63644-62-2 (BioDeep_00000866546)
Main id: BioDeep_00000000514
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H20O6 (356.126)
中文名称: 阿魏酸松柏酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=CC(=C1)C=CCOC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChI: InChI=1S/C20H20O6/c1-24-18-12-14(5-8-16(18)21)4-3-11-26-20(23)10-7-15-6-9-17(22)19(13-15)25-2/h3-10,12-13,21-22H,11H2,1-2H3/b4-3+,10-7+
描述信息
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.
同义名列表
8 个代谢物同义名
(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid [(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] ester; (E)-3-(4-hydroxy-3-methoxy-phenyl)acrylic acid [(E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enyl] ester; 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenyl ester; [(E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoate; [(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; Coniferyl ferulate; 63644-62-2; Coniferyl ferulate
数据库引用编号
6 个数据库交叉引用编号
- KEGG: C17855
- PubChem: 6441913
- ChEMBL: CHEMBL3823769
- CAS: 63644-62-2
- PubChem: 135626099
- medchemexpress: HY-N1916
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
10 个相关的物种来源信息
- 165353 - Angelica sinensis:
- 1532923 - Coreopsis venusta: 10.1016/S0031-9422(00)80835-3
- 165499 - Hansenia forbesii: 10.1016/J.BMC.2007.12.021
- 48042 - Levisticum officinale:
- 2689076 - Ligusticum chuanxiong:
- 54719 - Ligusticum porteri:
- 1508160 - Ligusticum striatum:
- 33090 - Plants: -
- 33090 - 当归: -
- 33090 - 羌活: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wen-Zhi Hao, Qing-Yu Ma, Gabriel Tao, Jun-Qing Huang, Jia-Xu Chen. Oral coniferyl ferulate attenuated depression symptoms in mice via reshaping gut microbiota and microbial metabolism.
Food & function.
2021 Dec; 12(24):12550-12564. doi:
10.1039/d1fo02655k. [PMID: 34812830] - Wenxia Gong, Yuzhi Zhou, Wenlong Gong, Xuemei Qin. Coniferyl ferulate exerts antidepressant effect via inhibiting the activation of NMDAR-CaMKII-MAPKs and mitochondrial apoptotic pathways.
Journal of ethnopharmacology.
2020 Apr; 251(?):112533. doi:
10.1016/j.jep.2019.112533. [PMID: 31911178] - Xiaoqiong Xu, Tiantian Zhu, Tingting Shi, Juan Chen, Ling Jin. Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
PloS one.
2020; 15(12):e0243750. doi:
10.1371/journal.pone.0243750. [PMID: 33315941] - Wei-Hua Yan, Hong-Hong Cao, Shuang Guo, Li-Ya Gu, Wei Hu, Ming Cheng, De-Tao Bai, Jie Chen, Chun-Qin Mao, Lin Li, Tu-Lin Lu. [UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jun; 44(12):2499-2510. doi:
10.19540/j.cnki.cjcmm.20190321.311. [PMID: 31359717] - Xinlun Dai, Li Pang, Zhen Zhang, Chunfeng Yang, Yumei Li. Development of a sensitive LC-MS/MS method for quantification of coniferyl ferulate and its metabolite coniferyl alcohol in rat plasma: Application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2017 Nov; 146(?):201-205. doi:
10.1016/j.jpba.2017.08.033. [PMID: 28886520] - Yu-Qing Jin, Guang-Hua Lu, Bo-Ping Wei, Yuan-Linh Hong, Jian-Rui Li, Xi Li. [Chemical change of chuanxiong raw materials during storage].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2013 Jan; 36(1):38-41. doi:
. [PMID: 23750406] - Jing-Jing Xie, Jia Lu, Zheng-Ming Qian, Yue Yu, Jin-Ao Duan, Shao-Ping Li. Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis.
Molecules (Basel, Switzerland).
2009 Jan; 14(1):555-65. doi:
10.3390/molecules14010555. [PMID: 19169202] - Liang Kong, Zhiyuan Yu, Yongming Bao, Xingye Su, Hanfa Zou, Xin Li. Screening and analysis of an antineoplastic compound in Rhizoma Chuanxiong by means of in vitro metabolism and HPLC-MS.
Analytical and bioanalytical chemistry.
2006 Sep; 386(2):264-74. doi:
10.1007/s00216-006-0621-0. [PMID: 16868728] - Guang-Hua Lu, Kelvin Chan, Kelvin Leung, Chi-Leung Chan, Zhong-Zhen Zhao, Zhi-Hong Jiang. Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis.
Journal of chromatography. A.
2005 Mar; 1068(2):209-19. doi:
10.1016/j.chroma.2005.01.082. [PMID: 15830926]
