Furanodienone (BioDeep_00000000467)

 

Secondary id: BioDeep_00000268754, BioDeep_00000268774

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


CYCLODECA(B)FURAN-4(7H)-ONE, 8,11-DIHYDRO-3,6,10-TRIMETHYL-, (5E,9E)-

化学式: C15H18O2 (230.1307)
中文名称: 莪术呋喃二烯酮, 呋喃二烯酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 71.43%

分子结构信息

SMILES: C/C1=C/C(=O)c2c(C)coc2C/C(C)=C/CC1
InChI: InChI=1S/C15H18O2/c1-10-5-4-6-11(2)8-14-15(13(16)7-10)12(3)9-17-14/h6-7,9H,4-5,8H2,1-3H3/b10-7+,11-6+

描述信息

Furanodienone is a germacrane sesquiterpenoid.
(5E,9E)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one is a natural product found in Curcuma amada, Curcuma aeruginosa, and other organisms with data available.
Isofuranodienone is a constituent of Curcuma zedoaria (zedoary).
Constituent of Curcuma zedoaria (zedoary)
Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].
Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].

同义名列表

21 个代谢物同义名

CYCLODECA(B)FURAN-4(7H)-ONE, 8,11-DIHYDRO-3,6,10-TRIMETHYL-, (5E,9E)-; Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5E,9E)-; Cyclodeca[b]furan-4(7H)-one,8,11-dihydro-3,6,10-trimethyl-, (5E,9E)-; Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (E,E)-; CYCLODECA(B)FURAN-4(7H)-ONE, 8,11-DIHYDRO-3,6,10-TRIMETHYL-, (E,E)-; (5E,9E)-3,6,10-Trimethyl-7,8-dihydrocyclodeca[b]furan-4(11H)-one; (5E,9E)-3,6,10-trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one; (5E,9E)-8,11-DIHYDRO-3,6,10-TRIMETHYLCYCLODECA(B)FURAN-4(7H)-ONE; (5E,9E)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one; (5E,9E)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]uran-4-one; (1(10)E,4E)-8,12-Epoxygermacra-1(10),4,7,11-tetraen-6-one; Germacra-1(10),4,7,11-tetraen-6-one, 8,12-epoxy-, (E,E)-; 3,6,10-trimethyl-4H,7H,8H,11H-cyclodeca[b]furan-4-one; 3,6,10-trimethyl-7H,8H,11H-cyclodeca[b]furan-4-one; furanogermacra-1(10)Z,4Z-dien-6-one; XVOHELPNOXGRBQ-NXAIOARDSA-N; Isofuranodienone; furanodienone; Furanodienon; DH78SKJ88K; Furanodienone



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

139 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AIMP2, ALOX5, ANXA5, BCL2, CASP3, CCND1, CDK4, CDKN1A, EGFR, EGR1, ESR1, MAPK8, MYC
Peripheral membrane protein 3 ALOX5, ANXA5, ESR1
Endosome membrane 2 CLCN5, EGFR
Endoplasmic reticulum membrane 2 BCL2, EGFR
Nucleus 11 AIMP2, BCL2, CASP3, CCND1, CDK4, CDKN1A, EGFR, EGR1, ESR1, MAPK8, MYC
cytosol 12 AIMP2, ALOX5, ANXA5, BCL2, CASP3, CCND1, CDK4, CDKN1A, CLCN5, ESR1, GPT, MAPK8
nuclear body 1 CDKN1A
centrosome 1 CCND1
nucleoplasm 11 ALOX5, ANO1, CASP3, CCND1, CDK4, CDKN1A, CSPG4, EGR1, ESR1, MAPK8, MYC
Cell membrane 5 ANO1, CLCN5, CSPG4, EGFR, ESR1
Cytoplasmic side 1 ESR1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ANO1, CLCN5, PRG4
Golgi apparatus membrane 1 CLCN5
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 2 CSPG4, EGFR
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 2 CLCN5, ESR1
Golgi membrane 2 CLCN5, EGFR
lysosomal membrane 2 CLCN5, EGF
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
synaptic vesicle 1 CLCN5
Cytoplasm, cytosol 2 AIMP2, ALOX5
Presynapse 1 ANO1
endosome 1 EGFR
plasma membrane 7 ANO1, CLCN5, CSPG4, EGF, EGFR, ESR1, PRG4
Membrane 11 AIMP2, ANO1, ANXA5, BCL2, CLCN5, CSPG4, EGF, EGFR, ESR1, MYC, PRG4
apical plasma membrane 3 ANO1, CSPG4, EGFR
axon 1 MAPK8
basolateral plasma membrane 1 EGFR
extracellular exosome 5 ANO1, ANXA5, CSPG4, EGF, GPT
endoplasmic reticulum 1 BCL2
extracellular space 4 ALOX5, EGF, EGFR, PRG4
lysosomal lumen 1 CSPG4
perinuclear region of cytoplasm 3 ALOX5, CDKN1A, EGFR
bicellular tight junction 2 CCND1, CDK4
mitochondrion 1 BCL2
protein-containing complex 5 BCL2, CDKN1A, EGFR, ESR1, MYC
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 CSPG4, EGFR
Secreted 1 PRG4
extracellular region 5 ALOX5, ANXA5, CSPG4, EGF, PRG4
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Extracellular side 1 CSPG4
transcription regulator complex 2 CDK4, ESR1
Nucleus membrane 4 ALOX5, BCL2, CCND1, CDK4
Bcl-2 family protein complex 1 BCL2
nuclear membrane 5 ALOX5, BCL2, CCND1, CDK4, EGFR
external side of plasma membrane 1 ANXA5
nucleolus 3 CDK4, CDKN1A, MYC
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
Apical cell membrane 2 ANO1, CSPG4
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 EGFR
pore complex 1 BCL2
focal adhesion 3 ANXA5, CSPG4, EGFR
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 3 ANXA5, CSPG4, PRG4
ruffle 1 CSPG4
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
chromatin 4 CDK4, EGR1, ESR1, MYC
cell projection 1 ANO1
Nucleus, nucleolus 1 MYC
nuclear envelope 2 ALOX5, MYC
Nucleus envelope 1 ALOX5
chloride channel complex 1 ANO1
Nucleus, nucleoplasm 1 MYC
euchromatin 1 ESR1
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
Golgi lumen 1 CSPG4
nuclear matrix 1 ALOX5
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 EGF
RNA polymerase II transcription repressor complex 1 MYC
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
[Isoform 1]: Nucleus 1 ESR1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Rough endoplasmic reticulum 1 MYC
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK4, CDKN1A
lamellipodium membrane 1 CSPG4
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
Cell projection, lamellipodium membrane 1 CSPG4
endothelial microparticle 1 ANXA5
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 2 CCND1, CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
PCNA-p21 complex 1 CDKN1A
cyclin D1-CDK6 complex 1 CCND1
nucleoplasmic reticulum 1 MYC


文献列表

  • Zhipeng Deng, Qian Liu, Weihong Wu, Hong Wang. Validation and application of a novel UHPLC-MS/MS method for the measurement of furanodienone in rat plasma. Biomedical chromatography : BMC. 2020 Jan; 34(1):e4717. doi: 10.1002/bmc.4717. [PMID: 31634986]
  • Nadiah Syafiqah Nor Azman, Md Shahadat Hossan, Veeranoot Nissapatorn, Chairat Uthaipibull, Parichat Prommana, Khoo Teng Jin, Mohammed Rahmatullah, Tooba Mahboob, Chandramathi Samudi Raju, Hassan Mahmood Jindal, Banasri Hazra, Mohd Ridzuan Mohd Abd Razak, Vijay Kumar Prajapati, Rajan Kumar Pandey, Norhaniza Aminudin, Khozirah Shaari, Nor Hadiani Ismail, Mark S Butler, Vladimir V Zarubaev, Christophe Wiart. Anti-infective activities of 11 plants species used in traditional medicine in Malaysia. Experimental parasitology. 2018 Nov; 194(?):67-78. doi: 10.1016/j.exppara.2018.09.020. [PMID: 30268422]