Tropolone (BioDeep_00000010734)
Secondary id: BioDeep_00000396908
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
2-Hydroxy-2,4,6-cycloheptatrien-1-one
化学式: C7H6O2 (122.0368)
中文名称: 环庚三烯酚酮
谱图信息:
最多检出来源 Homo sapiens(blood) 57.58%
分子结构信息
SMILES: C1=CC=C(C(=O)C=C1)O
InChI: InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)
描述信息
Tropolone, a ?tropone derivative with a?hydroxyl group?in the 2-position, is a precursor?of manyazulene derivatives such as?methyl 2-methylazulene-1-carboxylate[1]. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU2+[2].
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:79966
- KEGG: C15474
- PubChem: 10789
- HMDB: HMDB0259299
- Metlin: METLIN70933
- ChEMBL: CHEMBL121188
- Wikipedia: Tropolone
- MeSH: Tropolone
- MetaCyc: CPD-7024
- KNApSAcK: C00011964
- chemspider: 10333
- CAS: 533-75-5
- PMhub: MS000024614
- PubChem: 17396468
- PDB-CCD: 0TR
- NIKKAJI: J44.110D
- medchemexpress: HY-N7135
- KNApSAcK: 79966
分类词条
相关代谢途径
Reactome(0)
BioCyc(6)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yue Jin, Zongxin Guo, Huilin Zhu, Zixuan Zhang, Xiaowen Jiang, Yiren Yang, Pengyu Liu, Yu Yang, Miao Wang, Huiyuan Gao. Discovery of potential components characteristic by conjugated enone from the branches and leaves of Croton lauioides with anti-neuroinflammatory activity via regulating the NF-κB pathway.
Bioorganic chemistry.
2024 May; 146(?):107301. doi:
10.1016/j.bioorg.2024.107301. [PMID: 38522392] - Sylwia Jafra, Magdalena Jabłońska, Tomasz Maciąg, Marta Matuszewska, Marcin Borowicz, Michał Prusiński, Wioletta Żmudzińska, Marcel Thiel, Paulina Czaplewska, Dorota M Krzyżanowska, Robert Czajkowski. An iron fist in a velvet glove: The cooperation of a novel pyoverdine from Pseudomonas donghuensis P482 with 7-hydroxytropolone is pivotal for its antibacterial activity.
Environmental microbiology.
2024 Jan; 26(1):e16559. doi:
10.1111/1462-2920.16559. [PMID: 38151794] - Hongxing Tang, Kejun He, Kun Zhao, Chen Zheng, Weichi Wu, Weilin Jin, Lixuan Yang, Baoshu Xie. Protective effects of Hinokitiol on neuronal ferroptosis by activating the KEAP1/NRF-2/HO-1 pathway in traumatic brain injury.
Journal of neurotrauma.
2023 Nov; ?(?):. doi:
10.1089/neu.2023.0150. [PMID: 37962273] - Zhiping Che, Yibo Liu, Luyao Chen, Puhou Xing, Xiangdong Li, Xiaobo Huang, Shengming Liu, Genqiang Chen, Xiaomin Lin, Yuee Tian. Synthesis of Hinokitiol Sulfonate Derivatives and Their Anti-Oomycete and Nematicidal Activities.
Chemistry & biodiversity.
2022 Sep; 19(9):e202200580. doi:
10.1002/cbdv.202200580. [PMID: 35975883] - Yamini Chelpuri, Shivakumar Pabbathi, Gopala Reddy Alla, Ravi Kumar Yadala, Mounika Kamishetti, Anil Kumar Banothu, Ramya Boinepally, Kala Kumar Bharani, Amit Khurana. Tropolone derivative hinokitiol ameliorates cerulein-induced acute pancreatitis in mice.
International immunopharmacology.
2022 Aug; 109(?):108915. doi:
10.1016/j.intimp.2022.108915. [PMID: 35679663] - Biao Wang, Bo He, Tianyu Chen, Hao Li, Liyifan Chen, Yiliang Chen, Kailin Tian, Kun Yang, Danyu Shen, Wei Yan, Yonghao Ye. Discovery of Tropolone Stipitaldehyde as a Potential Agent for Controlling Phytophthora Blight and Its Action Mechanism Research.
Journal of agricultural and food chemistry.
2022 Jul; 70(28):8693-8703. doi:
10.1021/acs.jafc.2c03163. [PMID: 35793537] - Xuan Tao, Lu Zhang, Liubing Du, Kai Lu, Zhennan Zhao, Yanxuan Xie, Xiaobo Li, Shuxiang Huang, Pei-Hui Wang, Ji-An Pan, Wei Xia, Jun Dai, Zong-Wan Mao. Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol.
Journal of inorganic biochemistry.
2022 06; 231(?):111777. doi:
10.1016/j.jinorgbio.2022.111777. [PMID: 35255411] - Christopher DeLaney, Yan Sheng, D Chase Pectol, Erol Vantansever, Hanyuan Zhang, Nattamai Bhuvanesh, Isaiah Salas, Wenshe R Liu, Carol F Fierke, Marcetta Y Darensbourg. Zinc thiotropolone combinations as inhibitors of the SARS-CoV-2 main protease.
Dalton transactions (Cambridge, England : 2003).
2021 Sep; 50(35):12226-12233. doi:
10.1039/d1dt02499j. [PMID: 34396374] - Jae Sung Park, Keebeom Ko, Seong-Hwan Kim, Jae Kyun Lee, Jin-Soo Park, Keunwan Park, Mi Ri Kim, Kyungsu Kang, Dong-Chan Oh, Sun Yeou Kim, Silvia Yumnam, Hak Cheol Kwon, Jongheon Shin. Tropolone-Bearing Sesquiterpenes from Juniperus chinensis: Structures, Photochemistry and Bioactivity.
Journal of natural products.
2021 07; 84(7):2020-2027. doi:
10.1021/acs.jnatprod.1c00321. [PMID: 34236881] - Ge Zou, Qi Tan, Yan Chen, Wencong Yang, Zhenming Zang, Hongming Jiang, Shenyu Chen, Bo Wang, Zhigang She. Furobenzotropolones A, B and 3-Hydroxyepicoccone B with Antioxidative Activity from Mangrove Endophytic Fungus Epicoccum nigrum MLY-3.
Marine drugs.
2021 Jul; 19(7):. doi:
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Phytochemical analysis : PCA.
2021 Jul; 32(4):446-456. doi:
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Scientific reports.
2021 05; 11(1):10994. doi:
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Fitoterapia.
2020 Oct; 146(?):104733. doi:
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Experimental parasitology.
2020 Jun; 213(?):107902. doi:
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International journal of medical sciences.
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PloS one.
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Fitoterapia.
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Environmental science & technology.
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Biochemical pharmacology.
2017 08; 138(?):150-162. doi:
10.1016/j.bcp.2017.06.119. [PMID: 28642033] - Huijuan Guo, René Benndorf, Daniel Leichnitz, Jonathan L Klassen, John Vollmers, Helmar Görls, Matthias Steinacker, Christiane Weigel, Hans-Martin Dahse, Anne-Kristin Kaster, Z Wilhelm de Beer, Michael Poulsen, Christine Beemelmanns. Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2.
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BMC cell biology.
2017 02; 18(1):14. doi:
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Biological & pharmaceutical bulletin.
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Journal of bacteriology.
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10.1128/jb.01028-15. [PMID: 27002128] - Yijun Yan, Ya-Tuan Ma, Jing Yang, Geoff P Horsman, Dan Luo, Xu Ji, Sheng-Xiong Huang. Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces.
Organic letters.
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Guang pu xue yu guang pu fen xi = Guang pu.
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