Classification Term: 3200

Naphthols and derivatives (ontology term: CHEMONTID:0002441)

Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position." []

found 39 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Child Taxonomies: There is no child term of current ontology term.

Torachrysone

1-(6-Methoxy-3-methyl-1,8-bis(oxidanyl)naphthalen-2-yl)ethanone

Torachrysone is a member of naphthols. Torachrysone is a natural product found in Rheum palmatum, Rumex japonicus, and other organisms with data available. Isolated from seeds of Cassia tora (charota). Torachrysone is found in coffee and coffee products, herbs and spices, and pulses. Torachrysone is found in coffee and coffee products. Torachrysone is isolated from seeds of Cassia tora (charota).

1-Naphthol

C10H8O (144.0575)

1-Naphthol, or ?-naphthol, is a colorless crystalline solid with the formula C10H7OH. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on naphthalene. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They can be used in the production of dyes and in organic synthesis.; 1-naphthol (1N) is a metabolite of carbaryl and naphthalene that is an intermediate in Metabolism of xenobiotics by cytochrome P450. It is generated by spontaneous reaction from (1R,2S)-Naphthalene epoxide then is it converted to 1,4-Dihydroxynaphthalene. Although 1-Naphthol is not persistent in the body, a single urine sample may adequately predict exposure over several months to chlorpyrifos, which is a broad-spectrum organophosphate insecticide. In adult men, TCPY and 1N were associated with reduced testosterone levels (PMID: 16357596, 15579421). Naphthalen-1-ol is found in black walnut. 1-naphthol (1N) is a metabolite of carbaryl and naphthalene that is an intermediate in Metabolism of xenobiotics by cytochrome P450. It is generated by spontaneous reaction from (1R,2S)-Naphthalene epoxide then is it converted to 1,4-Dihydroxynaphthalene. Although 1-Naphthol is not persistent in the body, a single urine sample may adequately predict exposure over several months to chlorpyrifos, which is a broad-spectrum organophosphate insecticide. In adult men, TCPY and 1N were associated with reduced testosterone levels (PMID:16357596, 15579421). CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8253; ORIGINAL_PRECURSOR_SCAN_NO 8251 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9487; ORIGINAL_PRECURSOR_SCAN_NO 9486 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8287; ORIGINAL_PRECURSOR_SCAN_NO 8285 ORIGINAL_PRECURSOR_SCAN_NO 9486; CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9487 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4807; ORIGINAL_PRECURSOR_SCAN_NO 4806 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4732; ORIGINAL_PRECURSOR_SCAN_NO 4731 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9506; ORIGINAL_PRECURSOR_SCAN_NO 9505 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4804; ORIGINAL_PRECURSOR_SCAN_NO 4799 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4717; ORIGINAL_PRECURSOR_SCAN_NO 4715 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8261; ORIGINAL_PRECURSOR_SCAN_NO 8259 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4771; ORIGINAL_PRECURSOR_SCAN_NO 4767 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8267; ORIGINAL_PRECURSOR_SCAN_NO 8265 CONFIDENCE standard compound; INTERNAL_ID 1136; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4779; ORIGINAL_PRECURSOR_SCAN_NO 4777 CONFIDENCE standard compound; INTERNAL_ID 46 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

2-Naphthol

naphthalen-2-ol

C10H8O (144.0575)

2-Naphthol is a colorless crystalline solid and an isomer of 1-naphthol, differing by the location of the hydroxyl group on naphthalene. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. 2-Naphthol has several different uses including dyes, pigments, fats, oils, insecticides, pharmaceuticals, perfumes, antiseptics, synthesis of fungicides, and antioxidants for rubber. Detection of 2-Naphthol in urine usually results from long-term persistent exposure to pesticides such as chlorpyrifos, but also due to exposure to naphthalene in older types of mothballs, fires that produce polyaromatic hydrocarbons (PAHs), and tobacco smoke. CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4804; ORIGINAL_PRECURSOR_SCAN_NO 4799 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8253; ORIGINAL_PRECURSOR_SCAN_NO 8251 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4807; ORIGINAL_PRECURSOR_SCAN_NO 4806 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4717; ORIGINAL_PRECURSOR_SCAN_NO 4715 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8227; ORIGINAL_PRECURSOR_SCAN_NO 8225 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8267; ORIGINAL_PRECURSOR_SCAN_NO 8265 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4779; ORIGINAL_PRECURSOR_SCAN_NO 4777 ORIGINAL_ACQUISITION_NO 8267; CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_PRECURSOR_SCAN_NO 8265 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8261; ORIGINAL_PRECURSOR_SCAN_NO 8259 ORIGINAL_PRECURSOR_SCAN_NO 4731; CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4732 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4732; ORIGINAL_PRECURSOR_SCAN_NO 4731 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8211; ORIGINAL_PRECURSOR_SCAN_NO 8209 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8287; ORIGINAL_PRECURSOR_SCAN_NO 8285 CONFIDENCE standard compound; INTERNAL_ID 877; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4771; ORIGINAL_PRECURSOR_SCAN_NO 4767 C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent Trace constituent of essential oils 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

Naphthalene-1,2-diol

1,2-Dihydroxynaphthalene monohydrate

C10H8O2 (160.0524)

This compound belongs to the family of Naphthols and Derivatives. These are hydroxylated naphthalenes.

1,4-Dihydroxynaphthalene

naphthalene-1,4-diol

C10H8O2 (160.0524)

C.I. Solvent Red 80

1-[(E)-2-(2,5-dimethoxyphenyl)diazen-1-yl]naphthalen-2-ol

C18H16N2O3 (308.1161)

Colourant for orange skins. Allowed on fruit which is not to be processed. Use prohibited in orange peel for human consumption. Colourant for orange skins. Allowed on fruit which is not to be processed. Use prohibited in orange peel for human consumption

4'-hydroxypropanolol

4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}naphthalen-1-ol

C16H21NO3 (275.1521)

4-hydroxypropanolol is a metabolite of propranolol. Propranolol is a sympatholytic non-selective beta blocker. Sympatholytics are used to treat hypertension, anxiety and panic. It was the first successful beta blocker developed. Propranolol is available in generic form as propranolol hydrochloride, as well as an AstraZeneca and Wyeth product under the brand names Inderal, Inderal LA, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilinum, Bedranol SR. (Wikipedia)

O-Desmethylnaproxen

2-(6-hydroxynaphthalen-2-yl)propanoic acid

C13H12O3 (216.0786)

O-Desmethylnaproxen is only found in individuals that have used or taken Naproxen. O-Desmethylnaproxen is a metabolite of Naproxen. O-desmethylnaproxen belongs to the family of Phenylacetic Acid Derivatives. These are compounds containing a phenylacetic acid moiety, which consists of a phenyl group substituted at the second position by an acetic acid.

4-[(2-Hydroxy-1-naphthalenyl)azo]benzenesulfonic acid

4-[(Z)-2-(2-Hydroxynaphthalen-1-yl)diazen-1-yl]benzene-1-sulphonic acid

C16H12N2O4S (328.0518)

4-[(2-Hydroxy-1-naphthalenyl)azo]benzenesulfonic acid is a food dye. Banned by the FDA for food use. Food dye. Banned by the FDA for food use

4-Methoxy-1-naphthol

1-Hydroxy-4-methoxynaphthalene

C11H10O2 (174.0681)

Constituent of the roots of Asperula odorata (sweet woodruff). 4-Methoxy-1-naphthol is found in tea, herbs and spices, and beverages. 4-Methoxy-1-naphthol is found in beverages. 4-Methoxy-1-naphthol is a constituent of the roots of Asperula odorata (sweet woodruff).

1,4,5-Naphthalenetriol

1,4,5-Trihydroxynaphthalene

C10H8O3 (176.0473)

1,4,5-Naphthalenetriol is found in nuts. 1,4,5-Naphthalenetriol occurs in green shells of unripe walnuts (Juglans sp.). Occurs in green shells of unripe walnuts (Juglans species). 1,4,5-Naphthalenetriol is found in nuts.

Orange I

4-[(Z)-2-(4-Hydroxynaphthalen-1-yl)diazen-1-yl]benzene-1-sulphonic acid

C16H12N2O4S (328.0518)

Orange I is formerly used as a food colouring; now banned by the FDA. Formerly used as a food colouring; now banned by the FDA.

4-Amino-2-methyl-1-naphthol

1-Naphthol, 4-amino-2-methyl-, hydrochloride (8ci)

C11H11NO (173.0841)

Vitamin. 4-Amino-2-methyl-1-naphthol is used as a food preservative. Vitamin. It is used as a food preservative.

Acetyl vitamin K5

N-(4-Hydroxy-3-methylnaphthalen-1-yl)ethanimidate

C13H13NO2 (215.0946)

Prothrombogenic vitamin. Prothrombogenic vitamin

1-[(2,5-Dimethylphenyl)azo]-2-naphthalenol

1-[(E)-2-(2,5-dimethylphenyl)diazen-1-yl]naphthalen-2-ol

C18H16N2O (276.1263)

1-[(2,5-Dimethylphenyl)azo]-2-naphthalenol is a food dye; delisted for foods by FDA. Food dye; delisted for foods by FDA

1,2-Dihydrodehydroguaiaretic acid

8-(4-hydroxy-3-methoxycyclohexa-1,5-dien-1-yl)-3-methoxy-6,7-dimethylnaphthalen-2-ol

C20H22O4 (326.1518)

1,2-Dihydrodehydroguaiaretic acid is found in herbs and spices. 1,2-Dihydrodehydroguaiaretic acid is a constituent of Myristica fragrans (nutmeg). Constituent of Myristica fragrans (nutmeg). 1,2-Dihydrodehydroguaiaretic acid is found in herbs and spices.

1-(2-Pyridylazo)-2-naphthol

1-[2-(pyridin-2-yl)diazen-1-yl]naphthalen-2-ol

C15H11N3O (249.0902)

1-Amino-2-naphthol

1-amino-2-naphthol hydrochloride

C10H9NO (159.0684)

1-Nitroso-2-naphthol

1-nitrosonaphthalen-2-ol

C10H7NO2 (173.0477)

2-Hydroxynaphthaldehydebenzoylhydrazone

N-[(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

C18H14N2O2 (290.1055)

2-Hydroxy-1-naphthaldehyde

2-Hydroxy-1-naphthalenecarboxaldehyde

C11H8O2 (172.0524)

CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].

2-Hydroxy-1-naphthaldehyde salicyloylhydrazone

2-hydroxy-N-[(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

C18H14N2O3 (306.1004)

3-(3-Hydroxy-4-methoxynaphthalen-1-yl)oxypropane-1,2-diol

3-[(3-hydroxy-4-methoxynaphthalen-1-yl)oxy]propane-1,2-diol

C14H16O5 (264.0998)

2-Naphthalenecarboxamide, 3-hydroxy-4-[(4-methyl-2-nitrophenyl)azo]-N-(3-nitrophenyl)-

3-hydroxy-4-[2-(4-methyl-2-nitrophenyl)diazen-1-yl]-N-(3-nitrophenyl)naphthalene-2-carboxamide

C24H17N5O6 (471.1179)

4-Amino-1-naphthol

4-aminonaphthalen-1-ol

C10H9NO (159.0684)

4-Hydroxy Duloxetine

4-[3-(methylamino)-1-(thiophen-2-yl)propoxy]naphthalen-1-ol

C18H19NO2S (313.1136)

4-Chloro-1-naphthol

4-Chloronaphthalen-1-ol

C10H7ClO (178.0185)

2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

N-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide

C17H13N3O2 (291.1008)

Apogossypol

3,3-dimethyl-5,5-bis(propan-2-yl)-[2,2-binaphthalene]-1,1,6,6,7,7-hexol

C28H30O6 (462.2042)

Apogossypolone

1,4,6,7-tetrahydroxy-3,3-dimethyl-5,5-bis(propan-2-yl)-1,4,6,7-tetrahydro-[2,2-binaphthalene]-1,4,6,7-tetrone

C28H26O8 (490.1628)

Cetocycline

3-acetyl-1-amino-4,4a,6,7-tetrahydroxy-8,11-dimethyl-1,2,4a,5,12,12a-hexahydrotetracene-2,5-dione

C22H21NO7 (411.1318)

Diospyros

3,3-dimethyl-[2,2-binaphthalene]-1,1,8,8-tetrol

C22H18O4 (346.1205)

Bis(2-hydroxy-1-naphthyl) disulfide

1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol

C20H14O2S2 (350.0435)

LUTEOSKYRIN

5,8,10,14,20,23,25,28-octahydroxy-6,21-dimethyloctacyclo[14.11.1.0²,¹¹.0²,¹⁵.0⁴,⁹.0¹³,¹⁷.0¹⁷,²⁶.0¹⁹,²⁴]octacosa-4,6,8,10,19,21,23,25-octaene-3,12,18,27-tetrone

C30H22O12 (574.1111)

Naftazone

[(1-hydroxynaphthalen-2-yl)imino]urea

C11H9N3O2 (215.0695)

C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent