20-hydroxy LTB4 (BioDeep_00000003313)
Main id: BioDeep_00000397621
代谢物信息卡片
5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
化学式: C20H32O5 (352.225)
中文名称: 20-羟基白三烯B4
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O)CCO
InChI: InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:15646
- KEGG: C04853
- PubChem: 5280745
- Metlin: METLIN36249
- ChEMBL: CHEMBL1593789
- CAS: 79516-82-8
- PubChem: 7409
- LipidMAPS: LMFA03020018
- 3DMET: B01798
- NIKKAJI: J381.079H
- RefMet: 20-Hydroxy LTB4
分类词条
相关代谢途径
Reactome(8)
BioCyc(0)
PlantCyc(0)
代谢反应
151 个相关的代谢反应过程信息。
Reactome(101)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Fatty acid metabolism:
Ac-CoA + H2O ⟶ CH3COO- + CoA-SH - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene C4 ⟶ L-Glu + leukotriene D4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + Trioxilin A3 ⟶ 20OH-TrXA3 + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Fatty acid metabolism:
Ac-CoA + H2O ⟶ CH3COO- + CoA-SH - Arachidonic acid metabolism:
H2O + leukotriene A4 ⟶ leukotriene B4 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
GSH + leukotriene A4 ⟶ leukotriene C4 - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Eicosanoids:
H+ + Oxygen + TPNH + leukotriene B4 ⟶ 20OH-LTB4 + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of Leukotrienes (LT) and Eoxins (EX):
H2O + leukotriene A4 ⟶ leukotriene B4 - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Eicosanoids:
prostaglandin H2 ⟶ Prostacyclin
BioCyc(0)
WikiPathways(3)
- Arachidonic acid (AA, ARA) oxylipin metabolism:
HXB3 ⟶ Trioxilin B3 - Eicosanoid metabolism via lipoxygenases (LOX):
Arachidonic acid ⟶ 12-HETE - Leukotriene metabolic pathway:
16-COOH-tetranor-LTE3 ⟶ 14-COOH-hexanor-LTE4
Plant Reactome(0)
INOH(1)
- Prostaglandin and Leukotriene metabolism ( Prostaglandin and Leukotriene metabolism ):
Glutathione + Leucotriene A4 ⟶ Leucotriene C4
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(46)
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Piroxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Acetylsalicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Etodolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ketoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ibuprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Rofecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Diclofenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Sulindac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Celecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ketorolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Suprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Bromfenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Indomethacin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Mefenamic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Oxaprozin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Nabumetone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Naproxen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Diflunisal Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Meloxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Valdecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Antipyrine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Antrafenine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Carprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Etoricoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Fenoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Flurbiprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Magnesium Salicylate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Lumiracoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Lornoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Phenylbutazone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Nepafenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Trisalicylate-Choline Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tolmetin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tiaprofenic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tenoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salsalate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salicylate-Sodium Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Acetaminophen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshiaki Okuno, Yoshiko Iizuka, Hiroshi Okazaki, Takehiko Yokomizo, Ryo Taguchi, Takao Shimizu. 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
The Journal of experimental medicine.
2008 Apr; 205(4):759-66. doi:
10.1084/jem.20072329. [PMID: 18378794] - M A Willemsen, L IJlst, P M Steijlen, J J Rotteveel, J G de Jong, P H van Domburg, E Mayatepek, F J Gabreëls, R J Wanders. Clinical, biochemical and molecular genetic characteristics of 19 patients with the Sjögren-Larsson syndrome.
Brain : a journal of neurology.
2001 Jul; 124(Pt 7):1426-37. doi:
10.1093/brain/124.7.1426. [PMID: 11408337] - T Yokomizo, T Izumi, K Chang, Y Takuwa, T Shimizu. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.
Nature.
1997 Jun; 387(6633):620-4. doi:
10.1038/42506. [PMID: 9177352] - J M Davis, R W Yurt, P S Barie, L C Hudgins, M Verma, P Dineen, G T Shires. Leukotriene B4 generation in patients with established pulmonary failure.
Archives of surgery (Chicago, Ill. : 1960).
1989 Dec; 124(12):1451-5. doi:
10.1001/archsurg.1989.01410120101019. [PMID: 2556091] - F J Zijlstra, A M van den Broek, J E Vincent, P P Diderich, A M op de Hoek-Fes, M Claeys. Formation of leukotriene B4, 20-hydroxy leukotriene B4 and other arachidonic acid metabolites by macrophages during peritonitis in patients with continuous ambulatory peritoneal dialysis.
Prostaglandins, leukotrienes, and medicine.
1987 May; 27(2-3):151-60. doi:
10.1016/0262-1746(87)90067-9. [PMID: 3039532] - R M Clancy, C A Dahinden, T E Hugli. Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors.
Proceedings of the National Academy of Sciences of the United States of America.
1984 Sep; 81(18):5729-33. doi:
10.1073/pnas.81.18.5729. [PMID: 6091105] - R D Camp, P M Woollard, A I Mallet, N J Fincham, A W Ford-Hutchinson, M A Bray. Neutrophil aggregating and chemokinetic properties of a 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid isolated from human leukocytes.
Prostaglandins.
1982 May; 23(5):631-41. doi:
10.1016/s0090-6980(82)80003-8. [PMID: 6289379]
