hypoxanthine (BioDeep_00000399879)

Main id: BioDeep_00000001351

Secondary id: BioDeep_00000229665

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


hypoxanthine

化学式: C5H4N4O (136.0385)
中文名称: 次黄嘌呤, 6-羟基嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 49.47%

分子结构信息

SMILES: C1=NC2=C(N1)C(=O)N=CN2
InChI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C62554 - Poly (ADP-Ribose) Polymerase Inhibitor
A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
COVID info from COVID-19 Disease Map
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; FDGQSTZJBFJUBT_STSL_0163_Hypoxanthine_0125fmol_180430_S2_LC02_MS02_115; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

同义名列表

5 个代谢物同义名

hypoxanthine; Purin-6-ol; Sarcine; Hypoxanthine; 6H-Purin-6-one, 1,7-dihydro-



数据库引用编号

90 个数据库交叉引用编号

分类词条

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADA, ALB, APRT, CAT, DHFR, ENDOV, MPG, PNP, XDH
Peripheral membrane protein 1 ADA
Nucleus 4 ADK, ALB, MPG, UNG
cytosol 11 ADA, ADK, ALB, APRT, CAT, DHFR, GPT, MPG, NT5E, PNP, XDH
centrosome 1 ALB
nucleoplasm 5 ADK, APRT, MPG, NT5E, UNG
Cell membrane 4 ADA, NT5E, SLC29A1, TNF
Multi-pass membrane protein 4 SLC22A6, SLC29A1, SLC29A2, SLC2A6
cell junction 1 ADA
cell surface 3 ADA, NT5E, TNF
Golgi apparatus 1 ALB
Golgi membrane 1 INS
lysosomal membrane 1 SLC2A6
neuronal cell body 1 TNF
postsynapse 1 SLC29A1
Lysosome 1 ADA
Presynapse 1 SLC29A1
plasma membrane 8 ADA, ADK, NT5E, SLC22A6, SLC29A1, SLC29A2, SLC2A6, TNF
Membrane 7 ADA, CAT, MPG, NT5E, SLC22A6, SLC29A1, SLC2A6
apical plasma membrane 2 SLC29A1, SLC29A2
basolateral plasma membrane 3 SLC22A6, SLC29A1, SLC29A2
caveola 1 SLC22A6
extracellular exosome 7 ALB, APRT, CAT, GPT, NT5E, PNP, SLC22A6
Lysosome membrane 1 SLC2A6
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, IL6, INS, PNP, TNF, XDH
mitochondrion 4 CAT, DHFR, MPG, UNG
protein-containing complex 3 ALB, CAT, SLC22A6
intracellular membrane-bounded organelle 1 CAT
Secreted 4 ALB, IL6, INS, PNP
extracellular region 7 ALB, APRT, CAT, IL6, INS, PNP, TNF
mitochondrial matrix 1 CAT
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 2 ADA, ALB
external side of plasma membrane 3 ADA, NT5E, TNF
nucleolus 2 ENDOV, SLC29A2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 SLC29A1, SLC29A2
Membrane raft 1 TNF
focal adhesion 1 CAT
mitochondrial nucleoid 1 MPG
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 SLC29A1
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Nucleus, nucleolus 1 ENDOV
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 3 SLC22A6, SLC29A1, SLC29A2
Lipid-anchor, GPI-anchor 1 NT5E
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ENDOV
cytoplasmic stress granule 1 ENDOV
side of membrane 1 NT5E
basal plasma membrane 1 SLC22A6
[Isoform 1]: Cytoplasm 1 ENDOV
ficolin-1-rich granule lumen 2 CAT, PNP
secretory granule lumen 4 APRT, CAT, INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 ADK
[Isoform 1]: Nucleus 1 ADK
Basal cell membrane 1 SLC22A6
[Isoform 7]: Cytoplasm 1 ENDOV
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Isoform 6]: Cytoplasm 1 ENDOV
Mitochondrion matrix, mitochondrion nucleoid 1 MPG
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hannah J Irvine, Animesh Acharjee, Zoe Wolcott, Zsuzsanna Ament, H E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth, W Taylor Kimberly. Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide. Cell reports. Medicine. 2022 06; 3(6):100654. doi: 10.1016/j.xcrm.2022.100654. [PMID: 35700741]
  • Zhi Luo, Hetao Wang, Simin Lin, Lili Liao, Lishan Cai, Xiaoxu Zhang, Yangying Tan, Mei Shen. Study on the levels of N-nitrosamine compounds and untargeted metabolomics in patients with colorectal cancer. Analytical and bioanalytical chemistry. 2022 May; 414(11):3483-3496. doi: 10.1007/s00216-022-03969-w. [PMID: 35174409]
  • Stefano Fornasaro, Alessandro Esposito, Fiorella Florian, Alberto Pallavicini, Luigina De Leo, Tarcisio Not, Cristina Lagatolla, Marica Mezzarobba, Alessia Di Silvestre, Valter Sergo, Alois Bonifacio. Spectroscopic investigation of faeces with surface-enhanced Raman scattering: a case study with coeliac patients on gluten-free diet. Analytical and bioanalytical chemistry. 2022 May; 414(11):3517-3527. doi: 10.1007/s00216-022-03975-y. [PMID: 35258650]
  • Enrico Marchetti, Daniela Pigini, Mariangela Spagnoli, Giovanna Tranfo, Flavia Buonaurio, Fabio Sciubba, Ottavia Giampaoli, Alfredo Miccheli, Alessandro Pinto, Nazzareno De Angelis, Luigi Fattorini. Hyperbaric Exposure of Scuba Divers Affects the Urinary Excretion of Nucleic Acid Oxidation Products and Hypoxanthine. International journal of environmental research and public health. 2022 03; 19(5):. doi: 10.3390/ijerph19053005. [PMID: 35270697]
  • Dmitri Svistounov, Marit D Solbu, Trond G Jenssen, Ulla Dorte Mathisen, Terkel Hansen, Katja Benedikte Prestø Elgstøen, Svetlana N Zykova. Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry. Scandinavian journal of clinical and laboratory investigation. 2022 02; 82(1):37-49. doi: 10.1080/00365513.2021.2015799. [PMID: 35048747]
  • Yogaraje Gowda C Varadaiah, Senthilkumar Sivanesan, Shivananda B Nayak, Kashinath R Thirumalarao. Purine metabolites can indicate diabetes progression. Archives of physiology and biochemistry. 2022 Feb; 128(1):87-91. doi: 10.1080/13813455.2019.1663219. [PMID: 31517540]
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