12S-HHTrE (BioDeep_00001868670)
Main id: BioDeep_00000004028
代谢物信息卡片
12-Hydroxyheptadecatrienoic acid
化学式: C17H28O3 (280.2038)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC=CCC=CCCCC(=O)O)O
InChI: InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
描述信息
A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent.
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:63977
- KEGG: C20388
- PubChem: 5283141
- ChEMBL: CHEMBL4632597
- CAS: 54397-84-1
- MetaboLights: MTBLC63977
- PubChem: 163312126
- RefMet: 12S-HHTrE
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yiyun Geng, Weichao Li, Nai-Kei Wong, Fuchong Xue, Qing Li, Yang Zhang, Jingyuan Xu, Zhangshuang Deng, Yiqing Zhou. Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics.
Journal of medicinal chemistry.
2024 Feb; 67(3):2083-2094. doi:
10.1021/acs.jmedchem.3c01989. [PMID: 38287228] - Tatsuro Nakamura. The roles of lipid mediators in type I hypersensitivity.
Journal of pharmacological sciences.
2021 Sep; 147(1):126-131. doi:
10.1016/j.jphs.2021.06.001. [PMID: 34294363] - Toshiaki Okuno, Takehiko Yokomizo. Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid.
Prostaglandins & other lipid mediators.
2021 02; 152(?):106502. doi:
10.1016/j.prostaglandins.2020.106502. [PMID: 33075476] - Malgorzata Cebo, Jörg Schlotterbeck, Meinrad Gawaz, Madhumita Chatterjee, Michael Lämmerhofer. Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin.
Analytica chimica acta.
2020 Jan; 1094(?):57-69. doi:
10.1016/j.aca.2019.10.005. [PMID: 31761048] - Elba Garreta-Lara, Antonio Checa, David Fuchs, Romà Tauler, Silvia Lacorte, Craig E Wheelock, Carlos Barata. Effect of psychiatric drugs on Daphnia magna oxylipin profiles.
The Science of the total environment.
2018 Dec; 644(?):1101-1109. doi:
10.1016/j.scitotenv.2018.06.333. [PMID: 30743823] - Kazuko Saeki, Takehiko Yokomizo. Identification, signaling, and functions of LTB4 receptors.
Seminars in immunology.
2017 10; 33(?):30-36. doi:
10.1016/j.smim.2017.07.010. [PMID: 29042026] - Yumiko Ishii, Kazuko Saeki, Min Liu, Fumiyuki Sasaki, Tomoaki Koga, Keiko Kitajima, Chikara Meno, Toshiaki Okuno, Takehiko Yokomizo. Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2016 Feb; 30(2):933-47. doi:
10.1096/fj.15-279653. [PMID: 26527063] - Toshiaki Okuno. [Identification of the old and new lipid mediator, 12-HHT and the role in skin wound healing].
Seikagaku. The Journal of Japanese Biochemical Society.
2015 Feb; 87(1):125-8. doi:
. [PMID: 26571566] - Min Liu, Kazuko Saeki, Takehiko Matsunobu, Toshiaki Okuno, Tomoaki Koga, Yukihiko Sugimoto, Chieko Yokoyama, Satoshi Nakamizo, Kenji Kabashima, Shuh Narumiya, Takao Shimizu, Takehiko Yokomizo. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
The Journal of experimental medicine.
2014 Jun; 211(6):1063-78. doi:
10.1084/jem.20132063. [PMID: 24821912] - Takehiko Matsunobu, Toshiaki Okuno, Chieko Yokoyama, Takehiko Yokomizo. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
Journal of lipid research.
2013 Nov; 54(11):2979-87. doi:
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Basic research in cardiology.
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The Journal of experimental medicine.
2008 Apr; 205(4):759-66. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2007 Jul; 77(1):21-8. doi:
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2005 May; 348(5):1163-76. doi:
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Prostaglandins & other lipid mediators.
2003 Jul; 71(3-4):217-34. doi:
10.1016/s1098-8823(03)00041-8. [PMID: 14518563] - Ana M Vecino, José L Teruel, José L Navarro, Jesús M Cesar. Phospholipase A2 activity in platelets of patients with uremia.
Platelets.
2002 Nov; 13(7):415-8. doi:
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Environmental health perspectives.
2001 Aug; 109 Suppl 4(?):613-8. doi:
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Prostaglandins & other lipid mediators.
1998 Jun; 56(2-3):53-76. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1998 Feb; 58(2):143-6. doi:
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The Biochemical journal.
1997 Jul; 325 ( Pt 2)(?):495-500. doi:
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Acta physiologica Hungarica.
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1996 Oct; 37(10):2244-50. doi:
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Journal of ethnopharmacology.
1995 Feb; 45(2):131-9. doi:
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Journal of applied toxicology : JAT.
1994 May; 14(3):167-71. doi:
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The International journal of biochemistry.
1994 Jan; 26(1):127-31. doi:
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Research communications in chemical pathology and pharmacology.
1992 Aug; 77(2):227-40. doi:
". [PMID: 1439191] - F Engels, B F Renirie, B A Hart, R P Labadie, F P Nijkamp. Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism.
FEBS letters.
1992 Jul; 305(3):254-6. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1992 Jul; 46(3):203-10. doi:
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Biochemistry.
1992 Jun; 31(23):5356-62. doi:
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Analytical biochemistry.
1990 Sep; 189(2):244-8. doi:
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1990 Jul; 59(2):227-35. doi:
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1990 Jul; 31(7):1241-6. doi:
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1990 Jun; 14(3):239-45. doi:
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1989 Jan; 21(1):43-50. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1988 Feb; 31(2):65-72. doi:
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1988 Feb; 49(3):331-42. doi:
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The American review of respiratory disease.
1988 Jan; 137(1):38-43. doi:
10.1164/ajrccm/137.1.38. [PMID: 2827547] - M Hecker, V Ullrich. 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro.
Eicosanoids.
1988; 1(1):19-25. doi:
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American heart journal.
1985 Dec; 110(6):1154-60. doi:
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". [PMID: 7386271]
