Folic acid (BioDeep_00000000725)

 

Secondary id: BioDeep_00000400036, BioDeep_00000415839

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


FOLVITE(Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1422)

化学式: C19H19N7O6 (441.1397)
中文名称: 维生素 B9, 维生素 M, 叶酸, DL-叶酸, 维生素B9
谱图信息: 最多检出来源 Homo sapiens(feces) 31.1%

分子结构信息

SMILES: C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
InChI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)

描述信息

Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482 °F.
Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a human metabolite, a nutrient and a mouse metabolite. It is a member of folic acids and a N-acyl-amino acid. It is functionally related to a pteroic acid. It is a conjugate acid of a folate(2-).
Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits. In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the bodys ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates. Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example.
Folic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
CID 6037 is a natural product found in Beta vulgaris, Angelica sinensis, and other organisms with data available.
Folic Acid is a collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treat...
Folic acid or folate, is a vitamin that belongs to the class of compounds known as pterins. Chemically, folate consists of three distinct chemical moieties linked together. A pterin (2-amino-4-hydroxy-pteridine) linked by a methylene bridge to a p-aminobenzoyl group that in turn is linked through an amide linkage to glutamic acid. It is a member of the vitamin B family and is primarily known as vitamin B9. Folate is required for the body to make DNA and RNA and metabolize amino acids necessary for cell division for the hematopoietic system. As humans cannot make folate, it is required in the diet, making it an essential nutrient (i.e. a vitamin). Folate occurs naturally in many foods including mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid, being biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by the enzyme known as dihydrofolate reductase. Tetrahydrofolate and methyltetrahydrofolate are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids and generate formic acid. Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in babies. Low levels in early pregnancy are believed to be the cause of more than half of babies born with NTDs (PMID: 28097362). Folic acid is also a microbial metabolite produced by Bifidobacterium and Lactobacillus (PMID: 22254078).
An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
B - Blood and blood forming organs > B03 - Antianemic preparations > B03B - Vitamin b12 and folic acid > B03BB - Folic acid and derivatives
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D006397 - Hematinics
D018977 - Micronutrients > D014815 - Vitamins
V - Various > V04 - Diagnostic agents
Dietary supplement
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Formula(Parent): C19H19N7O6; Bottle Name:Folic acid ,approx; PRIME Parent Name:Folic acid; PRIME in-house No.:V0080; SubCategory_DNP: Pteridines and analogues, Pteridine alkaloids
Acquisition and generation of the data is financially supported in part by CREST/JST.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.543
CONFIDENCE standard compound; INTERNAL_ID 134
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].

同义名列表

206 个代谢物同义名

FOLVITE(Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1422); Folic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=97\\%; (2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; (2S)-2-[(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L; N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid; (2S)-2-[(4-{[(2-AMINO-4-HYDROXYPTERIDIN-6-YL)METHYL]AMINO}PHENYL)FORMAMIDO]PENTANEDIOIC ACID; (2S)-2-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; (S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate; (S)-2-(4-((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methylamino)benzamido)pentanedioic acid; L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-; (2S)-2-[[4-[(2-amino-4-hydroxypteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; .beta.-D-ribo-2-Heptulopyranose, 2,7-anhydro-1,4-dideoxy-3-O-methyl-5-O-(phenylmethyl)-; L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid; L-Glutamic acid, N-(4-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; L-glutamic acid, N-[4-[[(2-amino-4,8-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; N-(4-(((2-AMINO-4-OXO-1,4-DIHYDROPTERIDIN-6-YL)METHYL)AMINO)BENZOYL)-L-GLUTAMIC ACID; N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; N-[4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoyl]-l-glutamic acid; N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-; 2-(4-((2-amino-4-oxo-1H-pteridin-6-yl)methylamino)benzoyl)aminopentanedioic acid; N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-; Folic acid, Pharmaceutical Secondary Standard; Certified Reference Material; 2-AMINO-6-((P-((1,3-DICARBOXYPROPYL)CARBAMOYL)ANILINO)METHYL)-4-PTERIDINOL; N-{p-[(2-amino-4-hydroxypteridin-6-yl)methylamino]benzoyl}glutamic acid; .beta.-D-Allopyranose, 1,6-anhydro-2,3-di-O-methyl-4-O-(phenylmethyl)-; Folic acid, United States Pharmacopeia (USP) Reference Standard; Folic acid, European Pharmacopoeia (EP) Reference Standard; Folic acid, British Pharmacopoeia (BP) Reference Standard; Folic acid, meets USP testing specifications; Folic acid, Vetec(TM) reagent grade, >=97\\%; CALCIUM FOLINATE IMPURITY C [EP IMPURITY]; PteGlu;Vitamin M;Pteroyl-L-glutamic acid; Folic acid, tested according to Ph.Eur.; Liver Lactobacillus casei factor; FOLIC ACID COMPONENT OF FOLVRON; Folic acid, analytical standard; Folic Acid, Monopotassium Salt; Folic Acid, Calcium Salt (1:1); ACIDUM FOLICUM [WHO-IP LATIN]; Folic acid (USP:INN:BAN:JAN); FOLVRON COMPONENT FOLIC ACID; Folic acid [USP:INN:BAN:JAN]; Glutamic acid, pteroyl-, l-; Pteroyl-L-monoglutamic acid; Folic Acid, Monosodium Salt; Acido folico [INN-Spanish]; Acide folique [INN-French]; Acidum folicum [INN-Latin]; FOLIC ACID (USP MONOGRAPH); FOLIC ACID [USP MONOGRAPH]; Acidum folicum (INN-Latin); Acide folique (INN-French); Folic Acid, Potassium Salt; Acido folico (INN-Spanish); Folic acid (JP17/USP/INN); N-pteroyl-L-glutamic acid; Kyselina listova [Czech]; Folic acid [BAN:INN:JAN]; FOLIC ACID (EP IMPURITY); FOLIC ACID [EP IMPURITY]; FOLIC ACID [ORANGE BOOK]; Pteroylmonoglutamic acid; Pteroyl-L-monoglutamate; Pteroyl-L-glutamic acid; FOLIC ACID [GREEN BOOK]; Folic acid, crystalline; Folic Acid, Sodium Salt; Folic Acid, (DL)-Isomer; Folaemin (Netherlands); Folic Acid, (D)-Isomer; Folaemin [Netherlands]; Folic acid, USP grade; N-Pteroyl-L-glutamate; Pteroylglutamic acid; T-dol JIANG SUAN BAO; Novofolacid [Canada]; Novofolacid (Canada); Pteroylmonoglutamate; FOLIC ACID [WHO-DD]; Folasic (Australia); FOLIC ACID [WHO-IP]; FOLIC ACID [USP-RS]; Pteroyglutamic acid; FOLIC ACID (USP-RS); Pteroyl-L-glutamate; FOLIC ACID [VANDF]; FOLIC ACID [MART.]; FOLIC ACID (MART.); Folic acid, >=97\\%; Nifolin (Denmark); Nifolin [Denmark]; Antianemia factor; Prestwick3_000627; FOLIC ACID [HSDB]; FOLIC ACID [INCI]; Dosfolat B activ; Foldine [France]; Spectrum2_001459; Spectrum3_000749; Pteroylglutamate; Spectrum4_001751; Kyselina listova; Spectrum5_000602; FOLIC ACID [FCC]; Mission prenatal; Foldine (France); FOLIC ACID [JAN]; FOLIC ACID [INN]; FOLIC ACID [DSC]; FOLIC ACID [MI]; [3H]-folic acid; [3H]folic acid; Folina (Italy); Folic Acid,(S); Tox21_111559_1; Folico (Italy); Folcidin (VAN); Acidum folicum; Acfol (Spain); Acide folique; DivK1c_000494; BPBio1_000654; Tox21_111559; Folicet (TN); KBio2_001861; KBio2_006997; Tox21_300127; KBio3_001558; KBio2_004429; Acido folico; KBio1_000494; Folcysteine; CAS-59-30-3; Vitamin B11; SMP2_000137; IDI1_000494; Bio Science; Novofolacid; Preconceive; B9, Vitamin; Usaf cb-13; folic-acid; Folic acid; Vitamin Bc; Natur Flow; Vitamin Be; Vitamin B9; AI3-26387; Folsaeure; Incafolic; Vitamin M; PGA (VAN); Folcidin; Folaemin; Folettes; Folicare; Folic D3; Foliamin; Folsaure; Millafol; Neocepri; Factor U; Mittafol; Acifolic; Cytofol; B03BB01; Folvite; Foluite; Megafol; Foldine; Folicet; Folacid; Nifolin; Folipac; V04CX02; Folacin; Folico; Lexpec; PteGlu; Folate; Folsan; folite; Folsav; Folbal; Folina; Folan; Acfol; Facid; Folic; 2d0k; PGA; FOL; Folic acid ,approx; Vitamin B9; Folate; Folic acid



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

77 个相关的代谢反应过程信息。

Reactome(56)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(16)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, AKT1, FBP1, MTHFD1, SHMT1, SLC46A1, TYMS
Endosome membrane 2 SLC46A1, TFRC
Endoplasmic reticulum membrane 2 CD4, TKT
Mitochondrion membrane 1 ABCG2
Nucleus 7 AKT1, DNMT1, DNMT3B, FBP1, RFC1, SHMT1, TYMS
cytosol 10 AKT1, COMT, FBP1, GSR, MTHFD1, MTHFR, NAT1, SHMT1, TKT, TYMS
dendrite 1 COMT
mitochondrial membrane 1 ABCG2
nuclear body 1 TKT
nucleoplasm 7 ABCG2, AKT1, DNMT1, DNMT3B, RFC1, SHMT1, TKT
Cell membrane 10 ABCG2, ACE, AKT1, CD4, COMT, NAT1, RFC1, SLC46A1, TFRC, TKT
lamellipodium 1 AKT1
Multi-pass membrane protein 4 ABCG2, NAT1, RFC1, SLC46A1
Synapse 2 COMT, NAT1
cell cortex 1 AKT1
cell surface 3 NAT1, SLC46A1, TFRC
glutamatergic synapse 2 AKT1, TFRC
mitochondrial inner membrane 1 TYMS
postsynapse 1 AKT1
presynaptic membrane 1 NAT1
Lysosome 1 ACE
endosome 3 ACE, SLC46A1, TFRC
plasma membrane 11 ABCG2, ACE, AKT1, CD4, COMT, NAT1, RFC1, SLC46A1, TCN2, TFRC, TKT
synaptic vesicle membrane 1 NAT1
Membrane 8 ABCG2, ACE, AKT1, COMT, MTHFD1, NAT1, SLC46A1, TFRC
apical plasma membrane 5 ABCG2, NAT1, RFC1, SLC46A1, TKT
axon 2 COMT, NAT1
basolateral plasma membrane 4 NAT1, RFC1, SLC46A1, TFRC
extracellular exosome 9 ACE, COMT, FBP1, GSR, MTHFD1, RFC1, SHMT1, TFRC, TKT
extracellular space 4 ACE, PTH, TCN2, TFRC
lysosomal lumen 1 TCN2
perinuclear region of cytoplasm 1 TFRC
mitochondrion 5 DNMT1, GSR, MTHFD1, SHMT1, TYMS
protein-containing complex 1 AKT1
intracellular membrane-bounded organelle 2 COMT, TFRC
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 3 ACE, CD4, TKT
Secreted 2 ACE, TCN2
extracellular region 4 ACE, PTH, TCN2, TFRC
neuronal cell body membrane 1 NAT1
Mitochondrion matrix 1 TYMS
mitochondrial matrix 2 GSR, TYMS
Extracellular side 1 COMT
external side of plasma membrane 5 ACE, CD4, GSR, TCN2, TFRC
Extracellular vesicle 1 TFRC
actin cytoskeleton 1 TKT
cytoplasmic vesicle 1 TFRC
microtubule cytoskeleton 1 AKT1
Early endosome 2 CD4, TFRC
cell-cell junction 1 AKT1
clathrin-coated pit 1 TFRC
recycling endosome 1 TFRC
Single-pass type II membrane protein 2 COMT, TFRC
vesicle 2 AKT1, TKT
Apical cell membrane 3 ABCG2, RFC1, SLC46A1
Mitochondrion inner membrane 1 TYMS
Membrane raft 2 ABCG2, CD4
focal adhesion 1 TKT
spindle 1 AKT1
Peroxisome 1 TKT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
receptor complex 1 TKT
ciliary basal body 1 AKT1
brush border membrane 4 ABCG2, ACE, RFC1, SLC46A1
blood microparticle 1 TFRC
sperm midpiece 1 ACE
Basolateral cell membrane 3 NAT1, RFC1, SLC46A1
Recycling endosome membrane 1 TFRC
female germ cell nucleus 1 DNMT1
Melanosome 1 TFRC
replication fork 1 DNMT1
basal plasma membrane 1 ACE
HFE-transferrin receptor complex 1 TFRC
endoplasmic reticulum lumen 1 CD4
clathrin-coated endocytic vesicle membrane 2 CD4, TFRC
external side of apical plasma membrane 1 ABCG2
postsynaptic recycling endosome membrane 1 TFRC
T cell receptor complex 1 CD4
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
catalytic complex 1 DNMT3B
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
DNA replication factor C complex 1 RFC1
Elg1 RFC-like complex 1 RFC1


文献列表

  • Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu. The relationship between thiamin, folic acid and cognitive function in a rat model of uremia. Renal failure. 2024 Dec; 46(1):2329257. doi: 10.1080/0886022x.2024.2329257. [PMID: 38482596]
  • Yunsong Jiang, Mengzhen Xing, Jinyuan Sun, Xin-An Zeng, Charles Brennan, Jayani Chandrapala, Mahsa Majzoobi, Baoguo Sun. Construction of resveratrol and quercetin nanoparticles based on folic acid targeted Maillard products between Jiuzao glutelin isolate and carboxymethyl chitosan: Improved stability and function. Food chemistry. 2024 Aug; 450(?):139296. doi: 10.1016/j.foodchem.2024.139296. [PMID: 38636381]
  • Li He, Lisheng Peng, Lianan Wang, Xiaoyan Jiang, Xinfeng Sun, Haiwen Li, Tong Lin, Zhulin Wu, Sen Lin. Investigation of folate-modified EGCG-loaded thermosensitive nanospheres inducing immunogenic cell death and damage-associated molecular patterns in hepatocellular carcinoma. Biochemical and biophysical research communications. 2024 Jun; 714(?):149976. doi: 10.1016/j.bbrc.2024.149976. [PMID: 38677007]
  • Shijing Yang, Yaoxing Li, Xiaoman Zheng, Xirui Zheng, Yongshi Lin, Shining Guo, Cui Liu. Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155415. doi: 10.1016/j.phymed.2024.155415. [PMID: 38503151]
  • Federica Fogacci, Carmine Pizzi, Luca Bergamaschi, Valentina Di Micoli, Arrigo F G Cicero. Folic acid and plasma lipids: Interactions and effect of folate supplementation. Current problems in cardiology. 2024 Jun; 49(6):102539. doi: 10.1016/j.cpcardiol.2024.102539. [PMID: 38521293]
  • Chi-Yen Hung, Hsin-Ju Lee, Zhao-Ting Tsai, Shu-Jung Huang, Hsin-Yi Huang, Hui-Ju Tsai, Tsung-Chieh Yao. Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity. Obesity (Silver Spring, Md.). 2024 Jun; 32(6):1179-1186. doi: 10.1002/oby.24012. [PMID: 38572577]
  • Min Hong, Juan Wang, Haobin Chen, Jiayu Qi, Qinghong Ji, Xiaoyan Liu, Qiaoli Yue, Lei Li, Shuang Cheng. Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug. European journal of pharmacology. 2024 May; 970(?):176482. doi: 10.1016/j.ejphar.2024.176482. [PMID: 38452835]
  • Changhao Fang, Karen Kanemaru, Wildemar S P Carvalho, Krista R Fruehauf, Sunshine Zhang, Prem P Das, Caishuang Xu, Yuping Lu, Nandhakishore Rajagopalan, Marianna Kulka, Darren A Makeiff, Michael J Serpe. Self-assembled poloxamer-legumin/vicilin nanoparticles for the nanoencapsulation and controlled release of folic acid. International journal of biological macromolecules. 2024 May; 268(Pt 2):131646. doi: 10.1016/j.ijbiomac.2024.131646. [PMID: 38636765]
  • Yaqi Zhao, Junyan Shi, Bihong Feng, Shuzhi Yuan, Xiaozhen Yue, Wenlin Shi, Zhicheng Yan, Dongying Xu, Jinhua Zuo, Qing Wang. Multi-omic analysis of the extension of broccoli quality during storage by folic acid. Journal of advanced research. 2024 May; 59(?):65-78. doi: 10.1016/j.jare.2023.07.001. [PMID: 37406731]
  • Xiaowan Hou, Zhiwei Lu, Taifei Yu, Yuanyuan Zhang, Quansheng Yao, Chunyi Zhang, Yiding Niu, Qiuju Liang. Two maize homologs of mammalian proton-coupled folate transporter, ZmMFS_1-62 and ZmMFS_1-73, are essential to salt and drought tolerance. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108623. doi: 10.1016/j.plaphy.2024.108623. [PMID: 38626656]
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