Benzimidazole (BioDeep_00000003033)

 

Secondary id: BioDeep_00001867692

human metabolite blood metabolite


代谢物信息卡片


Benzimidazole monohydrochloride

化学式: C7H6N2 (118.0531)
中文名称: 苯并咪唑
谱图信息: 最多检出来源 Homo sapiens(blood) 10.7%

分子结构信息

SMILES: C1=CC=C2C(=C1)NC=N2
InChI: InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H,(H,8,9)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3587; ORIGINAL_PRECURSOR_SCAN_NO 3586
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2303; ORIGINAL_PRECURSOR_SCAN_NO 2299
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2278; ORIGINAL_PRECURSOR_SCAN_NO 2277
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3578; ORIGINAL_PRECURSOR_SCAN_NO 3577
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3557; ORIGINAL_PRECURSOR_SCAN_NO 3556
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2260; ORIGINAL_PRECURSOR_SCAN_NO 2259
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2273; ORIGINAL_PRECURSOR_SCAN_NO 2271
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2284; ORIGINAL_PRECURSOR_SCAN_NO 2282
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3585; ORIGINAL_PRECURSOR_SCAN_NO 3584
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3606; ORIGINAL_PRECURSOR_SCAN_NO 3604
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3575; ORIGINAL_PRECURSOR_SCAN_NO 3574
CONFIDENCE standard compound; INTERNAL_ID 1348; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2284; ORIGINAL_PRECURSOR_SCAN_NO 2282
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
CONFIDENCE standard compound; INTERNAL_ID 8120
KEIO_ID B007

同义名列表

13 个代谢物同义名

Benzimidazole monohydrochloride; Benzimidazole mononitrate; 1H-1,3-benzodiazole; 1,3-Benzodiazole; Benzoglyoxaline; 1,3-Diazaindene; O-Benzimidazole; BENZIMIDAZOLE; Azindole; Hbzim; Hbim; Benzimidazole; Benzimidazole



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AKT1, ALOX5, ANXA5, AXIN2, CASP3, CASP7, CNR2, DHFR, MAPK8, PIK3CA, PRKX, PTGS2, TNK1, TP53, TUBB4B, VEGFA
Peripheral membrane protein 4 ALOX5, ANXA5, PTGS2, TNK1
Endoplasmic reticulum membrane 2 CYP51A1, PTGS2
Nucleus 10 AKT1, AXIN2, CASP3, CASP7, MAPK8, PARP1, PRKX, TP53, TUBB4B, VEGFA
cytosol 13 AKT1, ALOX5, ANXA5, ATP12A, AXIN2, CASP3, CASP7, DHFR, MAPK8, PARP1, PIK3CA, TP53, TUBB4B
dendrite 1 CNR2
nuclear body 1 PARP1
centrosome 2 AXIN2, TP53
nucleoplasm 8 AKT1, ALOX5, CASP3, CASP7, MAPK8, PARP1, PRKX, TP53
Cell membrane 2 AKT1, PROKR2
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 2 ATP12A, PROKR2
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 VEGFA
neuronal cell body 1 CASP3
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 3 ALOX5, CASP7, PARP1
plasma membrane 7 AKT1, ATP12A, AXIN2, CNR2, PIK3CA, PROKR2, TNK1
Membrane 7 AKT1, ANXA5, CYP51A1, PARP1, TNK1, TP53, VEGFA
apical plasma membrane 1 ATP12A
axon 1 MAPK8
basolateral plasma membrane 1 ATP12A
caveola 1 PTGS2
extracellular exosome 2 ANXA5, TUBB4B
endoplasmic reticulum 4 CNR2, PTGS2, TP53, VEGFA
extracellular space 3 ALOX5, CASP7, VEGFA
perinuclear region of cytoplasm 2 ALOX5, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 DHFR, PARP1, TP53
protein-containing complex 4 AKT1, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 1 CYP51A1
Microsome membrane 2 CYP51A1, PTGS2
postsynaptic density 1 CASP3
Secreted 1 VEGFA
extracellular region 4 ALOX5, ANXA5, TUBB4B, VEGFA
Single-pass membrane protein 1 CYP51A1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 1 ANXA5
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ATP12A
perikaryon 1 CNR2
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 2 AKT1, TUBB4B
nucleolus 2 PARP1, TP53
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 1 CNR2
Apical cell membrane 1 ATP12A
Cytoplasm, perinuclear region 1 ALOX5
Cytoplasm, cytoskeleton 2 TP53, TUBB4B
focal adhesion 1 ANXA5
microtubule 1 TUBB4B
spindle 1 AKT1
extracellular matrix 1 VEGFA
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 PARP1, TP53
mitotic spindle 1 TUBB4B
Chromosome 1 PARP1
cytoskeleton 1 TUBB4B
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 2 PARP1, TP53
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 2 ALOX5, PARP1
Nucleus envelope 1 ALOX5
axonemal microtubule 1 TUBB4B
Cell projection, dendrite 1 CNR2
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 2 ALOX5, TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 TUBB4B
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
Nucleus intermembrane space 1 ALOX5
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
potassium:proton exchanging ATPase complex 1 ATP12A
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Yushuai Mao, Haoran Li, Wen Song, Baoquan Zhao, Yiqiang Cai, Jianxin Wang, Mingguo Zhou, Yabing Duan. Evolution of Benzimidazole Resistance Caused by Multiple Double Mutations of β-Tubulin in Corynespora cassiicola. Journal of agricultural and food chemistry. 2022 Dec; 70(48):15046-15056. doi: 10.1021/acs.jafc.2c05912. [PMID: 36443900]
  • Providence Moyo, Glynnis Cook, Elaine Basson, Chanel Steyn, Rachelle Bester, Charmaine Olivier, Paul H Fourie. Monitoring Benzimidazole Resistance in Phyllosticta citricarpa Using a Molecular Assay Targeting Mutations in Codons 198 and 200 of the β-Tubulin Gene. Plant disease. 2022 May; 106(5):1374-1380. doi: 10.1094/pdis-07-21-1459-re. [PMID: 34879724]
  • In-Ho Song, Gyu Seong Yeom, Anil Kuwar, Satish Balasaheb Nimse. Elimination Reaction-Based Benzimidazole Probe for Cysteine Detection and Its Application in Serum Sample Analysis. Biosensors. 2022 Apr; 12(4):. doi: 10.3390/bios12040224. [PMID: 35448284]
  • Rafael Silveira Porto, Rafael Silvio Bonilha Pinheiro, Susanne Rath. Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta. Environmental science and pollution research international. 2021 Nov; 28(42):59040-59049. doi: 10.1007/s11356-020-08389-w. [PMID: 32207020]
  • Javier Gandasegui, Berta Grau-Pujol, María Cambra-Pelleja, Valdemiro Escola, Maria Antonietta Demontis, Anelsio Cossa, José Carlos Jamine, Rafael Balaña-Fouce, Lisette van Lieshout, José Muñoz, María Martínez-Valladares. Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs. Parasites & vectors. 2021 Sep; 14(1):490. doi: 10.1186/s13071-021-04941-w. [PMID: 34563247]
  • Hoon Sik Choi, Young Shin Ko, Hana Jin, Ki Mun Kang, In Bong Ha, Hojin Jeong, Haa-Na Song, Hye Jung Kim, Bae Kwon Jeong. Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175118. [PMID: 34500557]
  • Yun Qian, Jun Zhang, Rui Xu, Qiang Li, Qi Shen, Guofu Zhu. Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment. International journal of biological macromolecules. 2021 Jul; 183(?):2215-2226. doi: 10.1016/j.ijbiomac.2021.05.204. [PMID: 34097964]
  • Suxing Liu, Dong Liu, Ru Shen, Di Li, Qiyue Hu, Yinfa Yan, Jiakang Sun, Fengqi Zhang, Hong Wan, Ping Dong, Jun Feng, Rumin Zhang, Jing Li, Lianshan Zhang, Weikang Tao. Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis. Scientific reports. 2021 04; 11(1):9132. doi: 10.1038/s41598-021-88492-1. [PMID: 33911101]
  • Pengcheng Nie, Fangfang Qu, Lei Lin, Yong He, Xuping Feng, Liang Yang, Huaqi Gao, Lihua Zhao, Lingxia Huang. Trace Identification and Visualization of Multiple Benzimidazole Pesticide Residues on Toona sinensis Leaves Using Terahertz Imaging Combined with Deep Learning. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073425. [PMID: 33810447]
  • Kyohei Hayashi, Noriyasu Kondo, Naoki Omori, Ryo Yoshimoto, Megumi Hato, Shuhei Shigaki, Ayumi Nagasawa, Mana Ito, Takayuki Okuno. Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors. Bioorganic & medicinal chemistry letters. 2021 02; 33(?):127722. doi: 10.1016/j.bmcl.2020.127722. [PMID: 33285268]
  • Xin Chen, Xi Yang, Fei Mao, Jinlian Wei, Yixiang Xu, Baoli Li, Jin Zhu, Shuaishuai Ni, Lijun Jia, Jian Li. Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo. European journal of medicinal chemistry. 2021 Jan; 210(?):112964. doi: 10.1016/j.ejmech.2020.112964. [PMID: 33129593]
  • Taylan Çakmak, Oihane Simón, Mehmet Bora Kaydan, Denis Achiri Tange, Agueda Mª González Rodríguez, Ana Piedra-Buena Díaz, Primitivo Caballero Murillo, Estrella Hernández Suárez. Effects of several UV-protective substances on the persistence of the insecticidal activity of the Alphabaculovirus of Chrysodeixis chalcites (ChchNPV-TF1) on banana (Musa acuminata, Musaceae, Colla) under laboratory and open-field conditions. PloS one. 2021; 16(5):e0250217. doi: 10.1371/journal.pone.0250217. [PMID: 33979364]
  • Alžbeta Königová, Michaela Urda Dolinská, Michal Babják, Georg von Samson-Himmelstjerna, Michaela Komáromyová, Marián Várady. Experimental evidence for the lack of sensitivity of in vivo faecal egg count reduction testing for the detection of early development of benzimidazole resistance. Parasitology research. 2021 Jan; 120(1):153-159. doi: 10.1007/s00436-020-06965-0. [PMID: 33174071]
  • Luis Fernando Viana Furtado, Talita Rodrigues Dos Santos, Valéria Nayara Gomes Mendes de Oliveira, Élida Mara Leite Rabelo. Genotypic profile of benzimidazole resistance associated with SNP F167Y in the beta-tubulin gene of Necator americanus helminths obtained from Brazilian populations. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2020 12; 86(?):104594. doi: 10.1016/j.meegid.2020.104594. [PMID: 33080381]
  • Arisa Masuda, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Yukiko Yamashita, Keisuke Oda, Mizuho Une, Naoki Teno. N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR). Bioorganic & medicinal chemistry. 2020 07; 28(14):115512. doi: 10.1016/j.bmc.2020.115512. [PMID: 32616182]
  • Léa Bordes, Nicolas Dumont, Anne Lespine, Elise Souil, Jean-François Sutra, Françoise Prévot, Christelle Grisez, Lola Romanos, Aurélie Dailledouze, Philippe Jacquiet. First report of multiple resistance to eprinomectin and benzimidazole in Haemonchus contortus on a dairy goat farm in France. Parasitology international. 2020 Jun; 76(?):102063. doi: 10.1016/j.parint.2020.102063. [PMID: 31978599]
  • Lynsey A Melville, Elizabeth Redman, Alison A Morrison, Pai Chia Rebecca Chen, Russell Avramenko, Sian Mitchell, Jan Van Dijk, Giles Innocent, Fiona Sargison, Catriona Aitken, John S Gilleard, Dave J Bartley. Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms. International journal for parasitology. Drugs and drug resistance. 2020 04; 12(?):68-76. doi: 10.1016/j.ijpddr.2020.03.001. [PMID: 32251964]
  • Khalid M Mohammedsalih, Jürgen Krücken, Amna Khalafalla, Ahmed Bashar, Fathel-Rahman Juma, Adam Abakar, Abdalhakaim A H Abdalmalaik, Gerald Coles, Georg von Samson-Himmelstjerna. New codon 198 β-tubulin polymorphisms in highly benzimidazole resistant Haemonchus contortus from goats in three different states in Sudan. Parasites & vectors. 2020 Mar; 13(1):114. doi: 10.1186/s13071-020-3978-6. [PMID: 32122383]
  • Xueqin Jiang, Zengjin Liu, Youzhe Yang, Hao Li, Xiaoyi Qi, Wen Xiu Ren, Mingming Deng, Muhan Lü, Jianming Wu, Sicheng Liang. A mitochondria-targeted two-photon fluorescent probe for sensing and imaging pH changes in living cells. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jan; 224(?):117435. doi: 10.1016/j.saa.2019.117435. [PMID: 31400745]
  • Xu Yuan, Qingyi Yang, Tongyan Liu, Ke Li, Yuwen Liu, Changcheng Zhu, Zhiyun Zhang, Linghua Li, Conghai Zhang, Mingjin Xie, Jun Lin, Jihong Zhang, Yi Jin. Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase. European journal of medicinal chemistry. 2019 Oct; 179(?):147-165. doi: 10.1016/j.ejmech.2019.06.054. [PMID: 31252306]
  • Denis A Babkov, Olga N Zhukowskaya, Alexander V Borisov, Valentina A Babkova, Elena V Sokolova, Anastasia A Brigadirova, Roman A Litvinov, Alexandra A Kolodina, Anatolii S Morkovnik, Vadim S Sochnev, Gennady S Borodkin, Alexander A Spasov. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators. Bioorganic & medicinal chemistry letters. 2019 09; 29(17):2443-2447. doi: 10.1016/j.bmcl.2019.07.035. [PMID: 31358465]
  • Yanjun Li, Dongming Chen, Shunwen Luo, Yuanye Zhu, Xiaojing Jia, Yabing Duan, Mingguo Zhou. Intron-mediated regulation of β-tubulin genes expression affects the sensitivity to carbendazim in Fusarium graminearum. Current genetics. 2019 Aug; 65(4):1057-1069. doi: 10.1007/s00294-019-00960-4. [PMID: 30941494]
  • Mengli Zi, Feifei Liu, Di Wu, Ke Li, Da Zhang, Changcheng Zhu, Zhiyun Zhang, Linghua Li, Conghai Zhang, Mingjin Xie, Jun Lin, Jihong Zhang, Yi Jin. Discovery of 6-Arylurea-2-arylbenzoxazole and 6-Arylurea-2-arylbenzimidazole Derivatives as Angiogenesis Inhibitors: Design, Synthesis and in vitro Biological Evaluation. ChemMedChem. 2019 07; 14(13):1291-1302. doi: 10.1002/cmdc.201900216. [PMID: 31131561]
  • Iqubal Singh, Vijay Luxami, Kamaldeep Paul. Synthesis and in vitro evaluation of naphthalimide-benzimidazole conjugates as potential antitumor agents. Organic & biomolecular chemistry. 2019 05; 17(21):5349-5366. doi: 10.1039/c8ob02973c. [PMID: 31099353]
  • Guogang Deng, Bei Zhou, Jing Wang, Zhuo Chen, Liang Gong, Yaxiao Gong, Dongmei Wu, Yan Li, Hongbin Zhang, Xiaodong Yang. Synthesis and antitumor activity of novel steroidal imidazolium salt derivatives. European journal of medicinal chemistry. 2019 Apr; 168(?):232-252. doi: 10.1016/j.ejmech.2019.02.025. [PMID: 30822712]
  • Guohua An, Daryl J Murry, Kiran Gajurel, Thanh Bach, Greg Deye, Larissa V Stebounova, Ellen E Codd, John Horton, Armando E Gonzalez, Hector H Garcia, Dilek Ince, Denice Hodgson-Zingman, Effie Y H Nomicos, Thomas Conrad, Jessie Kennedy, Walt Jones, Robert H Gilman, Patricia Winokur. Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study. Antimicrobial agents and chemotherapy. 2019 04; 63(4):. doi: 10.1128/aac.02255-18. [PMID: 30745383]
  • Godfrey Mayoka, Jennifer Keiser, Cécile Häberli, Kelly Chibale. Structure-Activity Relationship and in Vitro Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Studies of N-aryl 3-Trifluoromethyl Pyrido[1,2- a]benzimidazoles That Are Efficacious in a Mouse Model of Schistosomiasis. ACS infectious diseases. 2019 03; 5(3):418-429. doi: 10.1021/acsinfecdis.8b00313. [PMID: 30580519]
  • Luis Fernando Viana Furtado, Celi da Silva Medeiros, Luciana Werneck Zuccherato, William Pereira Alves, Valéria Nayara Gomes Mendes de Oliveira, Vivian Jordania da Silva, Guilherme Silva Miranda, Ricardo Toshio Fujiwara, Élida Mara Leite Rabelo. First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides. PloS one. 2019; 14(10):e0224108. doi: 10.1371/journal.pone.0224108. [PMID: 31622428]
  • Graham R Foster, Gregory J Dore, Stanley Wang, Jason Grebely, Kenneth E Sherman, Axel Baumgarten, Brian Conway, Daniel Jackson, Tarik Asselah, Michael Gschwantler, Krzysztof Tomasiewicz, Humberto Aguilar, Armen Asatryan, Yiran Hu, Federico J Mensa. Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies. Drug and alcohol dependence. 2019 01; 194(?):487-494. doi: 10.1016/j.drugalcdep.2018.11.007. [PMID: 30529905]
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