Paeonol (BioDeep_00000017307)

 

Secondary id: BioDeep_00000003699, BioDeep_00000402993, BioDeep_00000860033

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark -methoxyacetophenone

化学式: C9H10O3 (166.063)
中文名称: 丹皮酚, 芍药醇, 牡丹酚
谱图信息: 最多检出来源 Viridiplantae(plant) 58.05%

分子结构信息

SMILES: CC(=O)C1=C(C=C(C=C1)OC)O
InChI: InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3

描述信息

Paeonol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.
Paeonol is a natural product found in Vincetoxicum paniculatum, Vincetoxicum glaucescens, and other organisms with data available.
See also: Paeonia lactiflora root (part of); Paeonia X suffruticosa root (part of).
A natural product found in Paeonia rockii subspeciesrockii.
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.

同义名列表

47 个代谢物同义名

2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark -methoxyacetophenone; 2 inverted exclamation marka-Hydroxy-4 inverted exclamation marka-methoxyacetophenone; InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H; quinuclidin-3-one oxime hydrochloride;Paeonol; 4-08-00-01793 (Beilstein Handbook Reference); Acetophenone, 2-hydroxy-4-methoxy-(7CI,8CI); 2-HYDROXY-4-METHOXYACETOPHENONE (4,4,4-D3); 1-[2-hydroxy-4-(methyloxy)phenyl]ethanone; 1-(2-hydroxy-4-methoxyphenyl)ethane-1-one; Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one; 1-(2-Hydroxy-4-methoxyphenyl)ethanone #; 1-(4-Methoxy-2-hydroxy-phenyl)-ethanone; 2-HYDROXY-4-METHOXYPHENYL METHYL KETONE; 1-(2-hydroxy-4-methoxy-phenyl)-ethanone; 1-(2-hydroxy-4-methoxy-phenyl)ethanone; 1-(2-hydroxy-4-methoxyphenyl)-ethanone; 1-(2-Hydroxy-4-methoxyphenyl)ethanone; 1-(4-METHOXY-2-HYDROXYPHENYL)ETHANONE; 2-Hydroxy-4-methoxyacetophenone, 99\\%; Acetophenone, 2-hydroxy-4-methoxy-; Resacetophenone, 4-O-methyl ester; 2`-Hydroxy-4`-methoxyacetophenone; 4-methoxy 2-hydroxy acetophenone; RESACETOPHENONE 4-O-METHYL ETHER; 2-Hydroxy-4-methoxyacetophenone; 4-Methoxy-2-hydroxyacetophenone; 2-hydroxy-4-methoxyacetophenone; Resacetophenone-4-methyl ether; 4-O-Methylresacetophenone; 2-Acetyl-5-methoxy-phenol; 2-acetyl-5-methoxyphenol; Spectrum2_001981; PAEONOL [WHO-DD]; Spectrum3_001686; Paeonol (Peonol); UNII-3R834EPI82; PAEONOL [INCI]; ICCB4_000282; KBio3_002432; 3R834EPI82; AI3-10581; Paeonal; Paeonol; peonol; Paeonol; Paeonol



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

129 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ANXA5, BDNF, CASP9, HMGB1, MAPK14, MAPK8, MTOR, NOS2, PIK3C3, PIK3CA, TYR
Peripheral membrane protein 3 ANXA5, HMGB1, MTOR
Endoplasmic reticulum membrane 2 HMOX1, MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 9 AKT1, CASP9, GABPA, HMGB1, HMOX1, MAPK14, MAPK8, MTOR, NOS2
autophagosome 1 PIK3C3
cytosol 11 AKT1, ANXA5, CASP9, GPT, HMOX1, MAPK14, MAPK8, MTOR, NOS2, PIK3C3, PIK3CA
dendrite 2 BDNF, MTOR
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 8 AKT1, GABPA, HMGB1, HMOX1, MAPK14, MAPK8, MTOR, NOS2
Cell membrane 3 AKT1, HMGB1, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 HMGB1, TNF
glutamatergic synapse 3 AKT1, MAPK14, PIK3C3
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NOS2
Lysosome 2 MTOR, TYR
endosome 2 HMGB1, PIK3C3
plasma membrane 5 AKT1, HMGB1, NOS2, PIK3CA, TNF
Membrane 6 AKT1, ANXA5, BDNF, HMOX1, MTOR, PIK3C3
axon 2 BDNF, MAPK8
extracellular exosome 2 ANXA5, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 HMGB1, HMOX1
extracellular space 8 BDNF, HMGB1, HMOX1, IL10, IL17A, IL4, IL6, TNF
perinuclear region of cytoplasm 5 BDNF, HMOX1, NOS2, PIK3CA, TYR
intercalated disc 1 PIK3CA
mitochondrion 2 CASP9, MAPK14
protein-containing complex 2 AKT1, CASP9
intracellular membrane-bounded organelle 1 TYR
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TYR
Secreted 6 BDNF, HMGB1, IL10, IL17A, IL4, IL6
extracellular region 9 ANXA5, BDNF, HMGB1, IL10, IL17A, IL4, IL6, MAPK14, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 HMOX1, MTOR
Extracellular side 1 HMGB1
external side of plasma membrane 3 ANXA5, IL17A, TNF
microtubule cytoskeleton 1 AKT1
Melanosome membrane 1 TYR
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
focal adhesion 1 ANXA5
spindle 1 AKT1
GABA-ergic synapse 1 PIK3C3
Peroxisome 2 NOS2, PIK3C3
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
axoneme 1 PIK3C3
nuclear speck 1 MAPK14
Late endosome 1 PIK3C3
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 1 GABPA
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 PIK3C3
Chromosome 1 HMGB1
spindle pole 1 MAPK14
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Melanosome 1 TYR
ficolin-1-rich granule lumen 2 HMGB1, MAPK14
secretory granule lumen 2 HMGB1, MAPK14
endoplasmic reticulum lumen 2 BDNF, IL6
transcription repressor complex 1 HMGB1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
presynaptic endosome 1 PIK3C3
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
basal dendrite 1 MAPK8
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
postsynaptic endosome 1 PIK3C3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
Autolysosome 1 PIK3C3
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Guiming Yan, Luning Zhang, Daqiang Wu, Shengnan Jiang, Qifeng Wu, Min Dai. Paeonol attenuates nonalcoholic steatohepatitis by regulating intestinal flora and AhR/NLRP3/Caspase-1 metabolic pathway. Journal of ethnopharmacology. 2024 Jul; 329(?):118147. doi: 10.1016/j.jep.2024.118147. [PMID: 38574779]
  • Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai. The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway. Biochemical and biophysical research communications. 2024 May; 708(?):149788. doi: 10.1016/j.bbrc.2024.149788. [PMID: 38518720]
  • Yuzhen Niu, Yingying Jin, Yongxi Hao, Wei Liang, Fan Tang, Ziyi Qin, Tao Liang, Le Shi. Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages. Molecular immunology. 2024 May; 169(?):66-77. doi: 10.1016/j.molimm.2024.03.004. [PMID: 38503139]
  • Jinjin Yan, Yulong Yang, Yarong Liu, Xiaoyan Shi, Hongfei Wu, Min Dai. MicroRNA let-7g links foam cell formation and adipogenic differentiation: A key regulator of Paeonol treating atherosclerosis-osteoporosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155447. doi: 10.1016/j.phymed.2024.155447. [PMID: 38394732]
  • Rong Li, Qingping Yi, Jinsong Wang, Yuanxin Miao, Qingchan Chen, Yan Xu, Mingfang Tao. Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116368. doi: 10.1016/j.biopha.2024.116368. [PMID: 38471269]
  • Ling Meng, Yan Chen, Zhenjia Zheng, Lei Wang, Yahui Xu, Xiujun Li, Zhijian Xiao, Zheng Tang, Zhaosheng Wang. Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030622. [PMID: 38338367]
  • Min Zhou, Xiaolin Ma, Menglong Gao, Hongfei Wu, Yarong Liu, Xiaoyan Shi, Min Dai. Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010261. [PMID: 38202844]
  • Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Guo. Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats. Brain research bulletin. 2023 Dec; 205(?):110830. doi: 10.1016/j.brainresbull.2023.110830. [PMID: 38036272]
  • Minghui Zou, Qiqi Xue, Qiao Teng, Qiqi Zhang, Ting Liu, Yuanyuan Li, Jinhong Zhao. Acaricidal activities of paeonol from Moutan Cortex, dried bark of Paeonia × suffruticosa, against the grain pest mite Aleuroglyphus ovatus (Acari: Acaridae). Experimental & applied acarology. 2023 Dec; 91(4):615-628. doi: 10.1007/s10493-023-00861-9. [PMID: 37979065]
  • Rong-Qing Zhu, Chun-Fang Tian, Xiao-Yan Lan, Zi-Han Wang, Xiang Li, Li Zhou, Mei-Lan Chen, Li-Ping Kang. [Chemical and nutrient differences between medicinal material, residues, and residue compost of Moutan Cortex]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(23):6361-6370. doi: 10.19540/j.cnki.cjcmm.20231017.102. [PMID: 38211992]
  • Rui Wu, Yanfang Liu, Fang Zhang, Shu Dai, Xinyan Xue, Cheng Peng, Yan Li, Yunxia Li. Protective mechanism of Paeonol on central nervous system. Phytotherapy research : PTR. 2023 Oct; ?(?):. doi: 10.1002/ptr.8049. [PMID: 37872838]
  • Huan-Zheng Li, Xue-Fang Tang, Yu Lin, Fang-Fang Xu, Xin Zhang, Hui-Qing Ye, Wei Xiao, Zhen-Zhong Wang, Bing Xu. [Discrete element simulation study of mixing process of Guizhi Fuling Capsules: parameter calibration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Aug; 48(15):4007-4014. doi: 10.19540/j.cnki.cjcmm.20230711.301. [PMID: 37802768]
  • Lixin Zhang, Lihua Wu, Xiangrui Zhu, Jian Mei, Yingli Chen. Paeonol represses A549 cell glycolytic reprogramming and proliferation by decreasing m6A modification of Acyl-CoA dehydrogenase. The Chinese journal of physiology. 2023 Jul; 66(4):248-256. doi: 10.4103/cjop.cjop-d-22-00166. [PMID: 37635484]
  • Shiqin Chen, Yingying Shan, Chunlin Liu, Chungui Du, Jiawei Zhu, Fei Yang, Yuran Shao, Qichao Bao, Yuting Wang, Ying Ran, Wenxiu Yin. Antimildew Effect of Three Phenolic Compounds and the Efficacy of Antimildew Sliced Bamboo Veneer. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28134941. [PMID: 37446603]
  • Yuanyuan Ding, Baowen Dang, Yonghui Zhang, Shiting Hu, Yuejin Wang, Chenrui Zhao, Tao Zhang, Zijun Gao. Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells. Cellular immunology. 2023 May; 388-389(?):104728. doi: 10.1016/j.cellimm.2023.104728. [PMID: 37224634]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Xin Li, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Yachun Zheng, Shiquan Chang, Li Gao, Guoping Zhao. Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS neuroscience & therapeutics. 2023 Apr; ?(?):. doi: 10.1111/cns.14211. [PMID: 37032648]
  • Yulong Yang, Yuning Liang, Xiaoyan Shi, Hongfei Wu, Yarong Liu, Tingting Jiang, Jinjin Yan, Min Zhou, Menglong Gao, Min Dai. Paeonol Attenuates the Endothelial-to-Mesenchymal Transition Induced by TGF-β1 in Human Umbilical Vein Endothelial Cells through ALK5-Smad2/3 Signaling Pathway. Current neurovascular research. 2023 Feb; ?(?):. doi: 10.2174/1567202620666230202124037. [PMID: 36733198]
  • Taotao Sun, Wenchao Xu, Jiaxin Wang, Jingyu Song, Tao Wang, Shaogang Wang, Kang Liu, Jihong Liu. Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway. Andrology. 2023 02; 11(2):344-357. doi: 10.1111/andr.13203. [PMID: 35678254]
  • Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji, Jun Li. Review of the Protective Mechanism of Paeonol on Cardiovascular Disease. Drug design, development and therapy. 2023; 17(?):2193-2208. doi: 10.2147/dddt.s414752. [PMID: 37525853]
  • Wei Zhang, Manli Yu, Cenxi Zhang, Qing Yu, Sheng Xu, Qiongzhi Yan, Zhifu Guo, Yawei Xu. Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway. Oxidative medicine and cellular longevity. 2023; 2023(?):3271057. doi: 10.1155/2023/3271057. [PMID: 36785789]
  • Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu. Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154593. doi: 10.1016/j.phymed.2022.154593. [PMID: 36610113]
  • Yang Wang, Zheng Wang, Xiao Wu, Song Zhu, Qiru Guo, Zhong Jin, Zixian Chen, Delai Zhang, Wangming Hu, Huan Xu, Liangqin Shi, Lan Yang, Yong Wang. Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway. Drug design, development and therapy. 2023; 17(?):1567-1582. doi: 10.2147/dddt.s403134. [PMID: 37249931]
  • Cheng-Wen Jia, Ying-Dong Li, Hu-Gang Jiang, Guo-Wei Han, Xin-Ke Zhao. [Study on the mechanism of paeonol in improving low-density lipoprotein-induced human vascular endothelial cell injury]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2022 Sep; 38(5):537-542. doi: 10.12047/j.cjap.6325.2022.100. [PMID: 37088766]
  • Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian. Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities. Pest management science. 2022 Aug; 78(8):3442-3455. doi: 10.1002/ps.6985. [PMID: 35567371]
  • Yuling Wang, Zeyan Tang, Xueping Guo, Yuqi Zhao, Shujing Ren, Zhenhai Zhang, Huixia Lv. Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis. International journal of pharmaceutics. 2022 Jul; 623(?):121916. doi: 10.1016/j.ijpharm.2022.121916. [PMID: 35714817]
  • Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jul; 257(?):109339. doi: 10.1016/j.cbpc.2022.109339. [PMID: 35378299]
  • Jikun Du, Daibo Song, Jinwen Li, Yuanhua Li, Baohong Li, Li Li. Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway. Psychopharmacology. 2022 Jul; 239(7):2083-2092. doi: 10.1007/s00213-021-05811-0. [PMID: 33710373]
  • Jian-Hong Qi, Fang-Xu Dong, Xiao-Long Wang. Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology. Molecular diversity. 2022 Jun; 26(3):1731-1742. doi: 10.1007/s11030-021-10301-8. [PMID: 34463943]
  • Wenjing Liu, Zhonggui Gong, Kanglei Zhang, Wenxuan Dong, Hui Zou, Ruilong Song, Jianchun Bian, Jiaqiao Zhu, Gang Liu, Zongping Liu. Paeonol protects renal tubular cells against cadmium-induced cytotoxicity via alleviating oxidative stress, inhibiting inflammatory responses and restoring autophagy. Journal of inorganic biochemistry. 2022 05; 230(?):111733. doi: 10.1016/j.jinorgbio.2022.111733. [PMID: 35131642]
  • Jing Lv, Shibing Zhu, Huiping Chen, Ying Xu, Qingyu Su, Guofen Yu, Wei Ma. Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR-126-5p/ZEB2 axis. Drug development research. 2022 04; 83(2):432-446. doi: 10.1002/ddr.21873. [PMID: 34636432]
  • Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila. Fish & shellfish immunology. 2022 Apr; 123(?):479-488. doi: 10.1016/j.fsi.2022.03.005. [PMID: 35314333]
  • Min Pan, Qirui Wang, Yulong Liu, Nan Xiao, Xiaojia Niu, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao. Paeonol enhances treatment of fluconazole and amphotericin B against oropharyngeal candidiasis through HIF-1α related IL-17 signaling. Medical mycology. 2022 Mar; 60(3):. doi: 10.1093/mmy/myac011. [PMID: 35099003]
  • Yajing Chen, Yuchen Jia, Yuxin Li, Yuanqiang Zheng, Guojiang Chen, Yanchun Shi. Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation. Journal of ethnopharmacology. 2022 Mar; 285(?):114857. doi: 10.1016/j.jep.2021.114857. [PMID: 34813895]
  • Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu, Yong Wang. Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 2022 02; 29(1):117-131. doi: 10.1177/15266028211032956. [PMID: 34355606]
  • Ming Li, Ou Cai, Yuanjie Yu, Shiyun Tan. Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153903. doi: 10.1016/j.phymed.2021.153903. [PMID: 35026514]
  • Shengxi Meng, Bing Wang, Wentao Li. Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice. Journal of integrative neuroscience. 2021 Dec; 20(4):1001-1010. doi: 10.31083/j.jin2004101. [PMID: 34997723]
  • Conghui Pang, Zhijuan Wu, Xiaoyan Xu, Wenxiu Yang, Xiaoxuan Wang, Yinghua Qi. Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis. Frontiers in bioscience (Landmark edition). 2021 09; 26(9):485-495. doi: 10.52586/4961. [PMID: 34590461]
  • Min Pan, Qirui Wang, Ting Cheng, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao. Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans. Biofouling. 2021 09; 37(8):922-937. doi: 10.1080/08927014.2021.1985473. [PMID: 34615415]
  • Shanshan Guo, Qiang Zhang. Paeonol protects melanocytes against hydrogen peroxide-induced oxidative stress through activation of Nrf2 signaling pathway. Drug development research. 2021 09; 82(6):861-869. doi: 10.1002/ddr.21793. [PMID: 33491230]
  • Shalini Vellasamy, Dharmani Murugan, Razif Abas, Aspalilah Alias, Wu Yuan Seng, Choy Ker Woon. Biological Activities of Paeonol in Cardiovascular Diseases: A Review. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164976. [PMID: 34443563]
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