Lanosterin (BioDeep_00000636694)

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds

代谢物信息卡片

Lanosta-8,24-dien-3beta-ol

化学式: C30H50O (426.386145)
中文名称: 羊毛甾醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C@@]21C
InChI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1

描述信息

A tetracyclic triterpenoid that is lanosta-8,24-diene substituted by a beta-hydroxy group at the 3beta position. It is the compound from which all steroids are derived.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

5 个代谢物同义名

Lanosterin; Lanosterol; Lanosta-8,24-dien-3beta-ol; ST 30:2;O; Lanosterol

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:16521
KEGG: C01724
PubChem: 246983
DrugBank: DB03696
ChEMBL: CHEMBL225111
LipidMAPS: LMST01010017
MeSH: Lanosterol
CAS: 79-63-0
MetaboLights: MTBLC16521
PubChem: 4861
KNApSAcK: C00003657
PDB-CCD: LAN
3DMET: B01488
NIKKAJI: J4.237D
BioNovoGene_Lab2019: BioNovoGene_Lab2019-586
KNApSAcK: 16521

分类词条

Cholesterol and derivatives [ST0101]

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

54 个相关的物种来源信息

202113 - Aplysina fistularis: 10.1016/0305-0491(91)90140-9
1712201 - Archidendron chevalieri: 10.1055/S-2006-959392
12959 - Axinella polypoides: 10.1016/0305-0491(91)90140-9
237119 - Axinella verrucosa: 10.1016/0305-0491(91)90140-9
4443 - Camellia japonica: 10.1007/BF02534064
4442 - Camellia sinensis: 10.1007/BF02534064
56154 - Campanula medium: 10.1007/S10600-014-1165-8
4072 - Capsicum annuum: 10.1016/0039-128X(77)90011-3
211714 - Clusia pernambucensis: 10.1016/0040-4039(96)00656-9
120407 - Dictyuchus monosporus: 10.1016/S0031-9422(00)80786-4
2864 - Dinophyceae: 10.1016/0305-1978(91)90037-Z
105886 - Eleutherococcus sessiliflorus: 10.1007/BF00576204
3991 - Euphorbia characias: 10.1016/0031-9422(90)85028-E
1138347 - Euphorbia guyoniana: 10.1016/J.PHYTOCHEM.2007.01.017
318062 - Euphorbia hirta:
239687 - Euphorbia kansui: 10.1211/0022357001773607
1138348 - Euphorbia lactea: 10.1016/J.PHYMED.2009.05.009
212925 - Euphorbia lathyris:
212926 - Euphorbia laurifolia: 10.1080/14786410412331280096
1091634 - Euphorbia mellifera: 10.1016/S0031-9422(00)85859-8
38846 - Euphorbia peplus: 10.1021/NP990081G
482938 - Euphorbia pseudocactus: 10.1016/0031-9422(90)80134-3
154997 - Euphorbia stygiana: 10.1016/S0031-9422(00)85859-8
142860 - Euphorbia tirucalli: 10.1021/NP50006A011
97096 - Eutypa lata: 10.1016/0031-9422(96)00227-0
3847 - Glycine max: 10.1016/S0031-9422(00)94844-1
5627 - Grifola frondosa: 10.1271/NOGEIKAGAKU1924.59.1053
9606 - Homo sapiens:
167356 - Inonotus obliquus:
160619 - Kryptoperidinium foliaceum: 10.1016/0305-1978(91)90037-Z
4803 - Lagenidium giganteum: 10.1007/BF01946701
3860 - Lathyrus sativus: 10.1016/S0031-9422(00)94844-1
3864 - Lens culinaris: 10.1016/S0031-9422(00)94844-1
73653 - Leucilla nuttingi: 10.1016/0305-0491(91)90140-9
282297 - Leucosolenia eleanor: 10.1016/0305-0491(91)90140-9
160621 - Lingulodinium polyedra: 10.1016/0305-1978(91)90037-Z
64518 - Mortierella alpina: 10.1016/J.PHYTOCHEM.2006.02.023
2869 - Peridinium foliaceum: 10.1016/0305-1978(91)90037-Z
68564 - Petrosia ficiformis: 10.1016/0305-0491(91)90140-9
4837 - Phycomyces blakesleeanus:
3527 - Phytolacca americana: 10.1007/BF02534064
29920 - Phytophthora cactorum: 10.1007/BF01946701
150515 - Polyscias bracteata: 10.1007/BF00576204
135480 - Salilagenidium callinectes: 10.1007/BF01946701
4770 - Saprolegnia ferax: 10.1007/BF01946701
4114 - Solanum aviculare: 10.1021/NP50032A024
2951 - Symbiodinium microadriaticum: 10.1016/0305-1978(91)90037-Z
13702 - Symphoricarpos albus: 10.1016/S0031-9422(00)80074-6
281732 - Tethya aurantium: 10.1016/0305-0491(91)90140-9
588385 - Tillandsia recurvata: 10.1021/NP50126A020
3915 - Vigna mungo: 10.1016/S0031-9422(00)94844-1
292385 - Vitellaria paradoxa: 10.1007/BF02534064
81056 - Wolfiporia cocos: 10.1002/(SICI)1099-1573(199611)10:7<581::AID-PTR907>3.0.CO;2-3
78907 - Zoophagus insidians: 10.1016/0031-9422(82)83069-0

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Binbin Luo, Linyi Song, Limiao Chen, Yue Cai, Mingwei Zhang, Shenyi Wang. Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155675. doi: 10.1016/j.phymed.2024.155675. [PMID: 38678954]
Lingling Wei, Haiping Shi, Bin Chen, Xiujuan Li, Wenchan Chen, Chengdong Wu, Yunpeng Gai, Changjun Chen. Functional Plasticity, Redundancy, and Specificity of Lanosterol 14α-Demethylase in Regulating the Sensitivity to DMIs in Calonectria ilicicola. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8444-8459. doi: 10.1021/acs.jafc.4c01948. [PMID: 38574108]
Yan Li, Guangyu Li, Chenwei Zuo, Xiaolin Wang, Fang Han, Yi Jia, Hai Shang, Yu Tian. Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer. European journal of medicinal chemistry. 2024 Apr; 270(?):116367. doi: 10.1016/j.ejmech.2024.116367. [PMID: 38581732]
Ayumi Okayama, Tatsuya Hoshino, Kohei Wada, Hiroshi Takahashi. Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers. Chemistry and physics of lipids. 2024 03; 259(?):105376. doi: 10.1016/j.chemphyslip.2024.105376. [PMID: 38325710]
Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, Chunchao Han. Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review. International journal of medicinal mushrooms. 2024; 26(2):11-23. doi: 10.1615/intjmedmushrooms.2023051918. [PMID: 38421693]
Ilijana Begcevic Brkovic, Madlen Reinicke, Soroth Chey, Ingo Bechmann, Uta Ceglarek. Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry. Cells. 2023 03; 12(7):. doi: 10.3390/cells12070974. [PMID: 37048046]
Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, Bi-Yang Liu, Gao-Qiang Liu. The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi. Communications biology. 2023 01; 6(1):1. doi: 10.1038/s42003-022-04154-6. [PMID: 36596887]
Fook-Hwa Lim, Omar Abd Rasid, Abu Seman Idris, Abdul Wahab Mohd As'wad, Ganesan Vadamalai, Ghulam Kadir Ahmad Parveez, Mui-Yun Wong. Induced expression of Ganoderma boninense Lanosterol 14α-Demethylase (ERG11) during interaction with oil palm. Molecular biology reports. 2022 Dec; ?(?):. doi: 10.1007/s11033-022-08131-4. [PMID: 36580194]
Dominik Šťastný, Lívia Petrisková, Dana Tahotná, Jacob Bauer, Lucia Pokorná, Roman Holič, Martin Valachovič, Vladimír Pevala, Shamshad Cockcroft, Peter Griač. Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol. FEBS letters. 2022 Dec; ?(?):. doi: 10.1002/1873-3468.14558. [PMID: 36482167]
Thais Latansio de Oliveira, Ariádine Reder Custodio de Souza, Pâmela Dias Fontana, Milena Carvalho Carneiro, Flávio Luís Beltrame, Iara Jose de Messias Reason, Lorena Bavia. Bioactive Secondary Plant Metabolites from Euphorbia umbellata (PAX) BRUYNS (Euphorbiaceae). Chemistry & biodiversity. 2022 Dec; 19(12):e202200568. doi: 10.1002/cbdv.202200568. [PMID: 36259393]
Yong-Li Li, Zhuo-Ni Xu, Jie Li, Shuang Liang, Min-Jie Xue, Jian-Jun Wu, Xian-Wen Yang. Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis. Chemistry & biodiversity. 2022 Dec; 19(12):e202200941. doi: 10.1002/cbdv.202200941. [PMID: 36398785]
Ao Lu, Ping Duan, Jing Xie, Hui Gao, Mengmeng Chen, Yu Gong, Jiawen Li, Haiwei Xu. Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. European journal of pharmacology. 2022 Nov; 934(?):175299. doi: 10.1016/j.ejphar.2022.175299. [PMID: 36181780]
Felix Rüttler, Tim Hammerschick, Sarah Schlag, Walter Vetter. Isolation of lanosterol and dihydrolanosterol from the unsaponifiable matter of lanolin by urea complexation and countercurrent chromatography in heart-cut recycling mode. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Nov; 1210(?):123470. doi: 10.1016/j.jchromb.2022.123470. [PMID: 36191441]
Hezhong Ouyang, Jinquan Hu, XingYing Qiu, Shaochang Wu, Fudong Guo, Youguo Tan. Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route. Pharmaceutical development and technology. 2022 Sep; 27(7):853-863. doi: 10.1080/10837450.2022.2124521. [PMID: 36124550]
Mohd Waseem, Jitendra K Thakur, Naidu Subbarao. Prediction of novel and potent inhibitors of lanosterol 14-α demethylase. Journal of biomolecular structure & dynamics. 2022 Jul; ?(?):1-13. doi: 10.1080/07391102.2022.2096116. [PMID: 35815531]
Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano. Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106116. doi: 10.1016/j.jsbmb.2022.106116. [PMID: 35533918]
Yi-Ni Cao, Shan-Shan Yue, An-Yi Wang, Lu Xu, Yi-Tong Hu, Xue Qiao, Tung-Ying Wu, Min Ye, Yang-Chang Wu, Rong Qi. Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. Journal of ethnopharmacology. 2022 Jun; 292(?):115146. doi: 10.1016/j.jep.2022.115146. [PMID: 35304272]
Xu-Cong Lv, Qi Wu, Ying-Jia Cao, Yi-Chen Lin, Wei-Ling Guo, Ping-Fan Rao, Yan-Yan Zhang, You-Ting Chen, Lian-Zhong Ai, Li Ni. Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition. Food & function. 2022 May; 13(10):5820-5837. doi: 10.1039/d1fo03219d. [PMID: 35543349]
Xiao-Li Zhang, Er-Kun Chao, Meng-Chu Sun, Hong-Fei Zhao, Cai-Xia Wang, Bo-Lin Zhang. [Effects of tHMGR from three different plant sources on mevalonate (MVA) pathway flux in Saccharomyces cerevisiae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(10):2614-2622. doi: 10.19540/j.cnki.cjcmm.20220116.102. [PMID: 35718479]
Dan Wang, Xianhua Cai, Feng Xu, Hui Kang, Yanjin Li, Ruibing Feng. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 05; 13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. [PMID: 35506157]
Roubi Abuobeid, Javier Sánchez-Marco, María J Felices, Carmen Arnal, Juan Carlos Burillo, Roberto Lasheras, Rebeca Busto, Miguel A Lasunción, María Jesús Rodríguez-Yoldi, Roberto Martínez-Beamonte, Jesús Osada. Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084172. [PMID: 35456988]
Yu-Ting Li, Zhen Zhang, Yunjiang Feng, Yuanyuan Cheng, Shuyuan Li, Can Li, Li-Wen Tian. Cardioprotective 22-hydroxylanostane triterpenoids from the fruiting bodies of Phellinus igniarius. Phytochemistry. 2021 Nov; 191(?):112907. doi: 10.1016/j.phytochem.2021.112907. [PMID: 34399303]
B Sangeetha, A S Krishnamoorthy, D Jeya Sundara Sharmila, P Renukadevi, V G Malathi, D Amirtham. Molecular modelling of coat protein of the Groundnut bud necrosis tospovirus and its binding with Squalene as an antiviral agent: In vitro and in silico docking investigations. International journal of biological macromolecules. 2021 Oct; 189(?):618-634. doi: 10.1016/j.ijbiomac.2021.08.143. [PMID: 34437921]
Tao Wang, Huihe Lu. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2021 Oct; 30(10):1031-1041. doi: 10.17219/acem/137914. [PMID: 34329545]
Weibo Qiao, Wei Feng, Lu Yang, Changfu Li, Xudong Qu, Yansheng Zhang. De Novo Biosynthesis of the Anticancer Compound Euphol in Saccharomyces cerevisiae. ACS synthetic biology. 2021 09; 10(9):2351-2358. doi: 10.1021/acssynbio.1c00257. [PMID: 34445867]
Zsófia Garádi, Miklós Dékány, Ágnes M Móricz, Anikó Gaál, Viktor Papp, Szabolcs Béni, Attila Ványolós. Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185453. [PMID: 34576923]
Yuyuan Li, He Liu, Huawen Qi, Wei Tang, Caihua Zhang, Zhaiyi Liu, Yinhui Liu, Xiaoqing Wei, Zhen Kong, Shangyi Jia, Borong Du, Jieli Yuan, Chaoran Wang, Ming Li. Probiotic fermentation of Ganoderma lucidum fruiting body extracts promoted its immunostimulatory activity in mice with dexamethasone-induced immunosuppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111909. doi: 10.1016/j.biopha.2021.111909. [PMID: 34328088]
Jie-Qiong Ma, Yu-Jia Zhang, Zhi-Kai Tian. Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway. Chemico-biological interactions. 2021 Aug; 344(?):109529. doi: 10.1016/j.cbi.2021.109529. [PMID: 34029542]
Yue Jia, Dandan Zhang, Hua Yin, Haoran Li, Jing Du, Hongkun Bao. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochemical research. 2021 Jul; 46(7):1725-1736. doi: 10.1007/s11064-021-03303-3. [PMID: 33821438]
Dieter Lütjohann, Frans Stellaard, Anja Kerksiek, Jörn Lötsch, Bruno G Oertel. Serum 4β-hydroxycholesterol increases during fluconazole treatment. European journal of clinical pharmacology. 2021 May; 77(5):659-669. doi: 10.1007/s00228-020-03041-5. [PMID: 33201347]
Nonhlakanipho F Sangweni, Rebamang A Mosa, Phiwayinkosi V Dludla, Abidemi P Kappo, Andy R Opoku, Christo J F Muller, Rabia Johnson. The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153546. doi: 10.1016/j.phymed.2021.153546. [PMID: 33799221]
Mahfoozur Rahman, Waleed H Almalki, Imran Kazmi, Obaid Afzal, Hanadi A Katouah, Majed Alrobaian, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Mohammed S Alshammari, Rehan Abdur Rub, Sarwar Beg, Vikas Kumar. Development and validation of a new UPLC-MS/MS method for quantification of ganoderic acid-A loaded nanolipidic carrier in rat plasma and application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jan; 1163(?):122501. doi: 10.1016/j.jchromb.2020.122501. [PMID: 33388522]
Pooja M, Gangavaram Jyothi Reddy, Kanipakam Hema, Sujatha Dodoala, Bharathi Koganti. Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. European journal of pharmacology. 2021 Jan; 890(?):173688. doi: 10.1016/j.ejphar.2020.173688. [PMID: 33130280]
Lu Xu, An-Kang Peng, Yi-Ni Cao, Xue Qiao, Shan-Shan Yue, Min Ye, Rong Qi. Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease. Current molecular pharmacology. 2021; 14(5):871-882. doi: 10.2174/1874467214666210120152140. [PMID: 33494689]
Nitish Boodhoo, Nitin Kamble, Shahriar Behboudi. De Novo Cholesterol Biosynthesis and Its Trafficking in LAMP-1-Positive Vesicles Are Involved in Replication and Spread of Marek's Disease Virus. Journal of virology. 2020 11; 94(24):. doi: 10.1128/jvi.01001-20. [PMID: 32999035]
Hai-Guo Su, Qian Wang, Lin Zhou, Xing-Rong Peng, Wen-Yong Xiong, Ming-Hua Qiu. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. Bioorganic chemistry. 2020 11; 104(?):104263. doi: 10.1016/j.bioorg.2020.104263. [PMID: 32920365]
Beibei Zhao, Yan Zhang, Hua Li, Jiawen Deng, Haodi Gong, Zhicheng Chen. Nutritional Component and Chemical Characterization of Chinese Highland Barley Bran Oil. Journal of oleo science. 2020 Nov; 69(11):1339-1347. doi: 10.5650/jos.ess19318. [PMID: 33055435]
Jianxin Han, Wei Liu, Miaomiao Li, Yanpei Gu, Ying Zhang, Tao Yuan. Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204807. [PMID: 33086725]
Nomadlozi Blessings Hlophe, Andrew Rowland Opoku, Foluso Oluwagbemiga Osunsanmi, Trayana Georgieva Djarova-Daniels, Oladipupo Adejumobi Lawal, Rebamang Anthony Mosa. A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats. Molecules (Basel, Switzerland). 2020 Sep; 25(17):. doi: 10.3390/molecules25174010. [PMID: 32887389]
Wei-Ling Guo, Jian-Bin Guo, Bin-Yu Liu, Jin-Qiang Lu, Min Chen, Bin Liu, Wei-Dong Bai, Ping-Fan Rao, Li Ni, Xu-Cong Lv. Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet. Food & function. 2020 Aug; 11(8):6818-6833. doi: 10.1039/d0fo00436g. [PMID: 32686808]
Songyot Anuchapreeda, Riki Anzawa, Natsima Viriyaadhammaa, Waranya Neimkhum, Wantida Chaiyana, Siriporn Okonogi, Toyonobu Usuki. Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves. Bioorganic & medicinal chemistry letters. 2020 07; 30(14):127256. doi: 10.1016/j.bmcl.2020.127256. [PMID: 32527555]
Fuli Liu, Kejian Shi, Jiaojiao Dong, Zhousheng Jin, Yiquan Wu, Yaoyao Cai, Tingting Lin, Qianqian Cai, Le Liu, Yujian Zhang. Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. Archives of pharmacal research. 2020 Jul; 43(7):744-754. doi: 10.1007/s12272-020-01256-9. [PMID: 32715385]
Jia Meng, Sai-Zhen Wang, Jin-Zhao He, Shuai Zhu, Bo-Yue Huang, Shu-Yuan Wang, Min Li, Hong Zhou, Shu-Qian Lin, Bao-Xue Yang. Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease. Acta pharmacologica Sinica. 2020 Jun; 41(6):782-790. doi: 10.1038/s41401-019-0329-2. [PMID: 31911637]
Zhongpeng Hu, Ruiping Du, Lei Xiu, Ziyao Bian, Chaomei Ma, Naoto Sato, Masao Hattori, Haochi Zhang, Yanchen Liang, Shuixing Yu, Xiao Wang. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine. 2020 03; 127(?):154917. doi: 10.1016/j.cyto.2019.154917. [PMID: 31775117]
Noriaki Nagai, Yuya Fukuoka, Kanta Sato, Hiroko Otake, Atsushi Taga, Mikako Oka, Noriko Hiramatsu, Naoki Yamamoto. The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats. International journal of molecular sciences. 2020 Feb; 21(3):. doi: 10.3390/ijms21031048. [PMID: 32033321]
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