1,4-Dihydroxynaphthalene (BioDeep_00000010141)

 

Secondary id: BioDeep_00001873740

human metabolite blood metabolite


代谢物信息卡片


1,4-Dihydroxynaphthalene

化学式: C10H8O2 (160.0524)
中文名称: 1,4-萘二酚
谱图信息: 最多检出来源 Viridiplantae(plant) 25.6%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CC=C2O)O
InChI: InChI=1S/C10H8O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,11-12H



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACAT2, AIMP2, CASP3, CAT, JAK2, MTOR, NFATC1, NQO1, TNFSF11
Peripheral membrane protein 5 CTSK, GORASP1, HSD17B6, JAK2, MTOR
Endosome membrane 1 DCSTAMP
Endoplasmic reticulum membrane 3 ACAT2, DCSTAMP, MTOR
Nucleus 8 AIMP2, CASP3, FOS, JAK2, MTOR, NFATC1, NQO1, PARP1
cytosol 11 ACAT2, AIMP2, CASP3, CAT, FOS, JAK2, MTOR, NFATC1, NQO1, PARP1, TNFRSF11A
dendrite 2 MTOR, NQO1
nuclear body 2 NFATC1, PARP1
phagocytic vesicle 1 MTOR
nucleoplasm 7 CASP3, CTSK, FOS, JAK2, MTOR, NFATC1, PARP1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 CTSK, DCSTAMP, ITGAM, TNF, TNFSF11
Cytoplasmic side 2 GORASP1, MTOR
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 ACAT2, DCSTAMP
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 NQO1
cell surface 3 DCSTAMP, ITGAM, TNF
glutamatergic synapse 2 CASP3, JAK2
Golgi apparatus 1 GORASP1
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, NQO1, TNF
postsynapse 1 JAK2
Cytoplasm, cytosol 4 ACAT2, AIMP2, NQO1, PARP1
Lysosome 2 CTSK, MTOR
endosome 1 DCSTAMP
plasma membrane 8 CTSK, DCSTAMP, F2, ITGAM, JAK2, TNF, TNFRSF11A, TNFSF11
Membrane 9 AIMP2, CAT, DCSTAMP, ITGAM, JAK2, MTOR, NQO1, PARP1, TNFSF11
apical plasma membrane 1 CTSK
brush border 1 ACAT2
caveola 1 JAK2
extracellular exosome 4 ACAT2, CAT, F2, ITGAM
Lysosome membrane 1 MTOR
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 ACAT2, FOS, HSD17B6
extracellular space 6 CTRL, CTSK, F2, ITGAM, TNF, TNFSF11
lysosomal lumen 1 CTSK
perinuclear region of cytoplasm 1 NFATC1
mitochondrion 3 ACAT2, CAT, PARP1
protein-containing complex 2 CAT, PARP1
intracellular membrane-bounded organelle 3 CAT, CTSK, HSD17B6
Microsome membrane 2 HSD17B6, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ITGAM, TNFRSF11A
Secreted 3 CTSK, F2, TNFSF11
extracellular region 5 CAT, CTSK, F2, TNF, TNFSF11
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 CTSK
transcription regulator complex 2 NFATC1, PARP1
external side of plasma membrane 4 CTSK, ITGAM, TNF, TNFRSF11A
nucleolus 1 PARP1
sarcoplasm 1 NFATC1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
Apical cell membrane 1 CTSK
Membrane raft 4 ITGAM, JAK2, TNF, TNFRSF11A
focal adhesion 2 CAT, JAK2
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 F2
chromatin 3 FOS, NFATC1, PARP1
phagocytic cup 1 TNF
Chromosome 1 PARP1
cytoskeleton 1 JAK2
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 F2
site of double-strand break 1 PARP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 2 JAK2, MTOR
endosome lumen 1 JAK2
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 1 JAK2
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
nuclear matrix 1 FOS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 DCSTAMP, GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
protein-DNA complex 2 FOS, PARP1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 TNFRSF11A
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
site of DNA damage 1 PARP1
integrin complex 1 ITGAM
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
integrin alphaM-beta2 complex 1 ITGAM
endolysosome lumen 1 CTSK
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform RANK-e5a]: Cell membrane 1 TNFRSF11A


文献列表

  • Si-Meng Zhao, Zhe Wang, Guang-Zhi Zeng, Wei-Wu Song, Xiao-Qiang Chen, Xiao-Nian Li, Ning-Hua Tan. New cytotoxic naphthohydroquinone dimers from Rubia alata. Organic letters. 2014 Nov; 16(21):5576-9. doi: 10.1021/ol502603f. [PMID: 25310176]
  • Da Ma, Gaya Hettiarachchi, Duc Nguyen, Ben Zhang, James B Wittenberg, Peter Y Zavalij, Volker Briken, Lyle Isaacs. Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals. Nature chemistry. 2012 Apr; 4(6):503-10. doi: 10.1038/nchem.1326. [PMID: 22614387]
  • Joel D Parry, Amy V Pointon, Ursula Lutz, Friederike Teichert, Joanne K Charlwood, Pui Hei Chan, Toby J Athersuch, Emma L Taylor, Rajinder Singh, Jinli Luo, Kate M Phillips, Angelique Vetillard, Jonathan J Lyon, Hector C Keun, Werner K Lutz, Timothy W Gant. Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress. Chemical research in toxicology. 2009 Apr; 22(4):717-25. doi: 10.1021/tx800472z. [PMID: 19338340]
  • Till Opatz, Heinz Kolshorn, Eckhard Thines, Heidrun Anke. Ascomycones A-C, heptaketide metabolites from an unidentified ascomycete. Journal of natural products. 2008 Nov; 71(11):1973-6. doi: 10.1021/np800570w. [PMID: 18989977]
  • Renan Wu, Suramya Waidyanatha, Alistair P Henderson, Berrin Serdar, Yuxin Zheng, Stephen M Rappaport. Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Nov; 826(1-2):206-13. doi: 10.1016/j.jchromb.2005.08.022. [PMID: 16169295]
  • Heiko Rischer, Andreas Hamm, Gerhard Bringmann. Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin. Phytochemistry. 2002 Mar; 59(6):603-9. doi: 10.1016/s0031-9422(02)00003-1. [PMID: 11867092]
  • L S Tsuruda, M W Lamé, A D Jones. Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone. Archives of toxicology. 1995; 69(6):362-7. doi: 10.1007/s002040050185. [PMID: 7495373]
  • K K Kaistha. Guide to urine testing in drug abuse prevention and multi-modality treatment programs. Journal of chromatography. 1977 Aug; 141(2):145-96. doi: 10.1016/s0021-9673(00)99132-5. [PMID: 19493]