(8):1205-1213. doi:
10.1002/pca.3171. [PMID: 36111358] - Magda A Rogowska-van der Molen, Dmitrii Nagornîi, Silvia Coolen, Rob M de Graaf, Tom Berben, Theo van Alen, Mathilde A C H Janssen, Floris P J T Rutjes, Robert S Jansen, Cornelia U Welte. Insect Gut Isolate Pseudomonas sp. Strain Nvir Degrades the Toxic Plant Metabolite Nitropropionic Acid.
Applied and environmental microbiology.
2022 10; 88(19):e0071922. doi:
10.1128/aem.00719-22. [PMID: 36154165] - Hanne Bendiksen Skogvold, Mazyar Yazdani, Elise Mørk Sandås, Anja Østeby Vassli, Erle Kristensen, Dagfinn Haarr, Helge Rootwelt, Katja Benedikte Prestø Elgstøen. A pioneer study on human 3-nitropropionic acid intoxication: Contributions from metabolomics.
Journal of applied toxicology : JAT.
2022 05; 42(5):818-829. doi:
10.1002/jat.4259. [PMID: 34725838] - Nanxia Fu, Tobias Becker, Wolfgang Brandt, Maritta Kunert, Antje Burse, Wilhelm Boland. Involvement of CYP347W1 in neurotoxin 3-nitropropionic acid-based chemical defense in mustard leaf beetle Phaedon cochleariae.
Insect science.
2022 Apr; 29(2):453-466. doi:
10.1111/1744-7917.12944. [PMID: 34235855] - Armando da Costa Garcia, Orivaldo Teixeira de Menezes Júnior, Lissa Apolonia Mariano, Letícia Corrêa Santiago, Ângela Regina Araújo, Julia Dietsche Monfardini, Rejane de Castro Simões, André Correa de Oliveira, Rosemary Aparecida Roque, Wanderli Pedro Tadei, Helder Lopes Teles, Camila Martins de Oliveira. Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae).
Revista da Sociedade Brasileira de Medicina Tropical.
2022; 55(?):e00182022. doi:
10.1590/0037-8682-0018-2022. [PMID: 36287467] - Paula Dietrich, Shanta Alli, Megan K Mulligan, Rachel Cox, David G Ashbrook, Robert W Williams, Ioannis Dragatsis. Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration.
Neurobiology of disease.
2022 01; 162(?):105581. doi:
10.1016/j.nbd.2021.105581. [PMID: 34871739] - Shannon Darby, L Chris Sanchez, Martha F Mallicote, Amanda M House, Caryn E Plummer, Veridiana Nadruz, Rachel H Benmoha, Stephen M Roberts, Hartmut Derendorf, Cecilia Silva-Sanchez, Jami Claire, Robert J MacKay. Plasma l-indospicine and 3-nitropropionic acid in ponies fed creeping indigo: Comparison with results from an episode of presumptive creeping indigo toxicosis.
Equine veterinary journal.
2022 Jan; 54(1):145-152. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
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Food additives & contaminants. Part B, Surveillance.
2020 Sep; 13(3):155-161. doi:
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Chemical communications (Cambridge, England).
2020 May; 56(40):5389-5392. doi:
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International journal of molecular sciences.
2020 Apr; 21(7):. doi:
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Archives of physiology and biochemistry.
2020 Feb; 126(1):1-6. doi:
10.1080/13813455.2018.1484771. [PMID: 30269600] - Anna Michno, Katarzyna Grużewska, Hanna Bielarczyk, Marlena Zyśk, Andrzej Szutowicz. Inhibition of pyruvate dehydrogenase complex activity by 3-bromopyruvate affects blood platelets responses in type 2 diabetes.
Pharmacological reports : PR.
2020 Feb; 72(1):225-237. doi:
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Reproduction, fertility, and development.
2019 Apr; 31(5):1017-1032. doi:
10.1071/rd18406. [PMID: 30836053] - Akram Sidhu, Vishal Diwan, Harsimran Kaur, Deepak Bhateja, Charan K Singh, Saurabh Sharma, Satyanarayana S V Padi. Nicotinamide reverses behavioral impairments and provides neuroprotection in 3-nitropropionic acid induced animal model ofHuntington's disease: implication of oxidative stress- poly(ADP- ribose) polymerase pathway.
Metabolic brain disease.
2018 12; 33(6):1911-1921. doi:
10.1007/s11011-018-0297-0. [PMID: 30054774] - Armando Valenzuela Peraza, David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Miroslava Lindoro Silva, Belén Juárez Tapia, Gerardo Barragán Mejía. Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats.
BMC neuroscience.
2018 Nov; 19(1):71. doi:
10.1186/s12868-018-0474-4. [PMID: 30413185] - Sidharth Mehan, Vikramdeep Monga, Manju Rani, Rajesh Dudi, Krishna Ghimire. Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction.
Indian journal of pharmacology.
2018 Nov; 50(6):309-319. doi:
10.4103/ijp.ijp_11_18. [PMID: 30783323] - Surekha Ramachandran, Sumathi Thangarajan. Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's disease.
Metabolic brain disease.
2018 10; 33(5):1459-1470. doi:
10.1007/s11011-018-0252-0. [PMID: 29855977] - Peng Liu, Yinjie Li, Danyang Liu, Xuefei Ji, Tianyan Chi, Lin Li, Libo Zou. Tolfenamic Acid Attenuates 3-Nitropropionic Acid-Induced Biochemical Alteration in Mice.
Neurochemical research.
2018 Oct; 43(10):1938-1946. doi:
10.1007/s11064-018-2615-7. [PMID: 30120653] - Ravi Chandra Sekhara Reddy Danduga, Subba Reddy Dondapati, Phani Kumar Kola, Lilly Grace, Rahil Vandana Bisky Tadigiri, Vijaya Kishore Kanakaraju. Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):1254-1268. doi:
10.1016/j.biopha.2018.06.079. [PMID: 30021362] - Wenqing Cao, Zhenxing Wu, Chengzhu Liang, Ping Jing, Shuhua Cui, Guipeng Yang, Liming Lin. [Determination of deltamethrin and its toxicity biomarkers in rabbit urine by high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2018 Jun; 36(6):523-530. doi:
10.3724/sp.j.1123.2018.03002. [PMID: 30136473] - Marisol Orozco-Ibarra, Jazmín García-Morales, Francisco José Calvo-Silva, Francisca Fernández-Valverde, Norma Serrano-García. Striatal mitochondria response to 3-nitropropionic acid and fish oil treatment.
Nutritional neuroscience.
2018 Feb; 21(2):132-142. doi:
10.1080/1028415x.2016.1237074. [PMID: 27682807] - Jai Malik, Maninder Karan, Rachna Dogra. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism.
Pharmaceutical biology.
2017 Dec; 55(1):980-990. doi:
10.1080/13880209.2017.1285945. [PMID: 28164735] - Xavier Nadal, Carmen Del Río, Salvatore Casano, Belén Palomares, Carlos Ferreiro-Vera, Carmen Navarrete, Carolina Sánchez-Carnerero, Irene Cantarero, Maria Luz Bellido, Stefan Meyer, Gaetano Morello, Giovanni Appendino, Eduardo Muñoz. Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.
British journal of pharmacology.
2017 Dec; 174(23):4263-4276. doi:
10.1111/bph.14019. [PMID: 28853159] - Bojiang Li, Qiannan Weng, Zequn Liu, Ming Shen, Jiaqing Zhang, Wangjun Wu, Honglin Liu. Selection of antioxidants against ovarian oxidative stress in mouse model.
Journal of biochemical and molecular toxicology.
2017 Dec; 31(12):. doi:
10.1002/jbt.21997. [PMID: 29205955] - Norberto Alarcón-Herrera, Saúl Flores-Maya, Belén Bellido, Ana M García-Bores, Ernesto Mendoza, Guillermo Ávila-Acevedo, Elizabeth Hernández-Echeagaray. Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Nov; 109(Pt 2):1018-1025. doi:
10.1016/j.fct.2017.04.048. [PMID: 28478101] - Sara A Wahdan, Mariane G Tadros, Amani E Khalifa. Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Sep; 390(9):905-917. doi:
10.1007/s00210-017-1392-1. [PMID: 28643087] - Huaizhi Liu, Suqin Shao, Mike Schellenberg. A Simple and Fast Procedure to Determine 3-Nitropropanoic Acid and 3-Nitropropanol in Freeze Dried Canadian Milkvetch (Astragalus canadensis).
Toxins.
2017 06; 9(7):. doi:
10.3390/toxins9070204. [PMID: 28661437] - Kiran Yanamandra, Tirth K Patel, Hong Jiang, Suzanne Schindler, Jason D Ulrich, Adam L Boxer, Bruce L Miller, Diana R Kerwin, Gilbert Gallardo, Floy Stewart, Mary Beth Finn, Nigel J Cairns, Philip B Verghese, Ilana Fogelman, Tim West, Joel Braunstein, Grace Robinson, Jennifer Keyser, Joseph Roh, Stephanie S Knapik, Yan Hu, David M Holtzman. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.
Science translational medicine.
2017 04; 9(386):. doi:
10.1126/scitranslmed.aal2029. [PMID: 28424326] - Sarumani Natarajan Suganya, Thangarajan Sumathi. Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats.
Metabolic brain disease.
2017 04; 32(2):471-481. doi:
10.1007/s11011-016-9929-4. [PMID: 27928694] - Sumit Jamwal, Puneet Kumar. L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway.
Molecular neurobiology.
2017 04; 54(3):2327-2337. doi:
10.1007/s12035-016-9822-5. [PMID: 26957301] - Marisol Maya-López, Hipolito A Ruiz-Contreras, María de Jesús Negrete-Ruíz, Julián Elías Martínez-Sánchez, Juan Benítez-Valenzuela, Ana Laura Colín-González, Juana Villeda-Hernández, Laura Sánchez-Chapul, Carmen Parra-Cid, Edgar Rangel-López, Abel Santamaría. URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):745-753. doi:
10.1016/j.biopha.2017.01.116. [PMID: 28157650] - Lu Wang, Jing Wang, Le Yang, Shi-Meng Zhou, Shao-Yu Guan, Liu-Kun Yang, Qi-Xin Shi, Ming-Gao Zhao, Qi Yang. Effect of Praeruptorin C on 3-nitropropionic acid induced Huntington's disease-like symptoms in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Feb; 86(?):81-87. doi:
10.1016/j.biopha.2016.11.111. [PMID: 27939523] - Bushra N Al-Sabahi, Majekodunmi O Fatope, Musthafa Mohamed Essa, Selvaraju Subash, Saleh N Al-Busafi, Fatma S M Al-Kusaibi, Thamilarasan Manivasagam. Pomegranate seed oil: Effect on 3-nitropropionic acid-induced neurotoxicity in PC12 cells and elucidation of unsaturated fatty acids composition.
Nutritional neuroscience.
2017 Jan; 20(1):40-48. doi:
10.1179/1476830514y.0000000155. [PMID: 25238165] - Bethany R Baumgart, Katherine L Gray, Jochen Woicke, Roderick T Bunch, Thomas P Sanderson, Terry R Van Vleet. MicroRNA as biomarkers of mitochondrial toxicity.
Toxicology and applied pharmacology.
2016 Dec; 312(?):26-33. doi:
10.1016/j.taap.2015.10.007. [PMID: 26476301] - Sumathi Thangarajan, Surekha Ramachandran, Priya Krishnamurthy. Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair-Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax-Bad genes in male wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):514-525. doi:
10.1016/j.biopha.2016.09.070. [PMID: 27690136] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Ernestina Hernández García, Gerardo Barragán Mejía, Hugo Juárez Olguín, Armando Valenzuela Peraza, Jonas Attilus, Norma Labra Ruíz. Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid.
Acta pharmaceutica (Zagreb, Croatia).
2016 Sep; 66(3):443-8. doi:
10.1515/acph-2016-0027. [PMID: 27383892] - Surekha Ramachandran, Sumathi Thangarajan. A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington's disease-like symptoms in wistar rats.
Chemico-biological interactions.
2016 Aug; 256(?):25-36. doi:
10.1016/j.cbi.2016.05.020. [PMID: 27206696] - Tobias Becker, Kerstin Ploss, Wilhelm Boland. Biosynthesis of isoxazolin-5-one and 3-nitropropanoic acid containing glucosides in juvenile Chrysomelina.
Organic & biomolecular chemistry.
2016 Jul; 14(26):6274-80. doi:
10.1039/c6ob00899b. [PMID: 27272952] - Sumit Jamwal, Puneet Kumar. Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters.
Physiology & behavior.
2016 Mar; 155(?):180-7. doi:
10.1016/j.physbeh.2015.12.015. [PMID: 26703234] - Gerhard Pauls, Tobias Becker, Peter Rahfeld, Rene R Gretscher, Christian Paetz, Jacques Pasteels, Stephan H von Reuss, Antje Burse, Wilhelm Boland. Two Defensive Lines in Juvenile Leaf Beetles; Esters of 3-nitropropionic Acid in the Hemolymph and Aposematic Warning.
Journal of chemical ecology.
2016 Mar; 42(3):240-8. doi:
10.1007/s10886-016-0684-0. [PMID: 27033853] - Dirleise Colle, Danúbia Bonfanti Santos, Juliana Montagna Hartwig, Marcelo Godoi, Daiane Fátima Engel, Andreza Fabro de Bem, Antonio L Braga, Marcelo Farina. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Molecular neurobiology.
2016 Mar; 53(2):1280-1295. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Feb; 77(?):52-8. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2016 Jan; 45(1):56-60. doi:
NULL. [PMID: 26987197] - Prathapan Ayyappan, Salin Raj Palayyan, Raghu Kozhiparambil Gopalan. Attenuation of Oxidative Damage by Boerhaavia diffusa L. Against Different Neurotoxic Agents in Rat Brain Homogenate.
Journal of dietary supplements.
2016; 13(3):300-12. doi:
10.3109/19390211.2015.1036186. [PMID: 26268727] - Mandeep Kaur, Atish Prakash, Ajudhia Nath Kalia. Neuroprotective potential of antioxidant potent fractions from Convolvulus pluricaulis Chois. in 3-nitropropionic acid challenged rats.
Nutritional neuroscience.
2016; 19(2):70-8. doi:
10.1179/1476830515y.0000000022. [PMID: 25896328] - Arpit Mehrotra, Abhilasha Sood, Rajat Sandhir. Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Molecular and cellular biochemistry.
2015 Dec; 410(1-2):281-92. doi:
10.1007/s11010-015-2561-5. [PMID: 26374445] - Gopinath Kulasekaran, Sudhandiran Ganapasam. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells.
Molecular and cellular biochemistry.
2015 Nov; 409(1-2):199-211. doi:
10.1007/s11010-015-2525-9. [PMID: 26280522] - Shih-Hsin Chang, Chi-Shin Hwang, Jiu-Haw Yin, Shang-Der Chen, Ding-I Yang. Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Biochimica et biophysica acta.
2015 Oct; 1853(10 Pt A):2306-25. doi:
10.1016/j.bbamcr.2015.05.014. [PMID: 25986861] - Alexey Novoselov, Tobias Becker, Gerhard Pauls, Stephan H von Reuß, Wilhelm Boland. Spodoptera littoralis detoxifies neurotoxic 3-nitropropanoic acid by conjugation with amino acids.
Insect biochemistry and molecular biology.
2015 Aug; 63(?):97-103. doi:
10.1016/j.ibmb.2015.05.013. [PMID: 26092560] - J J MacAskill, M Manley-Harris, Richard J Field. Quantification of nitropropanoyl glucosides in karaka nuts before and after treatment.
Food chemistry.
2015 May; 175(?):543-8. doi:
10.1016/j.foodchem.2014.12.022. [PMID: 25577118] - Anna Andolfi, Angela Boari, Marco Evidente, Alessio Cimmino, Maurizio Vurro, Gavin Ash, Antonio Evidente. Gulypyrones A and B and Phomentrioloxins B and C Produced by Diaporthe gulyae, a Potential Mycoherbicide for Saffron Thistle (Carthamus lanatus).
Journal of natural products.
2015 Apr; 78(4):623-9. doi:
10.1021/np500570h. [PMID: 25700035] - Yan Gao, Shi-feng Chu, Jian-ping Li, Zhao Zhang, Jia-qing Yan, Zhi-lin Wen, Cong-yuan Xia, Zheng Mou, Zhen-zhen Wang, Wen-bin He, Xiao-feng Guo, Gui-ning Wei, Nai-hong Chen. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease.
Acta pharmacologica Sinica.
2015 Mar; 36(3):311-22. doi:
10.1038/aps.2014.107. [PMID: 25640478] - A Khan, S Jamwal, K R V Bijjem, A Prakash, P Kumar. Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats.
Neuroscience.
2015 Feb; 287(?):66-77. doi:
10.1016/j.neuroscience.2014.12.018. [PMID: 25536048] - Jai Malik, Sunayna Choudhary, Puneet Kumar. Protective effect of Convolvulus pluricaulis standardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats.
Pharmaceutical biology.
2015; 53(10):1448-57. doi:
10.3109/13880209.2014.984856. [PMID: 25853968] - Sara Valdeolivas, Carmen Navarrete, Irene Cantarero, María L Bellido, Eduardo Muñoz, Onintza Sagredo. Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2015 Jan; 12(1):185-99. doi:
10.1007/s13311-014-0304-z. [PMID: 25252936] - Esther T Menze, Ahmed Esmat, Mariane G Tadros, Ashraf B Abdel-Naim, Amani E Khalifa. Genistein improves 3-NPA-induced memory impairment in ovariectomized rats: impact of its antioxidant, anti-inflammatory and acetylcholinesterase modulatory properties.
PloS one.
2015; 10(2):e0117223. doi:
10.1371/journal.pone.0117223. [PMID: 25675218] - Ashwini Hariharan, Shruthi Shetty, Trupti Shirole, Aarti G Jagtap. Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: mitochondrial dysfunction and neurodegeneration.
Neurotoxicology.
2014 Dec; 45(?):139-48. doi:
10.1016/j.neuro.2014.10.004. [PMID: 25445565] - Jie Liu, Qiu-Ling Wang, Qing Chang, Li-Na Han, Guo-Liang Pei, Yue-Qing Xue, Lu-Meng Jia, Kun Zhang, Yuan-Yuan Duan, Zhen-Sheng Kang. Isocitrate lyase is required for urediniospore germination of Puccinia striiformis f. sp. tritici.
Molecular biology reports.
2014 Dec; 41(12):7797-806. doi:
10.1007/s11033-014-3672-x. [PMID: 25103024] - Jadiswami C, Megha H M, Shivsharan B Dhadde, Sharanbasappa Durg, Pandharinath P Potadar, Thippeswamy B S, Veerapur V P. Piroxicam attenuates 3-nitropropionic acid-induced brain oxidative stress and behavioral alteration in mice.
Toxicology mechanisms and methods.
2014 Dec; 24(9):672-8. doi:
10.3109/15376516.2014.961216. [PMID: 25191831] - Kaja Kannike, Mari Sepp, Chiara Zuccato, Elena Cattaneo, Tõnis Timmusk. Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.
The Journal of biological chemistry.
2014 Nov; 289(47):32845-57. doi:
10.1074/jbc.m114.612424. [PMID: 25271153] - A-Rang Im, Sung-Wook Chae, Gui Jun Zhang, Mi-Young Lee. Neuroprotective effects of Psoralea corylifolia Linn seed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid.
BMC complementary and alternative medicine.
2014 Oct; 14(?):370. doi:
10.1186/1472-6882-14-370. [PMID: 25277760] - Sumathi Thangarajan, Asha Deivasigamani, Suganya Sarumani Natarajan, Prasanna Krishnan, Sandhya Koombankallil Mohanan. Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum.
The International journal of neuroscience.
2014 Sep; 124(9):673-84. doi:
10.3109/00207454.2013.872642. [PMID: 24325390] - Surbhi Gupta, Bhupesh Sharma. Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease.
Pharmacology, biochemistry, and behavior.
2014 Jul; 122(?):122-35. doi:
10.1016/j.pbb.2014.03.022. [PMID: 24704436] - Chang-Kwon Kim, Inn-Hye Song, Ha Young Park, Yeon-Ju Lee, Hyi-Seung Lee, Chung J Sim, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin. Suvanine sesterterpenes and deacyl irciniasulfonic acids from a tropical Coscinoderma sp. sponge.
Journal of natural products.
2014 Jun; 77(6):1396-403. doi:
10.1021/np500156n. [PMID: 24828374] - Arpit Mehrotra, Rajat Sandhir. Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
Behavioural brain research.
2014 Mar; 261(?):345-55. doi:
10.1016/j.bbr.2013.12.035. [PMID: 24393741] - Rajat Sandhir, Aarti Yadav, Arpit Mehrotra, Aditya Sunkaria, Amandeep Singh, Sadhna Sharma. Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease.
Neuromolecular medicine.
2014 Mar; 16(1):106-18. doi:
10.1007/s12017-013-8261-y. [PMID: 24008671] - Surbhi Gupta, Bhupesh Sharma. Pharmacological benefit of I(1)-imidazoline receptors activation and nuclear factor kappa-B (NF-κB) modulation in experimental Huntington's disease.
Brain research bulletin.
2014 Mar; 102(?):57-68. doi:
10.1016/j.brainresbull.2014.02.007. [PMID: 24582883] - Heba M Mahdy, Mohamed R Mohamed, Manal A Emam, Amr M Karim, Ashraf B Abdel-Naim, Amani E Khalifa. Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms.
Neurochemical research.
2014 Feb; 39(2):321-32. doi:
10.1007/s11064-013-1225-7. [PMID: 24346712] - Pushpender Kumar, Puneet Kumar, Aamir Khan, Rahul Deshmukh, Pyare Lal Sharma. Role of neurosteroids in experimental 3-nitropropionic acid induced neurotoxicity in rats.
European journal of pharmacology.
2014 Jan; 723(?):38-45. doi:
10.1016/j.ejphar.2013.11.036. [PMID: 24333475] - Jia-Qing Zhang, Ming Shen, Cheng-Cheng Zhu, Feng-Xiang Yu, Ze-Qun Liu, Nazim Ally, Shao-Chen Sun, Kui Li, Hong-Lin Liu. 3-Nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse.
PloS one.
2014; 9(2):e86589. doi:
10.1371/journal.pone.0086589. [PMID: 24505260] - I Garcia, C Pouzet, M Brulas, E Bauza, J M Botto, N Domloge. Evaluation of THP-1 cell line as an in vitro model for long-term safety assessment of new molecules.
International journal of cosmetic science.
2013 Dec; 35(6):568-74. doi:
10.1111/ics.12078. [PMID: 23841697] - Yogita Binawade, Aarti Jagtap. Neuroprotective effect of lutein against 3-nitropropionic acid-induced Huntington's disease-like symptoms: possible behavioral, biochemical, and cellular alterations.
Journal of medicinal food.
2013 Oct; 16(10):934-43. doi:
10.1089/jmf.2012.2698. [PMID: 24138168] - B D Shivasharan, Pandian Nagakannan, Boreddy Shivanandappa Thippeswamy, Veeresh Prabakar Veerapur, Punit Bansal, Mazhuvancherry K Unnikrishnan. Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats.
Drug and chemical toxicology.
2013 Oct; 36(4):466-73. doi:
10.3109/01480545.2013.776583. [PMID: 23590827] - Kevin Francis, Crystal Smitherman, Shirley F Nishino, Jim C Spain, Giovanni Gadda. The biochemistry of the metabolic poison propionate 3-nitronate and its conjugate acid, 3-nitropropionate.
IUBMB life.
2013 Sep; 65(9):759-68. doi:
10.1002/iub.1195. [PMID: 23893873] - Rajat Sandhir, Arpit Mehrotra. Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: implications in Huntington's disease.
Biochimica et biophysica acta.
2013 Mar; 1832(3):421-30. doi:
10.1016/j.bbadis.2012.11.018. [PMID: 23220257] - Dirleise Colle, Danúbia B Santos, Juliana M Hartwig, Marcelo Godoi, Antonio L Braga, Marcelo Farina. Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro.
Mitochondrion.
2013 Mar; 13(2):125-33. doi:
10.1016/j.mito.2013.01.005. [PMID: 23333792] - K M Denny Joseph, Muralidhara. Enhanced neuroprotective effect of fish oil in combination with quercetin against 3-nitropropionic acid induced oxidative stress in rat brain.
Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jan; 40(?):83-92. doi:
10.1016/j.pnpbp.2012.08.018. [PMID: 22960609] - Dirleise Colle, Danúbia Bonfanti Santos, Eduardo Luiz Gasnhar Moreira, Juliana Montagna Hartwig, Alessandra Antunes dos Santos, Luciana Teixeira Zimmermann, Mariana Appel Hort, Marcelo Farina. Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats.
PloS one.
2013; 8(6):e67658. doi:
10.1371/journal.pone.0067658. [PMID: 23799154] - Chunjie Tian, Young Ho Kim, Young Chul Kim, Kyung Tae Park, Seung Won Kim, Youn Ju Kim, Hye Jin Lim, Yun-Hoon Choung. Korean red ginseng ameliorates acute 3-nitropropionic acid-induced cochlear damage in mice.
Neurotoxicology.
2013 Jan; 34(?):42-50. doi:
10.1016/j.neuro.2012.10.008. [PMID: 23164932] - Nieves Herrera-Mundo, María Sitges. Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings.
Journal of neurochemistry.
2013 Jan; 124(2):233-40. doi:
10.1111/jnc.12082. [PMID: 23121080] - Esther T Menze, Mariane G Tadros, Ahmed M Abdel-Tawab, Amani E Khalifa. Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats.
Neurotoxicology.
2012 Oct; 33(5):1265-75. doi:
10.1016/j.neuro.2012.07.007. [PMID: 22850463] - George K Shinomol, M M Srinivas Bharath, Muralidhara. Neuromodulatory propensity of Bacopa monnieri leaf extract against 3-nitropropionic acid-induced oxidative stress: in vitro and in vivo evidences.
Neurotoxicity research.
2012 Aug; 22(2):102-14. doi:
10.1007/s12640-011-9303-6. [PMID: 22203611] - Rupali A Patil, Yogesh A Hiray, Sanjay B Kasture. Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi.
Indian journal of pharmacology.
2012 May; 44(3):340-4. doi:
10.4103/0253-7613.96307. [PMID: 22701243] - George K Shinomol, M M Srinivas Bharath, Muralidhara. Pretreatment with Bacopa monnieri extract offsets 3-nitropropionic acid induced mitochondrial oxidative stress and dysfunctions in the striatum of prepubertal mouse brain.
Canadian journal of physiology and pharmacology.
2012 May; 90(5):595-606. doi:
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Brain research bulletin.
2012 Mar; 87(4-5):397-405. doi:
10.1016/j.brainresbull.2012.01.003. [PMID: 22245028] - Puneet Kumar, Harikesh Kalonia, Anil Kumar. Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity.
European journal of pharmacology.
2012 Jan; 674(2-3):265-74. doi:
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European journal of pharmacology.
2012 Jan; 674(1):33-43. doi:
10.1016/j.ejphar.2011.10.029. [PMID: 22056833] - Ilkay Erdogan Orhan. Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):946259. doi:
10.1155/2012/946259. [PMID: 22666298] - Mohamed Abdouh, Wassim Chatoo, Jida El Hajjar, Jocelyn David, José Ferreira, Gilbert Bernier. Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons.
PloS one.
2012; 7(2):e31870. doi:
10.1371/journal.pone.0031870. [PMID: 22384090] - Xiaofang Quan, Yi Wang, Xiaofeng Ma, Yan Liang, Weixi Tian, Qingyun Ma, Hezhong Jiang, Youxing Zhao. α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.
PloS one.
2012; 7(3):e33376. doi:
10.1371/journal.pone.0033376. [PMID: 22428036] - Rajat Sandhir, Aditi Sood, Arpit Mehrotra, Sukhdev S Kamboj. N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease.
Neuro-degenerative diseases.
2012; 9(3):145-57. doi:
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Oxidative medicine and cellular longevity.
2012; 2012(?):907162. doi:
10.1155/2012/907162. [PMID: 22685624] - Chia Lin Chang, Che San Lin, Guia Hung Lai. Phytochemical characteristics, free radical scavenging activities, and neuroprotection of five medicinal plant extracts.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):984295. doi:
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TheScientificWorldJournal.
2012; 2012(?):482575. doi:
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Human molecular genetics.
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