Camphorquinone (BioDeep_00000009949)

Main id: BioDeep_00000012238

 

human metabolite blood metabolite natural product


代谢物信息卡片


1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione bornane-2,3-dione

化学式: C10H14O2 (166.0994)
中文名称: 1,7,7-三甲基-二环[2.2.1]庚烷-2,3-二酮, (±)-樟脑醌, 樟脑醌
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12C(C(=O)C(CC1)(C)C2(C)C)=O
InChI: InChI=1S/C10H14O2/c1-9(2)6-4-5-10(9,3)8(12)7(6)11/h6H,4-5H2,1-3H3



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANXA5, ATG12, BCL2, BECN1, CASP3, CAT, CCNB1, CDC25C, CHEK2, NOX4, PRKAA2, SIRT1
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 4 ANXA5, ATG12, BECN1, CTSL
Endosome membrane 1 BECN1
Endoplasmic reticulum membrane 4 BCL2, BECN1, HMOX1, NOX4
Mitochondrion membrane 1 BECN1
Cytoplasmic vesicle, autophagosome 1 BECN1
Nucleus 12 BCL2, BECN1, CASP3, CCNB1, CDC25C, CHEK2, CTSL, HMOX1, NOX4, OGG1, PRKAA2, SIRT1
autophagosome 2 ATG12, BECN1
cytosol 12 ANXA5, ATG12, BCL2, BECN1, CASP3, CAT, CCNB1, CDC25C, HMOX1, OGG1, PRKAA2, SIRT1
dendrite 2 BECN1, PRKAA2
mitochondrial membrane 1 BECN1
nuclear body 1 BECN1
phagocytic vesicle 1 BECN1
phosphatidylinositol 3-kinase complex, class III 1 BECN1
trans-Golgi network 1 BECN1
centrosome 1 CCNB1
nucleoplasm 10 ATG12, CASP3, CCNB1, CDC25C, CHEK2, FAM20C, HMOX1, OGG1, PRKAA2, SIRT1
Cell membrane 2 MAG, NOX4
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 1 NOX4
Golgi apparatus membrane 1 FAM20C
cell surface 1 HBEGF
glutamatergic synapse 1 CASP3
Golgi apparatus 4 CHEK2, CTSL, FAM20C, PRKAA2
Golgi membrane 1 FAM20C
neuronal cell body 2 CASP3, PRKAA2
sarcolemma 1 ANXA5
Lysosome 1 CTSL
endosome 1 BECN1
plasma membrane 4 CTSL, HBEGF, MAG, NOX4
Membrane 8 ANXA5, BCL2, CAT, CCNB1, HMOX1, MAG, NOX4, PRKAA2
apical plasma membrane 1 CTSL
axon 1 PRKAA2
extracellular exosome 4 ANXA5, CAT, CTSL, FAM20C
endoplasmic reticulum 5 BCL2, BECN1, FAM20C, HMOX1, NOX4
extracellular space 4 CTSL, FAM20C, HBEGF, HMOX1
lysosomal lumen 1 CTSL
perinuclear region of cytoplasm 3 CDC25C, HMOX1, NOX4
mitochondrion 5 BCL2, CAT, NOX4, OGG1, SIRT1
protein-containing complex 4 ATG12, BCL2, CAT, OGG1
intracellular membrane-bounded organelle 3 ATG12, CAT, CTSL
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 MAG
Secreted 2 CTSL, FAM20C
extracellular region 4 ANXA5, CAT, CTSL, HBEGF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, MAG
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 3 CAT, CCNB1, OGG1
Extracellular side 1 CTSL
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
multivesicular body 1 CTSL
nucleolus 2 NOX4, SIRT1
Single-pass type II membrane protein 1 FAM20C
Apical cell membrane 1 CTSL
Cytoplasm, perinuclear region 1 NOX4
heterochromatin 1 SIRT1
Membrane raft 1 MAG
pore complex 1 BCL2
Cell junction, focal adhesion 1 NOX4
focal adhesion 3 ANXA5, CAT, NOX4
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 SIRT1
PML body 2 CHEK2, SIRT1
mitochondrial intermembrane space 1 CDC25C
collagen-containing extracellular matrix 2 ANXA5, CTSL
nuclear speck 2 OGG1, PRKAA2
nuclear inner membrane 1 SIRT1
Zymogen granule membrane 1 ANXA5
chromatin 1 SIRT1
autophagosome membrane 1 ATG12
phagocytic vesicle membrane 1 ATG12
[Isoform 5]: Cytoplasm 1 NOX4
Secreted, extracellular space 1 CTSL
Nucleus, nucleolus 1 NOX4
spindle pole 1 CCNB1
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
phagophore assembly site 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type I 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type II 1 BECN1
Preautophagosomal structure membrane 1 ATG12
Atg12-Atg5-Atg16 complex 1 ATG12
phagophore assembly site membrane 1 ATG12
Nucleus, nucleoplasm 1 OGG1
cytoplasmic stress granule 1 PRKAA2
Nucleus speckle 1 OGG1
euchromatin 1 SIRT1
myelin sheath 2 BCL2, MAG
[Isoform 3]: Cytoplasm 1 NOX4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 FAM20C
nuclear matrix 1 OGG1
endocytic vesicle membrane 1 HBEGF
paranode region of axon 1 MAG
Schmidt-Lanterman incisure 1 MAG
Single-pass type IV membrane protein 1 HMOX1
perinuclear endoplasmic reticulum 1 NOX4
Nucleus matrix 1 OGG1
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 HBEGF
[Isoform 2]: Nucleus 1 CTSL
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
[Isoform 4]: Nucleus 1 NOX4
transferase complex 1 ATG12
endocytic vesicle lumen 1 CTSL
compact myelin 1 MAG
catalase complex 1 CAT
NADPH oxidase complex 1 NOX4
cyclin B1-CDK1 complex 1 CCNB1
myelin sheath adaxonal region 1 MAG
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 CTSL
chromaffin granule 1 CTSL
endolysosome lumen 1 CTSL
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[Isoform 6]: Cytoplasm 1 NOX4
mesaxon 1 MAG
cytoplasmic side of mitochondrial outer membrane 1 BECN1
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Renke Perduns, Joachim Volk, Melanie Plum, André Jochums, Frank Gutzki, Volkhard Kaever, Werner Geurtsen. Camphorquinone alters the expression of extracellular proteases in a 3D co-culture model of the oral mucosa. Dental materials : official publication of the Academy of Dental Materials. 2021 02; 37(2):236-248. doi: 10.1016/j.dental.2020.11.005. [PMID: 33257085]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Mingsheng Chen, Ying Zhang, Vladimir Dusevich, Yi Liu, Qingsong Yu, Yong Wang. Non-thermal atmospheric plasma brush induces HEMA grafting onto dentin collagen. Dental materials : official publication of the Academy of Dental Materials. 2014 Dec; 30(12):1369-77. doi: 10.1016/j.dental.2014.10.004. [PMID: 25458523]
  • Ying Zhang, Qingsong Yu, Yong Wang. Non-thermal atmospheric plasmas in dental restoration: improved resin adhesive penetration. Journal of dentistry. 2014 Aug; 42(8):1033-42. doi: 10.1016/j.jdent.2014.05.005. [PMID: 24859333]
  • Joachim Volk, Gabriele Leyhausen, Miriam Wessels, Werner Geurtsen. Reduced glutathione prevents camphorquinone-induced apoptosis in human oral keratinocytes. Dental materials : official publication of the Academy of Dental Materials. 2014 Feb; 30(2):215-26. doi: 10.1016/j.dental.2013.11.008. [PMID: 24355435]
  • Mingsheng Chen, Ying Zhang, Xiaomei Yao, Hao Li, Qingsong Yu, Yong Wang. Effect of a non-thermal, atmospheric-pressure, plasma brush on conversion of model self-etch adhesive formulations compared to conventional photo-polymerization. Dental materials : official publication of the Academy of Dental Materials. 2012 Dec; 28(12):1232-9. doi: 10.1016/j.dental.2012.09.005. [PMID: 23018084]
  • F H F Loureiro, S Consani, R D Guiraldo, R L X Consani, S B Berger, R V Carvalho, L Correr-Sobrinho, M A C Sinhoreti. Comparison between two methods to evaluate temperature changes produced by composite light curing units and polymerization techniques. Minerva stomatologica. 2011 Oct; 60(10):501-8. doi: NULL. [PMID: 22082855]
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  • Hiroyuki Arikawa, Hideo Takahashi, Takahito Kanie, Seiji Ban. Effect of various visible light photoinitiators on the polymerization and color of light-activated resins. Dental materials journal. 2009 Jul; 28(4):454-60. doi: 10.4012/dmj.28.454. [PMID: 19721283]
  • Rahul A Datar, Fredrick A Rueggeberg, Gretchen B Caughman, John C Wataha, Jill B Lewis, George S Schuster. Effects of sub-toxic concentrations of camphorquinone on cell lipid metabolism. Journal of biomaterials science. Polymer edition. 2005; 16(10):1293-302. doi: 10.1163/156856205774269557. [PMID: 16268254]
  • Ralf Janda, Jean-François Roulet, Martin Kaminsky, Glenn Steffin, Mark Latta. Color stability of resin matrix restorative materials as a function of the method of light activation. European journal of oral sciences. 2004 Jun; 112(3):280-5. doi: 10.1111/j.1600-0722.2004.00125.x. [PMID: 15154928]
  • Maria Cattani-Lorente, Serge Bouillaguet, Chantal Godin, Jean-Marc Meyer, Pierre Payot, Jacques Forchelet. [Characterization of three light sources. Study of their efficiency]. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia. 2003; 113(11):1165-70. doi: NULL. [PMID: 14699950]
  • Tomoko Magoshi, Takehisa Matsuda. Formation of polymerized mixed heparin/albumin surface layer and cellular adhesional responses. Biomacromolecules. 2002 Sep; 3(5):976-83. doi: 10.1021/bm0200377. [PMID: 12217043]
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  • W Chai, H Hamada, J Suhara, C A Horiuchi. Biotransformation of (+)- and (-)-camphorquinones by plant cultured cells. Phytochemistry. 2001 Jul; 57(5):669-73. doi: 10.1016/s0031-9422(01)00133-9. [PMID: 11397432]
  • H V Thulasiram, V B Bhat, M K Madyastha. Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. Drug metabolism and disposition: the biological fate of chemicals. 2001 Jun; 29(6):821-9. doi: NULL. [PMID: 11353750]
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