(-)-Wikstromol (BioDeep_00000003742)

 

Secondary id: BioDeep_00000396539, BioDeep_00000859732

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds


代谢物信息卡片


dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone

化学式: C20H22O7 (374.1365462)
中文名称: 去甲络石甙元, NORTRACHELOGENIN, 去甲螯合素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 58.33%

分子结构信息

SMILES: COC1=C(C=CC(=C1)CC2COC(=O)C2(CC3=CC(=C(C=C3)O)OC)O)O
InChI: InChI=1S/C20H22O7/c1-25-17-8-12(3-5-15(17)21)7-14-11-27-19(23)20(14,24)10-13-4-6-16(22)18(9-13)26-2/h3-6,8-9,14,21-22,24H,7,10-11H2,1-2H3

描述信息

(-)-Wikstromol is found in fruits. (-)-Wikstromol is obtained from Pinus palustris (pitch pine) and Carissa edulis (agam
obtained from Pinus palustris (pitch pine) and Carissa edulis (agam). (-)-Wikstromol is found in fruits and sesame.

同义名列表

13 个代谢物同义名

dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone; 3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; 8-(R)-4,4,8-trihydroxy-3,3-dimethoxylignanolide; nortrachelogenin, (3R-cis)-isomer; Dibenzylbutyrolactone; (-)-Nortrachelogenin; (+)-Nortrachelogenin; Nortrachelogenin; (-)-Wikstromol; wikstromol; arbo 6; Nortrachelogenin; Nortrachelogenin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli Wei. Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway. Journal of natural medicines. 2021 Jan; 75(1):178-185. doi: 10.1007/s11418-020-01447-0. [PMID: 32865667]
  • Antti Pemmari, Tiina Leppänen, Erja-Leena Paukkeri, Morena Scotece, Mari Hämäläinen, Eeva Moilanen. Attenuating Effects of Nortrachelogenin on IL-4 and IL-13 Induced Alternative Macrophage Activation and on Bleomycin-Induced Dermal Fibrosis. Journal of agricultural and food chemistry. 2018 Dec; 66(51):13405-13413. doi: 10.1021/acs.jafc.8b03023. [PMID: 30458613]
  • Heejeong Lee, Young Rae Ji, Zae Young Ryoo, Myung-Sook Choi, Eun-Rhan Woo, Dong Gun Lee. Antibacterial Mechanism of (-)-Nortrachelogenin in Escherichia coli O157. Current microbiology. 2016 Jan; 72(1):48-54. doi: 10.1007/s00284-015-0918-3. [PMID: 26420306]
  • Oue-artorn Rajachan, Somdej Kanokmedhakul, Phitak Nasomjai, Kwanjai Kanokmedhakul. Chemical constituents and biological activities from roots of Enkleia siamensis. Natural product research. 2014; 28(4):268-70. doi: 10.1080/14786419.2013.838241. [PMID: 24047498]
  • Emrah Yatkin, Lauri Polari, Teemu D Laajala, Annika Smeds, Christer Eckerman, Bjarne Holmbom, Niina M Saarinen, Tero Aittokallio, Sari I Mäkelä. Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model. PloS one. 2014; 9(4):e93764. doi: 10.1371/journal.pone.0093764. [PMID: 24699425]
  • Anni M Harju, Martti Venäläinen, Tapio Laakso, Pekka Saranpää. Wounding response in xylem of Scots pine seedlings shows wide genetic variation and connection with the constitutive defence of heartwood. Tree physiology. 2009 Jan; 29(1):19-25. doi: 10.1093/treephys/tpn006. [PMID: 19203929]
  • Shugeng Cao, Mohamed M Radwan, Andrew Norris, James S Miller, Fidy Ratovoson, Andrianjafy Mamisoa, Rabodo Andriantsiferana, Vincent E Rasamison, Stephan Rakotonandrasana, David G I Kingston. Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. Journal of natural products. 2006 Feb; 69(2):284-6. doi: 10.1021/np050351x. [PMID: 16499333]
  • N M Saarinen, P E Penttinen, A I Smeds, T T Hurmerinta, S I Mäkelä. Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo. The Journal of steroid biochemistry and molecular biology. 2005 Feb; 93(2-5):209-19. doi: 10.1016/j.jsbmb.2004.12.004. [PMID: 15860264]
  • Wei-sheng Feng, Xiao-ke Zheng, Yan-zhi Wang, Yue-feng Bi. [Isolation and structure identification of lignans from pine needles of pinus massoniana Lamb]. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Dec; 38(12):927-30. doi: ". [PMID: 15040087]
  • E Yeşilada, H Taninaka, Y Takaishi, G Honda, E Sezik, H Momota, Y Ohmoto, T Taki. In vitro inhibitory effects of Daphne oleoides ssp. oleoides on inflammatory cytokines and activity-guided isolation of active constituents. Cytokine. 2001 Mar; 13(6):359-64. doi: 10.1006/cyto.2001.0838. [PMID: 11292319]
  • J X Guo, S S Handa, J M Pezzuto, A D Kinghorn, N R Farnsworth. Plant anticancer agents XXXIII. Constituents of Passerina vulgaris. Planta medica. 1984 Jun; 50(3):264-5. doi: ". [PMID: 6484032]