7-Amino-4-methylcoumarin (BioDeep_00001868361)
Main id: BioDeep_00000003064
代谢物信息卡片
7-Amino-4-methylcoumarin
化学式: C10H9NO2 (175.0633)
中文名称: 7-氨基-4-甲基香豆素(AMC), 7-氨基-4-甲基香豆素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)N
InChI: InChI=1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
同义名列表
3 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:51771
- KEGG: C01386
- PubChem: 92249
- DrugBank: DB08168
- ChEMBL: CHEMBL270672
- CAS: 26093-31-2
- PubChem: 4580
- KNApSAcK: C00048593
- PDB-CCD: MCM
- NIKKAJI: J150.531I
- RefMet: 7-Amino-4-methylcoumarin
- KNApSAcK: 51771
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sandrine Cadel, Cécile Darmon, Alexandre Désert, Mouna Mahbouli, Christophe Piesse, Thanos Ghélis, René Lafont, Thierry Foulon. The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity.
Biochemical and biophysical research communications.
2019 05; 512(4):832-837. doi:
10.1016/j.bbrc.2019.02.143. [PMID: 30928100] - J A Molina-Bolívar, F Galisteo-González, C Carnero Ruiz, M Medina-O'Donnell, A Martínez, A Parra. Maslinic acid conjugate with 7-amino-4-methylcoumarin as probe to monitor the temperature dependent conformational changes of human serum albumin by FRET.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 May; 214(?):161-169. doi:
10.1016/j.saa.2019.02.014. [PMID: 30776717] - Wioletta Romaniuk, Lukasz Bolkun, Joanna Kalita, Marzenna Galar, Malgorzata Bernatowicz, Halina Ostrowska, Janusz Kloczko. High chymotrypsin-like activity in the plasma of patients with newly diagnosed multiple myeloma treated with bortezomib is predictive of a better response and longer PFS.
Annals of hematology.
2018 Oct; 97(10):1879-1887. doi:
10.1007/s00277-018-3393-7. [PMID: 29946907] - Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano. Identification of tissue-restricted bioreaction suitable for in vivo targeting by fluorescent substrate library-based enzyme discovery.
Journal of the American Chemical Society.
2015 Sep; 137(38):12187-90. doi:
10.1021/jacs.5b05884. [PMID: 26360463] - Zulfiqar A Malik, Sumaira Amir, István Venekei. SERINE proteinase like activity in apolipophorin III from the hemolymph of desert locust, Schistocerca gregaria.
Archives of insect biochemistry and physiology.
2012 Jun; 80(1):26-41. doi:
10.1002/arch.21020. [PMID: 22499434] - Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.
BMC cancer.
2012 Jan; 12(?):4. doi:
10.1186/1471-2407-12-4. [PMID: 22217342] - Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.
International journal of molecular sciences.
2012; 13(3):3101-3133. doi:
10.3390/ijms13033101. [PMID: 22489144] - Didik Priyandoko, Tetsuro Ishii, Sunil C Kaul, Renu Wadhwa. Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite.
PloS one.
2011 May; 6(5):e19552. doi:
10.1371/journal.pone.0019552. [PMID: 21573189] - Elena I Sinauridze, Alexey N Romanov, Irina V Gribkova, Olga A Kondakova, Stepan S Surov, Aleksander S Gorbatenko, Andrey A Butylin, Mikhail Yu Monakov, Alexey A Bogolyubov, Yuryi V Kuznetsov, Vladimir B Sulimov, Fazoyl I Ataullakhanov. New synthetic thrombin inhibitors: molecular design and experimental verification.
PloS one.
2011; 6(5):e19969. doi:
10.1371/journal.pone.0019969. [PMID: 21603576] - Haixia Yang, Xiaoping Fu, Meiliang Li, Xiaojing Leng, Bin Chen, Guanghua Zhao. Protein association and dissociation regulated by extension peptide: a mode for iron control by phytoferritin in seeds.
Plant physiology.
2010 Nov; 154(3):1481-91. doi:
10.1104/pp.110.163063. [PMID: 20841455] - Joseph A Davis, Shuchita Singh, Sachin Sethi, Subhasis Roy, Shivani Mittra, Geetavani Rayasam, Vinay Bansal, Jitendra Sattigeri, Abhijit Ray. Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals.
Indian journal of pharmacology.
2010 Aug; 42(4):229-33. doi:
10.4103/0253-7613.68425. [PMID: 20927248] - Myung-Gyu Kim, Ha Na Yang, Hye-Won Kim, Sang-Kyung Jo, Won Yong Cho, Hyoung-Kyu Kim. IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity.
Journal of Korean medical science.
2010 Apr; 25(4):557-63. doi:
10.3346/jkms.2010.25.4.557. [PMID: 20357998] - Maruska Budic, Marjetka Kidric, Vladimir Meglic, Blaz Cigić. A quantitative technique for determining proteases and their substrate specificities and pH optima in crude enzyme extracts.
Analytical biochemistry.
2009 May; 388(1):56-62. doi:
10.1016/j.ab.2009.01.045. [PMID: 20334826] - Dale S Edgerton, Kathryn M S Johnson, Doss W Neal, Melanie Scott, Charles H Hobbs, Xia Zhang, Alokesh Duttaroy, Alan D Cherrington. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog.
Diabetes.
2009 Jan; 58(1):243-9. doi:
10.2337/db08-0515. [PMID: 18840785] - Sarah Chapelsky, Sarah Batty, Mia Frost, Jeremy Mogridge. Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.
PloS one.
2008 Jan; 3(1):e1421. doi:
10.1371/journal.pone.0001421. [PMID: 18183301] - Ji-Hong Yao, Ying-Hua Li, Zhen-Zhen Wang, Xue-Song Zhang, Yu-Zhu Wang, Jin-Chan Yuan, Qin Zhou, Ke-Xin Liu, Xiao-Feng Tian. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion.
Clinical and experimental pharmacology & physiology.
2007 Nov; 34(11):1102-8. doi:
10.1111/j.1440-1681.2007.04674.x. [PMID: 17880361] - André Catic, Shahram Misaghi, Gregory A Korbel, Hidde L Ploegh. ElaD, a Deubiquitinating protease expressed by E. coli.
PloS one.
2007 Apr; 2(4):e381. doi:
10.1371/journal.pone.0000381. [PMID: 17440617] - Frank Rasche, Verania Hödl, Christian Poll, Ellen Kandeler, Martin H Gerzabek, Jan D van Elsas, Angela Sessitsch. Rhizosphere bacteria affected by transgenic potatoes with antibacterial activities compared with the effects of soil, wild-type potatoes, vegetation stage and pathogen exposure.
FEMS microbiology ecology.
2006 May; 56(2):219-35. doi:
10.1111/j.1574-6941.2005.00027.x. [PMID: 16629752] - Naghi Momeni, Berit M Nordström, Vibeke Horstmann, Hassan Avarseji, Bengt V Sivberg. Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders.
BMC psychiatry.
2005 Jun; 5(?):27. doi:
10.1186/1471-244x-5-27. [PMID: 15932649] - Bertrand Liagre, Pascale Vergne-Salle, Cecile Corbiere, Jean L Charissoux, Jean L Beneytout. Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression.
Arthritis research & therapy.
2004; 6(4):R373-83. doi:
10.1186/ar1199. [PMID: 15225373] - O Fromigue, N Kheddoumi, J-J Body. Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival.
British journal of cancer.
2003 Jul; 89(1):178-84. doi:
10.1038/sj.bjc.6601009. [PMID: 12838321] - Andrei Yu Kondratovich, Alexandra V Pokhilko, Fazoil I Ataullakhanov. Spatiotemporal dynamics of contact activation factors of blood coagulation.
Biochimica et biophysica acta.
2002 Jan; 1569(1-3):86-104. doi:
10.1016/s0304-4165(01)00247-1. [PMID: 11853962] - Y A Birney, B F O'Connor. Purification and characterization of a Z-pro-prolinal-insensitive Z-Gly-Pro-7-amino-4-methyl coumarin-hydrolyzing peptidase from bovine serum--a new proline-specific peptidase.
Protein expression and purification.
2001 Jul; 22(2):286-98. doi:
10.1006/prep.2001.1450. [PMID: 11437605] - E A Stroev, N N Bulaeva, M Y Kochukov. Intracellular distribution and regulation of calpains in the thyroid gland.
Bulletin of experimental biology and medicine.
2001 Feb; 131(2):124-6. doi:
10.1023/a:1017575424807. [PMID: 11391391] - Y V Krasotkina, E I Sinauridze, F I Ataullakhanov. Spatiotemporal dynamics of fibrin formation and spreading of active thrombin entering non-recalcified plasma by diffusion.
Biochimica et biophysica acta.
2000 May; 1474(3):337-45. doi:
10.1016/s0304-4165(00)00019-2. [PMID: 10779685] - A Davy, K K Thomsen, M A Juliano, L C Alves, I Svendsen, D J Simpson. Purification and characterization of barley dipeptidyl peptidase IV.
Plant physiology.
2000 Feb; 122(2):425-32. doi:
10.1104/pp.122.2.425. [PMID: 10677435] - S P Gallagher, R M O'Leary, B O'Connor. The development of two fluorimetric assays for the determination of pyroglutamyl aminopeptidase type-II activity.
Analytical biochemistry.
1997 Jul; 250(1):1-9. doi:
10.1006/abio.1997.2195. [PMID: 9234892] - B Nerli, D Romanini, G Picó. Structural specificity requirements in the binding of beta lactam antibiotics to human serum albumin.
Chemico-biological interactions.
1997 May; 104(2-3):179-202. doi:
10.1016/s0009-2797(97)00024-0. [PMID: 9212783] - Z Kolár, E Krepela, J Kovarík, M Kohoutek, M Rypka, J Vicar. Clinical experience with the testing of serum proteinase activity by cathepsin B-like sensitive amino acid derivatives of 7-amino-4-methylcoumarine.
Neoplasma.
1987; 34(5):601-8. doi:
. [PMID: 3122064] - C J Olbricht, J K Cannon, L C Garg, C C Tisher. Activities of cathepsins B and L in isolated nephron segments from proteinuric and nonproteinuric rats.
The American journal of physiology.
1986 Jun; 250(6 Pt 2):F1055-62. doi:
10.1152/ajprenal.1986.250.6.f1055. [PMID: 3717347] - V Dufek, B Matous, M Hrebícek. [Fluorometric determination of serum levels of cathepsin B using 7-amino-4-methylcoumarin as the specific substrate].
Sbornik lekarsky.
1983 Dec; 85(11-12):289-96. doi:
. [PMID: 6658359] - T Kato, M Okada, T Nagatsu. Distribution of post-proline cleaving enzyme in human brain and the peripheral tissues.
Molecular and cellular biochemistry.
1980 Nov; 32(3):117-21. doi:
10.1007/bf00227437. [PMID: 7007867]
