Femara (BioDeep_00000868123)
Main id: BioDeep_00000000718
PANOMIX_OTCML-2023
代谢物信息卡片
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
化学式: C17H11N5 (285.1014)
中文名称: 来曲唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
InChI: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BG - Aromatase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
同义名列表
28 个代谢物同义名
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile; Benzonitrile, 4,4-(1H-1,2,4-triazol-1-ylmethylene)bis-; 4,4-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile; 4,4-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile; Letrozole (JAN\USP\INN); Letrozole [USAN:INN]; Prestwick3_001025; Prestwick1_001025; Prestwick0_001025; Prestwick2_001025; CAS-112809-51-5; NCGC00016973-01; BSPBio_001209; BPBio1_001331; SPBio_003070; MLS000759455; SMR000466343; 112809-51-5; Femara (TN); CGS-20267; CGS 20267; Letrozole; NSC719345; FEM-345; D00964; C08163; Femara; Letrozole
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6413
- KEGG: C08163
- PubChem: 3902
- DrugBank: DB01006
- ChEMBL: CHEMBL1444
- MeSH: Letrozole
- CAS: 112809-51-5
- PubChem: 10363
- NIKKAJI: J390.644B
- medchemexpress: HY-14248
- KNApSAcK: 6413
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 款冬花: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tarun Kumar Kar, Sananda Sil, Angshita Ghosh, Ananya Barman, Sandip Chattopadhyay. Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds.
Journal of ovarian research.
2024 Apr; 17(1):76. doi:
10.1186/s13048-024-01378-4. [PMID: 38589892] - Yuechong Li, Zixi Deng, Yingjiao Wang, Songjie Shen. Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study.
Lipids in health and disease.
2024 Jan; 23(1):9. doi:
10.1186/s12944-024-02002-6. [PMID: 38191454] - Shiya Huang, Chuyi Yu, Min Hu, Qidan Wen, Xiaohui Wen, Shuna Li, Kunyin Li, Hongxia Ma. Electroacupuncture ameliorates hepatic defects in a rat model of polycystic ovary syndrome induced by letrozole and a high-fat diet.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2023 Dec; ?(?):9645284231207863. doi:
10.1177/09645284231207863. [PMID: 38044823] - Hanem M Rabah, Darin A Mohamed, Reham A Mariah, Sarah R Abd El-Khalik, Haidy A Khattab, Norhan A AbuoHashish, Amal M Abdelsattar, Mohamed A Raslan, Eman E Farghal, Amira K Eltokhy. Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.
Redox report : communications in free radical research.
2023 Dec; 28(1):2160569. doi:
10.1080/13510002.2022.2160569. [PMID: 36661246] - Maisra Azhar Butt, Hafiz Muhammad Shafique, Mahjabeen Mustafa, Nurain Baig Moghul, Anum Munir, Urwah Shamas, Sobia Tabassum, Mubin Mustafa Kiyani. Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats.
Biological trace element research.
2023 Nov; 201(11):5213-5229. doi:
10.1007/s12011-023-03579-2. [PMID: 36694071] - Hanan S Anbar, Nisha Yarifbhai Vahora, Hajra Laghman Shah, Mariyam Mohammed Azam, Tamanna Islam, Fatima Hersi, Hany A Omar, Wolfgang Dohle, Barry V L Potter, Mohammed I El-Gamal. Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin.
European journal of pharmacology.
2023 Oct; ?(?):176119. doi:
10.1016/j.ejphar.2023.176119. [PMID: 37852569] - Al-Amin M Bashir, Kehinde S Olaniyi. Butyrate alleviates renal inflammation and fibrosis in a rat model of polycystic ovarian syndrome by suppression of SDF-1.
BMC pharmacology & toxicology.
2023 10; 24(1):48. doi:
10.1186/s40360-023-00692-9. [PMID: 37789355] - Tingting Zhang, Huimin Gao, Yali Fan, Shuya Chen, Yingying Li, Ruixia Liu, Tianhe Li, Chenghong Yin. Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid.
Life sciences.
2023 Oct; 330(?):121912. doi:
10.1016/j.lfs.2023.121912. [PMID: 37423380] - Kehinde S Olaniyi, Stephanie E Areloegbe. Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression.
Canadian journal of physiology and pharmacology.
2023 Aug; ?(?):. doi:
10.1139/cjpp-2023-0169. [PMID: 37590975] - Wenting Zuo, Xiangfei Liu, Jianhuai Chen, Wenren Zuo, Yanyun Yin, Xiaowei Nie, Peipei Tang, Yunke Huang, Qian Yu, Qiaoyun Hu, Jie Zhou, Yong Tan, Xi Huang, Qingling Ren. Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS.
American journal of physiology. Endocrinology and metabolism.
2023 Aug; ?(?):. doi:
10.1152/ajpendo.00165.2023. [PMID: 37584608] - Ya Gao, Siyi Mo, Houkang Cao, Yueping Zhi, Xiaohui Ma, Zhipeng Huang, Bo Li, Jianzhao Wu, Kefeng Zhang, Ling Jin. The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Aug; 120(?):155013. doi:
10.1016/j.phymed.2023.155013. [PMID: 37639812] - Kehinde S Olaniyi, Stephanie E Areloegbe, Emmanuel D Areola, Isaiah W Sabinari, Adedamola A Fafure, Richard D Agbana, Chukwubueze L Atuma, Mohd Zahoor Ul Haq Shah, Isaac O Ajadi, Lawrence A Olatunji. Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome.
Toxicology and applied pharmacology.
2023 Jun; 473(?):116604. doi:
10.1016/j.taap.2023.116604. [PMID: 37328115] - Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang. Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome.
European journal of pharmacology.
2023 Jun; ?(?):175825. doi:
10.1016/j.ejphar.2023.175825. [PMID: 37269973] - Joy Fehintoluwa Femi-Olabisi, Ahmed Adebayo Ishola, Folakemi Omolara Olujimi. Effect of Parquetina nigrescens (Afzel.) Leaves on Letrozole-Induced PCOS in Rats: a Molecular Insight into Its Phytoconstituents.
Applied biochemistry and biotechnology.
2023 May; ?(?):. doi:
10.1007/s12010-023-04537-3. [PMID: 37171758] - Zhi Zhou, Xiaopo Zhang, Guohui Yi, Yong Zhang, Juan Zhang, Can Tan, Bangbei Wan, Yejuan Li, Hui Lu, Weiying Lu. LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A.
Reproductive biology.
2023 Apr; 23(2):100764. doi:
10.1016/j.repbio.2023.100764. [PMID: 37084543] - Sorelle Ines Fotsing, Judith Christiane Ngo Pambe, Kevine Kamga Silihe, Natacha Lena Yembeau, Armand Choupo, Dieudonné Njamen, Constant Anatole Pieme, Stéphane Zingue. Breast cancer cell growth arrest and chemopreventive effects of Passiflora edulis Sims (Passifloraceae) ethanolic leaves extract on a rat model of mammary carcinoma.
Journal of ethnopharmacology.
2023 Mar; 311(?):116408. doi:
10.1016/j.jep.2023.116408. [PMID: 36966851] - Kehinde S Olaniyi, Stephanie E Areloegbe. Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
Nutrition (Burbank, Los Angeles County, Calif.).
2023 03; 107(?):111914. doi:
10.1016/j.nut.2022.111914. [PMID: 36521396] - Neven Hassan, Maha Rashad, Ebtihal Elleithy, Zainab Sabry, Ghada Ali, Sherif Elmosalamy. L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling.
Drug and chemical toxicology.
2023 Mar; 46(2):357-368. doi:
10.1080/01480545.2022.2039180. [PMID: 35176959] - Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang. Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis.
Obstetrics and gynecology.
2023 03; 141(3):523-534. doi:
10.1097/aog.0000000000005070. [PMID: 36735392] - Meiting Cui, Yanli Hong, Jingyu Huang, Kailu Liu, Juan Chen, Yong Tan, Xiaowei Nie. Efficiency of Chinese medicine Bushen Huatan formula for treatment of polycystic ovary syndrome in mice via regulating gut microbiota and PPARγ pathway.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2023 Feb; 52(1):33-45. doi:
10.3724/zdxbyxb-2022-0456. [PMID: 37283116] - Yuwei Zhang, Haili Zhou, Caifei Ding. The ameliorative effect of CangFu Daotan Decoction on polycystic ovary syndrome of rodent model is associated with m6A methylation and Wnt/β-catenin pathway.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2023 Feb; ?(?):2181637. doi:
10.1080/09513590.2023.2181637. [PMID: 36822223] - Dan-Dan Wang, Jing-Xian Cao, Wen-Jing Jiang, Jin-Wei Hou, Meng-Han Yan, Zhen-Gao Sun, Jing-Yan Song. Comparison of pregnancy outcomes of letrozole-induced frozen-thawed embryo transfer cycles in PCOS women with two different abnormal ovulation patterns: A retrospective cohort study.
Medicine.
2023 Feb; 102(7):e33049. doi:
10.1097/md.0000000000033049. [PMID: 36800580] - Yang Hai, Ling Zuo, Meng Wang, Ruoyu Zhang, Munan Wang, Li Ren, Congwen Yang, Jianwei Wang. Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation.
Molecules (Basel, Switzerland).
2023 Jan; 28(2):. doi:
10.3390/molecules28020517. [PMID: 36677577] - Kehinde S Olaniyi, Stephanie E Areloegbe. Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome.
The Journal of steroid biochemistry and molecular biology.
2023 01; 225(?):106179. doi:
10.1016/j.jsbmb.2022.106179. [PMID: 36150640] - Natalia Respekta, Agnieszka Maślanka, Ewa Mlyczyńska, Maria Billert, Agata Szlaga, Patryk Sambak, Piotr Pawlicki, Bartosz Płachno, Marek Skrzypski, Małgorzata Kotula-Balak, Anna Błasiak, Agnieszka Rak. Levels of spexin and its receptors GALR2 and GALR3 in the hypothalamus and ovary of letrozole-induced polycystic ovary syndrome in rats.
Biochemical and biophysical research communications.
2022 10; 627(?):207-213. doi:
10.1016/j.bbrc.2022.08.059. [PMID: 36055012] - Naser Mirazi, Sheida Hesami, Alireza Nourian, Abdolkarim Hosseini. Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats: hormonal, biochemical, and histopathological investigation.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 10; 42(5):741-748. doi:
10.19852/j.cnki.jtcm.2022.05.007. [PMID: 36083481] - Yan-Xiang Wu, Xiu-Yan Yang, Bao-Sheng Han, Yuan-Yuan Hu, Tian An, Bo-Han Lv, Juan Lian, Ting-Ye Wang, Xue-Li Bao, Lin Gao, Guang-Jian Jiang. Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113286. doi:
10.1016/j.biopha.2022.113286. [PMID: 35724506] - Mmenyene U Peter, Stephanie E Areloegbe, Christopher O Akintayo, Adesola A Oniyide, Ayodeji Aturamu, Kehinde S Olaniyi. Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model.
Canadian journal of physiology and pharmacology.
2022 Sep; 100(9):890-902. doi:
10.1139/cjpp-2022-0176. [PMID: 35771488] - Bin Guo, Jiao-Jiao Li, Ya-Ling Ma, Yu-Tao Zhao, Jian-Guo Liu. Efficacy and safety of letrozole or anastrozole in the treatment of male infertility with low testosterone-estradiol ratio: A meta-analysis and systematic review.
Andrology.
2022 07; 10(5):894-909. doi:
10.1111/andr.13185. [PMID: 35438843] - Kehinde S Olaniyi, Stephanie E Areloegbe. Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome.
Life sciences.
2022 Jul; 300(?):120560. doi:
10.1016/j.lfs.2022.120560. [PMID: 35452635] - Jiayu Tian, Yanqiu Xu, Yu Xiong, Ling Zuo, Min Zhou, Chunhao Cao, Xuekuan Huang, Jianwei Wang. Metabolomics combined with network pharmacology to explore the mechanisms of modified Guishen pill to ameliorate polycystic ovary syndrome.
Computers in biology and medicine.
2022 Jun; 148(?):105790. doi:
10.1016/j.compbiomed.2022.105790. [PMID: 35839542] - Joanna Maria Pieczyńska, Ewa Pruszyńska-Oszmałek, Paweł Antoni Kołodziejski, Anna Łukomska, Joanna Bajerska. The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice.
Nutrients.
2022 Jun; 14(12):. doi:
10.3390/nu14122478. [PMID: 35745209] - Arpi Dey, Shivani Dhadhal, Radha Maharjan, Padamnabhi S Nagar, Laxmipriya Nampoothiri. Partially purified non-polar phytocomponents from Aloe barbadensis Mill. gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary syndrome rodent model- an "in-vivo" study.
Journal of ethnopharmacology.
2022 Jun; 291(?):115161. doi:
10.1016/j.jep.2022.115161. [PMID: 35271948] - Imane Lalami, Julie Labrosse, Isabelle Cedrin-Durnerin, Marjorie Comtet, Claire Vinolas, Fabien Krief, Christophe Sifer, Maeliss Peigne, Michael Grynberg. Is letrozole during ovarian stimulation useful in breast cancer patients undergoing fertility preservation to reduce early luteal progesterone levels following GnRH-agonist trigger?.
Reproductive biology and endocrinology : RB&E.
2022 Jun; 20(1):87. doi:
10.1186/s12958-022-00958-7. [PMID: 35690817] - Yuan Xiang, Hui Liu, Hao Hu, Le-Wei Li, Qi-Bei Zong, Tang-Wei Wu, Xiao-Yi Li, Shi-Qiang Fang, Yi-Wen Liu, Yu Zhan, Hui Wang, Zhong-Xin Lu. LINC00094/miR-19a-3p/CYP19A1 axis affects the sensitivity of ER positive breast cancer cells to Letrozole through EMT pathway.
Aging.
2022 06; 14(11):4755-4768. doi:
10.18632/aging.204110. [PMID: 35657638] - Yuan-Yuan Wu, Shu-Yu Li, Hui-Qing Zhu, Zi-Ming Zhuang, Meng Shao, Fei-Long Chen, Chang-Shun Liu, Qing-Fa Tang. Network pharmacology integrated with experimental validation reveals the regulatory mechanism of action of Hehuan Yin decoction in polycystic ovary syndrome with insulin resistance.
Journal of ethnopharmacology.
2022 May; 289(?):115057. doi:
10.1016/j.jep.2022.115057. [PMID: 35121050] - Eric M Zwiefelhofer, Will Lillico, Gregg P Adams. Development of a letrozole-based synchronization protocol for fixed-time artificial insemination in beef cattle.
Animal reproduction science.
2022 May; 240(?):106975. doi:
10.1016/j.anireprosci.2022.106975. [PMID: 35483319] - Yasmine F Ibrahim, Mohammed Alorabi, Walaa Yehia Abdelzaher, Nisreen Dm Toni, Khaled Thabet, AbdelRahman Hegazy, Haitham Ahmed Bahaa, Gaber El-Saber Batiha, Nermeen N Welson, Mohamed A Morsy, Katharigatta N Venugopala, Asmaa Mohamed Abdel-Aziz. Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 May; 149(?):112870. doi:
10.1016/j.biopha.2022.112870. [PMID: 35367769] - Yuxuan Zhang, Lingling Xu. Comparative study of DHEA and letrozole induced polycystic ovary syndrome in post-pubertal rats.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2022 May; 38(5):425-431. doi:
10.1080/09513590.2022.2052843. [PMID: 35311605] - Bjørn-Erik Bertelsen, Kristin Viste, Thomas Helland, Magnus Hagland, Håvard Søiland, Jürgen Geisler, Tone Hoel Lende, Per Eystein Lønning, Jørn V Sagen, Gunnar Mellgren, Bjørg Almås. Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients.
The Journal of clinical endocrinology and metabolism.
2022 04; 107(5):1368-1374. doi:
10.1210/clinem/dgab923. [PMID: 34958096] - Hindole Ghosh, Seema Rai, Md Dilshad Manzar, Seithikurippu R Pandi-Perumal, Gregory M Brown, Russel J Reiter, Daniel P Cardinali. Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome.
Life sciences.
2022 Apr; 295(?):120086. doi:
10.1016/j.lfs.2021.120086. [PMID: 34710445] - Wei Guo, Hang Wun Raymond Li, Zi Yang, Lin Zeng, Rui Yang, Jie Qiao, Rong Li, Ernest Hung Yu Ng. Live birth after letrozole as an adjunct to follicle-stimulating hormone versus follicle-stimulating hormone alone for ovarian stimulation in in vitro fertilisation cycles-study protocol for a randomised controlled trial.
Trials.
2022 Apr; 23(1):247. doi:
10.1186/s13063-022-06185-0. [PMID: 35365197] - Nathalie Søderhamn Bülow, Marianne Dreyer Holt, Sven Olaf Skouby, Kathrine Birch Petersen, Anne Lis Mikkelsen Englund, Anja Pinborg, Nicholas Stephen Macklon. Co-treatment with letrozole during ovarian stimulation for IVF/ICSI: a systematic review and meta-analysis.
Reproductive biomedicine online.
2022 04; 44(4):717-736. doi:
10.1016/j.rbmo.2021.12.006. [PMID: 35183444] - Yao Yao, Yangyang Wan, Xiaoyun Shi, Lan Guo, Hui Jiang, Xiansheng Zhang, Bo Xu, Juan Hua. Letrozole protects against cadmium-induced inhibition of spermatogenesis via LHCGR and Hsd3b6 to activate testosterone synthesis in mice.
Reproductive biology and endocrinology : RB&E.
2022 Mar; 20(1):43. doi:
10.1186/s12958-022-00915-4. [PMID: 35236366] - Marwa M M Refaie, Maram El-Hussieny, Wedad M Abdelraheem. Diacerein ameliorates induced polycystic ovary in female rats via modulation of inflammasome/caspase1/IL1β and Bax/Bcl2 pathways.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 03; 395(3):295-304. doi:
10.1007/s00210-021-02175-2. [PMID: 34994825] - Chih-Ning Chen, Lu-Te Chang, Chi-Huang Chen, Ka-Wai Tam. Fertility preservation for women with breast cancer before chemotherapy: a systematic review and meta-analysis.
Reproductive biomedicine online.
2022 02; 44(2):357-369. doi:
10.1016/j.rbmo.2021.08.003. [PMID: 34656436] - Heta Huttunen, Tero Varimo, Hanna Huopio, Raimo Voutilainen, Sirpa Tenhola, Päivi J Miettinen, Taneli Raivio, Matti Hero. Serum testosterone and oestradiol predict the growth response during puberty promoting treatment.
Clinical endocrinology.
2022 02; 96(2):220-226. doi:
10.1111/cen.14605. [PMID: 34596269] - Nathalie Søderhamn Bülow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grøndahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon. Impact of letrozole co-treatment during ovarian stimulation with gonadotrophins for IVF: a multicentre, randomized, double-blinded placebo-controlled trial.
Human reproduction (Oxford, England).
2022 Jan; 37(2):309-321. doi:
10.1093/humrep/deab249. [PMID: 34792133] - Jun H Heo, Sang R Lee, Seong Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong. Letrozole Accelerates Metabolic Remodeling through Activation of Glycolysis in Cardiomyocytes: A Role beyond Hormone Regulation.
International journal of molecular sciences.
2022 Jan; 23(1):. doi:
10.3390/ijms23010547. [PMID: 35008972] - Yanyuan Zhou, Huan Lan, Zhewen Dong, Wanying Li, Bo Qian, Zhen Zeng, Wen He, Jia-Le Song. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome.
Oxidative medicine and cellular longevity.
2022; 2022(?):5558599. doi:
10.1155/2022/5558599. [PMID: 35663203] - Xinli Lu, Cheng Qian. Efficacy, Safety, and Prognosis of Sequential Therapy with Tamoxifen and Letrozole versus Letrozole Monotherapy for Breast Carcinoma.
Computational and mathematical methods in medicine.
2022; 2022(?):1979254. doi:
10.1155/2022/1979254. [PMID: 35464999] - Yue Wang, Jie Chen, Han Dong, Ruilin Ma, Ying Zou, Wei Wang, Qingmei Zheng, Ying Feng, Zhangyun Tan, Xiaoqin Zeng, Yinqing Zhao, Yan Deng, Yanfang Wang, Bei Gu, Aijun Sun. The Disparity in the Management of Polycystic Ovary Syndrome between Obstetrician-Gynecologists in Different-Level Hospitals under the Hierarchical Medical System.
BioMed research international.
2022; 2022(?):9778678. doi:
10.1155/2022/9778678. [PMID: 36158894] - Yang Wang, Hui Xiao, Yanxia Liu, Qing Tong, Yanyan Yu, Bing Qi, Xiaoling Bu, Tianyuan Pan, Yu Xing. Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome.
Frontiers in endocrinology.
2022; 13(?):891297. doi:
10.3389/fendo.2022.891297. [PMID: 36017323] - Shuai Jiang, Ting Tang, Yongmei Sheng, Rui Li, Hua Xu. The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome.
Journal of healthcare engineering.
2022; 2022(?):3712166. doi:
10.1155/2022/3712166. [PMID: 35368950] - Kok-Min Seow, Pin-Shiou Liu, Kuo-Hu Chen, Chien-Wei Chen, Luen-Kui Chen, Chi-Hong Ho, Jiann-Loung Hwang, Peng-Hui Wang, Chi-Chang Juan. Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010134. [PMID: 35008567] - Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali. Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.
Redox report : communications in free radical research.
2021 Dec; 26(1):94-104. doi:
10.1080/13510002.2021.1927396. [PMID: 34018905] - Xiaohong Ma, Xiaorong Li, LiLi Ma, Yan Chen, Shengyu He. Soy isoflavones alleviate polycystic ovary syndrome in rats by regulating NF- κB signaling pathway.
Bioengineered.
2021 12; 12(1):7215-7223. doi:
10.1080/21655979.2021.1979864. [PMID: 34546841] - Mehmet Bugra Kivrak, Orhan Corum, Hasan Alkan, Orkun Atik, Ibrahim Aydin, Kamil Uney. The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes.
Theriogenology.
2021 Dec; 176(?):225-232. doi:
10.1016/j.theriogenology.2021.09.033. [PMID: 34628085] - Nazli Bahrami, Shakila Jabeen, Andliena Tahiri, Torill Sauer, Hilde Presterud Ødegård, Stephanie Beate Geisler, Berit Gravdehaug, Laurens Cornelus Reitsma, Knut Selsås, Vessela Kristensen, Jürgen Geisler. Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin.
Breast cancer research and treatment.
2021 Dec; 190(3):435-449. doi:
10.1007/s10549-021-06399-x. [PMID: 34554372] - Ilkay Gulturk, Mesut Yilmaz, Aykut Ozmen, Seher Yıldız Tacar, Gülçin Sahingoz Erdal, Deniz Tural. Ribociclib induced acute kidney injury: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Dec; 27(8):2023-2026. doi:
10.1177/10781552211007202. [PMID: 33847193] - Muhammad Aliff Haslan, Nurdiana Samsulrizal, Nooraain Hashim, Noor Syaffinaz Noor Mohamad Zin, Farshad H Shirazi, Yong Meng Goh. Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats.
BMC complementary medicine and therapies.
2021 Nov; 21(1):291. doi:
10.1186/s12906-021-03452-6. [PMID: 34844580] - Ariana Soledad Poetto, Bianca Posocco, Sara Gagno, Marco Orleni, Martina Zanchetta, Valentina Iacuzzi, Giovanni Canil, Mauro Buzzo, Marcella Montico, Michela Guardascione, Debora Basile, Giacomo Pelizzari, Martina Alberti, Lorenzo Gerratana, Fabio Puglisi, Giuseppe Toffoli. A new dried blood spot LC-MS/MS method for therapeutic drug monitoring of palbociclib, ribociclib, and letrozole in patients with cancer.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Nov; 1185(?):122985. doi:
10.1016/j.jchromb.2021.122985. [PMID: 34700133] - Geethika S G Liyanage, Ryo Inoue, Mina Fujitani, Tomoko Ishijima, Taisei Shibutani, Keiko Abe, Taro Kishida, Shinji Okada. Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats.
Nutrients.
2021 Oct; 13(11):. doi:
10.3390/nu13113759. [PMID: 34836015] - Basma Abdel Fattah Helal, Ghada Mahmoud Ismail, Salma Elwy Nassar, Abeer Abed Abo Zeid. Effect of vitamin D on experimental model of polycystic ovary syndrome in female rats.
Life sciences.
2021 Oct; 283(?):119558. doi:
10.1016/j.lfs.2021.119558. [PMID: 33930367] - Sara E Ali, Shymaa A El Badawy, Sherif H Elmosalamy, Shimaa R Emam, Asmaa A Azouz, Mona K Galal, Reham M Abd-Elsalam, Marwa Y Issa, Bardes B Hassan. Novel promising reproductive and metabolic effects of Cicer arietinum L. extract on letrozole induced polycystic ovary syndrome in rat model.
Journal of ethnopharmacology.
2021 Oct; 278(?):114318. doi:
10.1016/j.jep.2021.114318. [PMID: 34111539] - Yue-Lian Yang, Wei-Wei Zhou, Shan Wu, Wen-Li Tang, Zong-Wei Wang, Zu-Yi Zhou, Ze-Wen Li, Qing-Fa Huang, Yan He, Hong-Wei Zhou. Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome.
Endocrinology.
2021 10; 162(10):. doi:
10.1210/endocr/bqab118. [PMID: 34145455] - Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari. Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.
The Journal of steroid biochemistry and molecular biology.
2021 10; 213(?):105954. doi:
10.1016/j.jsbmb.2021.105954. [PMID: 34298098] - Shruti R Hansda, Chandana Haldar. Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
Life sciences.
2021 Sep; 281(?):119755. doi:
10.1016/j.lfs.2021.119755. [PMID: 34175318] - Yuan Xu, Yan-Hong Zhang, Qiu-Ping Zhang, Qian-Qian Zhao, Xiao-Fu Cao, Mei Zhang, Xue Li, Xi-Ting Liu, Zhuo-Xiang Sun, Min Kan, Bin Du, Yue Zhou, Fan Yang, Bo Ban, Wei Zhao. Off-label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure-response analysis.
British journal of clinical pharmacology.
2021 09; 87(9):3599-3607. doi:
10.1111/bcp.14775. [PMID: 33576060] - Aurore Collin, Julie Vein, Yohann Wittrant, Bruno Pereira, Raalib Amode, Christelle Guillet, Damien Richard, Alain Eschalier, David Balayssac. A new clinically-relevant rat model of letrozole-induced chronic nociceptive disorders.
Toxicology and applied pharmacology.
2021 08; 425(?):115600. doi:
10.1016/j.taap.2021.115600. [PMID: 34081940] - Tao Cai, Nashmi Naife Al-Jubairi, Heitor O Santos, Ivan G O de Souza, Youdong Chen. Does letrozole treatment have favorable effects on the lipid profile? A systematic review and meta-analysis of randomized clinical trials.
Steroids.
2021 08; 172(?):108875. doi:
10.1016/j.steroids.2021.108875. [PMID: 34116112] - Caitlin E Martin, Christopher Lewis, Kenan Omurtag. Successful oocyte cryopreservation using letrozole as an adjunct to stimulation in a transgender adolescent after GnRH agonist suppression.
Fertility and sterility.
2021 08; 116(2):522-527. doi:
10.1016/j.fertnstert.2021.02.025. [PMID: 33795140] - Anna Pilutin, Kamila Misiakiewicz-Has, Agnieszka Kolasa-Wołosiuk, Grzegorz Trybek, Fabian Urban, Mariola Marchlewicz, Bartosz Leszczyński, Andrzej Wróbel, Barbara Wiszniewska. Morphology and serum and bone tissue calcium and magnesium concentrations in the bones of male rats chronically treated with letrozole, a nonsteroidal cytochrome P450 aromatase inhibitor.
Connective tissue research.
2021 07; 62(4):454-463. doi:
10.1080/03008207.2020.1771329. [PMID: 32419518] - Daniel L Hertz, Julie A Douglas, Kelley M Kidwell, Christina L Gersch, Zeruesenay Desta, Ana-Maria Storniolo, Vered Stearns, Todd C Skaar, Daniel F Hayes, N Lynn Henry, James M Rae. Genome-wide association study of letrozole plasma concentrations identifies non-exonic variants that may affect CYP2A6 metabolic activity.
Pharmacogenetics and genomics.
2021 07; 31(5):116-123. doi:
10.1097/fpc.0000000000000429. [PMID: 34096894] - Stylianos Vagios, Caitlin R Sacha, Karissa C Hammer, Irene Dimitriadis, Kaitlyn E James, Charles L Bormann, Irene Souter. Response to ovulation induction treatments in women with polycystic ovary syndrome as a function of serum anti-Müllerian hormone levels.
Journal of assisted reproduction and genetics.
2021 Jul; 38(7):1827-1833. doi:
10.1007/s10815-021-02217-x. [PMID: 33934267] - Binghe Xu, Huiping Li, Qingyuan Zhang, Wan Sun, Yanke Yu, Wei Li, Shusen Wang, Ning Liao, Peng Shen, Yuan Liu, Yaling Huang, Carlos Linn, Huadong Zhao, John Jiang, Diane Wang. Pharmacokinetics, safety, activity, and biomarker analysis of palbociclib plus letrozole as first-line treatment for ER+/HER2- advanced breast cancer in Chinese women.
Cancer chemotherapy and pharmacology.
2021 07; 88(1):131-141. doi:
10.1007/s00280-021-04263-9. [PMID: 33835229] - Meng-Fan Peng, Shuo Tian, Ya-Gang Song, Cai-Xia Li, Ming-San Miao, Zhen Ren, Ming Li. Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Journal of ethnopharmacology.
2021 Jun; 273(?):113947. doi:
10.1016/j.jep.2021.113947. [PMID: 33617969] - Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari. Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis.
European journal of pharmacology.
2021 Jun; 900(?):174062. doi:
10.1016/j.ejphar.2021.174062. [PMID: 33798596] - Mária Faltinová, Leena Vehmanen, Heli Lyytinen, Mikko Haanpää, Esa Hämäläinen, Aila Tiitinen, Carl Blomqvist, Johanna Mattson. Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial.
Breast cancer research and treatment.
2021 Jun; 187(3):769-775. doi:
10.1007/s10549-021-06168-w. [PMID: 33710439] - Mervat H El-Saka, Ramez A Barhoma, Rowida R Ibrahim, Amira Elsaadany, Ghada M Alghazaly, Shereef Elshwaikh, Karima E Marea, Nermin M Madi. Potential effect of adrenomedullin on metabolic and endocrinal dysfunctions in the experimentally induced polycystic ovary: Targeting implication of endoplasmic reticulum stress.
Journal of biochemical and molecular toxicology.
2021 May; 35(5):e22725. doi:
10.1002/jbt.22725. [PMID: 33491863] - Yanyuan Zhou, Huan Lan, Zhewen Dong, Wenjing Cao, Zhen Zeng, Jia-Le Song. Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole-induced polycystic ovary syndrome in rats.
Journal of food biochemistry.
2021 05; 45(5):e13723. doi:
10.1111/jfbc.13723. [PMID: 33818798] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ning Zhang, Lili Zhuang, Shukun Gai, Yinghua Shan, Shuang Wang, Fenghua Li, Lili Chen, Dongmei Zhao, Xiaoyan Liu. Beneficial phytoestrogenic effects of resveratrol on polycystic ovary syndromein rat model.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2021 Apr; 37(4):337-341. doi:
10.1080/09513590.2020.1812569. [PMID: 32851887] - Ying Xu, Jialing Tang, Qianyu Guo, Yidan Xu, Kaixuan Yan, Lihong Wu, Kang Xie, Anming Zhu, Xianglu Rong, Dewei Ye, Jiao Guo. Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice.
Journal of ethnopharmacology.
2021 Mar; 268(?):113587. doi:
10.1016/j.jep.2020.113587. [PMID: 33212180] - Steve X Yang, Gregg P Adams, Eric M Zwiefelhofer, Kosala Rajapaksha, Muhammad Anzar. Cholesterol-cyclodextrin complex as a replacement for egg yolk in bull semen extender: sperm characteristics post-thawing and in vivo fertility.
Animal reproduction science.
2021 Feb; 225(?):106691. doi:
10.1016/j.anireprosci.2021.106691. [PMID: 33454617] - Jin Luo, Qianrong Qi, Yinmei Chen, Yaqin Wang, Qingzhen Xie. Effect of GnRH-antagonist, mifepristone and letrozole on preventing ovarian hyperstimulation syndrome in rat model.
Reproductive biomedicine online.
2021 Feb; 42(2):291-300. doi:
10.1016/j.rbmo.2020.10.006. [PMID: 33249057] - Selma Amrane, Sally F Vitez, Katherine L Palmerola, Roger A Lobo. Do lipid parameters change during clomiphene citrate or letrozole therapy in women being treated for infertility? A pilot study.
European journal of obstetrics, gynecology, and reproductive biology.
2021 Feb; 257(?):151-152. doi:
10.1016/j.ejogrb.2020.12.010. [PMID: 33390278] - Hamideh Adeldust, Amjad Farzinpour, Abbas Farshad, Jalal Rostamzadeh, Manel López Béjar. Effect of orally administrated letrozole on reproduction performance and gene expression of FOXJ1, LPR2 and PVRL3 in reproductive tract in aged roosters.
Theriogenology.
2021 Feb; 161(?):131-139. doi:
10.1016/j.theriogenology.2020.11.020. [PMID: 33310231] - Mina Shaban, Saba Ghaffary, Jalal Hanaee, Ayda Karbakhshzadeh, Somaieh Soltani. Synthesis and characterization of new surface modified magnetic nanoparticles and application for the extraction of letrozole from human plasma and analysis with HPLC-fluorescence.
Journal of pharmaceutical and biomedical analysis.
2021 Jan; 193(?):113659. doi:
10.1016/j.jpba.2020.113659. [PMID: 33176243] - Kehinde S Olaniyi, Adesola A Oniyide, Oluwaseun A Adeyanju, Lekan S Ojulari, Adams O Omoaghe, Oluranti E Olaiya. Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS.
Toxicology and applied pharmacology.
2021 01; 411(?):115381. doi:
10.1016/j.taap.2020.115381. [PMID: 33359182] - Muhammed A Saad, Muhammad A Eltarzy, Rania M Abdel Salam, Maha A E Ahmed. Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome.
Life sciences.
2021 Jan; 265(?):118731. doi:
10.1016/j.lfs.2020.118731. [PMID: 33160995] - Malgorzata Grzesiak, Gabriela Burzawa, Patrycja Kurowska, Klaudia Blaszczyk, Agata Szlaga, Anna Blasiak, Andrzej Sechman, Agnieszka Rak. Altered vitamin D3 metabolism in the ovary and periovarian adipose tissue of rats with letrozole-induced PCOS.
Histochemistry and cell biology.
2021 Jan; 155(1):101-116. doi:
10.1007/s00418-020-01928-z. [PMID: 33095902] - Shumei Sun, Hao Zhang, Peicheng Zhong, Zhihong Xu. The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis.
BioMed research international.
2021; 2021(?):9946060. doi:
10.1155/2021/9946060. [PMID: 34901283] - Xing Tang, Qinwan Huang, Chengcheng Wang, Da Zhang, Shoujin Dong, Congcong Yu. Kuntai Capsule Combined With Letrozole on Gonadal Hormone Levels and Ovarian Function in Patients With PCOS: A Systematic Review and Meta-Analysis.
Frontiers in endocrinology.
2021; 12(?):789909. doi:
10.3389/fendo.2021.789909. [PMID: 35027910] - Priyanka Arora, Gary Gudelsky, Pankaj B Desai. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights.
PloS one.
2021; 16(4):e0248579. doi:
10.1371/journal.pone.0248579. [PMID: 33798227] - Amir M Ramezani, Yadollah Yamini. Electrodeposition of poly-ethylenedioxythiophene-graphene oxide nanocomposite in a stainless steel tube for solid-phase microextraction of letrozole in plasma samples.
Journal of separation science.
2020 Dec; 43(23):4338-4346. doi:
10.1002/jssc.202000838. [PMID: 32997397] - Ladan Marbouti, Maryam Zahmatkesh, Esmail Riahi, Mahdi Shafiee Sabet. GnRH protective effects against amyloid β-induced cognitive decline: A potential role of the 17β-estradiol.
Molecular and cellular endocrinology.
2020 12; 518(?):110985. doi:
10.1016/j.mce.2020.110985. [PMID: 32805333] - Ladan Marbouti, Maryam Zahmatkesh, Esmail Riahi, Seyed Shahabeddin Sadr. Inhibition of brain 17β-estradiol synthesis by letrozole induces cognitive decline in male and female rats.
Neurobiology of learning and memory.
2020 11; 175(?):107300. doi:
10.1016/j.nlm.2020.107300. [PMID: 32882397] - Chunren Zhang, Chuyi Yu, Zengxian Lin, Haixia Pan, Kunyin Li, Hongxia Ma. MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance.
Archives of gynecology and obstetrics.
2020 11; 302(5):1205-1213. doi:
10.1007/s00404-020-05730-z. [PMID: 32757043]
