ST 27:1;O2 (BioDeep_00000397338)
PANOMIX_OTCML-2023
代谢物信息卡片
(3S,5S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one
化学式: C27H46O2 (402.34976159999997)
中文名称: 3Β-羟基-5Α-(1,5-二甲基己基)环戊烷三环己烷-6-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC(=O)C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-16-25(29)24-15-19(28)11-13-27(24,5)23(20)12-14-26(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,26-,27-/m1/s1
描述信息
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential[1].
同义名列表
25 个代谢物同义名
(3S,5S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one; (3S,5S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-3-hydroxy-10,13-dimethyl-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one; Cholestan-6-one, 3-hydroxy-, (3.beta.,5.alpha.)-; 3-Hydroxycholestan-6-one, (3.beta.,5.alpha.)-; Cholestan-6-one, 3-hydroxy-, (3beta,5alpha)-; 5.alpha.-Cholestan-6-one, 3.beta.-hydroxy-; 6-ketocholestanol, (3alpha,5alpha)-isomer; 6-ketocholestanol, (3beta,5alpha)-isomer; 3.BETA.-HYDROXY-5.ALPHA.-CHOLESTAN-6-ONE; 5alpha-Cholestan-6-one, 3beta-hydroxy-; 3beta-Hydroxy-5alpha-cholestan-6-one; 5.ALPHA.-CHOLESTAN-3.BETA.-OL-6-ONE; 5alpha-cholestan-6-oxo-3beta-ol; 5alpha-Cholestan-3beta-ol-6-one; 3b-hydroxy-5a-cholestan-6-one; 5I+/--Cholestan-3I(2)-ol-6-on; JQMQKOQOLPGBBE-ZNCJEFCDSA-N; 5alpha-Cholestan-6-one; 6-Keto Cholestanol; 6-Ketocholestanol; 6-Oxocholestanol; UNII-2V12D4A742; 2V12D4A742; ST 27:1;O2; 3β-Hydroxy-5α-cholestan-6-one
数据库引用编号
9 个数据库交叉引用编号
- PubChem: 102008
- LipidMAPS: LMST01010276
- MeSH: 6-ketocholestanol
- ChemIDplus: 0001175060
- CAS: 1175-06-0
- medchemexpress: HY-N9608
- RefMet: 6-Oxocholestanol
- PubChem: 52931314
- RefMet: ST 27:1;O2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Iliuza R Iaubasarova, Ljudmila S Khailova, Alexander M Firsov, Vera G Grivennikova, Roman S Kirsanov, Galina A Korshunova, Elena A Kotova, Yuri N Antonenko. The mitochondria-targeted derivative of the classical uncoupler of oxidative phosphorylation carbonyl cyanide m-chlorophenylhydrazone is an effective mitochondrial recoupler.
PloS one.
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10.1371/journal.pone.0244499. [PMID: 33378414] - Hujun Shen, Zhenhua Wu, Kun Zhao, Hengxiu Yang, Mingsen Deng, Shuiguo Wen. Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Potential and Sterol Flip-Flop Motion in Bilayer Membranes.
Langmuir : the ACS journal of surfaces and colloids.
2019 08; 35(34):11232-11241. doi:
10.1021/acs.langmuir.9b01802. [PMID: 31373497] - Rebika Shrestha, Cari M Anderson, Alfredo E Cardenas, Ron Elber, Lauren J Webb. Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on the Membrane Dipole Electric Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations.
The journal of physical chemistry. B.
2017 04; 121(15):3424-3436. doi:
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Journal of chromatography. A.
2014 Sep; 1358(?):102-9. doi:
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The Journal of membrane biology.
2014 Aug; 247(8):721-7. doi:
10.1007/s00232-014-9697-1. [PMID: 24935731] - M Przybylo, J Procek, M Hof, M Langner. The alteration of lipid bilayer dynamics by phloretin and 6-ketocholestanol.
Chemistry and physics of lipids.
2014 Feb; 178(?):38-44. doi:
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2007 Jun; 23(13):6889-92. doi:
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2007 Jan; 1768(1):107-14. doi:
10.1016/j.bbamem.2006.06.022. [PMID: 16904627] - Víctor Buzón, Josep Cladera. Effect of cholesterol on the interaction of the HIV GP41 fusion peptide with model membranes. Importance of the membrane dipole potential.
Biochemistry.
2006 Dec; 45(51):15768-75. doi:
10.1021/bi060622i. [PMID: 17176099] - Tudor Luchian, Loredana Mereuta. Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes.
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2005 Aug; 5(4):272-81. doi:
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2005 Jun; 1712(2):128-36. doi:
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International journal of pharmaceutics.
2005 Apr; 294(1-2):149-55. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2004 Mar; 57(2):329-36. doi:
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Biophysical journal.
2003 Dec; 85(6):3788-801. doi:
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Journal of pharmaceutical sciences.
2003 May; 92(5):1018-27. doi:
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The Journal of biological chemistry.
2001 Oct; 276(42):38457-63. doi:
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2001 Jul; 112(1):31-9. doi:
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2001 Apr; 217(1-2):79-86. doi:
10.1016/s0378-5173(01)00590-7. [PMID: 11292544] - S Bala, M H Kombrabail, B S Prabhananda. Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles.
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Membrane & cell biology.
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1997 Aug; 73(2):850-4. doi:
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FEBS letters.
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