Betaine aldehyde (BioDeep_00000003339)

 

Secondary id: BioDeep_00001868712

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


N,N,N-Trimethyl-2-oxo-ethanaminium

化学式: [C5H12NO]+ (102.0919)
中文名称: 甜菜碱醛
谱图信息: 最多检出来源 Homo sapiens(plant) 11.87%

分子结构信息

SMILES: C[N+](C)(C)CC=O
InChI: InChI=1/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1

描述信息

Betaine aldehyde, also known as BTL, belongs to the class of organic compounds known as tetraalkylammonium salts. These are organonitrogen compounds containing a quaternary ammonium substituted with four alkyl chains. Betaine aldehyde is an extremely weak basic (essentially neutral) compound (based on its pKa). In humans, betaine aldehyde is involved in betaine metabolism. Outside of the human body, betaine aldehyde has been detected, but not quantified in, several different foods, such as sourdoughs, summer savouries, loganberries, burbots, and celery stalks. This could make betaine aldehyde a potential biomarker for the consumption of these foods. Betaine aldehyde is an intermediate in the metabolism of glycine, serine, and threonine. The human aldehyde dehydrogenase (EC 1.2.1.3) facilitates the conversion of betaine aldehyde into glycine betaine. Betaine aldehyde is a substrate for choline dehydrogenase (PMID: 12467448, 7646513).
Betaine aldehyde is an intermediate in the metabolism of glycine, serine and threonine. The human aldehyde dehydrogenase (EC 1.2.1.3) facilitates the conversion of betaine aldehyde to glycine betaine. Betaine aldehyde is a substrate for Choline dehydrogenase (mitochondrial). (PMID: 12467448, 7646513) [HMDB]. Betaine aldehyde is found in many foods, some of which are celery leaves, pummelo, star anise, and grape.
COVID info from COVID-19 Disease Map
KEIO_ID B044
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

14 个代谢物同义名

N,N,N-Trimethyl-2-oxo-ethanaminium; N,N,N-Trimethyl-2-oxo ethanaminium; N,N,N-Trimethyl-2-oxoethanaminium; (Formylmethyl)trimethyl-ammonium; Trimethyl(formylmethyl)ammonium; (Formylmethyl)trimethylammonium; trimethyl-(2-oxoethyl)ammonium; trimethyl(2-oxoethyl)azanium; Betaine Aldehyde Chloride; Glycine betaine aldehyde; betaine aldehyde; BTL; Betaine aldehyde; Betaine aldehyde cation



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(6)

PlantCyc(1)

代谢反应

529 个相关的代谢反应过程信息。

Reactome(46)

BioCyc(38)

WikiPathways(2)

Plant Reactome(296)

INOH(0)

PlantCyc(125)

COVID-19 Disease Map(1)

PathBank(21)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ADH5, ALDH3A2, ALDH9A1, AOC3, CAT, CHKA, CUTC, G6PD, KHK, PKM, RHOA
Peripheral membrane protein 6 AOC1, CYP27A1, FDXR, G6PD, HSD17B6, MBP
Endoplasmic reticulum membrane 2 ALDH3A2, RHOA
Mitochondrion membrane 1 CYP27A1
Nucleus 6 ALDH7A1, CUTC, MBP, PKM, PLCZ1, RHOA
cytosol 13 ADH5, ALDH3A2, ALDH7A1, ALDH9A1, CAT, CHKA, CUTC, G6PD, KHK, MBP, PKM, PLCZ1, RHOA
nucleoplasm 3 ATP2B1, CUTC, PLCZ1
Cell membrane 4 AOC1, AOC3, ATP2B1, RHOA
Lipid-anchor 1 RHOA
Cytoplasmic side 3 ALDH3A2, MBP, RHOA
Cleavage furrow 1 RHOA
lamellipodium 1 RHOA
ruffle membrane 1 RHOA
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 ATP2B1
Synapse 2 ATP2B1, MBP
cell cortex 1 RHOA
cell junction 1 RHOA
cell surface 2 AOC3, MBP
glutamatergic synapse 2 ATP2B1, RHOA
Golgi apparatus 1 AOC3
lysosomal membrane 1 GAA
mitochondrial inner membrane 2 CYP27A1, FDXR
neuronal cell body 1 MBP
postsynapse 1 RHOA
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 3 ALDH9A1, CHKA, G6PD
Lysosome 1 GAA
endosome 1 RHOA
plasma membrane 6 AOC1, AOC3, ATP2B1, GAA, MBP, RHOA
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ALDH3A2, AOC3, ATP2B1, CAT, G6PD, GAA
basolateral plasma membrane 1 ATP2B1
extracellular exosome 12 ADH5, ALDH7A1, ALDH9A1, AOC1, ATP2B1, CAT, G6PD, GAA, KHK, MBP, PKM, RHOA
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 AOC3, HSD17B6
extracellular space 1 AOC1
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 PLCZ1
bicellular tight junction 1 AOC1
mitochondrion 7 ADH5, ALDH7A1, ALDH9A1, CAT, CYP27A1, FDXR, PKM
protein-containing complex 2 CAT, MBP
intracellular membrane-bounded organelle 6 ALDH3A2, ATP2B1, CAT, G6PD, GAA, HSD17B6
Microsome membrane 2 ALDH3A2, HSD17B6
pronucleus 1 PLCZ1
Secreted 1 GAA
extracellular region 5 AOC1, CAT, GAA, MBP, PKM
cytoplasmic side of plasma membrane 2 G6PD, RHOA
Single-pass membrane protein 1 ALDH3A2
mitochondrial matrix 4 ALDH7A1, CAT, CYP27A1, FDXR
Extracellular side 1 AOC1
centriolar satellite 1 G6PD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Extracellular vesicle 1 PKM
dendritic spine 1 RHOA
nucleolus 2 CUTC, PLCZ1
midbody 1 RHOA
Early endosome 1 AOC3
Single-pass type II membrane protein 1 AOC3
vesicle 2 PKM, RHOA
Cell projection, lamellipodium 1 RHOA
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 2 CYP27A1, FDXR
focal adhesion 2 CAT, RHOA
Peroxisome 3 ALDH3A2, AOC1, CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 ALDH3A2, CAT
collagen-containing extracellular matrix 2 MBP, PKM
lateral plasma membrane 1 ATP2B1
cilium 1 PKM
cell projection 1 ATP2B1
cell periphery 2 MBP, RHOA
cytoskeleton 1 RHOA
[Isoform 3]: Nucleus 1 MBP
Secreted, extracellular space 1 AOC1
[Isoform 1]: Mitochondrion 1 ALDH7A1
Cytoplasm, cell cortex 1 RHOA
Basolateral cell membrane 1 ATP2B1
microvillus 1 AOC3
Lipid droplet 1 CHKA
Cell projection, dendrite 1 RHOA
tertiary granule membrane 1 GAA
[Isoform 2]: Cytoplasm, cytosol 1 ALDH7A1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 MBP
ficolin-1-rich granule lumen 3 CAT, MBP, PKM
secretory granule lumen 2 CAT, PKM
secretory granule membrane 1 RHOA
specific granule lumen 1 AOC1
transport vesicle 1 MBP
azurophil granule membrane 1 GAA
immunological synapse 1 ATP2B1
ficolin-1-rich granule membrane 2 GAA, RHOA
apical junction complex 1 RHOA
Rough endoplasmic reticulum 1 PKM
compact myelin 1 MBP
internode region of axon 1 MBP
catalase complex 1 CAT
sperm head 1 PLCZ1
autolysosome lumen 1 GAA
photoreceptor ribbon synapse 1 ATP2B1
[Bone marrow proteoglycan]: Secreted 1 MBP
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[Isoform 1]: Lipid droplet 1 CHKA
Myelin membrane 1 MBP


文献列表

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