Retinal (BioDeep_00000001872)
Secondary id: BioDeep_00000866948, BioDeep_00000875153
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds natural product
代谢物信息卡片
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal
化学式: C20H28O (284.2140038)
中文名称: 13-顺式视黄醇, 全反式视黄醛, 视黄醛
谱图信息:
最多检出来源 Homo sapiens(blood) 0.74%
分子结构信息
SMILES: C/C(=C\C=C\C(=C\C=O)\C)/C=C/C1=C(C)CCCC1(C)C
InChI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
描述信息
A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration. [HMDB]. Retinal is found in many foods, some of which are flaxseed, pepper (c. baccatum), climbing bean, and other soy product.
Retinal is a carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
CONFIDENCE standard compound; INTERNAL_ID 142
同义名列表
27 个代谢物同义名
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal; 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal; all-trans-Vitamin a aldehyde; trans-Vitamin a aldehyde; all-trans-Retinaldehyde; Vitamin a1 aldehyde; all-epsilon-Retinal; Aldehyde, vitamin a; Vitamin a aldehyde; all-trans-Retinene; all trans-Retinal; All-trans-retinal; Retinal, 13-cis-; epsilon-Retinal; 11-cis-retinal; alpha-Retinene; 11 cis Retinal; Retinaldehyde; all-e-Retinal; trans-Retinal; Axerophthal; Retinene 1; e-Retinal; Retinene; Retinal; Retinal
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:17898
- KEGG: C00376
- PubChem: 638015
- HMDB: HMDB0001358
- Metlin: METLIN2276
- ChEMBL: CHEMBL81379
- Wikipedia: Retinal
- LipidMAPS: LMPR01090002
- MeSH: Retinaldehyde
- MetaCyc: RETINAL
- foodb: FDB022576
- CAS: 116-31-4
- MoNA: RP014203
- MoNA: RP014201
- MoNA: RP014202
- PMhub: MS000001355
- PubChem: 3666
- PDB-CCD: RET
- 3DMET: B00095
- NIKKAJI: J5.279E
- RefMet: Retinal
- KNApSAcK: 17898
- LOTUS: LTS0275050
分类词条
相关代谢途径
Reactome(12)
BioCyc(0)
PlantCyc(0)
代谢反应
272 个相关的代谢反应过程信息。
Reactome(253)
- Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by Nuclear Receptors:
ATP + MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb ⟶ ADP + MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb - Signaling by Retinoic Acid:
ATP + lipo-PDH ⟶ ADP + p-lipo-PDH - RA biosynthesis pathway:
9cRA + H+ + Oxygen + TPNH ⟶ 4OH-9cRA + H2O + TPN - Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
E2QW22 + E2RPT1 + ESR1:ER:PGR:P4 + F6UTY3 + J9P0C0 ⟶ ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + F8W2D1 + HSP90:HSP90 + Pi + Q7SZQ8 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
E9QD41 + atRA ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H+ + TPNH + atRAL ⟶ TPN + atROL - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Q9VH95 + Q9VL78 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
atRA + fabp ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
CRABP1 + atRA ⟶ SUMO-CRABP1:atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
11cROL + TPN ⟶ 11cRAL + H+ + TPNH - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Immunophilin FKBP52 + Pi + cPGES - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + Fkbp4 + HSP90:HSP90 + Pi + Q9R0Q7 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by Nuclear Receptors:
ATP + MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb ⟶ ADP + MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb - Signaling by Retinoic Acid:
ATP + lipo-PDH ⟶ ADP + p-lipo-PDH - RA biosynthesis pathway:
9cRA + H+ + Oxygen + TPNH ⟶ 4OH-9cRA + H2O + TPN - Signaling Pathways:
H2O + cAMP ⟶ AMP - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Ptges3 + Q9QVC8 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Visual phototransduction:
H+ + TPNH + atRAL ⟶ TPN + atROL - The canonical retinoid cycle in rods (twilight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - RA biosynthesis pathway:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by Retinoic Acid:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - RA biosynthesis pathway:
H2O + NAD + atRAL ⟶ H+ + NADH + atRA - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
H2O + cAMP ⟶ AMP - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (i) signalling events:
H2O + cAMP ⟶ AMP - Visual phototransduction:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Nuclear Receptors:
ESR1:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ ADP + ESR1:ER:PGR:P4 + H0ZSE5 + H0ZZA2 + HSP90-beta dimer + Pi - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Visual phototransduction:
atREs + nascent CM ⟶ nascent CM:atREs - The retinoid cycle in cones (daylight vision):
F6T9Q4 + atROL ⟶ RLBP1:atROL - Signaling by Nuclear Receptors:
ESR1 dimer:ESTG + HSP90:ATP:PTGES3:FKBP52:PGR:P4 ⟶ A0A310SUH5 + ADP + ESR1:ER:PGR:P4 + HSP90:HSP90 + Pi + Q5U4Z0 - Signaling by Retinoic Acid:
CAR + PALM-CoA ⟶ CoA-SH + L-PCARN - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - The retinoid cycle in cones (daylight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Signaling by Retinoic Acid:
H+ + TPNH + atRAL ⟶ TPN + atROL - RA biosynthesis pathway:
H+ + TPNH + atRAL ⟶ TPN + atROL - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
H2O + RPALM ⟶ PALM + atROL - Sensory Perception:
H+ + TPNH + atRAL ⟶ TPN + atROL - Sensory Perception:
atREs + nascent CM ⟶ nascent CM:atREs - Sensory Perception:
GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 - The canonical retinoid cycle in rods (twilight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
Homologues of TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
H+ + RBP2:atRAL + TPNH ⟶ RBP2:atROL + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
TTPA + alpha-TOH ⟶ TTPA:alpha-TOH - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
Oxygen + betaC ⟶ atRAL - Retinoid metabolism and transport:
Oxygen + betaC ⟶ atRAL - Signaling by GPCR:
2AG + H2O ⟶ AA + Glycerol + H+ - GPCR downstream signalling:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (i) signalling events:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Visual phototransduction:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Retinoid metabolism and transport:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Metabolism of fat-soluble vitamins:
atREs + nascent CM ⟶ nascent CM:atREs - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of fat-soluble vitamins:
Oxygen + betaC ⟶ atRAL - Retinoid metabolism and transport:
Oxygen + betaC ⟶ atRAL - Signaling by GPCR:
2AG + H2O ⟶ AA + Glycerol + H+ - GPCR downstream signalling:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (i) signalling events:
ATP + Calmodulin:CaMK IV ⟶ ADP + phospho-CaMK IV:Calmodulin - Visual phototransduction:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - The canonical retinoid cycle in rods (twilight vision):
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - The canonical retinoid cycle in rods (twilight vision):
H+ + TPNH + atRAL ⟶ TPN + atROL - Transport of small molecules:
CHOL + NPC2 ⟶ NPC2:CHOL - ABC-family proteins mediated transport:
ATP + Cl- + H2O ⟶ ADP + Cl- + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Visual phototransduction:
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - The canonical retinoid cycle in rods (twilight vision):
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Transport of small molecules:
CHOL + phosphatidylcholines ⟶ 1-acyl LPC + CHEST - ABC-family proteins mediated transport:
ATP + Cl- + H2O ⟶ ADP + Cl- + Pi - Visual phototransduction:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - ABC-family proteins mediated transport:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - The canonical retinoid cycle in rods (twilight vision):
DHA + H+ + Oxygen + TPNH ⟶ H2O + HDoHE + TPN - The canonical retinoid cycle in rods (twilight vision):
RLBP1:11cROL + TPN ⟶ H+ + RLBP1:11cRAL + TPNH - The canonical retinoid cycle in rods (twilight vision):
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - Sensory Perception:
Q54YX3 + atROL ⟶ RLBP1:atROL - Sensory Perception:
ATP + H2O + atRAL ⟶ ADP + Pi + atRAL - The phototransduction cascade:
GTP ⟶ PPi + cGMP - Inactivation, recovery and regulation of the phototransduction cascade:
GTP ⟶ PPi + cGMP - The phototransduction cascade:
Homologues of GNAT1 ⟶ Homologues of GNAT1 (Met removed) + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
Homologues of GNAT1 ⟶ Homologues of GNAT1 (Met removed) + L-Met - The phototransduction cascade:
GNAT1 ⟶ GNAT1 (Met removed) + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
GNAT1 ⟶ GNAT1 (Met removed) + L-Met - The phototransduction cascade:
Q90WX6 ⟶ L-Met + Q90WX6 - Inactivation, recovery and regulation of the phototransduction cascade:
Q90WX6 ⟶ L-Met + Q90WX6 - The phototransduction cascade:
cGMP:CNG channel ⟶ CNG channel + cGMP - Inactivation, recovery and regulation of the phototransduction cascade:
CNG channel + cGMP ⟶ cGMP:CNG channel - Biosynthesis of A2E, implicated in retinal degradation:
PE + atRAL ⟶ NRPE - The phototransduction cascade:
Transducin alpha-1 chain ⟶ GNAT1 (Met removed) + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
Transducin alpha-1 chain ⟶ GNAT1 (Met removed) + L-Met - Disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Diseases associated with visual transduction:
PE + atRAL ⟶ NRPE - Retinoid cycle disease events:
PE + atRAL ⟶ NRPE - The phototransduction cascade:
Gnat1 ⟶ GNAT1 (Met removed) + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
Gnat1 ⟶ GNAT1 (Met removed) + L-Met - The phototransduction cascade:
D3ZSS5 ⟶ D3ZSS5 + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
D3ZSS5 ⟶ D3ZSS5 + L-Met - The phototransduction cascade:
A0A287BRP2 ⟶ A0A287BRP2 + L-Met - Inactivation, recovery and regulation of the phototransduction cascade:
A0A287BRP2 ⟶ A0A287BRP2 + L-Met - The phototransduction cascade:
ATP + Q9IA36 ⟶ ADP + phospho-p-S334,338,343-at-retinyl-RHO - Inactivation, recovery and regulation of the phototransduction cascade:
ATP + Q9IA36 ⟶ ADP + phospho-p-S334,338,343-at-retinyl-RHO - Diseases of the neuronal system:
PE + atRAL ⟶ NRPE
BioCyc(5)
- retinol biosynthesis:
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - the visual cycle I (vertebrates):
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - retinol biosynthesis:
H2O + a dietary all-trans-retinyl ester ⟶ all-trans-retinol + H+ + a fatty acid - the visual cycle I (vertebrates):
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH - retinol biosynthesis:
all-trans-retinol + NADP+ ⟶ all-trans-retinal + H+ + NADPH
WikiPathways(4)
- Retinol metabolism:
beta-Carotene ⟶ all-trans-retinal - Vitamin A and carotenoid metabolism:
Betacarotene ⟶ all-trans Retinal - Vitamin A1 and A5/X pathways:
ATROL ⟶ ATRA - 10q22q23 copy number variation:
Retinal ⟶ 11-cis-Retinaldehyde
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
2-Methyl-3-acetoacetyl-CoA + Coenzyme A ⟶ Acetyl-CoA + Propanoyl-CoA
PathBank(9)
- Retinol Metabolism:
11-cis-Retinaldehyde + NADP ⟶ NADPH + Retinal - Vitamin A Deficiency:
11-cis-Retinaldehyde + NADP ⟶ NADPH + Retinal - Retinol Metabolism:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Vitamin A Deficiency:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Retinol Metabolism:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Retinol Metabolism:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Retinol Metabolism:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Retinol Metabolism:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid - Vitamin A Deficiency:
NAD + Vitamin A + Water ⟶ NADH + all-trans-Retinoic acid
PharmGKB(0)
58 个相关的物种来源信息
- 8292 - Amphibia: LTS0275050
- 4050 - Araliaceae: LTS0275050
- 2157 - Archaea: LTS0275050
- 6656 - Arthropoda: LTS0275050
- 2 - Bacteria: LTS0275050
- 7711 - Chordata: LTS0275050
- 3028117 - Cyanophyceae: LTS0275050
- 6042 - Demospongiae: LTS0275050
- 2759 - Eukaryota: LTS0275050
- 28890 - Euryarchaeota: LTS0275050
- 7136 - Galleria: LTS0275050
- 7137 - Galleria mellonella: 10.1073/PNAS.0807805105
- 7137 - Galleria mellonella: LTS0275050
- 2237 - Haloarcula: LTS0275050
- 29282 - Haloarcula japonica: 10.1128/JB.02523-14
- 29282 - Haloarcula japonica: LTS0275050
- 183963 - Halobacteria: LTS0275050
- 2236 - Halobacteriaceae: LTS0275050
- 9604 - Hominidae: LTS0275050
- 9605 - Homo: LTS0275050
- 9606 - Homo sapiens:
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0275050
- 50557 - Insecta: LTS0275050
- 3398 - Magnoliopsida: LTS0275050
- 40674 - Mammalia: LTS0275050
- 33208 - Metazoa: LTS0275050
- 10066 - Muridae: LTS0275050
- 10088 - Mus: LTS0275050
- 10090 - Mus musculus: LTS0275050
- 10090 - Mus musculus: NA
- 1762 - Mycobacteriaceae: LTS0275050
- 1763 - Mycobacterium: LTS0275050
- 1773 - Mycobacterium tuberculosis: LTS0275050
- 1177 - Nostoc: 10.1074/JBC.M606299200
- 1177 - Nostoc: LTS0275050
- 1162 - Nostocaceae: LTS0275050
- 4053 - Panax: LTS0275050
- 4054 - Panax ginseng: 10.1016/J.PHYMED.2009.03.014
- 4054 - Panax ginseng: LTS0275050
- 6040 - Porifera: LTS0275050
- 7135 - Pyralidae: LTS0275050
- 8399 - Rana: LTS0275050
- 8407 - Rana temporaria: 10.1042/BJ0450612
- 8407 - Rana temporaria: LTS0275050
- 8397 - Ranidae: LTS0275050
- 4070 - Solanaceae: LTS0275050
- 4107 - Solanum: LTS0275050
- 4081 - Solanum lycopersicum: 10.1016/S0031-9422(00)89781-2
- 4081 - Solanum lycopersicum: LTS0275050
- 35493 - Streptophyta: LTS0275050
- 55566 - Suberites: LTS0275050
- 55567 - Suberites domuncula: 10.3390/MD10010177
- 55567 - Suberites domuncula: LTS0275050
- 55660 - Suberitidae: LTS0275050
- 58023 - Tracheophyta: LTS0275050
- 33090 - Viridiplantae: LTS0275050
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 164(?):114930. doi:
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Cell reports.
2023 02; 42(2):112091. doi:
10.1016/j.celrep.2023.112091. [PMID: 36763501] - Chao Chen, Kunhuan Yang, Danxue He, Bo Yang, Lei Tao, Jingmeng Chen, Yalin Wu. Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal.
Free radical biology & medicine.
2023 01; 194(?):245-254. doi:
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International journal of cosmetic science.
2022 Apr; 44(2):201-215. doi:
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Nutrition (Burbank, Los Angeles County, Calif.).
2022 02; 94(?):111539. doi:
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Methods in enzymology.
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The Journal of biological chemistry.
2021 12; 297(6):101359. doi:
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Science (New York, N.Y.).
2021 Sep; 373(6562):1532-1536. doi:
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Developmental biology.
2021 08; 476(?):68-78. doi:
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BioMed research international.
2021; 2021(?):3236892. doi:
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The Journal of biological chemistry.
2021 Jan; 296(?):100187. doi:
10.1074/jbc.ra120.015779. [PMID: 33334878] - Elliot H Choi, Anahita Daruwalla, Susie Suh, Henri Leinonen, Krzysztof Palczewski. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor.
Journal of lipid research.
2021; 62(?):100040. doi:
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Journal of lipid research.
2021; 62(?):100042. doi:
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Cellular signalling.
2020 05; 69(?):109547. doi:
10.1016/j.cellsig.2020.109547. [PMID: 31982549] - Raquel Pequerul, Javier Vera, Joan Giménez-Dejoz, Isidro Crespo, Joan Coines, Sergio Porté, Carme Rovira, Xavier Parés, Jaume Farrés. Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.
Archives of biochemistry and biophysics.
2020 03; 681(?):108256. doi:
10.1016/j.abb.2020.108256. [PMID: 31923393] - Jun Han, Min-Lu Han, Hao Xing, Zhen-Li Li, Dao-Yi Yuan, Han Wu, Han Zhang, Ming-da Wang, Chao Li, Lei Liang, Yan-Yan Song, Ai-Jing Xu, Meng-Chao Wu, Feng Shen, Ying Xie, Tian Yang. Tissue and serum metabolomic phenotyping for diagnosis and prognosis of hepatocellular carcinoma.
International journal of cancer.
2020 03; 146(6):1741-1753. doi:
10.1002/ijc.32599. [PMID: 31361910] - Yang Li, Haichuang Lan, Xia Yan, Xiaotao Shi, Xiao Liu, Shuzhang Xiao. Retinal-based polyene fluorescent probe for selectively detection of Cu2+ in physiological saline and serum.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 227(?):117565. doi:
10.1016/j.saa.2019.117565. [PMID: 31670041] - Chris P F Redfern. Vitamin A and its natural derivatives.
Methods in enzymology.
2020; 637(?):1-25. doi:
10.1016/bs.mie.2020.02.002. [PMID: 32359642] - Mark K Adams, Olga V Belyaeva, Natalia Y Kedishvili. Generation and isolation of recombinant retinoid oxidoreductase complex.
Methods in enzymology.
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Experimental dermatology.
2019 11; 28(11):1219-1226. doi:
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The journal of physical chemistry. B.
2019 10; 123(43):9123-9133. doi:
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International journal of molecular sciences.
2019 Aug; 20(15):. doi:
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The journal of physical chemistry. B.
2019 03; 123(9):2032-2039. doi:
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Advances in experimental medicine and biology.
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The American journal of clinical nutrition.
2018 10; 108(4):784-792. doi:
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Journal of lipid research.
2018 09; 59(9):1620-1629. doi:
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Scientific reports.
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The journal of physical chemistry. B.
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Nature communications.
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The Journal of biological chemistry.
2018 05; 293(18):6996-7007. doi:
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Molecular pharmacology.
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Journal of drug targeting.
2018 04; 26(4):333-344. doi:
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The American journal of pathology.
2017 Oct; 187(10):2222-2231. doi:
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Biophysical journal.
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Biophysical journal.
2017 Mar; 112(5):943-952. doi:
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Biochemistry.
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Science (New York, N.Y.).
2016 12; 354(6319):1552-1557. doi:
10.1126/science.aah3497. [PMID: 28008064] - Junhua Wang, Peter D Westenskow, Mingliang Fang, Martin Friedlander, Gary Siuzdak. Quantitative metabolomics of photoreceptor degeneration and the effects of stem cell-derived retinal pigment epithelium transplantation.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences.
2016 Oct; 374(2079):. doi:
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Biochemistry.
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Journal of the American Chemical Society.
2016 Apr; 138(14):4757-62. doi:
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Sub-cellular biochemistry.
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