Levomycin (BioDeep_00000010866)
Main id: BioDeep_00000419657
代谢物信息卡片
化学式: C51H64N12O12S2 (1100.4208)
中文名称: 棘霉素HIF-1α抑制剂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OCC(C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C
InChI: InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents
同义名列表
4 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:80052
- KEGG: C15722
- PubChem: 3197
- Metlin: METLIN71053
- ChEMBL: CHEMBL263730
- MeSH: Echinomycin
- CAS: 1403-88-9
- CAS: 512-64-1
- PMhub: MS000024764
- PubChem: 47205048
- NIKKAJI: J34.323D
- KNApSAcK: 80052
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 67293 - Streptomyces echinatus:
- 45399 - Streptomyces triostinicus: 10.1002/BTPR.34
- 2062 - Streptomycetaceae: 10.1007/BF02877251
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Linlin Xu, Hiroshi Ishikawa, Yanruo Zhou, Tatsuya Kobayashi, Makio Shozu. Antitumor effect of the selective hypoxia-inducible factor-1 inhibitors echinomycin and PX-478 on uterine fibroids.
F&S science.
2022 05; 3(2):187-196. doi:
10.1016/j.xfss.2022.01.005. [PMID: 35560016] - Priyanka S Radadiya, Mackenzie M Thornton, Emily A Daniel, Jessica Y Idowu, Wei Wang, Brenda Magenheimer, Dharmalingam Subramaniam, Pamela V Tran, James P Calvet, Darren P Wallace, Madhulika Sharma. Quinomycin A reduces cyst progression in polycystic kidney disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 05; 35(5):e21533. doi:
10.1096/fj.202002490r. [PMID: 33826787] - Junna Yamaguchi, Tetsuhiro Tanaka, Hisako Saito, Seitaro Nomura, Hiroyuki Aburatani, Hironori Waki, Takashi Kadowaki, Masaomi Nangaku. Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.
Scientific reports.
2017 07; 7(1):6516. doi:
10.1038/s41598-017-06761-4. [PMID: 28747725] - Alessandra Milesi-Hallé, Sandra McCullough, Jack A Hinson, Richard C Kurten, Laura W Lamps, Aliza Brown, Laura P James. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Basic & clinical pharmacology & toxicology.
2012 Apr; 110(4):327-34. doi:
10.1111/j.1742-7843.2011.00812.x. [PMID: 21985601] - Michael H T Li, Peter M U Ung, James Zajkowski, Sylvie Garneau-Tsodikova, David H Sherman. Automated genome mining for natural products.
BMC bioinformatics.
2009 Jun; 10(?):185. doi:
10.1186/1471-2105-10-185. [PMID: 19531248] - Jianming Yin, Pablo Aviles, William Lee, Carl Ly, Maria Jose Guillen, Pilar Calvo, Ignacio Manzanares, Glynn Faircloth. Validation of a sensitive assay for thiocoraline in mouse plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 794(1):89-98. doi:
10.1016/s1570-0232(03)00418-5. [PMID: 12888201] - Uvidelio Castillo, James K Harper, Gary A Strobel, Joseph Sears, Kara Alesi, Eugene Ford, Janine Lin, Michelle Hunter, Michelle Maranta, Haiyan Ge, Debbie Yaver, James B Jensen, Heidi Porter, Richard Robison, D Millar, Wilford M Hess, Margret Condron, David Teplow. Kakadumycins, novel antibiotics from Streptomyces sp NRRL 30566, an endophyte of Grevillea pteridifolia.
FEMS microbiology letters.
2003 Jul; 224(2):183-90. doi:
10.1016/s0378-1097(03)00426-9. [PMID: 12892881] - A Y Chang, Z N Tu, G T Bryan, J M Kirkwood, M M Oken, D L Trump. Phase II study of echinomycin in the treatment of renal cell carcinoma ECOG study E2885.
Investigational new drugs.
1994; 12(2):151-3. doi:
10.1007/bf00874447. [PMID: 7860234] - M E Marshall, M K Wolf, E D Crawford, S Taylor, B Blumenstein, R Flanigan, F J Meyers, H E Hynes, B Barlogie, M Eisenberger. Phase II trial of echinomycin for the treatment of advanced renal cell carcinoma. A Southwest Oncology Group study.
Investigational new drugs.
1993 May; 11(2-3):207-9. doi:
10.1007/bf00874157. [PMID: 8262733] - J H Harvey, M McFadden, W G Andrews, P J Byrne, J D Ahlgren, P V Woolley. Phase I study of echinomycin administered on an intermittent bolus schedule.
Cancer treatment reports.
1985 Dec; 69(12):1365-8. doi:
. [PMID: 4075312] - S V SOLOV'EV, K I MATVEEV. [Effect of synthomycin and levomycin alone or in combination with anti-gangrene serum in experimental gas infection produced by an association of microorganisms].
Eksperimental'naia khirurgiia.
1960 Mar; 5(?):62. doi:
NULL. [PMID: 13832691]
