Angecin (BioDeep_00000862425)

Main id: BioDeep_00000000012

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, .delta.-lactone

化学式: C11H6O3 (186.0316926)
中文名称: 当归素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3
InChI: InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 μM; inhibits MHV-68, IC50: 5.39 μg/ml (28.95 μM).
Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 μM; inhibits MHV-68, IC50: 5.39 μg/ml (28.95 μM).

同义名列表

34 个代谢物同义名

2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, .delta.-lactone; 2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone; 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone; Angelicin plus ultraviolet A radiation [Angelicins]; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; 5-19-04-00447 (Beilstein Handbook Reference); 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran; 2H-Furo[2,3-H]-1-benzopyran-2-one; 2H-Furo(2,3-h)(1)benzopyran-2-one; 2H-Furo(2,3-H)-1-benzopyran-2-one; Angelicin (coumarin derivative); 2H-Furo[2,3-H]chromen-2-one; Angelicin (coumarin deriv); furo[2,3-h]chromen-2-one; 2-furo[2,3-h]chromenone; Furo[5,4:7,8]coumarin; Furo(5,4:7,8)coumarin; Furo(2,3-h)coumarin; Oprea1_022970; ZINC00073700; BRN 0153970; A0956_SIGMA; CHEBI:28928; Isopsoralen; 39310-13-9; NSC 404563; CCRIS 4276; HSDB 3554; Angelicin; NSC404563; 523-50-2; ST023306; Angecin; C09060



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xi Wu, Zhong-Qi Wang, Juan-Juan Wei, Xin Bai, Yu-Hai Gao, Ke-Ming Chen. [Effects of isopsoralen on tibial fracture and vascular healing in mice]. Zhongguo gu shang = China journal of orthopaedics and traumatology. 2023 Dec; 36(12):1169-76. doi: 10.12200/j.issn.1003-0034.2023.12.012. [PMID: 38130227]
  • Zhu Zhu, Zitian Wang, Changyan Ma, Junbo Zhou, Wei Zhang. Isopsoralen promotes osteogenic differentiation of human jawbone marrow mesenchymal cells through Notch signaling pathway. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023 Sep; 250(?):152156. doi: 10.1016/j.aanat.2023.152156. [PMID: 37678499]
  • Wei-Jie Men, Zhao-Jun Meng, Qin Wang, Meng-Ying Chen, Yu-Xia Zhai, Hong Shi, An-Hong Wang, Kun Zhou. The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice. Pharmaceutical biology. 2022 Dec; 60(1):1701-1709. doi: 10.1080/13880209.2022.2116057. [PMID: 36066106]
  • Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun, Hui-Jun Li. Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression. Journal of ethnopharmacology. 2022 Oct; 297(?):115577. doi: 10.1016/j.jep.2022.115577. [PMID: 35872289]
  • Yi Han, Jinguang Wang, Shufeng Li, Yi Li, Yongli Zhang, Ruojia Zhang, Yuang Zhang, Huancai Fan, Haojun Shi, Jihong Pan, Guanhua Song, Luna Ge, Lin Wang. Isopsoralen ameliorates rheumatoid arthritis by targeting MIF. Arthritis research & therapy. 2021 09; 23(1):243. doi: 10.1186/s13075-021-02619-3. [PMID: 34535196]
  • Yang Gao, Meng-Meng Wei, Si-Yang Wu, Zheng Yuan, Shu-Yao Wang, Chen Kang, Wei Yang, Ying-Fei Li, Chuan Li. [Pharmacokinetic characteristics of psoralen,isopsoralen,psoralenoside and isopsoralenoside in rats after oral administration of Psoraleae Fructus extract]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Aug; 46(16):4244-4251. doi: 10.19540/j.cnki.cjcmm.20210318.202. [PMID: 34467739]
  • Xiaoyu Sui, Tingting Liu, Jicheng Liu, Jie Zhang, Honglian Zhang, Huiyu Wang, Ying Yang. Ultrasonic-enhanced surface-active ionic liquid-based extraction and defoaming for the extraction of psoralen and isopsoralen from Psoralea corylifolia seeds. Ultrasonics sonochemistry. 2020 Dec; 69(?):105263. doi: 10.1016/j.ultsonch.2020.105263. [PMID: 32711373]
  • Xiangyun Jian, Yucheng Zhao, Ziwen Wang, Shan Li, Li Li, Jun Luo, Lingyi Kong. Two CYP71AJ enzymes function as psoralen synthase and angelicin synthase in the biosynthesis of furanocoumarins in Peucedanum praeruptorum Dunn. Plant molecular biology. 2020 Oct; 104(3):327-337. doi: 10.1007/s11103-020-01045-4. [PMID: 32761540]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Xi-Yang Tang, Zi-Qin Dai, Qing-Chang Wu, Jia-Xing Zeng, Meng-Xue Gao, Hui-Hui Xiao, Zhi-Hong Yao, Yi Dai, Xin-Sheng Yao. Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112836. doi: 10.1016/j.jpba.2019.112836. [PMID: 31473481]
  • Lei Song, Bin Yu, Li Yang, Zhao-Xin Wang, Yue Zhang, Ying-Li Yu, Kun Zhou. The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats. Basic & clinical pharmacology & toxicology. 2019 Dec; 125(6):527-535. doi: 10.1111/bcpt.13287. [PMID: 31271704]
  • Lu Liu, Lei Zhang, Ze-Xu Cui, Xiao-Yan Liu, Wei Xu, Xiu-Wei Yang. Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224080. [PMID: 31718071]
  • Li-Shan Zhou, Su-Qi Yan, Xiao-Li Xiong, Juan Huang, Huan Qin, Ling-Ling Zhang, Lin-Li Zhang, Jian-Qiao Tang. [Psoralen and isopsoralen improve lipid metabolism disorder via inhibition of NF-κB activation in LO2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 May; 44(10):2118-2123. doi: 10.19540/j.cnki.cjcmm.20190129.004. [PMID: 31355570]
  • Luna Ge, Yazhou Cui, Baoyan Liu, Xiaoli Yin, Jingxiang Pang, Jinxiang Han. ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis. Molecular medicine reports. 2019 May; 19(5):3469-3476. doi: 10.3892/mmr.2019.9999. [PMID: 30864714]
  • Yue Zhang, Xiao-Mei Yuan, Yue-Fei Wang, Miao-Miao Jiang, Ya-Nan Bi, Ying Liu, Wei-Ling Pu, Lei Song, Ju-Yang Huang, Li-Kang Sun, Zhi-Xing Zhou, Kun Zhou. Isopsoralen induces different subchronic toxicities and metabolomic outcomes between male and female Wistar rats. Regulatory toxicology and pharmacology : RTP. 2019 Apr; 103(?):1-9. doi: 10.1016/j.yrtph.2019.01.010. [PMID: 30634019]
  • Yu Wang, Hong Zhang, Jia-Ming Jiang, Dan Zheng, Yu-Yu Chen, Shi-Jie Wan, Hong-Sheng Tan, Li-Ming Tang, Hong-Xi Xu. Hepatotoxicity induced by psoralen and isopsoralen from Fructus Psoraleae: Wistar rats are more vulnerable than ICR mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Mar; 125(?):133-140. doi: 10.1016/j.fct.2018.12.047. [PMID: 30597224]
  • Jie Du, Chun-Hua Wang, Jing Yang, Xin He, Xiao-Liang Han, Cong-Cong Li, Xin Chai, Yue-Fei Wang, Yan Zhu, Zheng Li. Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury. Natural product research. 2019 Mar; 33(5):673-680. doi: 10.1080/14786419.2017.1405407. [PMID: 29156966]
  • Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):35-42. doi: 10.1016/j.jchromb.2018.12.031. [PMID: 30639948]
  • Y Zhang, Y Zhang, J Li, Y Chen, L Han, Q He, J Chu, K Liu. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae. Human & experimental toxicology. 2019 Jan; 38(1):36-44. doi: 10.1177/0960327118774873. [PMID: 29774767]
  • Jinlan Lu, Ling Liu, Xingyu Zhu, Li Wu, Zhipeng Chen, Zisheng Xu, Weidong Li. Evaluation of the Absorption Behavior of Main Component Compounds of Salt-Fried Herb Ingredients in Qing'e Pills by Using Caco-2 Cell Model. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123321. [PMID: 30558187]
  • Luna Ge, Yazhou Cui, Kai Cheng, Jinxiang Han. Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102600. [PMID: 30314280]
  • Chia-Hsin Lin, Shinji Funayama, Shu-Fen Peng, Chao-Lin Kuo, Jing-Gung Chung. The ethanol extraction of prepared Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells. Environmental toxicology. 2018 Jul; 33(7):770-788. doi: 10.1002/tox.22564. [PMID: 29667321]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Kyoung-Jin Min, Hee Jung Um, Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Sang Hyun Kim, Yung Hyun Choi, Tae-Jin Lee, Taeg Kyu Kwon. Angelicin potentiates TRAIL-induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down-regulation of c-FLIP expression. Drug development research. 2018 02; 79(1):3-10. doi: 10.1002/ddr.21414. [PMID: 29044596]
  • Jian Wang, Gang Wang, Li Gong, Guanwen Sun, Bin Shi, Huhe Bao, Yan Duan. Isopsoralen regulates PPAR‑γ/WNT to inhibit oxidative stress in osteoporosis. Molecular medicine reports. 2018 Jan; 17(1):1125-1131. doi: 10.3892/mmr.2017.7954. [PMID: 29115612]
  • Xiaotian Li, Chunbo Yu, Yi Hu, Xinyi Xia, Yue Liao, Jing Zhang, Huiwen Chen, Weili Lu, Wei Zhou, Zhongchen Song. New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects. Frontiers in cellular and infection microbiology. 2018; 8(?):178. doi: 10.3389/fcimb.2018.00178. [PMID: 29922598]
  • Xu Ling, Li Zou, Zilin Chen. Polymeric monolith column composited with multiwalled carbon nanotubes-β-cyclodextrin for the selective extraction of psoralen and isopsoralen. Journal of separation science. 2017 Sep; 40(18):3718-3724. doi: 10.1002/jssc.201700562. [PMID: 28715109]
  • Aihong Yang, Junxiu Chen, Yetao Ma, Lili Wang, Yaowen Fan, Xin He. Studies on the metabolites difference of psoralen/isopsoralen in human and six mammalian liver microsomes in vitro by UHPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2017 Jul; 141(?):200-209. doi: 10.1016/j.jpba.2017.04.026. [PMID: 28448889]
  • Jian-Yun Pang, Xiao Liu, Bao-de Shen, Cheng-Ying Shen, Wang-Quan Lian, Juan Liu, Chun-Xiao Hu, Rui-Na Zhong, Run-Chun Xu, Hai-Long Yuan. [Preparation of isopsoralen loaded nanostructured carrier and its in vitro transdermal permeation characteristics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Jul; 42(13):2473-2478. doi: 10.19540/j.cnki.cjcmm.20170507.001. [PMID: 28840686]
  • Jia-Rong Gao, Shuang-Zhi Xu, Yan-Quan Han, Liang-Bing Wei, Hui Jiang, Jun-Mei Song, Xue Xue. [Determination and pharmacokinetics of main components for Psoralea corylifolia-Myristica fragrants drug pair by using UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 May; 42(9):1782-1786. doi: 10.19540/j.cnki.cjcmm.2017.0071. [PMID: 29082707]
  • Ling Liu, Ze-Bin Weng, Heng Wang, Xing-Yu Zhu, Zhi-Peng Chen, Li Wu, Wei-Dong Li. [Analysis on pharmacokinetics-pharmacodynamics correlation of effective ingredients of Qing'e wan]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Dec; 41(23):4436-4441. doi: 10.4268/cjcmm20162323. [PMID: 28933124]
  • Da-Zhen Wei, Xian-Yang Guo, Li-Na Lin, Meng-Xiang Lin, Yu-Qiang Gong, Bin-Yu Ying, Ming-Yuan Huang. Effects of Angelicin on Ovalbumin (OVA)-Induced Airway Inflammation in a Mouse Model of Asthma. Inflammation. 2016 Dec; 39(6):1876-1882. doi: 10.1007/s10753-016-0423-2. [PMID: 27581277]
  • Chao Niu, Guang Xian Pang, Gen Li, Jun Dou, Li Fei Nie, Helimay Himit, Madina Kabas, Haji Akber Aisa. Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorganic & medicinal chemistry. 2016 11; 24(22):5960-5968. doi: 10.1016/j.bmc.2016.09.056. [PMID: 27713014]
  • Qian qian Gao, Cui ping Yan, Zi sheng Xu, Yu Wu, Ze bin Weng, Gen hua Zhao, Liu jie Zhang, Jia yu He, Bao chang Cai, Zhi peng Chen, Wei dong Li. Evaluation of the influence of salt processing on pharmacokinetics of psoralen and isopsoralen in Psoralea corylifolia L. Biomedical chromatography : BMC. 2016 Apr; 30(4):528-35. doi: 10.1002/bmc.3578. [PMID: 26248603]
  • Xiaomei Yuan, Yanan Bi, Zeman Yan, Weiling Pu, Yuhong Li, Kun Zhou. Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. BioMed research international. 2016; 2016(?):6869452. doi: 10.1155/2016/6869452. [PMID: 27239473]
  • Guang-ming Xu, Zhe-ming Wang, Nian-zhen Liu, Wei-jun He, Shuai Peng, Xiao-jiang Zhou. [Study on Chemical Constituents from Ethyl Acetate Extraction of Sanicula lamelligera]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Aug; 38(8):1661-4. doi: ". [PMID: 26983240]
  • Maryia Mishyna, Nikolai Laman, Valery Prokhorov, Yoshiharu Fujii. Angelicin as the principal allelochemical in Heracleum sosnowskyi fruit. Natural product communications. 2015 May; 10(5):767-70. doi: . [PMID: 26058154]
  • Xiang-hui Han, Chun-li Wang, Yan Xie, Jiang Ma, Xiao-hui Zhang, Qian-wen Hu, Ge Lin, Sheng Liu, Jin-gen Lu. Anti-metastatic effect and mechanisms of Wenshen Zhuanggu Formula in human breast cancer cells. Journal of ethnopharmacology. 2015 Mar; 162(?):39-46. doi: 10.1016/j.jep.2014.12.036. [PMID: 25554638]
  • Honghui Lu, Lihai Zhang, Daohong Liu, Peifu Tang, Feixiang Song. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. African health sciences. 2014 Sep; 14(3):641-7. doi: 10.4314/ahs.v14i3.20. [PMID: 25352883]
  • Yue-Fei Wang, Ya-Nan Liu, Wen Xiong, Dong-Mei Yan, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Ai-Di Qi. A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. Journal of ethnopharmacology. 2014; 151(1):609-17. doi: 10.1016/j.jep.2013.11.013. [PMID: 24315982]
  • Eunhui Seo, Eun-Kyu Lee, Cheol Soon Lee, Kwang-Hoon Chun, Mi-Young Lee, Hee-Sook Jun. Psoralea corylifolia L. seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress. Oxidative medicine and cellular longevity. 2014; 2014(?):897296. doi: 10.1155/2014/897296. [PMID: 24803987]
  • Xiao-Mei Zhuang, Yu-Huan Zhong, Wei-Bin Xiao, Hua Li, Chuang Lu. Identification and characterization of psoralen and isopsoralen as potent CYP1A2 reversible and time-dependent inhibitors in human and rat preclinical studies. Drug metabolism and disposition: the biological fate of chemicals. 2013 Nov; 41(11):1914-22. doi: 10.1124/dmd.113.053199. [PMID: 23975028]
  • Taryn O'Neill, John A Johnson, Duncan Webster, Christopher A Gray. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. Journal of ethnopharmacology. 2013 May; 147(1):232-7. doi: 10.1016/j.jep.2013.03.009. [PMID: 23501157]
  • Chun-Yan Feng, Xiu-Rong Huang, Ming-Xin Qi, Song-Wen Tang, Yan-Hong Hu, Sheng Chen, Fa-Jie Ke. Mitochondrial proteomic analysis of isopsoralen protection against oxidative damage in human lens epithelial cells. Chinese journal of integrative medicine. 2012 Jul; 18(7):529-33. doi: 10.1007/s11655-012-1144-5. [PMID: 22772916]
  • David J Walker, Domingo Martínez-Fernández, Enrique Correal, Pascual Romero-Espinar, José Antonio Del Río. Accumulation of furanocoumarins by Bituminaria bituminosa in relation to plant development and environmental stress. Plant physiology and biochemistry : PPB. 2012 May; 54(?):133-9. doi: 10.1016/j.plaphy.2012.03.001. [PMID: 22459509]
  • Krystyna Skalicka-Woźniak, Kazimierz Głowniak. Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature. Molecules (Basel, Switzerland). 2012 Apr; 17(4):4133-41. doi: 10.3390/molecules17044133. [PMID: 22481536]
  • Xing Wang, Yu-Jie Lou, Ming-Xing Wang, Yun-Wei Shi, Hong-Xi Xu, Ling-Dong Kong. Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. Toxicology letters. 2012 Feb; 209(1):67-77. doi: 10.1016/j.toxlet.2011.11.030. [PMID: 22173200]
  • Eunmi Kim, Jinho Choi, Ikhyun Yeo. The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet. Nutrition research and practice. 2012 Feb; 6(1):9-15. doi: 10.4162/nrp.2012.6.1.9. [PMID: 22413035]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology. 2012; 3(?):69. doi: 10.3389/fphar.2012.00069. [PMID: 22557968]
  • María Pazos-Navarro, Mercedes Dabauza, Enrique Correal, Kelly Hanson, Natasha Teakle, Daniel Real, Matthew N Nelson. Next generation DNA sequencing technology delivers valuable genetic markers for the genomic orphan legume species, Bituminaria bituminosa. BMC genetics. 2011 Dec; 12(?):104. doi: 10.1186/1471-2156-12-104. [PMID: 22171578]
  • Domingo Martínez-Fernández, David J Walker, Pascual Romero-Espinar, Pilar Flores, José Antonio del Río. Physiological responses of Bituminaria bituminosa to heavy metals. Journal of plant physiology. 2011 Dec; 168(18):2206-11. doi: 10.1016/j.jplph.2011.08.008. [PMID: 21937143]
  • Leiguo Ming, Baofeng Ge, Keming Chen, Huiping Ma, Yuankun Zhai. [Effects of isopsoralen on bone marrow stromal stem cells differentiate and proliferate in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(15):2124-8. doi: . [PMID: 22066454]
  • Paola Barraja, Libero Caracausi, Patrizia Diana, Alessandra Montalbano, Anna Carbone, Alessia Salvador, Paola Brun, Ignazio Castagliuolo, Silvia Tisi, Francesco Dall'Acqua, Daniela Vedaldi, Girolamo Cirrincione. Pyrrolo[3,2-h]quinazolines as photochemotherapeutic agents. ChemMedChem. 2011 Jul; 6(7):1238-48. doi: 10.1002/cmdc.201100085. [PMID: 21574254]
  • Huichao Wu, Shouying Du, Yang Lu, Wen Chen, Yong Ma, Pengyue Li. [Comparative study of absorption kinetics in intestines of rats on Xianlinggubao capsule prepared by different technologies]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Apr; 36(8):992-6. doi: ". [PMID: 21809569]
  • Paola Barraja, Patrizia Diana, Alessandra Montalbano, Anna Carbone, Giampietro Viola, Giuseppe Basso, Alessia Salvador, Daniela Vedaldi, Francesco Dall'Acqua, Girolamo Cirrincione. Pyrrolo[3,4-h]quinolinones a new class of photochemotherapeutic agents. Bioorganic & medicinal chemistry. 2011 Apr; 19(7):2326-41. doi: 10.1016/j.bmc.2011.02.023. [PMID: 21397509]
  • Mehdi Mohammadi, Maryam Yousefi, Zohreh Habibi, Abbas Shafiee. Two new coumarins from the chloroform extract of Angelica urumiensis from Iran. Chemical & pharmaceutical bulletin. 2010 Apr; 58(4):546-8. doi: 10.1248/cpb.58.546. [PMID: 20410639]
  • Jiann-Yih Yeh, Mohane Selvaraj Coumar, Jim-Tong Horng, Hui-Yi Shiao, Fu-Ming Kuo, Hui-Ling Lee, In-Chun Chen, Chun-Wei Chang, Wen-Fang Tang, Sung-Nain Tseng, Chi-Jene Chen, Shin-Ru Shih, John T-A Hsu, Chun-Chen Liao, Yu-Sheng Chao, Hsing-Pang Hsieh. Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. Journal of medicinal chemistry. 2010 Feb; 53(4):1519-33. doi: 10.1021/jm901570x. [PMID: 20092255]
  • D Xin, H Wang, J Yang, Y-F Su, G-W Fan, Y-F Wang, Y Zhu, X-M Gao. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Feb; 17(2):126-31. doi: 10.1016/j.phymed.2009.05.015. [PMID: 19577453]
  • Liang Feng, Ling Wang, Xuehua Jiang. Pharmacokinetics, tissue distribution and excretion of coumarin components from Psoralea corylifolia L. in rats. Archives of pharmacal research. 2010 Feb; 33(2):225-30. doi: 10.1007/s12272-010-0206-5. [PMID: 20195822]
  • P S Khushboo, V M Jadhav, V J Kadam, N S Sathe. Psoralea corylifolia Linn.-'Kushtanashini'. Pharmacognosy reviews. 2010 Jan; 4(7):69-76. doi: 10.4103/0973-7847.65331. [PMID: 22228944]
  • Guo-Qang Liu, Jing Dong, Hong Wang, Yuki Hashi, Shi-Zhong Chen. Differentiation of four pairs of furocoumarin isomers by electrospray ionization tandem mass spectrometry. European journal of mass spectrometry (Chichester, England). 2010; 16(2):215-20. doi: 10.1255/ejms.1070. [PMID: 20212330]
  • Yuan Gu, Duanyun Si, Jing Gao, Yong Zeng, Changxiao Liu. Simultaneous quantification of psoralen and isopsoralen in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Haigou Pill. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):3137-43. doi: 10.1016/j.jchromb.2009.07.035. [PMID: 19671498]
  • Li-Qun Ouyang, Hai-Long Wu, Jin-Fang Nie, Yan Zhang, Hong-Yan Zou, Hai-Yan Fu, Ru-Qin Yu. Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm. Analytica chimica acta. 2009 Sep; 650(2):160-6. doi: 10.1016/j.aca.2009.07.024. [PMID: 19720187]
  • Nicole Raquet, Dieter Schrenk. Relative photomutagenicity of furocoumarins and limettin in the hypoxanthine phosphoribosyl transferase assay in V79 cells. Chemical research in toxicology. 2009 Sep; 22(9):1639-47. doi: 10.1021/tx9002287. [PMID: 19725558]
  • Tamsyn S A Thring, Pauline Hili, Declan P Naughton. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC complementary and alternative medicine. 2009 Aug; 9(?):27. doi: 10.1186/1472-6882-9-27. [PMID: 19653897]
  • Nicoletta Bianchi, Cristina Zuccato, Ilaria Lampronti, Monica Borgatti, Roberto Gambari. Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia. Evidence-based complementary and alternative medicine : eCAM. 2009 Jun; 6(2):141-51. doi: 10.1093/ecam/nem139. [PMID: 18955291]
  • Romain Larbat, Alain Hehn, Joachim Hans, Sarah Schneider, Hélène Jugdé, Bernd Schneider, Ulrich Matern, Frédéric Bourgaud. Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. The Journal of biological chemistry. 2009 Feb; 284(8):4776-85. doi: 10.1074/jbc.m807351200. [PMID: 19098286]
  • Hengchun Ren, Dingrong Wan, Zhongmei Zou. [Studies on chemical constituents from roots of Polygonum amplexicaule]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Jan; 34(2):183-5. doi: . [PMID: 19385182]
  • Paola Barraja, Patrizia Diana, Alessandra Montalbano, Anna Carbone, Girolamo Cirrincione, Giampietro Viola, Alessia Salvador, Daniela Vedaldi, Francesco Dall'acqua. Thiopyrano[2,3-e]indol-2-ones: angelicin heteroanalogues with potent photoantiproliferative activity. Bioorganic & medicinal chemistry. 2008 Nov; 16(22):9668-83. doi: 10.1016/j.bmc.2008.10.002. [PMID: 18951030]
  • Yinghao Mei, Jie Xu, Jihui Zhao, Nianping Feng, Ying Liu, Li Wei. An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 869(1-2):138-41. doi: 10.1016/j.jchromb.2008.05.005. [PMID: 18514594]
  • Sanjeewa G Rupasinghe, Zhimou Wen, Ting-Lan Chiu, Mary A Schuler. Helicoverpa zea CYP6B8 and CYP321A1: different molecular solutions to the problem of metabolizing plant toxins and insecticides. Protein engineering, design & selection : PEDS. 2007 Dec; 20(12):615-24. doi: 10.1093/protein/gzm063. [PMID: 18065401]
  • Huige Zhang, Jinhua Zhu, Shengda Qi, Xingguo Chen, Zhide Hu. Separation and determination of psoralen and isopsoralen by microemulsion electrokinetic chromatography. Biomedical chromatography : BMC. 2007 Oct; 21(10):1083-7. doi: 10.1002/bmc.859. [PMID: 17582232]
  • Yan-hua Guo, Tian-zhu Jia, Guei-mei Lin. [Study on micro-wave processed of Psoralea corylifolia with uniform and regression analysis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Jun; 32(12):1167-70. doi: ". [PMID: 17802878]
  • Ying Xie, Yi Chen, Mei Lin, Jun Wen, Guorong Fan, Yutian Wu. High-performance liquid chromatographic method for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma. Journal of pharmaceutical and biomedical analysis. 2007 May; 44(1):166-72. doi: 10.1016/j.jpba.2007.02.002. [PMID: 17344014]
  • Chun-Feng Qiao, Quan-Bin Han, Jing-Zheng Song, Shi-Fu Mo, Ling-Dong Kong, Hsiang-Fu Kung, Hong-Xi Xu. Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography. Journal of separation science. 2007 Apr; 30(6):813-8. doi: 10.1002/jssc.200600339. [PMID: 17536725]
  • Chi-Rei Wu, Chia-Lin Chang, Ping-Ying Hsieh, Li-Wei Lin, Hui Ching. Psoralen and isopsoralen, two coumarins of Psoraleae Fructus, can alleviate scopolamine-induced amnesia in rats. Planta medica. 2007 Mar; 73(3):275-8. doi: 10.1055/s-2007-967127. [PMID: 17318785]
  • Laura Palanker, Aleksandar S Necakov, Heidi M Sampson, Ruoyu Ni, Chun Hu, Carl S Thummel, Henry M Krause. Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development (Cambridge, England). 2006 Sep; 133(18):3549-62. doi: 10.1242/dev.02512. [PMID: 16914501]
  • Chantal Barthomeuf, Jérôme Grassi, Michel Demeule, Chantal Fournier, Dominique Boivin, Richard Béliveau. Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. Cancer chemotherapy and pharmacology. 2005 Aug; 56(2):173-81. doi: 10.1007/s00280-004-0914-y. [PMID: 15824923]
  • Annette Baumgart, Melanie Schmidt, Hans-Joachim Schmitz, Dieter Schrenk. Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes. Biochemical pharmacology. 2005 Feb; 69(4):657-67. doi: 10.1016/j.bcp.2004.11.017. [PMID: 15670584]
  • Masataka Sasabe, Zhimou Wen, May R Berenbaum, Mary A Schuler. Molecular analysis of CYP321A1, a novel cytochrome P450 involved in metabolism of plant allelochemicals (furanocoumarins) and insecticides (cypermethrin) in Helicoverpa zea. Gene. 2004 Sep; 338(2):163-75. doi: 10.1016/j.gene.2004.04.028. [PMID: 15315820]
  • Boyko Atanassov, Aneliya Velkova, Emil Mladenov, Boyka Anachkova, George Russev. Comparison of the global genomic and transcription-coupled repair rates of different lesions in human cells. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004 May; 59(5-6):445-53. doi: 10.1515/znc-2004-5-628. [PMID: 18998417]
  • Naznin A Khatune, M Ekramul Islam, M Ekramul Haque, Proma Khondkar, M Mukhlesur Rahman. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia. 2004 Mar; 75(2):228-30. doi: 10.1016/j.fitote.2003.12.018. [PMID: 15030932]
  • Nguyen Thanh Dong, KiHwan Bae, Young Ho Kim, Gwi Seo Hwang, Ok Soon Heo, Se Eun Kim, Jong Seong Kang. Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography. Archives of pharmacal research. 2003 Jul; 26(7):516-20. doi: 10.1007/bf02976873. [PMID: 12934641]
  • Jiangning Guo, Hou Wu, Xinchu Weng, Jianhua Yan, Kaishun Bi. [Studies on extraction and isolation of active constituents from Psoralen corylifolia L. and the antitumor effect of the constituents in vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2003 Mar; 26(3):185-7. doi: ". [PMID: 12856469]
  • C N Backhouse, C L Delporte, R E Negrete, S Erazo, A Zuñiga, A Pinto, B K Cassels. Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities. Journal of ethnopharmacology. 2001 Nov; 78(1):27-31. doi: 10.1016/s0378-8741(01)00309-9. [PMID: 11585684]
  • W Mar, K H Je, E K Seo. Cytotoxic constituents of Psoralea corylifolia. Archives of pharmacal research. 2001 Jun; 24(3):211-3. doi: 10.1007/bf02978259. [PMID: 11440079]
  • L D Kong, R X Tan, A Y Woo, C H Cheng. Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacology & toxicology. 2001 Feb; 88(2):75-80. doi: 10.1034/j.1600-0773.2001.d01-86.x. [PMID: 11169165]
  • L Lin, X Zhong, G Wei. [GC-MS analysis of volatile componments in root of Ficus hitra]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2000 Apr; 23(4):206-7. doi: ". [PMID: 12575126]
  • B Yang, S Yao. [Exploration of processing principles for fructus Psoralea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1997 Dec; 22(12):729-30, 764. doi: ". [PMID: 11243169]
  • H Zhen, N Xin, Y Chen, Y Lu. [Experimental studies on the quality control of Qing'e pills]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1997 Feb; 22(2):96-8, 127. doi: ". [PMID: 10743200]
  • B Yang, S Yao, S Cui. [Comparison of ancient and modern processing methods for fructus Psoraleae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1996 Sep; 21(9):537-9, 575. doi: ". [PMID: 9772642]
  • J B Hudson. Plant photosensitizers with antiviral properties. Antiviral research. 1989 Sep; 12(2):55-74. doi: 10.1016/0166-3542(89)90070-3. [PMID: 2688551]
  • X S Huang. [TLC-fluorometric determination of psoralen and isopsoralen in compound granules of Psoralea]. Zhong yao tong bao (Beijing, China : 1981). 1987 Jan; 12(1):26-9. doi: ". [PMID: 2954699]
  • S P Moore, H Blount, T P Coohill. SV40 induction from a mammalian cell line by ultraviolet radiation and the photosensitizers 8-methoxypsoralen and angelicin. Photochemistry and photobiology. 1983 Jun; 37(6):665-7. doi: 10.1111/j.1751-1097.1983.tb04537.x. [PMID: 6310653]
  • M E Zolan, G A Cortopassi, C A Smith, P C Hanawalt. Deficient repair of chemical adducts in alpha DNA of monkey cells. Cell. 1982 Mar; 28(3):613-9. doi: 10.1016/0092-8674(82)90216-1. [PMID: 7074686]
  • S Nocentini. Impairment of RNA synthesis and its recovery in angelicin photosensitized mammalian cells. A probe for DNA damage and repair. Biochimica et biophysica acta. 1978 Nov; 521(1):160-8. doi: 10.1016/0005-2787(78)90259-9. [PMID: 718926]
  • . . . . doi: . [PMID: 17068340]