Gnidicin (BioDeep_00000007166)

 

Secondary id: BioDeep_00001870656

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


thymeleatoxin

化学式: C36H36O10 (628.2308)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 95.41%

分子结构信息

SMILES: C=C(C)C12OC3(c4ccccc4)OC1C1C4OC4(CO)C(O)C4(O)C(=O)C(C)=CC4C1(O3)C(C)C2OC(=O)C=Cc1ccccc1
InChI: InChI=1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35+,36?/m1/s1

描述信息

同义名列表

4 个代谢物同义名

thymeleatoxin; CID 5281366; Gnidicin; Gnidicin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CDH1, EZR, GTPBP4, MARVELD1, PLA2G12A, PPP1R14A, PRKCA, PRKCB, PRKCD, PRKCE, PRKX
Peripheral membrane protein 4 EZR, PRKCA, PRKCB, PRKCD
Endoplasmic reticulum membrane 1 CD4
Mitochondrion membrane 1 PRKCA
Nucleus 10 CDH1, FOS, GTPBP4, MARVELD1, PLCZ1, PRKCA, PRKCB, PRKCD, PRKCE, PRKX
cytosol 10 CDH1, EZR, FOS, GTPBP4, PLCZ1, PPP1R14A, PRKCA, PRKCB, PRKCD, PRKCE
mitochondrial membrane 1 PRKCA
trans-Golgi network 1 CDH1
centrosome 1 PRKCB
nucleoplasm 8 CDH1, FOS, GTPBP4, PLCZ1, PRKCA, PRKCB, PRKCD, PRKX
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 7 CD4, CD8A, CDH1, MARVELD1, PRKCA, PRKCD, PRKCE
Cytoplasmic side 1 EZR
lamellipodium 1 CDH1
ruffle membrane 1 EZR
Multi-pass membrane protein 2 KCNA3, MARVELD1
Synapse 2 PRKCD, PRKCE
cell cortex 1 EZR
cell junction 1 CDH1
glutamatergic synapse 2 CDH1, KCNA3
Golgi apparatus 2 CDH1, PRKCE
Golgi membrane 1 INS
postsynapse 1 CDH1
presynaptic membrane 1 KCNA3
endosome 2 CDH1, EZR
plasma membrane 11 CD4, CD8A, CDH1, EZR, IFNLR1, KCNA3, MARVELD1, PRKCA, PRKCB, PRKCD, PRKCE
Membrane 9 CDH1, EZR, GTPBP4, IFNLR1, KCNA3, MARVELD1, PRKCA, PRKCB, PRKCD
apical plasma membrane 1 EZR
axon 1 KCNA3
basolateral plasma membrane 1 EZR
brush border 1 EZR
extracellular exosome 5 CDH1, EZR, PRKCA, PRKCB, PRKCD
endoplasmic reticulum 4 FOS, PRKCA, PRKCD, PRKCE
extracellular space 3 EZR, IL2, INS
perinuclear region of cytoplasm 8 CDH1, EZR, GTPBP4, KCNA3, PLCZ1, PRKCA, PRKCD, PRKCE
adherens junction 2 CDH1, EZR
mitochondrion 3 PRKCA, PRKCD, PRKCE
protein-containing complex 1 EZR
intracellular membrane-bounded organelle 1 PRKCE
filopodium 1 EZR
pronucleus 1 PLCZ1
Single-pass type I membrane protein 4 CD4, CD8A, CDH1, IFNLR1
Secreted 3 IL2, INS, PLA2G12A
extracellular region 7 CD8A, CDH1, DNAH9, IL2, INS, PLA2G12A, PRKCD
cytoplasmic side of plasma membrane 1 CDH1
[Isoform 2]: Secreted 1 CD8A
motile cilium 1 DNAH9
nuclear membrane 2 CDH1, GTPBP4
external side of plasma membrane 2 CD4, CD8A
actin cytoskeleton 2 CDH1, EZR
nucleolus 2 GTPBP4, PLCZ1
Early endosome 1 CD4
apical part of cell 1 EZR
cell-cell junction 1 PRKCD
vesicle 1 EZR
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 EZR
Cell projection, ruffle membrane 1 EZR
Cytoplasm, perinuclear region 3 PLCZ1, PRKCD, PRKCE
Membrane raft 2 CD4, KCNA3
Cytoplasm, cytoskeleton 3 EZR, MARVELD1, PRKCE
focal adhesion 1 EZR
microtubule 1 DNAH9
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
lateral plasma membrane 1 CDH1
axoneme 1 DNAH9
ruffle 1 EZR
receptor complex 1 CD8A
neuron projection 1 PRKCD
ciliary basal body 2 EZR, PRKCA
chromatin 1 FOS
cell projection 1 EZR
cell periphery 2 EZR, PRKCE
cytoskeleton 2 EZR, MARVELD1
brush border membrane 1 PRKCB
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 1 GTPBP4
Cytoplasm, cell cortex 1 EZR
actin filament 1 EZR
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Cell projection, microvillus membrane 1 EZR
microvillus membrane 1 EZR
[Isoform 2]: Cell membrane 1 KCNA3
fibrillar center 1 EZR
Endomembrane system 1 PRKCD
endosome lumen 1 INS
microvillus 1 EZR
Cell projection, microvillus 1 EZR
intermediate filament cytoskeleton 1 PRKCE
voltage-gated potassium channel complex 1 KCNA3
plasma membrane raft 2 CD8A, EZR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 CD4, INS
nuclear matrix 2 FOS, PRKCD
transport vesicle 1 INS
azurophil granule lumen 1 PRKCD
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 EZR
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
calyx of Held 2 KCNA3, PRKCB
clathrin-coated endocytic vesicle membrane 1 CD4
uropod 1 EZR
[Isoform 2]: Nucleus 1 CDH1
spectrin 1 PRKCB
Synapse, synaptosome 1 PRKCD
protein-DNA complex 1 FOS
apical junction complex 1 CDH1
[Isoform 1]: Cell membrane 2 CD8A, KCNA3
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
presynaptic cytosol 1 PRKCB
transcription factor AP-1 complex 1 FOS
T cell receptor complex 2 CD4, CD8A
cortical cytoskeleton 1 EZR
sperm head 1 PLCZ1
alphav-beta3 integrin-PKCalpha complex 1 PRKCA
endolysosome 1 PRKCD
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
interleukin-28 receptor complex 1 IFNLR1
outer dynein arm 1 DNAH9
distal portion of axoneme 1 DNAH9


文献列表

  • Vincent Vidal, Olivier Potterat, Séverine Louvel, François Hamy, Mahdi Mojarrab, Jean-Jacques Sanglier, Thomas Klimkait, Matthias Hamburger. Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium. Journal of natural products. 2012 Mar; 75(3):414-9. doi: 10.1021/np200855d. [PMID: 22148316]
  • Guang-Xiong Zhou, Yong-Chun Yang, Jian-Gong Shi. [Study of chemical constituents in stem rind of Daphne giraldii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Apr; 31(7):555-7. doi: . [PMID: 16780156]
  • S M Kupchan, J G Sweeney, R L Baxter, T Murae, V A Zimmerly, B R Sickles. Letter: Gnididin, gniditrin, and gnidicin, novel potent antileukemic diterpenoid esters from Gnidia lamprantha. Journal of the American Chemical Society. 1975 Feb; 97(3):672-3. doi: 10.1021/ja00836a051. [PMID: 1133369]