Gentisin (BioDeep_00000229847)

 

Secondary id: BioDeep_00000007854, BioDeep_00000862046

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


1,7-Dihydroxy-3-methoxyxanthone; 1,7-Dihydroxy-3-methoxyxanthen-9-one

化学式: C14H10O5 (258.0528)
中文名称: 龙胆根素, 龍膽根素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 42.14%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)cc(cc1)O)O)OC
InChI: InChI=1S/C14H10O5/c1-18-8-5-10(16)13-12(6-8)19-11-3-2-7(15)4-9(11)14(13)17/h2-6,15-16H,1H3

描述信息

Gentisin is a member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 7 and a methoxy group at position 3. It has a role as a plant metabolite. It is a member of xanthones, a polyphenol and an aromatic ether.
Gentisin is a natural product found in Pterocarpus santalinus, Gentiana orbicularis, and other organisms with data available.
See also: Menyanthes trifoliata leaf (part of).
A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 7 and a methoxy group at position 3.
Gentisin is found in alcoholic beverages. Gentisin is a pigment from root of Gentiana lutea (yellow gentian

同义名列表

21 个代谢物同义名

1,7-Dihydroxy-3-methoxyxanthone; 1,7-Dihydroxy-3-methoxyxanthen-9-one; 9H-Xanthen-9-one, 1,7-dihydroxy-3-methoxy-; 9H-Xanthen-9-one,1,7-dihydroxy-3-methoxy-; 1,7-dihydroxy-3-methoxy-9H-xanthen-9-one; Xanthen-9-one, 1,7-dihydroxy-3-methoxy-; 1,7-dihydroxy-3-methoxy-xanthen-9-one; 1,7-Dihydroxy-3-methoxyxanthen-9-one; 4,7-Dihydroxy-2-methoxyxanthone; 1,7-Dihydroxy-3-methoxyxanthone; 1,7-dihydroxy-3-methoxyanthone; UNII-K57MOP2HM0; GENTIANIC ACID; GENTISIN [MI]; K57MOP2HM0; Gentianin?; Gentianin; Gentisine; Gentisin; A1-01883; Gentiin; Gentisin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

88 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACE, AKT1, CAT, CCND1, GRB2, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 4 AKT1, CCND1, GRB2, PCNA
cytosol 4 AKT1, CAT, CCND1, GRB2
nuclear body 1 PCNA
centrosome 2 CCND1, PCNA
nucleoplasm 4 AKT1, CCND1, GRB2, PCNA
Cell membrane 3 ACE, AKT1, TNF
lamellipodium 1 AKT1
cell cortex 2 AKT1, GRB2
cell surface 2 TNF, TNR
glutamatergic synapse 2 AKT1, TNR
Golgi apparatus 1 GRB2
neuronal cell body 1 TNF
postsynapse 1 AKT1
Lysosome 1 ACE
endosome 2 ACE, GRB2
plasma membrane 4 ACE, AKT1, GRB2, TNF
Membrane 3 ACE, AKT1, CAT
caveola 1 PTGS2
extracellular exosome 4 ACE, CAT, GRB2, PCNA
endoplasmic reticulum 1 PTGS2
extracellular space 6 ACE, CRP, IL10, IL4, TNF, TNR
Schaffer collateral - CA1 synapse 1 TNR
bicellular tight junction 1 CCND1
mitochondrion 1 CAT
protein-containing complex 3 AKT1, CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 ACE
Secreted 4 ACE, CRP, IL10, IL4
extracellular region 8 ACE, CAT, CRP, DNAH9, IL10, IL4, TNF, TNR
mitochondrial matrix 1 CAT
motile cilium 1 DNAH9
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 2 ACE, TNF
Secreted, extracellular space, extracellular matrix 1 TNR
microtubule cytoskeleton 1 AKT1
nucleolus 1 GRB2
cell-cell junction 2 AKT1, GRB2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 TNF, TNR
focal adhesion 1 CAT
microtubule 1 DNAH9
spindle 1 AKT1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 TNR
axoneme 1 DNAH9
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 PCNA
phagocytic cup 1 TNF
COP9 signalosome 1 GRB2
brush border membrane 1 ACE
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
sperm midpiece 1 ACE
replication fork 1 PCNA
basal plasma membrane 1 ACE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 PTGS2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
perineuronal net 1 TNR
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
vesicle membrane 1 GRB2
nuclear lamina 1 PCNA
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
tenascin complex 1 TNR
cyclin D1-CDK6 complex 1 CCND1
Grb2-EGFR complex 1 GRB2
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Chaohong Yin, Longwei Xie, Yun Guo. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. Microbial pathogenesis. 2018 Jan; 114(?):25-28. doi: 10.1016/j.micpath.2017.10.049. [PMID: 29111322]
  • Qiwen Wang, Chenyao Ma, Yun Ma, Xiang Li, Yong Chen, Jianwei Chen. Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):447-449. doi: 10.1016/j.bmcl.2016.12.045. [PMID: 28065566]
  • Dya Fita Dibwe, Suresh Awale, Shigetoshi Kadota, Hiroyuki Morita, Yasuhiro Tezuka. Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata. Bioorganic & medicinal chemistry. 2013 Dec; 21(24):7663-8. doi: 10.1016/j.bmc.2013.10.027. [PMID: 24216090]
  • Namki Cho, Jungmoo Huh, Heejung Yang, Eun Ju Jeong, Young Choong Kim, Jinwoong Kim, Sang Hyun Sung. Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Journal of enzyme inhibition and medicinal chemistry. 2012 Feb; 27(1):1-4. doi: 10.3109/14756366.2011.562203. [PMID: 21740104]
  • Ngoc Trang Nhu Ngo, Vy Thuy Nguyen, Hoa Van Vo, Ole Vang, Fritz Duus, Thuy-Duong Huynh Ho, Hung Dinh Pham, Lien-Hoa Dieu Nguyen. Cytotoxic Coumarins from the Bark of Mammea siamensis. Chemical & pharmaceutical bulletin. 2010 Nov; 58(11):1487-91. doi: 10.1248/cpb.58.1487. [PMID: 21048341]
  • M Shekarchi, H Hajimehdipoor, M Khanavi, N Adib, M Bozorgi, B Akbari-Adergani. A validated method for analysis of Swerchirin in Swertia longifolia Boiss. by high performance liquid chromatography. Pharmacognosy magazine. 2010 Jan; 6(21):13-8. doi: 10.4103/0973-1296.59961. [PMID: 20548931]
  • Anita Aberham, Stefan Schwaiger, Hermann Stuppner, Markus Ganzera. Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. Journal of pharmaceutical and biomedical analysis. 2007 Nov; 45(3):437-42. doi: 10.1016/j.jpba.2007.07.001. [PMID: 17697760]
  • Jih-Jung Chen, Chien-Fang Peng, Hung-Yi Huang, Ih-Sheng Chen. Benzopyrans, biphenyls and xanthones from the root of Garcinia linii and their activity against Mycobacterium tuberculosis. Planta medica. 2006 Apr; 72(5):473-7. doi: 10.1055/s-2005-916253. [PMID: 16557464]
  • I Morimoto, T Nozaka, F Watanabe, M Ishino, Y Hirose, T Okitsu. Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae). Mutation research. 1983 Feb; 116(2):103-17. doi: 10.1016/0165-1218(83)90101-5. [PMID: 6338357]