Beta-Aminopropionitrile (BioDeep_00000003430)
Secondary id: BioDeep_00000269473
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
β-Aminopropionitrile
化学式: C3H6N2 (70.0531)
中文名称: 3-氨基丙腈
谱图信息:
最多检出来源 Homo sapiens(blood) 48.1%
分子结构信息
SMILES: C(CN)C#N
InChI: InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
描述信息
beta-Aminopropionitrile is a toxic amino-acid derivative. On an unusual case of the Cantrell-sequence in a premature infant with associated dysmelia, aplasia of the right kidney, cerebellar hypoplasia and circumscribed aplasia of the cutis, maternal history suggested an occupational exposure to aminopropionitriles prior to pregnancy. The characteristic features of the Cantrell-sequence--anterior thoraco-abdominal wall defect with ectopia cordis and diaphragm, sternum, pericardium, and heart defects--have been observed in animals following maternal administration of beta-aminopropionitrile. Some species of lathyrus (chickling pea, Lathyrus sativus- related), notably Lathyrus odoratus, are unable to induce human lathyrism but contain beta-aminopropionitrile, that induces pathological changes in bone ("osteolathyrism") and blood vessels ("angiolathyrism") of experimental animals without damaging the nervous system. The administration of beta-aminopropionitrile has been proposed for pharmacological control of unwanted scar tissue in human beings. beta-Aminopropionitrile is a reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid. (PMID:367235, 6422318, 9394169, Am J Perinatol. 1997 Oct;14(9):567-71.).
Constituent of chickling pea (Lathyrus sativus)
C471 - Enzyme Inhibitor
KEIO_ID A044
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].
同义名列表
27 个代谢物同义名
β-Aminopropionitrile; beta-Aminoethyl cyanide; beta Aminopropionitrile; Beta-Aminopropionitrile; 3-Aminopropiononitrile; 3-Aminopropanenitrile; b-Aminoethyl cyanide; 3-Aminopropionitrile; Β-aminoethyl cyanide; β aminopropionitrile; Β-aminopropionitrile; b-Aminopropionitrile; beta-Cyanoethylamine; beta-Alaminenitrile; beta-Alaninenitrile; Aminopropionitrile; b-Cyanoethylamine; Β-cyanoethylamine; 2-Cyanoethylamine; b-Alaninenitrile; Β-alaninenitrile; b-Alaminenitrile; H2NCH2CH2CN; BAPN; Z2CN; 3-Aminopropiononitrile; 3-Aminopropanenitrile
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:27413
- KEGG: C05670
- KEGGdrug: D77355
- PubChem: 1647
- HMDB: HMDB0004101
- Metlin: METLIN7017
- DrugBank: DB11483
- ChEMBL: CHEMBL1618272
- Wikipedia: Aminopropionitrile
- MeSH: Aminopropionitrile
- MetaCyc: BETA-AMINOPROPIONITRILE
- foodb: FDB012565
- chemspider: 21241485
- CAS: 68130-65-4
- CAS: 68130-66-5
- CAS: 151-18-8
- MoNA: KO002127
- MoNA: KO002124
- MoNA: KO002126
- MoNA: KO002125
- MoNA: KO002123
- PMhub: MS000009669
- PubChem: 7978
- 3DMET: B00834
- NIKKAJI: J10.983E
- medchemexpress: HY-Y1750
- KNApSAcK: 27413
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kang-Ni Chen, Qi-Lin Peng, Dan-Feng Cao, Zhao-Jun Wang, Kai Zhang, Xin-Yu Zhou, Dong-Yu Min, Bo-Ting Zhou, Xiao-Yuan Mao. Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder.
Brain research bulletin.
2024 May; 210(?):110928. doi:
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Journal of cellular physiology.
2022 05; 237(5):2516-2527. doi:
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1978 Jun; 28(3):267-78. doi:
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1978 May; 23(5):520-4. doi:
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1977 Dec; 41(12):1337-40. doi:
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1976 Oct; 3(4):151-8. doi:
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1976 Jul; 152(3):469-74. doi:
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1976; 4(3):193-203. doi:
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1976 Jan; 6(1):59-67. doi:
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1975 Oct; 31(10):1121-2. doi:
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1975 Oct; 56(5):466-70. doi:
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1975 Oct; 99(10):536-9. doi:
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1975 May; 16(9):1345-61. doi:
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1975 Feb; 32(2):133-9. doi:
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1975 Jan; 38(1):56-86. doi:
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1974 Dec; 9(?):283-94. doi:
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