carnosine (BioDeep_00000400031)
Main id: BioDeep_00000001305
Secondary id: BioDeep_00000897258, BioDeep_00001893266
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
L-Carnosine
化学式: C9H14N4O3 (226.1066)
中文名称: L-肌肽, 神经氨酸酶 来源于产气荚膜梭菌(纯化), 苹果酸脱氢酶(悬浮液), 磷酸葡萄糖变位酶, 磷酸葡萄糖异构酶, 丙酮酸激酶, 肌肽
谱图信息:
最多检出来源 Homo sapiens(blood) 28.92%
分子结构信息
SMILES: C(CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
InChI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
描述信息
A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.
C26170 - Protective Agent > C275 - Antioxidant
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
同义名列表
4 个代谢物同义名
数据库引用编号
75 个数据库交叉引用编号
- ChEBI: CHEBI:15727
- KEGG: C00386
- PubChem: 439224
- DrugBank: DB11695
- ChEMBL: CHEMBL242948
- MeSH: Carnosine
- CAS: 1370422-07-3
- CAS: 305-84-0
- CAS: 9001-67-6
- CAS: 9001-64-3
- CAS: 9001-81-4
- CAS: 9001-41-6
- CAS: 9001-59-6
- MoNA: Bruker_HCD_library000907
- MoNA: CCMSLIB00005464323
- MoNA: CCMSLIB00005464351
- MoNA: CCMSLIB00005464352
- MoNA: CCMSLIB00005720341
- MoNA: MoNA038675
- MoNA: MoNA038490
- MoNA: MoNA038085
- MoNA: MoNA037337
- MoNA: MoNA036499
- MoNA: MoNA036498
- MoNA: MoNA036496
- MoNA: MoNA036371
- MoNA: MoNA036370
- MoNA: MoNA036369
- MoNA: MoNA034637
- MoNA: MoNA034636
- MoNA: MoNA034635
- MoNA: MoNA032527
- MoNA: MoNA032525
- MoNA: MoNA032524
- MoNA: MoNA024349
- MoNA: EMBL-MCF_spec24872
- MoNA: MoNA016845
- MoNA: MoNA016671
- MoNA: MoNA002237
- MoNA: MoNA002236
- MoNA: MoNA002235
- MoNA: VF-NPL-QEHF025641
- MoNA: VF-NPL-QEHF025640
- MoNA: VF-NPL-QEHF025639
- MoNA: VF-NPL-QEHF025638
- MoNA: VF-NPL-QEHF025637
- MoNA: VF-NPL-QEHF025636
- MoNA: VF-NPL-QEHF025635
- MoNA: VF-NPL-QEHF025634
- MoNA: VF-NPL-QEHF025633
- MoNA: VF-NPL-QEHF025632
- MoNA: VF-NPL-QEHF025631
- MoNA: VF-NPL-QEHF025630
- MoNA: VF-NPL-QEHF025629
- MoNA: VF-NPL-QEHF025628
- MoNA: VF-NPL-QEHF025627
- MoNA: FiehnHILIC002629
- MoNA: FiehnHILIC001817
- MoNA: FiehnHILIC001106
- MoNA: FiehnHILIC000243
- MoNA: HMDB0000033_ms_ms_54
- MoNA: HMDB0000033_ms_ms_55
- MoNA: HMDB0000033_ms_ms_56
- MoNA: CCMSLIB00000578128
- MetaboLights: MTBLC15727
- PubChem: 3676
- PDB-CCD: 8V0
- 3DMET: B00100
- NIKKAJI: J5.496H
- RefMet: Carnosine
- medchemexpress: HY-W013494
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-58
- KEGG: C02601
- PubChem: 5589
- KNApSAcK: 15727
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Passent M E Gaafar, Ragwa M Farid, Heba A Hazzah, HussamElDin Y AbouKilila, Maged W Helmy, Ossama Y Abdallah. Magnetic Lipid-Based hybrid nanosystems: A combined stimuli- responsive nanocarriers for enriched chemotherapeutic potential of L-carnosine in induced breast Ehrlich ascites tumor model.
International journal of pharmaceutics.
2024 Apr; 655(?):124000. doi:
10.1016/j.ijpharm.2024.124000. [PMID: 38493840] - Fernando Moreto, Jéssica Leite Garcia, Ana Lúcia Dos Anjos Ferreira, Silvia Radrezza, Mariane Róvero Costa, Guilherme Ribeiro Romualdo, Nubia Alves Grandini, Giancarlo Aldini, Camila Renata Correa, Alfonsina D'Amato. Quantitative proteomics study of carnosine effect in an animal model of Western diet-induced nonalcoholic fatty liver disease.
Journal of biochemical and molecular toxicology.
2024 Feb; 38(2):e23644. doi:
10.1002/jbt.23644. [PMID: 38348714] - Yi Yao Li, Varoujan Yaylayan, Marie-France Palin, Tania M Ngapo, Simon Cliche, Hassan Sabik, Claude Gariépy. Dual effects of dietary carnosine during in vitro digestion of a Western meal model with added ascorbic acid.
Journal of food science.
2024 Jan; 89(1):710-726. doi:
10.1111/1750-3841.16854. [PMID: 38146794] - Saeede Saadati, James Cameron, Kirthi Menon, Alexander Hodge, Zhong X Lu, Maximilian de Courten, Jack Feehan, Barbora de Courten. Carnosine Did Not Affect Vascular and Metabolic Outcomes in Patients with Prediabetes and Type 2 Diabetes: A 14-Week Randomized Controlled Trial.
Nutrients.
2023 Nov; 15(22):. doi:
10.3390/nu15224835. [PMID: 38004228] - Jennifer K Frediani, Asim A Lal, Esther Kim, Sharon L Leslie, David W Boorman, Vinita Singh. The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review.
Pain practice : the official journal of World Institute of Pain.
2023 Aug; ?(?):. doi:
10.1111/papr.13291. [PMID: 37654090] - Beatrice Zoanni, Gilda Aiello, Anne Negre-Salvayre, Giancarlo Aldini, Marina Carini, Alfonsina D'Amato. Lipidome Investigation of Carnosine Effect on Nude Mice Skin to Prevent UV-A Damage.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms241210009. [PMID: 37373157] - Dheeraj Kumar Posa, Janice Miller, David Hoetker, Michael I Ramage, Hong Gao, Jingjing Zhao, Benjamin Doelling, Aruni Bhatnagar, Stephen J Wigmore, Richard J E Skipworth, Shahid P Baba. Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.
Journal of cachexia, sarcopenia and muscle.
2023 May; ?(?):. doi:
10.1002/jcsm.13258. [PMID: 37199284] - Ziqing Wang, Erin Brannick, Behnam Abasht. Integrative transcriptomic and metabolomic analysis reveals alterations in energy metabolism and mitochondrial functionality in broiler chickens with wooden breast.
Scientific reports.
2023 Mar; 13(1):4747. doi:
10.1038/s41598-023-31429-7. [PMID: 36959331] - Xin Liang, Ruyi Qian, Yiqun Ou, Dan Wang, Xianyong Lin, Chengliang Sun. Lipid peroxide-derived short-chain aldehydes promote programmed cell death in wheat roots under aluminum stress.
Journal of hazardous materials.
2023 02; 443(Pt A):130142. doi:
10.1016/j.jhazmat.2022.130142. [PMID: 36265378] - A Rašković, N Martić, D Zaklan, N Duborija-Kovačević, M Vujčić, B Andrejić-Višnjić, I Čapo, R Mijović, M Krga, N Pavlović, D Prodanović, P Arsenović, O Horvat. Antihyperlipidemic potential of dietary supplementation with carnosine in high-fat diet-fed rats.
European review for medical and pharmacological sciences.
2023 02; 27(3):1083-1094. doi:
10.26355/eurrev_202302_31211. [PMID: 36808356] - Hirofumi Enomoto, Nobuhiro Zaima. Desorption electrospray ionization-mass spectrometry imaging of carnitine and imidazole dipeptides in pork chop tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Feb; 1216(?):123601. doi:
10.1016/j.jchromb.2023.123601. [PMID: 36680959] - Raju Nalvothula, Surekha Challa, Vidyullatha Peddireddy, Ramchander Merugu, M P Pratap Rudra, Abed Alataway, Ahmed Z Dewidar, Hosam O Elansary. Isolation, Molecular Identification and Amino Acid Profiling of Single-Cell-Protein-Producing Phototrophic Bacteria Isolated from Oil-Contaminated Soil Samples.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196265. [PMID: 36234802] - Angelica Rodriguez-Niño, Diego O Pastene, Steffen A Hettler, Jiedong Qiu, Thomas Albrecht, Srishti Vajpayee, Rossana Perciaccante, Norbert Gretz, Stephan J L Bakker, Bernhard K Krämer, Benito A Yard, Jacob van den Born. Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics.
American journal of physiology. Renal physiology.
2022 07; 323(1):F69-F80. doi:
10.1152/ajprenal.00232.2021. [PMID: 35635322] - Lihua Wang-Eckhardt, Ivonne Becker, Yong Wang, Jing Yuan, Matthias Eckhardt. Absence of endogenous carnosine synthesis does not increase protein carbonylation and advanced lipoxidation end products in brain, kidney or muscle.
Amino acids.
2022 Jul; 54(7):1013-1023. doi:
10.1007/s00726-022-03150-8. [PMID: 35294673] - Sean Bennet, Martin Kaufmann, Kaede Takami, Calvin Sjaarda, Katya Douchant, Emily Moslinger, Henry Wong, David E Reed, Anne K Ellis, Stephen Vanner, Robert I Colautti, Prameet M Sheth. Small-molecule metabolome identifies potential therapeutic targets against COVID-19.
Scientific reports.
2022 Jun; 12(1):10029. doi:
10.1038/s41598-022-14050-y. [PMID: 35705626] - L I Serebryakova, I M Studneva, O M Veselova, I V Dobrokhotov, G G Konovalova, A A Timoshin, A A Abramov, D V Avdeev, M V Sidorova, V Z Lankin, O I Pisarenko. [The anti-ischemic and antioxidant activity of the pharmacological agonist of galanin receptor GalR2 and carnosine in in vitro and in vivo model systems].
Biomeditsinskaia khimiia.
2022 Jun; 68(3):190-200. doi:
10.18097/pbmc20226803190. [PMID: 35717583] - Laura Brugnara, Ana Isabel García, Serafín Murillo, Josep Ribalta, Guerau Fernandez, Susanna Marquez, Miguel Angel Rodriguez, Maria Vinaixa, Núria Amigó, Xavier Correig, Susana Kalko, Jaume Pomes, Anna Novials. Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes.
European journal of applied physiology.
2022 Jun; 122(6):1429-1440. doi:
10.1007/s00421-022-04929-z. [PMID: 35298695] - Chanadda Suwanvichanee, Panpradub Sinpru, Kasarat Promkhun, Satoshi Kubota, Cindy Riou, Wittawat Molee, Jirawat Yongsawatdigul, Kanjana Thumanu, Amonrat Molee. Effects of β-alanine and L-histidine supplementation on carnosine contents in and quality and secondary structure of proteins in slow-growing Korat chicken meat.
Poultry science.
2022 May; 101(5):101776. doi:
10.1016/j.psj.2022.101776. [PMID: 35303689] - Luca Regazzoni, Laura Fumagalli, Angelica Artasensi, Silvia Gervasoni, Ettore Gilardoni, Angelica Mazzolari, Giancarlo Aldini, Giulio Vistoli. Cyclo(His-Pro) Exerts Protective Carbonyl Quenching Effects through Its Open Histidine Containing Dipeptides.
Nutrients.
2022 Apr; 14(9):. doi:
10.3390/nu14091775. [PMID: 35565743] - Lello Zolla, Marcello Ceci. Plasma Metabolomics Profile of "Insulin Sensitive" Male Hypogonadism after Testosterone Replacement Therapy.
International journal of molecular sciences.
2022 Feb; 23(3):. doi:
10.3390/ijms23031916. [PMID: 35163837] - Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Samy. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin.
Journal of physiology and biochemistry.
2022 Feb; 78(1):109-124. doi:
10.1007/s13105-021-00845-6. [PMID: 35091983] - Akanksha Agrawal, Richa Rathor, Ravi Kumar, Som Nath Singh, Bhuvnesh Kumar, Geetha Suryakumar. Endogenous dipeptide-carnosine supplementation ameliorates hypobaric hypoxia-induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis.
IUBMB life.
2022 01; 74(1):101-116. doi:
10.1002/iub.2539. [PMID: 34455667] - Mohammed M Nooh, Sherine M Rizk, Nashwa M Saied, Sally M Abdelazim. Carnosine Remedial Effect on Fertility of Male Rats Receiving Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisone (CHOP).
Andrologia.
2021 Dec; 53(11):e14233. doi:
10.1111/and.14233. [PMID: 34535909] - Henry Oppermann, Stefanie Elsel, Claudia Birkemeyer, Jürgen Meixensberger, Frank Gaunitz. Erythrocytes Prevent Degradation of Carnosine by Human Serum Carnosinase.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312802. [PMID: 34884603] - Jan Spaas, Wouter M A Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P Baba, Wim Derave, Bert O Eijnde. Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation.
Journal of neuroinflammation.
2021 Nov; 18(1):255. doi:
10.1186/s12974-021-02306-9. [PMID: 34740381] - J Lackner, A Albrecht, M Mittler, A Marx, J Kreyenschmidt, V Hess, H Sauerwein. Effect of feeding histidine and β-alanine on carnosine concentration, growth performance, and meat quality of broiler chickens.
Poultry science.
2021 Nov; 100(11):101393. doi:
10.1016/j.psj.2021.101393. [PMID: 34530228] - Charlie Jr Lavilla, Merell P Billacura, Katie Hanna, David J Boocock, Clare Coveney, Amanda K Miles, Gemma A Foulds, Alice Murphy, Arnold Tan, Laura Jackisch, Sophie R Sayers, Paul W Caton, Craig L Doig, Philip G McTernan, Sergio L Colombo, Craig Sale, Mark D Turner. Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress.
Free radical biology & medicine.
2021 11; 175(?):65-79. doi:
10.1016/j.freeradbiomed.2021.08.233. [PMID: 34455039] - Sho Kobayashi, Takujiro Homma, Nobuaki Okumura, Jia Han, Keita Nagaoka, Hideyo Sato, Hiroyuki Konno, Sohsuke Yamada, Toshifumi Takao, Junichi Fujii. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides.
Free radical biology & medicine.
2021 10; 174(?):12-27. doi:
10.1016/j.freeradbiomed.2021.07.036. [PMID: 34324979] - Mark D Turner, Craig Sale, A Christopher Garner, Alan R Hipkiss. Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis.
Biochimica et biophysica acta. Molecular cell research.
2021 10; 1868(11):119117. doi:
10.1016/j.bbamcr.2021.119117. [PMID: 34384791] - Jordi Mayneris-Perxachs, Peter Meikle, Aya Mousa, Negar Naderpoor, José Manuel Fernández-Real, Barbora de Courten. Novel Relationship Between Plasmalogen Lipid Signatures and Carnosine in Humans.
Molecular nutrition & food research.
2021 10; 65(20):e2100164. doi:
10.1002/mnfr.202100164. [PMID: 34328693] - Behrad Darvishi, Rassoul Dinarvand, Hadiseh Mohammadpour, Tunku Kamarul, Ali Mohammad Sharifi. Dual l-Carnosine/Aloe vera Nanophytosomes with Synergistically Enhanced Protective Effects against Methylglyoxal-Induced Angiogenesis Impairment.
Molecular pharmaceutics.
2021 09; 18(9):3302-3325. doi:
10.1021/acs.molpharmaceut.1c00248. [PMID: 34297586] - Inge Everaert, Thibaux Van der Stede, Jan Stautemas, Maxime Hanssens, Cleo van Aanhold, Hans Baelde, Lynn Vanhaecke, Wim Derave. Oral anserine supplementation does not attenuate type-2 diabetes or diabetic nephropathy in BTBR ob/ob mice.
Amino acids.
2021 Aug; 53(8):1269-1277. doi:
10.1007/s00726-021-03033-4. [PMID: 34264387] - Weifeng Lin, Yingchun Yang, Yang Lei, Feifei An, Leming Sun, Yong Qin, Lianbing Zhang. Self-Assembly of an Antitumor Dipeptide Induced Near-Infrared Fluorescence and Improved Stability for Theranostic Applications.
ACS applied materials & interfaces.
2021 Jul; 13(28):32799-32809. doi:
10.1021/acsami.1c07983. [PMID: 34227796] - Lukuman Surakat Yaqub, Joseph Olusegun Ayo, Buhari Habibu, Maruf Lawal, Mohammad Umaru Kawu, Peter Ibrahim Rekwot. Thermoregulatory, oxidative stress and lipid responses in prepartum ewes administered with L-carnosine during the hot-dry season.
Tropical animal health and production.
2021 Jul; 53(3):388. doi:
10.1007/s11250-021-02832-x. [PMID: 34218302] - Giovanni S Molinari, Michal Wojno, Vance J McCracken, Karolina Kwasek. The use of dipeptide supplementation as a means of mitigating the negative effects of dietary soybean meal on Zebrafish Danio rerio.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2021 07; 257(?):110958. doi:
10.1016/j.cbpa.2021.110958. [PMID: 33865992] - Narongrit Siriwattanasit, Bancha Satirapoj, Ouppatham Supasyndh. Effect of Oral carnosine supplementation on urinary TGF-β in diabetic nephropathy: a randomized controlled trial.
BMC nephrology.
2021 06; 22(1):236. doi:
10.1186/s12882-021-02434-7. [PMID: 34174842] - L Blancquaert, I Everaert, A Baguet, T Bex, S Barbaresi, S de Jager, E Lievens, J Stautemas, S De Smet, G Baron, E Gilardoni, L Regazzoni, G Aldini, W Derave. Acute preexercise supplementation of combined carnosine and anserine enhances initial maximal power of Wingate tests in humans.
Journal of applied physiology (Bethesda, Md. : 1985).
2021 06; 130(6):1868-1878. doi:
10.1152/japplphysiol.00602.2020. [PMID: 33914660] - Nevin Kocaman, Serdar Altun, Ali Bal, Erhan Cahit Ozcan, Mehmet Sarac, Gokhan Artas, Betul Demir, Suleyman Aydin, Tuncay Kuloglu. Effects of Carnosine, Ankaferd, and Silver Sulfadiazine on an Experimental Burn Model: Roles of Irisin and HSP70.
Journal of burn care & research : official publication of the American Burn Association.
2021 05; 42(3):408-414. doi:
10.1093/jbcr/iraa156. [PMID: 32910166] - He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. Carnosine functionalized magnetic metal-organic framework nanocomposites for synergistic enrichment of phosphopeptides.
Analytica chimica acta.
2021 May; 1157(?):338383. doi:
10.1016/j.aca.2021.338383. [PMID: 33832591] - A S Kalnitsky, A Yu Zharikov, O N Mazko, O G Makarova, I P Bobrov, O V Azarova. Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis.
Bulletin of experimental biology and medicine.
2021 May; 171(2):218-221. doi:
10.1007/s10517-021-05198-0. [PMID: 34173110] - Jack Feehan, Maximilian de Courten, Vasso Apostolopoulos, Barbora de Courten. Nutritional Interventions for COVID-19: A Role for Carnosine?.
Nutrients.
2021 Apr; 13(5):. doi:
10.3390/nu13051463. [PMID: 33925783] - R F Akkoc, M Ogeturk, S Aydin, T Kuloglu, S Aydin. Effects of carnosine on apoptosis, transient receptor potential melastatin 2, and betatrophin in rats exposed to formaldehyde.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2021 Apr; 96(3):223-229. doi:
10.1080/10520295.2020.1783571. [PMID: 32580587] - Giancarlo Aldini, Barbora de Courten, Luca Regazzoni, Ettore Gilardoni, Giulio Ferrario, Giovanna Baron, Alessandra Altomare, Alfonsina D'Amato, Giulio Vistoli, Marina Carini. Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms.
Free radical research.
2021 Apr; 55(4):321-330. doi:
10.1080/10715762.2020.1856830. [PMID: 33302741] - Nehal A Afifi, A Ramadan, Emad Y Erian, Ahmed A Sedik, Mohamed M Amin, Azza Hassan, Dalia O Saleh. Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence.
Canadian journal of physiology and pharmacology.
2021 Mar; 99(3):332-347. doi:
10.1139/cjpp-2020-0212. [PMID: 32721224] - Silvia Barbaresi, Laura Blancquaert, Zoran Nikolovski, Sarah de Jager, Mathew Wilson, Inge Everaert, Siegrid De Baere, Siska Croubels, Stefaan De Smet, N Tim Cable, Wim Derave. Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial.
Journal of the International Society of Sports Nutrition.
2021 Feb; 18(1):15. doi:
10.1186/s12970-021-00408-6. [PMID: 33588872] - Yi Yao Li, Varoujan Yaylayan, Marie-France Palin, Brian Sullivan, Frederic Fortin, Simon Cliche, Hassan Sabik, Claude Gariépy. Protective effects of dietary carnosine during in-vitro digestion of pork differing in fat content and cooking conditions.
Journal of food biochemistry.
2021 02; 45(2):e13624. doi:
10.1111/jfbc.13624. [PMID: 33615508] - Cătălina Cuparencu, Åsmund Rinnan, Marta P Silvestre, Sally D Poppitt, Anne Raben, Lars O Dragsted. The anserine to carnosine ratio: an excellent discriminator between white and red meats consumed by free-living overweight participants of the PREVIEW study.
European journal of nutrition.
2021 Feb; 60(1):179-192. doi:
10.1007/s00394-020-02230-3. [PMID: 32246262] - Timothy E O'Toole, Xiaohong Li, Daniel W Riggs, David J Hoetker, Shahid P Baba, Aruni Bhatnagar. Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031383. [PMID: 33573153] - Robert Hider, Mayra Vera Aviles, Yu-Lin Chen, Gladys Oluyemisi Latunde-Dada. The Role of GSH in Intracellular Iron Trafficking.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031278. [PMID: 33525417] - Yadi Cao, Juan Xu, Di Cui, Lei Liu, Shiqi Zhang, Bing Shen, Yonggui Wu, Qiu Zhang. Protective effect of carnosine on hydrogen peroxide-induced oxidative stress in human kidney tubular epithelial cells.
Biochemical and biophysical research communications.
2021 01; 534(?):576-582. doi:
10.1016/j.bbrc.2020.11.037. [PMID: 33276949] - Hasnaa Ali Ebrahim, Dalia Mahmoud Abdelmonem Elsherbini. Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine.
Cells, tissues, organs.
2021; 210(4):275-292. doi:
10.1159/000516191. [PMID: 34461611] - Mehmet Kılıç, Şilem Özdem Alataş, Erdal Taşkın, Süleyman Aydın, Mehmet Onur Kaya. Evaluation of serum/salivary levels of carnosine and cotinine in recurrent wheezing of young children with passive smoking.
The Turkish journal of pediatrics.
2021; 63(3):404-416. doi:
10.24953/turkjped.2021.03.007. [PMID: 34254485] - N A Riger, E N Trushina, O K Mustafina, A N Timonin, I V Aksenov, G V Guseva, V A Tutelyan. [Pathogenetic mechanisms for the development of hematological disorders in induced fatty liver disease in Wistar rats and assessment of the regulatory effects of carnosine and α-lipoic acid].
Voprosy pitaniia.
2021 ; 90(3):6-19. doi:
10.33029/0042-8833-2021-90-3-6-19. [PMID: 34264552] - Xue-Qi Liu, Ling Jiang, Lei Lei, Zhen-Yong Nie, Wei Zhu, Sheng Wang, Han-Xu Zeng, Shi-Qi Zhang, Qiu Zhang, Benito Yard, Yong-Gui Wu. Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.
Clinical science (London, England : 1979).
2020 12; 134(23):3175-3193. doi:
10.1042/cs20201207. [PMID: 33241846] - Jan Stautemas, Natalia Jarzebska, Zhou Xiang Shan, Laura Blancquaert, Inge Everaert, Sarah de Jager, Siegrid De Baere, Arne Hautekiet, Anneke Volkaert, Filip B D Lefevere, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Chang Keun Kim, James Leiper, Norbert Weiss, Siska Croubels, Roman N Rodionov, Wim Derave. The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans.
European journal of applied physiology.
2020 Dec; 120(12):2749-2759. doi:
10.1007/s00421-020-04501-7. [PMID: 32948897] - B Jia, W Wang, S Lin, L Shi, Y Li, Y Gu, F Gao, Y Qin. The free amino acid profiles and metabolic biomarkers of predicting the chemotherapeutic response in advanced sarcoma patients.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2020 Dec; 22(12):2213-2221. doi:
10.1007/s12094-020-02494-5. [PMID: 32948983] - Loai M Saadah, Ghina'a I Abu Deiab, Qosay Al-Balas, Iman A Basheti. Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein.
Molecules (Basel, Switzerland).
2020 Nov; 25(23):. doi:
10.3390/molecules25235605. [PMID: 33260592] - Alexander V Lopachev, Rogneda B Kazanskaya, Anastasiya V Khutorova, Tatiana N Fedorova. An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment.
European journal of pharmacology.
2020 Nov; 886(?):173457. doi:
10.1016/j.ejphar.2020.173457. [PMID: 32750366] - Kirthi Menon, Clara Marquina, Pernille Hoj, Danny Liew, Aya Mousa, Barbora de Courten. Carnosine and histidine-containing dipeptides improve dyslipidemia: a systematic review and meta-analysis of randomized controlled trials.
Nutrition reviews.
2020 11; 78(11):939-951. doi:
10.1093/nutrit/nuaa022. [PMID: 32594145] - Timothy E O'Toole, Xiaohong Li, Daniel W Riggs, David J Hoetker, Ray Yeager, Pawel Lorkiewicz, Shahid P Baba, Nigel G F Cooper, Aruni Bhatnagar. Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants.
Inhalation toxicology.
2020 Nov; 32(13-14):468-476. doi:
10.1080/08958378.2020.1845257. [PMID: 33179563] - Hung-Yueh Yeh, John E Line, Arthur Hinton, Yue Gao, Hong Zhuang. Bacterial Community Assessed by Utilization of Single Carbon Sources in Broiler Ground Meat after Treatment with an Antioxidant, Carnosine, and Cold Plasma.
Journal of food protection.
2020 Nov; 83(11):1967-1973. doi:
10.4315/jfp-20-063. [PMID: 32609819] - Kensaku Sakae, Machi Suka, Hiroyuki Yanagisawa. Polaprezinc (Zinc-L-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions: A Pilot Study.
Journal of clinical psychopharmacology.
2020 Nov; 40(6):599-606. doi:
10.1097/jcp.0000000000001284. [PMID: 33044355] - Teppei Okamoto, Shingo Hatakeyama, Kyo Togashi, Tomoko Hamaya, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis.
Clinical and experimental nephrology.
2020 Oct; 24(10):955-962. doi:
10.1007/s10157-020-01911-x. [PMID: 32557260] - Anna E Thalacker-Mercer, Mary E Gheller. Benefits and Adverse Effects of Histidine Supplementation.
The Journal of nutrition.
2020 10; 150(Suppl 1):2588S-2592S. doi:
10.1093/jn/nxaa229. [PMID: 33000165] - Teppei Okamoto, Shingo Hatakeyama, Sakae Konishi, Kazutaka Okita, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2020 Oct; 24(5):568-577. doi:
10.1111/1744-9987.13461. [PMID: 31794152] - Nazim Husain, Riaz Mahmood. Mitigation of Cu(II)-induced damage in human blood cells by carnosine: An in vitro study.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Oct; 68(?):104956. doi:
10.1016/j.tiv.2020.104956. [PMID: 32745495] - Ettore Gilardoni, Silvia Gervasoni, Marco Maspero, Clelia Dallanoce, Giulio Vistoli, Marina Carini, Giancarlo Aldini, Luca Regazzoni. Development of a direct LC-ESI-MS method for the measurement of human serum carnosinase activity.
Journal of pharmaceutical and biomedical analysis.
2020 Sep; 189(?):113440. doi:
10.1016/j.jpba.2020.113440. [PMID: 32645617] - Tim Weigand, Florian Colbatzky, Tilman Pfeffer, Sven F Garbade, Kristina Klingbeil, Florian Colbatzky, Michael Becker, Johanna Zemva, Ruben Bulkescher, Robin Schürfeld, Christian Thiel, Nadine Volk, David Reuss, Georg F Hoffmann, Marc Freichel, Markus Hecker, Tanja Poth, Thomas Fleming, Gernot Poschet, Claus P Schmitt, Verena Peters. A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144887. [PMID: 32664451] - Graziella Bonetti, Filippo Manelli, Andrea Patroni, Alessandra Bettinardi, Gianluca Borrelli, Gianfranco Fiordalisi, Antonio Marino, Annamaria Menolfi, Sara Saggini, Roberta Volpi, Adriano Anesi, Giuseppe Lippi. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy.
Clinical chemistry and laboratory medicine.
2020 06; 58(7):1100-1105. doi:
10.1515/cclm-2020-0459. [PMID: 32573995] - Jingjing Zhao, Daniel J Conklin, Yiru Guo, Xiang Zhang, Detlef Obal, Luping Guo, Ganapathy Jagatheesan, Kartik Katragadda, Liqing He, Xinmin Yin, Md Aminul Islam Prodhan, Jasmit Shah, David Hoetker, Amit Kumar, Vijay Kumar, Michael F Wempe, Aruni Bhatnagar, Shahid P Baba. Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury.
Journal of the American Heart Association.
2020 06; 9(12):e015222. doi:
10.1161/jaha.119.015222. [PMID: 32515247] - Olga I Kulikova, Sergey L Stvolinsky, Vasily A Migulin, Ludmila A Andreeva, Igor Yu Nagaev, Olga M Lopacheva, Ksenia N Kulichenkova, Alexander V Lopachev, Irina E Trubitsina, Tatiana N Fedorova. A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Jun; 28(1):119-130. doi:
10.1007/s40199-019-00323-x. [PMID: 31902097] - Saurabh Jain, Eun-Sun Kim, Donghyun Kim, David Burrows, Milena De Felice, Minyeong Kim, Seung-Hoon Baek, Ali Ali, Jessica Redgrave, Thorsten R Doeppner, Iain Gardner, Ok-Nam Bae, Arshad Majid. Comparative Cerebroprotective Potential of d- and l-Carnosine Following Ischemic Stroke in Mice.
International journal of molecular sciences.
2020 Apr; 21(9):. doi:
10.3390/ijms21093053. [PMID: 32357505] - Kei Furihata, Masaru Tsuchikawa, Takaki Miwa, Yuji Naito, Koji Oba, Masafumi Sakagami. Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data.
Nutrients.
2020 Apr; 12(4):. doi:
10.3390/nu12041128. [PMID: 32316581] - Lívia de Souza Gonçalves, Caroline Kratz, Lívia Santos, Victor Henrique Carvalho, Lucas Peixoto Sales, Kleiner Nemezio, Igor Longobardi, Luiz Augusto Riani, Marcelo Miranda de Oliveira Lima, Tiemi Saito, Alan Lins Fernandes, Joice Rodrigues, Ruth Margaret James, Craig Sale, Bruno Gualano, Bruno Geloneze, Marisa Helena Gennari de Medeiros, Guilherme Giannini Artioli. Insulin does not stimulate β-alanine transport into human skeletal muscle.
American journal of physiology. Cell physiology.
2020 04; 318(4):C777-C786. doi:
10.1152/ajpcell.00550.2019. [PMID: 32101455] - Peng Li, Guoyao Wu. Composition of amino acids and related nitrogenous nutrients in feedstuffs for animal diets.
Amino acids.
2020 Apr; 52(4):523-542. doi:
10.1007/s00726-020-02833-4. [PMID: 32162082] - Guoyao Wu. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health.
Amino acids.
2020 Mar; 52(3):329-360. doi:
10.1007/s00726-020-02823-6. [PMID: 32072297] - Claudia G Fresta, Annamaria Fidilio, Giacomo Lazzarino, Nicolò Musso, Margherita Grasso, Sara Merlo, Angela M Amorini, Claudio Bucolo, Barbara Tavazzi, Giuseppe Lazzarino, Susan M Lunte, Filippo Caraci, Giuseppe Caruso. Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
10.3390/ijms21030776. [PMID: 31991717] - Verena Peters, Benito Yard, Claus Peter Schmitt. Carnosine and Diabetic Nephropathy.
Current medicinal chemistry.
2020; 27(11):1801-1812. doi:
10.2174/0929867326666190326111851. [PMID: 30914013] - Mohammad Mehdi Ommati, Omid Farshad, Vahid Ghanbarinejad, Hamid Reza Mohammadi, Mousavi Khadijeh, Azarpira Negar, Mahboubi Zahra, Farshid Ilkhaninasab, Leila Moezi, Reza Heidari. The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress.
Drug research.
2020 Jan; 70(1):49-56. doi:
10.1055/a-1017-5085. [PMID: 31671464] - Ken-Ichiro Tanaka, Masahiro Kawahara. Carnosine and Lung Disease.
Current medicinal chemistry.
2020; 27(11):1714-1725. doi:
10.2174/0929867326666190712140545. [PMID: 31309876] - Weixia Peng, Peijun Mao, Lijun Liu, Keli Chen, Yaqin Zhong, Wenping Xia, Qiaohong Guo, Shing Cheng Tan, Jamal Rahmani, Hamed Kord Varkaneh, Peixiang He. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: A systematic review and meta-analysis of long-term randomized controlled trials.
Complementary therapies in medicine.
2020 Jan; 48(?):102241. doi:
10.1016/j.ctim.2019.102241. [PMID: 31987255] - Katarzyna Kilis-Pstrusinska. Carnosine and Kidney Diseases: What We Currently Know?.
Current medicinal chemistry.
2020; 27(11):1764-1781. doi:
10.2174/0929867326666190730130024. [PMID: 31362685] - Nour A Al-Sawalha, Osama Y Alshogran, Mofleh S Awawdeh, Basima A Almomani. The effects of l-Carnosine on development of metabolic syndrome in rats.
Life sciences.
2019 Nov; 237(?):116905. doi:
10.1016/j.lfs.2019.116905. [PMID: 31610198] - Milan Holeček, Melita Vodeničarovová. Effects of histidine load on ammonia, amino acid, and adenine nucleotide concentrations in rats.
Amino acids.
2019 Nov; 51(10-12):1667-1680. doi:
10.1007/s00726-019-02803-5. [PMID: 31712921] - Felix Schmöhl, Verena Peters, Claus Peter Schmitt, Gernot Poschet, Michael Büttner, Xiaogang Li, Tim Weigand, Tanja Poth, Nadine Volk, Jakob Morgenstern, Thomas Fleming, Peter P Nawroth, Jens Kroll. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
Cellular and molecular life sciences : CMLS.
2019 Nov; 76(22):4551-4568. doi:
10.1007/s00018-019-03127-z. [PMID: 31073745] - Valeria Castelletto, Charlotte J C Edwards-Gayle, Francesca Greco, Ian W Hamley, Jani Seitsonen, Janne Ruokolainen. Self-Assembly, Tunable Hydrogel Properties, and Selective Anti-Cancer Activity of a Carnosine-Derived Lipidated Peptide.
ACS applied materials & interfaces.
2019 Sep; 11(37):33573-33580. doi:
10.1021/acsami.9b09065. [PMID: 31407889] - Hichem Moulahoum, Serdar Sanli, Suna Timur, Figen Zihnioglu. Potential effect of carnosine encapsulated niosomes in bovine serum albumin modifications.
International journal of biological macromolecules.
2019 Sep; 137(?):583-591. doi:
10.1016/j.ijbiomac.2019.07.003. [PMID: 31276721] - Weinan Li, Yu Liu, Wei Jiang, Xiaojun Yan. Proximate Composition and Nutritional Profile of Rainbow Trout (Oncorhynchus mykiss) Heads and Skipjack tuna (Katsuwonus Pelamis) Heads.
Molecules (Basel, Switzerland).
2019 Sep; 24(17):. doi:
10.3390/molecules24173189. [PMID: 31480782] - Cătălina Cuparencu, Åsmund Rinnan, Lars O Dragsted. Combined Markers to Assess Meat Intake-Human Metabolomic Studies of Discovery and Validation.
Molecular nutrition & food research.
2019 09; 63(17):e1900106. doi:
10.1002/mnfr.201900106. [PMID: 31141834] - Jameen Arm, Oun Al-Iedani, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan. Diurnal variability of cerebral metabolites in healthy human brain with 2D localized correlation spectroscopy (2D L-COSY).
Journal of magnetic resonance imaging : JMRI.
2019 08; 50(2):592-601. doi:
10.1002/jmri.26642. [PMID: 30629765] - Wesley Abplanalp, Petra Haberzettl, Aruni Bhatnagar, Daniel J Conklin, Timothy E O'Toole. Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice.
Journal of the American Heart Association.
2019 07; 8(13):e013041. doi:
10.1161/jaha.119.013041. [PMID: 31234700] - Patricia Mitry, Nina Wawro, Sabine Rohrmann, Pieter Giesbertz, Hannelore Daniel, Jakob Linseisen. Plasma concentrations of anserine, carnosine and pi-methylhistidine as biomarkers of habitual meat consumption.
European journal of clinical nutrition.
2019 05; 73(5):692-702. doi:
10.1038/s41430-018-0248-1. [PMID: 30018457] - Sheng-Lei Yan, Zhi-Hong Wang, Mei-Chin Mong, Ya-Chen Yang, Mei-Chin Yin. Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice than individual treatments of carnosine or asiatic acid alone.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Apr; 126(?):192-198. doi:
10.1016/j.fct.2019.02.027. [PMID: 30802477] - Giuseppe Caruso, Filippo Caraci, Renaud B Jolivet. Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders.
Progress in neurobiology.
2019 04; 175(?):35-53. doi:
10.1016/j.pneurobio.2018.12.004. [PMID: 30593839] - Florian Rohm, Thomas Skurk, Hannelore Daniel, Britta Spanier. Appearance of Di- and Tripeptides in Human Plasma after a Protein Meal Does Not Correlate with PEPT1 Substrate Selectivity.
Molecular nutrition & food research.
2019 03; 63(5):e1801094. doi:
10.1002/mnfr.201801094. [PMID: 30521147] - Panyu Zhou, Demeng Xia, Yan Xia, Hongyue Zhang, Yang Wang, Tao Tang, Shuogui Xu. Synergistic effect of vancomycin and l-homocarnosine alleviates Staphylococcus aureus-induced osteomyelitis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Mar; 111(?):31-35. doi:
10.1016/j.biopha.2018.11.102. [PMID: 30572244] - Fumitsugu Yoshikawa, Tetsu Nakajima, Masaharu Hanada, Kazuo Hirata, Tohru Masuyama, Ryuichi Aikawa. Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial.
Medicine.
2019 Mar; 98(10):e14637. doi:
10.1097/md.0000000000014637. [PMID: 30855449] - Kei Noguchi, Taha F S Ali, Junko Miyoshi, Kimihiko Orito, Tetsuya Negoto, Tanima Biswas, Naomi Taira, Ryoko Koga, Yoshinari Okamoto, Mikako Fujita, Masami Otsuka, Motohiro Morioka. Neuroprotective effects of a novel carnosine-hydrazide derivative on hippocampal CA1 damage after transient cerebral ischemia.
European journal of medicinal chemistry.
2019 Feb; 163(?):207-214. doi:
10.1016/j.ejmech.2018.11.060. [PMID: 30522055] - Guilherme Giannini Artioli, Craig Sale, Rebecca Louise Jones. Carnosine in health and disease.
European journal of sport science.
2019 Feb; 19(1):30-39. doi:
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