N-Methyl-N-nitrosourea (BioDeep_00000010005)

 

Secondary id: BioDeep_00001873761

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


N-(C-hydroxycarbonimidoyl)-N-nitrosomethanamine

化学式: C2H5N3O2 (103.038175)
中文名称: N-甲基-N-亚硝基脲, N-亚硝基-N-甲基脲
谱图信息: 最多检出来源 Mus musculus(blood) 0.87%

分子结构信息

SMILES: CN(C(=O)N)N=O
InChI: InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents

同义名列表

22 个代谢物同义名

N-(C-hydroxycarbonimidoyl)-N-nitrosomethanamine; 1-(Aminocarbonyl)-1-methyl-2-oxohydrazine; N-Methyl-N-nitrosocarbamide; N-Methyl-N-nitrosoharnstoff; N-Nitroso-N-methylcarbamide; N-Nitroso-N-methylharnstoff; 1-Nitroso-1-methylurea; Methylnitrosoharnstoff; N-Methyl-N-nitrosourea; N-Nitroso-N-methyluree; N-Methyl-N-nitrosouree; N-Nitroso-N-methylurea; N Methyl N nitrosourea; N-Nitrosomethylurea; Methylnitrosourea; Methylnitrosouree; Nitrosomethylurea; MNU; NMU; NMH; Methylnitrosourea; N-Nitroso-N-methylurea



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • O V Pershina, N N Ermakova, A V Pakhomova, M A Zhukova, E S Pan, L A Sandrikina, V A Krupin, O Yu Rybalkina, L V Kogai, A A Kubatiev, S G Morozov, A M Dygai, E G Skurikhin. The Role of Cancer and Somatic Stem Cells in the Anti-Inflammatory and Antitumor Effects of Aconitum baicalense Extract on Experimental Breast Cancer. Bulletin of experimental biology and medicine. 2023 Jun; 175(2):254-259. doi: 10.1007/s10517-023-05845-8. [PMID: 37466854]
  • Adedoyin O Adefisan, Solomon E Owumi, Kehinde O Soetan, Oluwatosin A Adaramoye. Chloroform extract of Calliandra portoricensis inhibits tumourigenic effect of N-methyl-N-nitrosourea and benzo(a)pyrene in breast experimental cancer. Drug and chemical toxicology. 2022 Nov; 45(6):2424-2438. doi: 10.1080/01480545.2021.1957556. [PMID: 34325589]
  • Kawthar A Diab, Maha A Fahmy, Emad M Hassan, Sayed A El-Toumy. Evaluation of the cytotoxic, anticancer, and genotoxic activities of Acacia nilotica flowers and their effects on N-methyl-N-nitrosourea-induced genotoxicity in mice. Molecular biology reports. 2022 Sep; 49(9):8439-8448. doi: 10.1007/s11033-022-07662-0. [PMID: 35934768]
  • Mehmet Ozcan, Duygu Aydemir, Merve Bacanlı, Hatice Gul Anlar, N Nuray Ulusu, Yasemin Aksoy. Protective Effects of Antioxidant Chlorophyllin in Chemically Induced Breast Cancer Model In vivo. Biological trace element research. 2021 Dec; 199(12):4475-4488. doi: 10.1007/s12011-021-02585-6. [PMID: 33624221]
  • Thiago de Freitas, Joyce R Zapaterini, Cristiane M Moreira, Ariana M de Aquino, Luiz G Alonso-Costa, Lucas T Bidinotto, Laura Kass, Jodi A Flaws, Wellerson R Scarano, Luis F Barbisan. Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Oct; 156(?):112519. doi: 10.1016/j.fct.2021.112519. [PMID: 34428494]
  • Yunhua Zhou, Guomin Zhou. Alterations of Lipidomes in Rat Photoreceptor Degeneration Induced by N-Methyl-N-nitrosourea. Lipids. 2021 07; 56(4):437-448. doi: 10.1002/lipd.12306. [PMID: 34058794]
  • Lakhveer Singh, Manjari Singh, Shubham Rastogi, Anurag Choudhary, Dinesh Kumar, Ritu Raj, Mohd Nazam Ansari, Abdulaziz S Saeedan, Gaurav Kaithwas. Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma. BMC molecular and cell biology. 2021 Jun; 22(1):33. doi: 10.1186/s12860-021-00371-9. [PMID: 34090331]
  • Jinglei Liu, Zhen Geng, Yingying Zhang, Sulaiman Ali Alharbi, Yulong Shi. Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models. Journal of biochemical and molecular toxicology. 2021 May; 35(5):e22723. doi: 10.1002/jbt.22723. [PMID: 33511709]
  • Adedoyin O Adefisan, Judith C Madu, Solomon E Owumi, Oluwatosin A Adaramoye. Calliandra portoricensis ameliorates ovarian and uterine oxido-inflammatory responses in N-methyl-N-nitrosourea and benzo[a]pyrene-treated rats. Experimental biology and medicine (Maywood, N.J.). 2020 10; 245(16):1490-1503. doi: 10.1177/1535370220947387. [PMID: 32746633]
  • Hyekyung Son, Backki Kim, Gileung Lee, Su Jang, Yunjoo Lee, Hee-Jong Koh. Identification and characterization of the stunted sterile (ss) mutant in rice. Genes & genomics. 2020 08; 42(8):869-882. doi: 10.1007/s13258-020-00954-4. [PMID: 32506267]
  • G Eğimezer, Ü V Üstündağ, P S Ateş, I Ünal, F D Üstündağ, A A Alturfan, E Emekli-Alturfan, M A Altinoz, I Elmaci. Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Human & experimental toxicology. 2020 Jul; 39(7):920-929. doi: 10.1177/0960327120905961. [PMID: 32054343]
  • Rajakumar Thangarasu, Pugalendhi Pachaiappan, Thilagavathi Subbaiyan. Anti-Estrogenic and Anti-Cell Proliferative Effect of Allyl Isothiocyanate in Chemoprevention of Chemically Induced Mammary Carcinogenesis in Rats. Pathology oncology research : POR. 2020 Apr; 26(2):913-925. doi: 10.1007/s12253-019-00638-9. [PMID: 30895454]
  • A F Poveshchenko, O V Kazakov, N B Orlov, O V Poveshchenko, I I Kim, N A Bondarenko, D N Strunkin, A V Kabakov, T V Raiter, A P Lykov, S S Bogachev, V I Konenkov. Cytokines of the Lymph and Blood Serum as Markers of Oncogenesis and Efficiency of Therapy in Chemically Induced Breast Cancer in Wistar Rats. Bulletin of experimental biology and medicine. 2020 Mar; 168(5):681-687. doi: 10.1007/s10517-020-04780-2. [PMID: 32248452]
  • O V Kazakov, A V Kabakov, A F Poveshchenko, T V Raiter, D N Strunkin, S S Bogachev, A P Lykov, V I Konenkov. Morphological Study of Mesenteric Lymph Nodes in Rats with Experimental Breast Cancer Treated with Fragmented Double-Stranded DNA. Bulletin of experimental biology and medicine. 2020 Mar; 168(5):704-708. doi: 10.1007/s10517-020-04784-y. [PMID: 32248451]
  • O V Kazakov, T V Raiter, A F Poveshchenko, N B Orlov, O V Poveshchenko, A V Kabakov, I I Kim, N A Bondarenko, D N Strunkin, A P Lykov, A Yu Letyagin, V I Konenkov. Correlation Analysis of Morphological Changes of Structural and Functional Areas of Mesenteric Lymph Nodes with Cytokines of Lymph of Thoracic Lymphatic Duct in Experimental Breast Cancer. Bulletin of experimental biology and medicine. 2020 Feb; 168(4):512-516. doi: 10.1007/s10517-020-04743-7. [PMID: 32147763]
  • Debjani P Mansingh, Shalini Pradhan, Deeptarup Biswas, R Barathidasan, Hannah R Vasanthi. Palliative Role of Aqueous Ginger Extract on N-Nitroso-N-Methylurea-Induced Gastric Cancer. Nutrition and cancer. 2020; 72(1):157-169. doi: 10.1080/01635581.2019.1619784. [PMID: 31155951]
  • A F Gal, L Stan, F Tăbăran, D Rugină, A F Cătoi, S Andrei. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative medicine and cellular longevity. 2020; 2020(?):4014838. doi: 10.1155/2020/4014838. [PMID: 32184916]
  • Weiwei Liu, Yuzhu Li, Chengzhen Li. Kirenol Exhibits the Protective Role against N-Methyl-N-Nitrosourea-Induced Gastric Cancer in Rats via Modulating the Oxidative Stress and Inflammatory Markers. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2020; 39(4):345-355. doi: 10.1615/jenvironpatholtoxicoloncol.2020035475. [PMID: 33389906]
  • Eunsoo Jung, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, Junghyun Kim. Aucubin, An Active Ingredient in Aucuba japonica, Prevents N-methyl-N-nitrosourea-induced Retinal Degeneration in Mice. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244437. [PMID: 31817154]
  • Saber Saedmocheshi, Marziyeh Saghebjoo, Zakaria Vahabzadeh, Dariush Sheikholeslami-Vatani. Aerobic Training and Green Tea Extract Protect against N-methyl-N-nitrosourea-induced Prostate Cancer. Medicine and science in sports and exercise. 2019 11; 51(11):2210-2216. doi: 10.1249/mss.0000000000002054. [PMID: 31626054]
  • Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S Saeedan, Mohd Nazam Ansari, Gaurav Kaithwas. Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling. BMC cancer. 2019 Oct; 19(1):996. doi: 10.1186/s12885-019-6152-9. [PMID: 31651285]
  • Adedoyin Adefisan, Solomon Owumi, Oluwatosin Adaramoye. Root bark extract of Calliandra portoricensis (Jacq.) Benth. chemoprevents N-methyl-N-nitrosourea-induced mammary gland toxicity in rats. Journal of ethnopharmacology. 2019 Apr; 233(?):22-33. doi: 10.1016/j.jep.2018.12.027. [PMID: 30599221]
  • Subhadeep Roy, Manjari Singh, Shreesh Raj Sammi, Rakesh Pandey, Gaurav Kaithwas. ALA-mediated biphasic downregulation of α-7nAchR/HIF-1α along with mitochondrial stress modulation strategy in mammary gland chemoprevention. Journal of cellular physiology. 2019 04; 234(4):4015-4029. doi: 10.1002/jcp.27168. [PMID: 30221357]
  • Bianka Bojková, Karol Kajo, Peter Kubatka, Peter Solár, Martin Péč, Marián Adamkov. Metformin and melatonin improve histopathological outcome of NMU-induced mammary tumors in rats. Pathology, research and practice. 2019 Apr; 215(4):722-729. doi: 10.1016/j.prp.2019.01.007. [PMID: 30642742]
  • Dai Kakiuchi, Yoshikazu Taketa, Etsuko Ohta, Yasuhiro Fujikawa, Kyoko Nakano-Ito, Shoji Asakura, Satoru Hosokawa. Combination of circulating microRNAs as indicators of specific targets of retinal toxicity in rats. Toxicology. 2019 01; 411(?):163-171. doi: 10.1016/j.tox.2018.10.008. [PMID: 30336191]
  • Keiichi Itoh, Shoji Masumori, Daisuke Mukai, Hiroyuki Sakakibara, Michiko Yasuda, Kayoko Shimoi. Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin. The Journal of toxicological sciences. 2019; 44(4):273-282. doi: 10.2131/jts.44.273. [PMID: 30944280]
  • Vladimir G Bespalov, Valerij A Alexandrov, Alexander L Semenov, Galina I Vysochina, Vera A Kostikova, Denis A Baranenko. The inhibitory effect of Filipendula ulmaria (L.) Maxim. on colorectal carcinogenesis induced in rats by methylnitrosourea. Journal of ethnopharmacology. 2018 Dec; 227(?):1-7. doi: 10.1016/j.jep.2018.08.013. [PMID: 30114518]
  • Erin D Giles, Sonali Jindal, Elizabeth A Wellberg, Troy Schedin, Steven M Anderson, Ann D Thor, Dean P Edwards, Paul S MacLean, Pepper Schedin. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast cancer research : BCR. 2018 06; 20(1):50. doi: 10.1186/s13058-018-0974-2. [PMID: 29898754]
  • Prachi Karia, Kirti V Patel, Shri S P Rathod. Breast cancer amelioration by Butea monosperma in-vitro and in-vivo. Journal of ethnopharmacology. 2018 May; 217(?):54-62. doi: 10.1016/j.jep.2017.12.026. [PMID: 29366766]
  • Hassan Muhammad Yankuzo, Yusha'u Shu'aibu Baraya, Zulkarnain Mustapha, Kah Keng Wong, Nik Soriani Yaacob. Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model. Journal of ethnopharmacology. 2018 Mar; 213(?):31-37. doi: 10.1016/j.jep.2017.10.024. [PMID: 29100935]
  • Xu Zheng, Bin Jia, Xue Song, Qing-You Kong, Mo-Li Wu, Ze-Wen Qiu, Hong Li, Jia Liu. Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis. Nutrients. 2018 Feb; 10(3):. doi: 10.3390/nu10030279. [PMID: 29495605]
  • Vladimir G Bespalov, Valerij A Alexandrov, Galina I Vysochina, Vera A Kostikova, Alexandr L Semenov, Denis A Baranenko. Inhibitory Effect of Filipendula ulmaria on Mammary Carcinogenesis Induced by Local Administration of Methylnitrosourea to Target Organ in Rats. Anti-cancer agents in medicinal chemistry. 2018; 18(8):1177-1183. doi: 10.2174/1871520618666180402125913. [PMID: 29607788]
  • Neveen A Salem, Amal Hamza, Hanan Alnahdi, Najla Ayaz. Biochemical and Molecular Mechanisms of Platelet-Rich Plasma in Ameliorating Liver Fibrosis Induced by Dimethylnitrosurea. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 47(6):2331-2339. doi: 10.1159/000491544. [PMID: 29982247]
  • Thangarasu Rajakumar, Pachaiappan Pugalendhi, Rajendran Jayaganesh, Dhanabalan Ananthakrishnan, Krishnaswamy Gunasekaran. Effect of allyl isothiocyanate on NF-κB signaling in 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea-induced mammary carcinogenesis. Breast cancer (Tokyo, Japan). 2018 Jan; 25(1):50-59. doi: 10.1007/s12282-017-0783-y. [PMID: 28501931]
  • T Kiskova, V Demeckova, Z Jendzelovska, M Kiktava, K Venglovska, M Bohmdorfer, W Jager, T Thalhammer. Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2017 Dec; 68(6):867-875. doi: . [PMID: 29550799]
  • O V Kazakov, A V Kabakov, A F Poveshchenko, T V Raiter, D N Strunkin, I Yu Ishchenko, A P Lykov, S V Michurina, V I Konenkov. Anterior Mediastinal Lymph Nodes in Chemically Induced Breast Cancer. Bulletin of experimental biology and medicine. 2017 Dec; 164(2):186-190. doi: 10.1007/s10517-017-3954-0. [PMID: 29177878]
  • Annekathrin M Keiler, Dana Macejova, Birgit M Dietz, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Richard B van Breemen, Dejan Nikolic, Florian Goerl, Michael H Muders, Oliver Zierau, Günter Vollmer. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. The Journal of steroid biochemistry and molecular biology. 2017 11; 174(?):234-241. doi: 10.1016/j.jsbmb.2017.09.020. [PMID: 28964928]
  • Hanaa H Ahmed, Hanan S El-Abhar, Elsayed Abdul Khalik Hassanin, Noha F Abdelkader, Mohamed B Shalaby. Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):387-393. doi: 10.1016/j.biopha.2017.08.103. [PMID: 28858737]
  • Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Min Gi, Hideki Wanibuchi. Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis. International journal of molecular sciences. 2017 Aug; 18(8):. doi: 10.3390/ijms18081801. [PMID: 28820464]
  • Iwona Malicka, Katarzyna Siewierska, Christopher Kobierzycki, Jedrzej Grzegrzolka, Aleksandra Piotrowska, Urszula Paslawska, Marek Cegielski, Piotr Dziegiel, Marzenna Podhorska-Okolow, Marek Wozniewski. Impact of Physical Training on Sex Hormones and Their Receptors During N-Methyl-N-nitrosourea-induced Carcinogenesis in Rats. Anticancer research. 2017 07; 37(7):3581-3589. doi: 10.21873/anticanres.11728. [PMID: 28668849]
  • Shan Zhuang, Yong-Mei Jian, Yong-Ning Sun. Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice. World journal of gastroenterology. 2017 Jun; 23(23):4233-4242. doi: 10.3748/wjg.v23.i23.4233. [PMID: 28694663]
  • Suman K Samanta, Anuradha Sehrawat, Su-Hyeong Kim, Eun-Ryeong Hahm, Yongli Shuai, Ruchi Roy, Subrata K Pore, Krishna B Singh, Susan M Christner, Jan H Beumer, Nancy E Davidson, Shivendra V Singh. Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. Journal of the National Cancer Institute. 2017 06; 109(6):. doi: 10.1093/jnci/djw293. [PMID: 28040797]
  • Shan Zhuang, Yongmei Jian, Yongning Sun. Metformin Inhibits N-Methyl-N-Nitrosourea Induced Gastric Tumorigenesis in db/db Mice. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2017 Jun; 125(6):392-399. doi: 10.1055/s-0043-100118. [PMID: 28407669]
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  • Marize de Lourdes Marzo Solano, Noeme Souza Rocha, Luis Fernando Barbisan, Carla Adriene da Silva Franchi, Ana Lúcia Tozzi Spinardi-Barbisan, Maria Luiza Cotrim Sartor de Oliveira, Daisy Maria Fávero Salvadori, Lúcia Regina Ribeiro, João Lauro Viana de Camargo. Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat. Toxicologic pathology. 2016 12; 44(8):1146-1159. doi: 10.1177/0192623316678931. [PMID: 28245158]
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  • Henrique Fonseca Sousa do Nascimento, Plínio Cerqueira Dos Santos Cardoso, Helem Ferreira Ribeiro, Tatiane Cristina Mota, Lorena Monteiro Gomes, André Salim Khayat, Adriana Costa Guimarães, Marucia Irena Medeiros Amorim, Rommel Rodriguéz Burbano, Marcelo de Oliveira Bahia. In vitro assessment of anticytotoxic and antigenotoxic effects of CANOVA(®). Homeopathy : the journal of the Faculty of Homeopathy. 2016 Aug; 105(3):265-269. doi: 10.1016/j.homp.2016.04.003. [PMID: 27473548]
  • Chetan Manral, Subhadeep Roy, Manjari Singh, Swetlana Gautam, Rajnish K Yadav, Jitendra K Rawat, Uma Devi, Md Nazam Ansari, Abdulaziz S Saeedan, Gaurav Kaithwas. Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats. BMC complementary and alternative medicine. 2016 Jul; 16(?):260. doi: 10.1186/s12906-016-1243-5. [PMID: 27473871]
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  • Jhoti Somanah, Srishti Ramsaha, Shalini Verma, Ashok Kumar, Poornima Sharma, Ranjan Kumar Singh, Okezie I Aruoma, Emmanuel Bourdon, Theeshan Bahorun. Fermented papaya preparation modulates the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice. Life sciences. 2016 Apr; 151(?):330-338. doi: 10.1016/j.lfs.2016.03.026. [PMID: 26979773]
  • Peter Kubatka, Andrea Kapinová, Martin Kello, Peter Kruzliak, Karol Kajo, Desanka Výbohová, Silvia Mahmood, Radovan Murin, Tischlerová Viera, Ján Mojžiš, Anthony Zulli, Martin Péč, Marián Adamkov, Monika Kassayová, Bianka Bojková, Nadežda Stollárová, Dušan Dobrota. Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer. European journal of nutrition. 2016 Apr; 55(3):955-65. doi: 10.1007/s00394-015-0910-5. [PMID: 25930965]
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