Classification Term: 170106

氮杂环 (ontology term: bfc9ec719a4995723879495bd723ae2b)

found 25 associated metabolites at no_class-level_20 metabolite taxonomy ontology rank level.

Ancestor: 有机杂环化合物

Child Taxonomies: 细菌叶绿素类, 吡嗪类, 卟啉衍生物, 吡啶杂环化合物

Sphingosine

D-(+)-Erythro-1,3-dihydroxy-2-amino-4-trans-octadecene

C18H37NO2 (299.2824142)


Sphingosine, also known as (4E)-sphingenine or sphing-4-enine, belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids. Sphingolipids are a class of cell membrane lipids that include sphingomyelin. Thus, sphingosine is considered to be a sphingoid base lipid. Sphingosine is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Sphingosine is found in all living organisms ranging from bacteria to plants to humans. Sphingosine is synthesized from palmitoyl CoA and serine in a condensation required to yield dehydrosphingosine. Dehydrosphingosine is then reduced by NADPH to dihydrosphingosine (sphinganine), and finally oxidized by FAD to sphingosine. Within humans and other mammals, sphingosine participates in a number of enzymatic reactions. In particular, sphingosine can be converted into sphingosine 1-phosphate through its interaction with the enzyme sphingosine kinase 2. sphingosine 1-phosphate is an important signaling molecule. In addition, sphingosine can be biosynthesized from sphingosine 1-phosphate; which is mediated by the enzyme sphingosine-1-phosphate phosphatase 2. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. In humans, sphingosine is involved in globoid cell leukodystrophy. Cerebrosides is the common name for a group of glycosphingolipids called monoglycosylceramides which are important components in animal muscle and nerve cell membranes. They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety. The sugar residue can be either glucose or galactose; the two major types are therefore called glucocerebrosides and galactocerebrosides. Galactocerebrosides are typically found in neural tissue, while glucocerebrosides are found in other tissues. Sphingosine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=123-78-4 (retrieved 2024-07-16) (CAS RN: 123-78-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

   

methapyrilene

N-[2-(dimethylamino)ethyl]-N-[(thiophen-2-yl)methyl]pyridin-2-amine

C14H19N3S (261.1299614)


R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist D018926 - Anti-Allergic Agents

   

Betaine aldehyde

N,N,N-Trimethyl-2-oxo-ethanaminium

[C5H12NO]+ (102.0918842)


Betaine aldehyde, also known as BTL, belongs to the class of organic compounds known as tetraalkylammonium salts. These are organonitrogen compounds containing a quaternary ammonium substituted with four alkyl chains. Betaine aldehyde is an extremely weak basic (essentially neutral) compound (based on its pKa). In humans, betaine aldehyde is involved in betaine metabolism. Outside of the human body, betaine aldehyde has been detected, but not quantified in, several different foods, such as sourdoughs, summer savouries, loganberries, burbots, and celery stalks. This could make betaine aldehyde a potential biomarker for the consumption of these foods. Betaine aldehyde is an intermediate in the metabolism of glycine, serine, and threonine. The human aldehyde dehydrogenase (EC 1.2.1.3) facilitates the conversion of betaine aldehyde into glycine betaine. Betaine aldehyde is a substrate for choline dehydrogenase (PMID: 12467448, 7646513). Betaine aldehyde is an intermediate in the metabolism of glycine, serine and threonine. The human aldehyde dehydrogenase (EC 1.2.1.3) facilitates the conversion of betaine aldehyde to glycine betaine. Betaine aldehyde is a substrate for Choline dehydrogenase (mitochondrial). (PMID: 12467448, 7646513) [HMDB]. Betaine aldehyde is found in many foods, some of which are celery leaves, pummelo, star anise, and grape. COVID info from COVID-19 Disease Map KEIO_ID B044 Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

Hexadecylamine

1-Hexadecaneamine hydrofluoride

C16H35N (241.276935)


   

2-Mercaptoethylguanidine

2-Mercaptoethylguanidine, sulfate(2:1) salt

C3H9N3S (119.0517154)


D004791 - Enzyme Inhibitors

   

Dibutylamine

Dibutylamine phosphate (3:1)

C8H19N (129.1517414)


   

Chinazolin

1,3-Diazanaphthalene

C8H6N2 (130.0530956)


   

N-Butylbenzenamine

N-(n-Butyl)aniline

C10H15N (149.120443)


   

Dodecanamine

DODECYLAMINE

C12H27N (185.2143382)


D013501 - Surface-Active Agents CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4948; ORIGINAL_PRECURSOR_SCAN_NO 4947 CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4956; ORIGINAL_PRECURSOR_SCAN_NO 4955 CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4959; ORIGINAL_PRECURSOR_SCAN_NO 4954 CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4962; ORIGINAL_PRECURSOR_SCAN_NO 4960 CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4969; ORIGINAL_PRECURSOR_SCAN_NO 4967 CONFIDENCE standard compound; INTERNAL_ID 1195; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4970; ORIGINAL_PRECURSOR_SCAN_NO 4969

   

N-Butylaniline

N-(n-Butyl)aniline

C10H15N (149.120443)


   
   

N'-(4-carbamoyldithiolan-4-yl)-N-[2-(5,6-dibromo-1H-indol-3-yl)ethenyl]oxamide

N'-(4-carbamoyldithiolan-4-yl)-N-[2-(5,6-dibromo-1H-indol-3-yl)ethenyl]oxamide

C16H14Br2N4O3S2 (531.8874014)


   

Hexadecylamine

1-Hexadecylamine

C16H35N (241.276935)


   

4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]-pyridine

C20H13FN4O2 (360.102249)


D004791 - Enzyme Inhibitors

   

Tetrabutylammonium

Tetrabutylammonium ion

C16H36N+ (242.2847596)


D013501 - Surface-Active Agents > D003902 - Detergents

   

Sphingosine

2R-aminooctadec-4Z-ene-1,3S-diol

C18H37NO2 (299.2824142)


A sphing-4-enine in which the double bond is trans. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

   

C18_Sphingosine

D-erythro-Sphingosine

C18H37NO2 (299.2824142)


D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

   

Allylhydrazine

Allylhydrazine

C3H8N2 (72.0687448)


   

Oleonitrile

Oleonitrile

C18H33N (263.2612858)


A fatty nitrile obtained by formal condensation of oleic acid with ammonia.

   

(2S,3R)-2-aminoheptadecane-1,3-diol

(2S,3R)-2-aminoheptadecane-1,3-diol

C17H37NO2 (287.2824142)


   

3-(N-Nitroso-N-methylamino)propionic acid

3-(N-Nitroso-N-methylamino)propionic acid

C4H8N2O3 (132.05348980000002)


   

AI3-15329

InChI=1\C8H19N\c1-3-5-7-9-8-6-4-2\h9H,3-8H2,1-2H

C8H19N (129.1517414)


   

betaine aldehyde

trimethyl-(2-oxoethyl)ammonium

C5H12NO+ (102.0918842)


A quaternary ammonium ion that is nitrogen substituted by three methyl groups and a 2-oxoethyl group. It is an intermediate in the metabolism of amino acids like glycine, serine and threonine. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

methapyrilene

methapyrilene

C14H19N3S (261.1299614)


R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist D018926 - Anti-Allergic Agents

   

Pentanal, oxime

Pentanal, oxime

(0)