Aurin (BioDeep_00000009766)

 

Secondary id: BioDeep_00000858874

human metabolite blood metabolite


代谢物信息卡片


4-[bis(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one

化学式: C19H14O3 (290.0943)
中文名称: 玫红酸
谱图信息: 最多检出来源 Homo sapiens(blood) 99.43%

分子结构信息

SMILES: C1=CC(=O)C=CC1=C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O
InChI: InChI=1S/C19H14O3/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-12,20-21H

描述信息

同义名列表

5 个代谢物同义名

4-[bis(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one; Rosolic acid; Aurin; Aurin; Aurin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AIMP2, ALB, ANG, AXIN2, CASP3, CAT, GLUL, MYLK
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 3 CD4, HMOX1, HSP90B1
Nucleus 10 ACHE, AIMP2, ALB, ANG, AXIN2, CASP3, GLUL, HMOX1, HSP90B1, PLCZ1
cytosol 13 AIMP2, ALB, ANG, AXIN2, CASP3, CAT, GLUL, GOLPH3, HMOX1, HSP90B1, MYLK, PLCZ1, PRKCQ
trans-Golgi network 1 GOLPH3
centrosome 2 ALB, AXIN2
nucleoplasm 4 ATP2B1, CASP3, HMOX1, PLCZ1
Cell membrane 5 ACHE, ATP2B1, CD4, GLUL, GOLPH3
Lipid-anchor 1 GLUL
Cytoplasmic side 1 HMOX1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 2 ATP2B1, ATP4A
Synapse 3 ACHE, ATP2B1, MYLK
cell surface 2 ACHE, ITGA2B
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 3 ACHE, ALB, GOLPH3
Golgi membrane 1 GOLPH3
growth cone 1 ANG
neuromuscular junction 1 ACHE
neuronal cell body 2 ANG, CASP3
presynaptic membrane 1 ATP2B1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 AIMP2, GLUL
endosome 1 GOLPH3
plasma membrane 11 ACHE, ATP2B1, ATP4A, AXIN2, CD4, F2, GLUL, GOLPH3, ITGA2B, MYLK, PRKCQ
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ACHE, AIMP2, ATP2B1, ATP4A, CAT, GOLPH3, HMOX1, HSP90B1, ITGA2B
apical plasma membrane 1 ATP4A
basolateral plasma membrane 1 ATP2B1
extracellular exosome 8 ALB, ATP2B1, CAT, F2, GLUL, HSP90B1, ITGA2B, VWF
endoplasmic reticulum 5 ALB, GLUL, HMOX1, HSP90B1, VWF
extracellular space 7 ACHE, ALB, ANG, ATP4A, F2, HMOX1, VWF
perinuclear region of cytoplasm 4 ACHE, HMOX1, HSP90B1, PLCZ1
mitochondrion 3 CAT, GLUL, GOLPH3
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 3 ATP2B1, CAT, GOLPH3
postsynaptic density 1 CASP3
pronucleus 1 PLCZ1
Single-pass type I membrane protein 2 CD4, ITGA2B
Secreted 5 ACHE, ALB, ANG, F2, VWF
extracellular region 7 ACHE, ALB, ANG, CAT, F2, HSP90B1, VWF
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD4, ITGA2B
Secreted, extracellular space, extracellular matrix 1 VWF
actin cytoskeleton 2 ANG, MYLK
beta-catenin destruction complex 1 AXIN2
nucleolus 2 ANG, PLCZ1
midbody 1 HSP90B1
Early endosome 1 CD4
Apical cell membrane 1 ATP4A
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 CD4
focal adhesion 3 CAT, HSP90B1, ITGA2B
extracellular matrix 1 VWF
Peroxisome 1 CAT
basement membrane 2 ACHE, ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 1 GOLPH3
collagen-containing extracellular matrix 3 F2, HSP90B1, VWF
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 3 ALB, F2, ITGA2B
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
Melanosome 1 HSP90B1
Golgi cisterna membrane 1 GOLPH3
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
side of membrane 1 ACHE
sperm plasma membrane 1 HSP90B1
stress fiber 1 MYLK
platelet alpha granule 1 VWF
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 4 ALB, CD4, F2, HSP90B1
platelet alpha granule lumen 2 ALB, VWF
endocytic vesicle 1 ANG
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 HMOX1
Golgi cisterna 1 GOLPH3
clathrin-coated endocytic vesicle membrane 1 CD4
Sarcoplasmic reticulum lumen 1 HSP90B1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
platelet alpha granule membrane 1 ITGA2B
integrin complex 1 ITGA2B
glial cell projection 1 GLUL
endocytic vesicle lumen 1 HSP90B1
T cell receptor complex 1 CD4
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
sperm head 1 PLCZ1
Weibel-Palade body 1 VWF
integrin alphaIIb-beta3 complex 1 ITGA2B
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP4A
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB


文献列表

  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Roberta Foresti, Martha Hoque, Diego Monti, Colin J Green, Roberto Motterlini. Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. The Journal of pharmacology and experimental therapeutics. 2005 Feb; 312(2):686-93. doi: 10.1124/jpet.104.074153. [PMID: 15537827]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • S L de Castro, M C Pinto, A V Pinto. Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship. Microbios. 1994; 78(315):83-90. doi: ". [PMID: 8047025]
  • A Batistatou, L A Greene. Internucleosomal DNA cleavage and neuronal cell survival/death. The Journal of cell biology. 1993 Aug; 122(3):523-32. doi: 10.1083/jcb.122.3.523. [PMID: 7687603]
  • W G Presswood, D K Strong. Modification of M-FC medium by eliminating rosolic acid. Applied and environmental microbiology. 1978 Jul; 36(1):90-4. doi: 10.1128/aem.36.1.90-94.1978. [PMID: 358922]