6-Phosphogluconic acid (BioDeep_00000003413)

 

Secondary id: BioDeep_00000265283

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid

化学式: C6H13O10P (276.0246)
中文名称: 6-磷酸葡萄糖酸, D-6-磷酸葡萄糖酸, 6-Phosphogluconic acid 三钠盐
谱图信息: 最多检出来源 Homo sapiens(blood) 11.42%

Reviewed

Last reviewed on 2024-07-02.

Cite this Page

6-Phosphogluconic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/6-phosphogluconic_acid (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000003413). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(C(C(=O)O)O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/t2-,3-,4+,5-/m1/s1

描述信息

6-phosphogluconic acid, also known as 6-phospho-D-gluconate or D-gluconic acid 6-(dihydrogen phosphate), is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 6-phosphogluconic acid is soluble (in water) and a moderately acidic compound (based on its pKa). 6-phosphogluconic acid can be found in a number of food items such as purple mangosteen, nopal, chicory leaves, and common sage, which makes 6-phosphogluconic acid a potential biomarker for the consumption of these food products. 6-phosphogluconic acid can be found primarily in blood, cellular cytoplasm, and saliva, as well as throughout most human tissues. 6-phosphogluconic acid exists in all living species, ranging from bacteria to humans. In humans, 6-phosphogluconic acid is involved in the pentose phosphate pathway. 6-phosphogluconic acid is also involved in few metabolic disorders, which include glucose-6-phosphate dehydrogenase deficiency, ribose-5-phosphate isomerase deficiency, transaldolase deficiency, and warburg effect. 6-phosphogluconic acid is formed by 6-phosphogluconolactonase, and acted upon by phosphogluconate dehydrogenase to produce ribulose 5-phosphate. It may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate .
6-Phosphogluconic acid, also known as 6-phospho-D-gluconate or gluconic acid-6-phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 6-Phosphogluconic acid exists in all living species, ranging from bacteria to humans. Within humans, 6-phosphogluconic acid participates in a number of enzymatic reactions. In particular, 6-phosphogluconic acid can be biosynthesized from gluconolactone; which is mediated by the enzyme 6-phosphogluconolactonase. In addition, 6-phosphogluconic acid can be converted into D-ribulose 5-phosphate through the action of the enzyme 6-phosphogluconate dehydrogenase, decarboxylating. In humans, 6-phosphogluconic acid is involved in the metabolic disorder called the transaldolase deficiency pathway. Outside of the human body, 6-Phosphogluconic acid has been detected, but not quantified in several different foods, such as cascade huckleberries, common chokecherries, half-highbush blueberries, american cranberries, and okra.
[Spectral] 6-Phospho-D-gluconate (exact mass = 276.02463) and Phosphoenolpyruvate (exact mass = 167.98237) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
KEIO_ID P031

同义名列表

16 个代谢物同义名

(2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid; 2,3,4,5-tetrahydroxy-6-phosphonooxyhexanoic acid; 6-Phosphogluconic acid Barium salt hydrate; D-Gluconic acid 6-(dihydrogen phosphate); 6-O-Phosphono-D-gluconic acid; D-Gluconic acid 6-phosphate; Gluconic acid-6-phosphate; 6-Phospho-D-gluconic acid; D-Gluconate 6-phosphate; 6-Phosphogluconic acid; 6-Phospho-D-gluconate; 6-phospho D-gluconate; Gluconate 6-phosphate; 6-Phosphogluconate; 6-p-Gluconate; 6-Phosphogluconic acid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

40 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(11)

WikiPathways(6)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(22)

PharmGKB(0)

51 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALB, CAT, FH, G6PD, GAPDH, GCK, GK, KHK, PGD, PKM, RGN, TXN
Peripheral membrane protein 3 G6PD, GCK, HSD17B6
Endoplasmic reticulum membrane 2 HSP90B1, TKT
Nucleus 10 ALB, FH, GAPDH, GCK, GK, HSP90B1, PGD, PKM, RGN, TXN
cytosol 15 ALB, CAT, FH, G6PD, GAPDH, GCK, GK, GSR, HSP90B1, KHK, PGD, PKM, TKT, TXN, XYLB
nuclear body 1 TKT
centrosome 1 ALB
nucleoplasm 4 CD2, GCK, TKT, TXN
Cell membrane 2 CD2, TKT
Early endosome membrane 1 HSD17B6
Golgi apparatus membrane 1 GCK
cell surface 1 CD2
Golgi apparatus 2 ALB, CD2
Golgi membrane 2 GCK, INS
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 3 G6PD, GAPDH, GK
plasma membrane 3 CD2, GAPDH, TKT
Membrane 4 CAT, G6PD, GAPDH, HSP90B1
apical plasma membrane 1 TKT
basolateral plasma membrane 1 GCK
extracellular exosome 13 ALB, CAT, FH, G6PD, GAPDH, GK, GSR, HSP90B1, KHK, PGD, PKM, TKT, TXN
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 ALB, H6PD, HSD17B6, HSP90B1
extracellular space 2 ALB, INS
perinuclear region of cytoplasm 2 GAPDH, HSP90B1
mitochondrion 6 CAT, FH, GCK, GK, GSR, PKM
protein-containing complex 4 ALB, CAT, CD2, HSP90B1
intracellular membrane-bounded organelle 4 CAT, G6PD, GAPDH, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 2 CD2, TKT
Secreted 3 ALB, INS, TXN
extracellular region 7 ALB, CAT, CD2, HSP90B1, INS, PKM, TXN
cytoplasmic side of plasma membrane 2 CD2, G6PD
Mitochondrion outer membrane 1 GK
Single-pass membrane protein 1 GK
mitochondrial outer membrane 1 GK
mitochondrial matrix 3 CAT, FH, GSR
anchoring junction 1 ALB
centriolar satellite 1 G6PD
nuclear membrane 1 GAPDH
external side of plasma membrane 2 CD2, GSR
Extracellular vesicle 1 PKM
actin cytoskeleton 1 TKT
microtubule cytoskeleton 1 GAPDH
midbody 1 HSP90B1
cell-cell junction 1 CD2
vesicle 3 GAPDH, PKM, TKT
Cytoplasm, perinuclear region 1 GAPDH
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 3 CAT, HSP90B1, TKT
Peroxisome 2 CAT, TKT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 HSP90B1, PKM
receptor complex 1 TKT
ciliary basal body 1 ALB
cilium 1 PKM
Chromosome 1 FH
cytoskeleton 1 GAPDH
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 GCK
site of double-strand break 1 FH
endosome lumen 1 INS
Lipid droplet 1 GAPDH
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
[Isoform 4]: Cytoplasm, cytosol 1 GK
ficolin-1-rich granule lumen 2 CAT, PKM
secretory granule lumen 3 CAT, INS, PKM
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, H6PD, HSP90B1, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Sarcoplasmic reticulum lumen 1 HSP90B1
ribonucleoprotein complex 1 GAPDH
Rough endoplasmic reticulum 1 PKM
GAIT complex 1 GAPDH
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[Isoform 3]: Mitochondrion outer membrane 1 GK
ciliary transition fiber 1 ALB


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