26-Hydroxycholesterol (BioDeep_00000843560)

Main id: BioDeep_00000636693

 


代谢物信息卡片


Cholest-5-ene-3beta,27-diol

化学式: C27H46O2 (402.34976159999997)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
InChI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.

同义名列表

4 个代谢物同义名

Cholest-5-ene-3beta,27-diol; Cholest-5-ene-3beta,26-diol; 26-Hydroxycholesterol; 27-Hydroxycholesterol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(12)

BioCyc(0)

PlantCyc(0)

代谢反应

83 个相关的代谢反应过程信息。

Reactome(82)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Matysik, H H Klünemann, G Schmitz. Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. Clinical chemistry. 2012 Nov; 58(11):1557-64. doi: 10.1373/clinchem.2012.189605. [PMID: 22997279]
  • Xin Zhang, Qianming Bai, Genta Kakiyama, Leyuan Xu, Jin Kyung Kim, William M Pandak, Shunlin Ren. Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. The Journal of steroid biochemistry and molecular biology. 2012 Nov; 132(3-5):262-70. doi: 10.1016/j.jsbmb.2012.06.001. [PMID: 22732306]
  • Akihiko Kimura, Hiroshi Nittono, Tatsuki Mizuochi, Isao Ueki, Takao Kurosawa, Akina Muto, Hajime Takei. Neonatal cholestasis with increased 3β-monohydroxy-Δ⁵ bile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. Clinica chimica acta; international journal of clinical chemistry. 2012 Oct; 413(19-20):1700-4. doi: 10.1016/j.cca.2012.05.016. [PMID: 22652365]
  • Julius Popp, Piotr Lewczuk, Heike Kölsch, Sabrina Meichsner, Wolfgang Maier, Johannes Kornhuber, Frank Jessen, Dieter Lütjohann. Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. Journal of neurochemistry. 2012 Oct; 123(2):310-6. doi: 10.1111/j.1471-4159.2012.07893.x. [PMID: 22845771]
  • M Bertolotti, M Del Puppo, F Corna, C Anzivino, C Gabbi, E Baldelli, L Carulli, P Loria, M Galli Kienle, N Carulli. Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2012 Oct; 22(10):823-30. doi: 10.1016/j.numecd.2011.02.009. [PMID: 21546230]
  • Tzu Pin Shentu, Dev K Singh, Myung-Jin Oh, Shan Sun, Laleh Sadaat, Ayako Makino, Theodore Mazzone, Papasani V Subbaiah, Michael Cho, Irena Levitan. The role of oxysterols in control of endothelial stiffness. Journal of lipid research. 2012 Jul; 53(7):1348-58. doi: 10.1194/jlr.m027102. [PMID: 22496390]
  • Johanne Poirier, Kevin A Cockell, Kylie A Scoggan, W M Nimal Ratnayake, Hélène Rocheleau, Heidi Gruber, Eleonora Swist, Philip Griffin, Claude Gagnon, Stan Kubow. High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. The British journal of nutrition. 2012 Jul; 108(2):257-66. doi: 10.1017/s0007114511005587. [PMID: 22152646]
  • Jeffrey G McDonald, Daniel D Smith, Ashlee R Stiles, David W Russell. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. Journal of lipid research. 2012 Jul; 53(7):1399-409. doi: 10.1194/jlr.d022285. [PMID: 22517925]
  • Charles Desmarchelier, Christoph Dahlhoff, Sylvia Keller, Manuela Sailer, Gerhard Jahreis, Hannelore Daniel. C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. BMC genomics. 2012 Mar; 13(?):84. doi: 10.1186/1471-2164-13-84. [PMID: 22394543]
  • Randy L Bogan, Andrea E Debarber, Jon D Hennebold. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biology of reproduction. 2012 Mar; 86(3):89. doi: 10.1095/biolreprod.111.096347. [PMID: 22156476]
  • Gavin Tansley, Daniel T Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L Wellington. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Current gerontology and geriatrics research. 2012; 2012(?):179318. doi: 10.1155/2012/179318. [PMID: 22649448]
  • Laura Mateos, Muhammad-Al-Mustafa Ismail, Bengt Winblad, Angel Cedazo-Mínguez. side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. Neuro-degenerative diseases. 2012; 10(1-4):313-6. doi: 10.1159/000333340. [PMID: 22236548]
  • Yvonne Lange, Jin Ye, Theodore L Steck. Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. PloS one. 2012; 7(1):e30051. doi: 10.1371/journal.pone.0030051. [PMID: 22276143]
  • Timothy M Hughes, Lewis H Kuller, Oscar L Lopez, James T Becker, Rhobert W Evans, Kim Sutton-Tyrrell, Caterina Rosano. Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2012; 30(1):53-61. doi: 10.3233/jad-2012-111460. [PMID: 22377780]
  • Elad Cohen, Michael Aviram, Soliman Khatib, Asaf Rabin, Dalit Mannheim, Ron Karmeli, Jacob Vaya. Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. Journal of lipids. 2012; 2012(?):762560. doi: 10.1155/2012/762560. [PMID: 22690338]
  • Bernard G Schreurs, Desheng Wang, Carrie A Smith-Bell, Lauren B Burhans, Roger Bell, Jimena Gonzalez-Joekes. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response. International journal of Alzheimer's disease. 2012; 2012(?):732634. doi: 10.1155/2012/732634. [PMID: 22567532]
  • Tiangang Li, John Y L Chiang. Bile Acid signaling in liver metabolism and diseases. Journal of lipids. 2012; 2012(?):754067. doi: 10.1155/2012/754067. [PMID: 21991404]
  • Jorge A López-Velázquez, Luis D Carrillo-Córdova, Norberto C Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez. Nuclear receptors in nonalcoholic Fatty liver disease. Journal of lipids. 2012; 2012(?):139875. doi: 10.1155/2012/139875. [PMID: 22187655]
  • Andrea Crosignani, Massimo Zuin, Mariangela Allocca, Marina Del Puppo. Oxysterols in bile acid metabolism. Clinica chimica acta; international journal of clinical chemistry. 2011 Nov; 412(23-24):2037-45. doi: 10.1016/j.cca.2011.07.028. [PMID: 21855537]
  • Rodrigo T Iborra, Adriana Machado-Lima, Gabriela Castilho, Valeria S Nunes, Dulcinéia S P Abdalla, Edna R Nakandakare, Marisa Passarelli. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids in health and disease. 2011 Sep; 10(?):172. doi: 10.1186/1476-511x-10-172. [PMID: 21957962]
  • Kristin L Bowden, Nicolas J Bilbey, Leanne M Bilawchuk, Emmanuel Boadu, Rohini Sidhu, Daniel S Ory, Hong Du, Teddy Chan, Gordon A Francis. Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. The Journal of biological chemistry. 2011 Sep; 286(35):30624-30635. doi: 10.1074/jbc.m111.274381. [PMID: 21757691]
  • Valerio Leoni, Claudio Caccia. Oxysterols as biomarkers in neurodegenerative diseases. Chemistry and physics of lipids. 2011 Sep; 164(6):515-24. doi: 10.1016/j.chemphyslip.2011.04.002. [PMID: 21515244]
  • Bhanu Dasari, Jaya Rp Prasanthi, Gurdeep Marwarha, Brij B Singh, Othman Ghribi. Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC ophthalmology. 2011 Aug; 11(?):22. doi: 10.1186/1471-2415-11-22. [PMID: 21851605]
  • Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki. Cholesterol 25-hydroxylation activity of CYP3A. Journal of lipid research. 2011 Aug; 52(8):1509-16. doi: 10.1194/jlr.m014084. [PMID: 21576599]
  • Laura Mateos, Muhammad-Al-Mustafa Ismail, Francisco-Javier Gil-Bea, Rebecca Schüle, Ludger Schöls, Maura Heverin, Ronnie Folkesson, Ingemar Björkhem, Angel Cedazo-Mínguez. Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. The Journal of biological chemistry. 2011 Jul; 286(29):25574-85. doi: 10.1074/jbc.m111.236877. [PMID: 21628469]
  • Jin-Hui Zhang, Liang Ge, Wei Qi, Liqing Zhang, Hong-Hua Miao, Bo-Liang Li, Maojun Yang, Bao-Liang Song. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. The Journal of biological chemistry. 2011 Jul; 286(28):25088-97. doi: 10.1074/jbc.m111.244475. [PMID: 21602275]
  • Raymond C S Seet, Chung-Yung J Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?. Free radical biology & medicine. 2011 Jun; 50(12):1787-93. doi: 10.1016/j.freeradbiomed.2011.03.019. [PMID: 21420490]
  • Paola Gamba, Gabriella Leonarduzzi, Elena Tamagno, Michela Guglielmotto, Gabriella Testa, Barbara Sottero, Simona Gargiulo, Fiorella Biasi, Alessandro Mauro, José Viña, Giuseppe Poli. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging cell. 2011 Jun; 10(3):403-17. doi: 10.1111/j.1474-9726.2011.00681.x. [PMID: 21272192]
  • V Leoni, C Mariotti, L Nanetti, E Salvatore, F Squitieri, A R Bentivoglio, M Bandettini di Poggio, M Bandettini Del Poggio, S Piacentini, D Monza, M Valenza, E Cattaneo, S Di Donato. Whole body cholesterol metabolism is impaired in Huntington's disease. Neuroscience letters. 2011 May; 494(3):245-9. doi: 10.1016/j.neulet.2011.03.025. [PMID: 21406216]
  • Marjan Shafaati, Amelia Marutle, Hanna Pettersson, Anita Lövgren-Sandblom, Maria Olin, Irina Pikuleva, Bengt Winblad, Agneta Nordberg, Ingemar Björkhem. Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. Journal of lipid research. 2011 May; 52(5):1004-10. doi: 10.1194/jlr.m014548. [PMID: 21335619]
  • Cynthia Hong, Robert Walczak, Helena Dhamko, Michelle N Bradley, Chaitra Marathe, Rima Boyadjian, Jon V Salazar, Peter Tontonoz. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of lipid research. 2011 Mar; 52(3):531-9. doi: 10.1194/jlr.m010686. [PMID: 21187453]
  • Danni Cheng, Andrew M Jenner, Guanghou Shui, Wei Fun Cheong, Todd W Mitchell, Jessica R Nealon, Woojin S Kim, Heather McCann, Markus R Wenk, Glenda M Halliday, Brett Garner. Lipid pathway alterations in Parkinson's disease primary visual cortex. PloS one. 2011 Feb; 6(2):e17299. doi: 10.1371/journal.pone.0017299. [PMID: 21387008]
  • Ratna Karuna, Adriaan G Holleboom, Mohammad M Motazacker, Jan Albert Kuivenhoven, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Spiros Georgopoulos, Miranda van Eck, Theo J C van Berkel, Arnold von Eckardstein, Katharina M Rentsch. Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. Atherosclerosis. 2011 Feb; 214(2):448-55. doi: 10.1016/j.atherosclerosis.2010.10.042. [PMID: 21130455]
  • Rosamaria Lappano, Anna Grazia Recchia, Ernestina Marianna De Francesco, Tommaso Angelone, Maria Carmela Cerra, Didier Picard, Marcello Maggiolini. The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. PloS one. 2011 Jan; 6(1):e16631. doi: 10.1371/journal.pone.0016631. [PMID: 21304949]
  • T M Jeitner, I Voloshyna, A B Reiss. Oxysterol derivatives of cholesterol in neurodegenerative disorders. Current medicinal chemistry. 2011; 18(10):1515-25. doi: 10.2174/092986711795328445. [PMID: 21428891]
  • Boris Bigalke, Brigitte Schreitmüller, Kateryna Sopova, Angela Paul, Elke Stransky, Meinrad Gawaz, Konstantinos Stellos, Christoph Laske. Adipocytokines and CD34 progenitor cells in Alzheimer's disease. PloS one. 2011; 6(5):e20286. doi: 10.1371/journal.pone.0020286. [PMID: 21633502]
  • Carlos Ramírez, Saleta Sierra, Inmaculada Tercero, Jose Antonio Vázquez, Antonia Pineda, Tatiana Manrique, Javier S Burgos. ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. PloS one. 2011; 6(7):e22712. doi: 10.1371/journal.pone.0022712. [PMID: 21829488]
  • Laura Mateos, Muhammad-Al-Mustafa Ismail, Francisco-Javier Gil-Bea, Valerio Leoni, Bengt Winblad, Ingemar Björkhem, Angel Cedazo-Mínguez. Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2011; 24(4):669-79. doi: 10.3233/jad-2011-101512. [PMID: 21297254]
  • Anne Vejux, Mohammad Samadi, Gérard Lizard. Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. Journal of ophthalmology. 2011; 2011(?):471947. doi: 10.1155/2011/471947. [PMID: 21577274]
  • Katayoon B Ebrahimi, James T Handa. Lipids, lipoproteins, and age-related macular degeneration. Journal of lipids. 2011; 2011(?):802059. doi: 10.1155/2011/802059. [PMID: 21822496]
  • Barbara D Pachikian, Ahmed Essaghir, Jean-Baptiste Demoulin, Audrey M Neyrinck, Emilie Catry, Fabienne C De Backer, Nicolas Dejeans, Evelyne M Dewulf, Florence M Sohet, Laurence Portois, Louise Deldicque, Olivier Molendi-Coste, Isabelle A Leclercq, Marc Francaux, Yvon A Carpentier, Fabienne Foufelle, Giulio G Muccioli, Patrice D Cani, Nathalie M Delzenne. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. PloS one. 2011; 6(8):e23365. doi: 10.1371/journal.pone.0023365. [PMID: 21853118]
  • Thomas J Berrodin, Qi Shen, Elaine M Quinet, Matthew R Yudt, Leonard P Freedman, Sunil Nagpal. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. Molecular pharmacology. 2010 Dec; 78(6):1046-58. doi: 10.1124/mol.110.065193. [PMID: 20837678]
  • Celine Ullrich, Michael Pirchl, Christian Humpel. Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Molecular and cellular neurosciences. 2010 Dec; 45(4):408-17. doi: 10.1016/j.mcn.2010.08.001. [PMID: 20696249]
  • Hauke Schneider, Alexandra Lingesleben, Hans-Peter Vogel, Rita Garuti, Sebastiano Calandra. A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis. Orphanet journal of rare diseases. 2010 Oct; 5(?):27. doi: 10.1186/1750-1172-5-27. [PMID: 20925952]
  • Heike Kölsch, Reinhard Heun, Frank Jessen, Julius Popp, Frank Hentschel, Wolfgang Maier, Dieter Lütjohann. Alterations of cholesterol precursor levels in Alzheimer's disease. Biochimica et biophysica acta. 2010 Aug; 1801(8):945-50. doi: 10.1016/j.bbalip.2010.03.001. [PMID: 20226877]
  • Janice M W Taylor, Faye Borthwick, Chris Bartholomew, Annette Graham. Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. Cardiovascular research. 2010 Jun; 86(3):526-34. doi: 10.1093/cvr/cvq015. [PMID: 20083572]
  • Raymond C-S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Shan-Hong Huang, Chin-Meng Khoo, Barry Halliwell. Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. Diabetes care. 2010 May; 33(5):1140-2. doi: 10.2337/dc09-2124. [PMID: 20185735]
  • Rebecca Schüle, Teepu Siddique, Han-Xiang Deng, Yi Yang, Sandra Donkervoort, Magnus Hansson, Ricardo E Madrid, Nailah Siddique, Ludger Schöls, Ingemar Björkhem. Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. Journal of lipid research. 2010 Apr; 51(4):819-23. doi: 10.1194/jlr.m002543. [PMID: 19812052]
  • T Vallim, A M Salter. Regulation of hepatic gene expression by saturated fatty acids. Prostaglandins, leukotrienes, and essential fatty acids. 2010 Apr; 82(4-6):211-8. doi: 10.1016/j.plefa.2010.02.016. [PMID: 20227267]
  • Allan D Sniderman, Jacqueline De Graaf, Patrick Couture, Ken Williams, Robert S Kiss, Gerald F Watts. Regulation of plasma LDL: the apoB paradigm. Clinical science (London, England : 1979). 2010 03; 118(5):333-9. doi: 10.1042/cs20090402. [PMID: 19922416]
  • Lea Tenenholz Grinberg, Dietmar Rudolf Thal. Vascular pathology in the aged human brain. Acta neuropathologica. 2010 Mar; 119(3):277-90. doi: 10.1007/s00401-010-0652-7. [PMID: 20155424]
  • Oliver Weingärtner, Ulrich Laufs, Michael Böhm, Dieter Lütjohann. An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. Atherosclerosis. 2010 Mar; 209(1):39-41. doi: 10.1016/j.atherosclerosis.2009.09.015. [PMID: 19801147]
  • Concetta Crisafulli, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocrea. Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. Respiratory research. 2010 Feb; 11(?):19. doi: 10.1186/1465-9921-11-19. [PMID: 20175894]
  • Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, June J H Tan, Amy M L Quek, Wan-Ling Chong, Woan-Foon Looi, Shan-Hong Huang, Huansong Wang, Yiong-Huak Chan, Barry Halliwell. Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free radical biology & medicine. 2010 Feb; 48(4):560-6. doi: 10.1016/j.freeradbiomed.2009.11.026. [PMID: 19969070]
  • Yu-Ming Wang, Bei Zhang, Yong Xue, Zhao-Jie Li, Jing-Feng Wang, Chang-Hu Xue, Teruyoshi Yanagita. The mechanism of dietary cholesterol effects on lipids metabolism in rats. Lipids in health and disease. 2010 Jan; 9(?):4. doi: 10.1186/1476-511x-9-4. [PMID: 20070910]
  • Luigi Iuliano, Roberto Monticolo, Giuseppe Straface, Ilaria Spoletini, Walter Gianni, Carlo Caltagirone, Paola Bossù, Gianfranco Spalletta. Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2010; 21(4):1383-92. doi: 10.3233/jad-2010-100780. [PMID: 21504117]
  • D Lütjohann, M Marinova, B Schneider, J Oldenburg, K von Bergmann, T Bieber, I Björkhem, U Diczfalusy. 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. International journal of clinical pharmacology and therapeutics. 2009 Dec; 47(12):709-15. doi: 10.5414/cpp47709. [PMID: 19954708]
  • Alina Solomon, Valerio Leoni, Miia Kivipelto, Ariadna Besga, Anne Rita Oksengård, Per Julin, Leif Svensson, Lars-Olof Wahlund, Niels Andreasen, Bengt Winblad, Hilkka Soininen, Ingemar Björkhem. Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. Neuroscience letters. 2009 Oct; 462(1):89-93. doi: 10.1016/j.neulet.2009.06.073. [PMID: 19560513]
  • Geneviève Escher, Isabelle Vögeli, Robert Escher, Robert C Tuckey, Sandra Erickson, Zygmunt Krozowski, Felix J Frey. Role of CYP27A1 in progesterone metabolism in vitro and in vivo. American journal of physiology. Endocrinology and metabolism. 2009 Oct; 297(4):E949-55. doi: 10.1152/ajpendo.00298.2009. [PMID: 19671838]
  • Yvonne Lange, Theodore L Steck, Jin Ye, Michael H Lanier, Vasumathi Molugu, Daniel Ory. Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. Journal of lipid research. 2009 Sep; 50(9):1881-8. doi: 10.1194/jlr.m900116-jlr200. [PMID: 19401598]
  • Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Leonard L L Yeo, Shan-Hong Huang, Barry Halliwell. Oxidative damage in dengue fever. Free radical biology & medicine. 2009 Aug; 47(4):375-80. doi: 10.1016/j.freeradbiomed.2009.04.035. [PMID: 19427377]
  • Janka Koschack, Dieter Lütjohann, Carsten Schmidt-Samoa, Eva Irle. Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. Neurobiology of aging. 2009 Jun; 30(6):898-902. doi: 10.1016/j.neurobiolaging.2007.10.010. [PMID: 18061309]
  • Vesa M Olkkonen, Riikka Hynynen. Interactions of oxysterols with membranes and proteins. Molecular aspects of medicine. 2009 Jun; 30(3):123-33. doi: 10.1016/j.mam.2009.02.004. [PMID: 19248802]
  • Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. Journal of lipid research. 2009 Feb; 50(2):350-7. doi: 10.1194/jlr.d800040-jlr200. [PMID: 18815436]
  • Takeshi Hirayama, Yuji Mizokami, Akira Honda, Yasuhiko Homma, Tadashi Ikegami, Yoshifumi Saito, Teruo Miyazaki, Yasushi Matsuzaki. Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level. Hepatology research : the official journal of the Japan Society of Hepatology. 2009 Feb; 39(2):149-56. doi: 10.1111/j.1872-034x.2008.00450.x. [PMID: 19208035]
  • Ratna Karuna, Arnold von Eckardstein, Katharina M Rentsch. Dopant assisted-atmospheric pressure photoionization (DA-APPI) liquid chromatography-mass spectrometry for the quantification of 27-hydroxycholesterol in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jan; 877(3):261-8. doi: 10.1016/j.jchromb.2008.12.033. [PMID: 19121981]
  • Changcheng Zhou, Suman Verma, Bruce Blumberg. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nuclear receptor signaling. 2009; 7(?):e001. doi: 10.1621/nrs.07001. [PMID: 19240808]
  • Tiangang Li, John Y L Chiang. Regulation of bile acid and cholesterol metabolism by PPARs. PPAR research. 2009; 2009(?):501739. doi: 10.1155/2009/501739. [PMID: 19636418]
  • Sandy Mosig, Knut Rennert, Petra Büttner, Siegfried Krause, Dieter Lütjohann, Muhidien Soufi, Regine Heller, Harald Funke. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC medical genomics. 2008 Nov; 1(?):60. doi: 10.1186/1755-8794-1-60. [PMID: 19040724]
  • Danni Cheng, Woojin Scott Kim, Brett Garner. Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. Neuroreport. 2008 Nov; 19(17):1685-9. doi: 10.1097/wnr.0b013e32831578b2. [PMID: 18841091]
  • Istvan Szatmari, Laszlo Nagy. Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function. The EMBO journal. 2008 Sep; 27(18):2353-62. doi: 10.1038/emboj.2008.160. [PMID: 18716631]
  • Andrea Crosignani, Marina Del Puppo, Emma De Fabiani, Donatella Caruso, Domenico Gallisai, Maria G Mela, Maria L Melzi, Marzia Galli Kienle, Carla Colombo. Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. Clinica chimica acta; international journal of clinical chemistry. 2008 Sep; 395(1-2):84-8. doi: 10.1016/j.cca.2008.05.011. [PMID: 18538136]
  • William J Griffiths, Martin Hornshaw, Gary Woffendin, Sharon F Baker, Andrew Lockhart, Sibylle Heidelberger, Magnus Gustafsson, Jan Sjövall, Yuqin Wang. Discovering oxysterols in plasma: a window on the metabolome. Journal of proteome research. 2008 Aug; 7(8):3602-12. doi: 10.1021/pr8001639. [PMID: 18605750]
  • Myron F Weiner, Gloria L Vega, Ramon Diaz-Arrastia, Carol Moore, Christopher Madden, Anne Hudak, Dieter Lütjohann. Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. Brain injury. 2008 Jul; 22(7-8):611-5. doi: 10.1080/02699050802196037. [PMID: 18568715]
  • Jessie R Zhang, Trey Coleman, S Joshua Langmade, David E Scherrer, Lindsay Lane, M Hunter Lanier, Chu Feng, Mark S Sands, Jean E Schaffer, Clay F Semenkovich, Daniel S Ory. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. The Journal of clinical investigation. 2008 Jun; 118(6):2281-90. doi: 10.1172/jci32561. [PMID: 18483620]
  • Heleen M de Vogel-van den Bosch, Nicole J W de Wit, Guido J E J Hooiveld, Hanneke Vermeulen, Jelske N van der Veen, Sander M Houten, Folkert Kuipers, Michael Müller, Roelof van der Meer. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. American journal of physiology. Gastrointestinal and liver physiology. 2008 May; 294(5):G1171-80. doi: 10.1152/ajpgi.00360.2007. [PMID: 18356535]
  • Chung-Yung J Lee, Shan Hong Huang, Andrew M Jenner, Barry Halliwell. Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. Free radical biology & medicine. 2008 Apr; 44(7):1314-22. doi: 10.1016/j.freeradbiomed.2007.12.026. [PMID: 18226605]
  • M B Patel, N A Oza, I S Anand, S S Deshpande, C N Patel. Liver x receptor: a novel therapeutic target. Indian journal of pharmaceutical sciences. 2008 Mar; 70(2):135-44. doi: 10.4103/0250-474x.41445. [PMID: 20046702]
  • Yvonne Lange, Daniel S Ory, Jin Ye, Michael H Lanier, Fong-Fu Hsu, Theodore L Steck. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of biological chemistry. 2008 Jan; 283(3):1445-1455. doi: 10.1074/jbc.m706967200. [PMID: 18024962]
  • Xiaobo Li, William M Pandak, Sandra K Erickson, Yongjie Ma, Lianhua Yin, Phillip Hylemon, Shunlin Ren. Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. Journal of lipid research. 2007 Dec; 48(12):2587-96. doi: 10.1194/jlr.m700301-jlr200. [PMID: 17890683]
  • C Knabe, T Sudhop, K von Bergmann, D Lütjohann. Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1. International journal of clinical pharmacology and therapeutics. 2007 Nov; 45(11):577-82. doi: 10.5414/cpp45577. [PMID: 18077921]
  • Michihisa Umetani, Hideharu Domoto, Andrew K Gormley, Ivan S Yuhanna, Carolyn L Cummins, Norman B Javitt, Kenneth S Korach, Philip W Shaul, David J Mangelsdorf. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nature medicine. 2007 Oct; 13(10):1185-92. doi: 10.1038/nm1641. [PMID: 17873880]
  • Kazuhiro Hojo, Hideki Hakamata, Ayumi Ito, Akira Kotani, Chisaki Furukawa, Yu-Ya Hosokawa, Fumiyo Kusu. Determination of total cholesterol in serum by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. A. 2007 Sep; 1166(1-2):135-41. doi: 10.1016/j.chroma.2007.08.020. [PMID: 17723233]
  • Ines Burkard, Arnold von Eckardstein, Gérard Waeber, Peter Vollenweider, Katharina M Rentsch. Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis. 2007 Sep; 194(1):71-8. doi: 10.1016/j.atherosclerosis.2006.09.026. [PMID: 17107679]
  • Andrea Crosignani, Marina Del Puppo, Matteo Longo, Emma De Fabiani, Donatella Caruso, Massimo Zuin, Mauro Podda, Norman B Javitt, Marzia Galli Kienle. Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. Clinica chimica acta; international journal of clinical chemistry. 2007 Jul; 382(1-2):82-8. doi: 10.1016/j.cca.2007.03.025. [PMID: 17482152]
  • Yann Gueguen, Luc Ferrari, Maâmar Souidi, Anne-Marie Batt, Claude Lutton, Gérard Siest, Sophie Visvikis. Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase. Basic & clinical pharmacology & toxicology. 2007 Jun; 100(6):392-7. doi: 10.1111/j.1742-7843.2007.00066.x. [PMID: 17516993]
  • C E Teunissen, S Floris, M Sonke, C D Dijkstra, H E De Vries, D Lütjohann. 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. Journal of neuroscience research. 2007 May; 85(7):1499-505. doi: 10.1002/jnr.21266. [PMID: 17410599]
  • M Hansson, M Olin, C-H Floren, S von Bahr, F van't Hooft, S Meaney, G Eggertsen, I Björkhem. Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. Journal of internal medicine. 2007 May; 261(5):504-10. doi: 10.1111/j.1365-2796.2007.01782.x. [PMID: 17444890]
  • Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem. Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. Journal of lipid research. 2007 Apr; 48(4):944-51. doi: 10.1194/jlr.m600529-jlr200. [PMID: 17251592]
  • Mari Luomala, Hannu Päivä, Karin Thelen, Reijo Laaksonen, Marika Saarela, Kari Mattila, Dieter Lütjohann, Terho Lehtimaki. Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients. Acta cardiologica. 2007 Apr; 62(2):177-81. doi: 10.2143/ac.62.2.2020239. [PMID: 17536607]
  • Tiangang Li, Wenling Chen, John Y L Chiang. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. Journal of lipid research. 2007 Feb; 48(2):373-84. doi: 10.1194/jlr.m600282-jlr200. [PMID: 17088262]
  • Wenling Chen, Guoxen Chen, Daphne L Head, David J Mangelsdorf, David W Russell. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell metabolism. 2007 Jan; 5(1):73-9. doi: 10.1016/j.cmet.2006.11.012. [PMID: 17189208]
  • Julia Holzapfel, Reinhard Heun, Dieter Lütjohann, Frank Jessen, Wolfgang Maier, Heike Kölsch. PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease. Neuroscience letters. 2006 Nov; 408(1):57-61. doi: 10.1016/j.neulet.2006.08.029. [PMID: 16979821]
  • Mari Luomala, Hannu Päivä, Reijo Laaksonen, Karin Thelen, Dieter Lütjohann, Nina Peltonen, Terho Lehtimäki. Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia. Scandinavian cardiovascular journal : SCJ. 2006 Oct; 40(5):280-4. doi: 10.1080/14017430600959978. [PMID: 17012138]
  • Karin M Thelen, Reijo Laaksonen, Hannu Päivä, Terho Lehtimäki, Dieter Lütjohann. High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. Journal of clinical pharmacology. 2006 Jul; 46(7):812-6. doi: 10.1177/0091270006289851. [PMID: 16809807]
  • Y Guéguen, M Souidi, C Baudelin, N Dudoignon, S Grison, I Dublineau, C Marquette, P Voisin, P Gourmelon, J Aigueperse. Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Archives of toxicology. 2006 Apr; 80(4):187-95. doi: 10.1007/s00204-005-0027-3. [PMID: 16231126]
  • D M Klass, K Bührmann, G Sauter, M Del Puppo, J Scheibner, M Fuchs, E F Stange. Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. Alimentary pharmacology & therapeutics. 2006 Apr; 23(7):895-905. doi: 10.1111/j.1365-2036.2006.02836.x. [PMID: 16573792]
  • Fred A Kummerow, Mohamedain M Mahfouz, Qi Zhou, L Scott Cook. 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. Life sciences. 2006 Jan; 78(9):958-63. doi: 10.1016/j.lfs.2005.06.023. [PMID: 16154158]
  • Karin M Thelen, Dieter Lütjohann, Risto Vesalainen, Tuula Janatuinen, Juhani Knuuti, Klaus von Bergmann, Terho Lehtimäki, Reijo Laaksonen. Effect of pravastatin on plasma sterols and oxysterols in men. European journal of clinical pharmacology. 2006 Jan; 62(1):9-14. doi: 10.1007/s00228-005-0068-9. [PMID: 16385401]