Classification Term: 1603
Germacrane sesquiterpenoids (ontology term: CHEMONTID:0002456)
Sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups." [ISBN:9780412466205]
found 27 associated metabolites at category metabolite taxonomy ontology rank level.
Ancestor: Sesquiterpenoids
Child Taxonomies: There is no child term of current ontology term.
Curdione
Curdione is a germacrane sesquiterpenoid. Germacr-1(10)-ene-5,8-dione is a natural product found in Curcuma aromatica, Curcuma wenyujin, and other organisms with data available. Curdione is found in turmeric. Curdione is a constituent of Curcuma zedoaria (zedoary) Constituent of Curcuma zedoaria (zedoary). Curdione is found in turmeric. Curdione, one of the major sesquiterpene compounds from Curcuma zedoaria, has been shown to exhibit multiple bioactive properties. IC50 value: 60–80 μM Target: In vitro: The study of the influence of curdione on the hemorheological changes in blood stasis model rats and thrombolysis in vitro showed that curdione only possessed thrombolytic effect in dose of 0.235 g·L-1 and 2.35 g·L-1, but has not the notable activity of thrombolysis [1]. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml) were tested in vitro. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC50: 60–80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression in PAF-activated platelets. Moreover, curdione caused an increase in cAMP levels and attenuated intracellular Ca2+ mobilization in PAF-activated platelets. In vivo: Curdione showed significant antithrombotic activity [2]. Curdione, one of the major sesquiterpene compounds from Curcuma zedoaria, has been shown to exhibit multiple bioactive properties. IC50 value: 60–80 μM Target: In vitro: The study of the influence of curdione on the hemorheological changes in blood stasis model rats and thrombolysis in vitro showed that curdione only possessed thrombolytic effect in dose of 0.235 g·L-1 and 2.35 g·L-1, but has not the notable activity of thrombolysis [1]. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml) were tested in vitro. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC50: 60–80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression in PAF-activated platelets. Moreover, curdione caused an increase in cAMP levels and attenuated intracellular Ca2+ mobilization in PAF-activated platelets. In vivo: Curdione showed significant antithrombotic activity [2].
Furanodienone
Furanodienone is a germacrane sesquiterpenoid. (5E,9E)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one is a natural product found in Curcuma amada, Curcuma aeruginosa, and other organisms with data available. Isofuranodienone is a constituent of Curcuma zedoaria (zedoary). Constituent of Curcuma zedoaria (zedoary) Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1]. Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].
Furanodiene
Furanodiene is a germacrane sesquiterpenoid. Furanodiene is a natural product found in Curcuma amada, Lactarius chrysorrheus, and other organisms with data available. Furanodiene is a constituent of Curcuma zedoaria (zedoary) Constituent of Curcuma zedoaria (zedoary)
Dehydrocurdione
Dehydrocurdione is a germacrane sesquiterpenoid. (6E,10S)-6,10-dimethyl-3-propan-2-ylidenecyclodec-6-ene-1,4-dione is a natural product found in Curcuma aromatica, Curcuma longa, and other organisms with data available. Dehydrocurdione is found in turmeric. Dehydrocurdione is from Curcuma zedoaria (zedoary From Curcuma zedoaria (zedoary). Dehydrocurdione is found in turmeric.
Germacrene
Germacrene, also known as (e,e)-germacra-1(10),4,7(11)-triene, is a member of the class of compounds known as germacrane sesquiterpenoids. Germacrane sesquiterpenoids are sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups. Thus, germacrene is considered to be an isoprenoid lipid molecule. Germacrene can be found in turmeric, which makes germacrene a potential biomarker for the consumption of this food product. Germacrenes are a class of volatile organic hydrocarbons, specifically, sesquiterpenes. Germacrenes are typically produced in a number of plant species for their antimicrobial and insecticidal properties, though they also play a role as insect pheromones. Two prominent molecules are germacrene A and germacrene D .
Germacrene D
Germacrene d, also known as germacrene d, (s-(e,e))-isomer, is a member of the class of compounds known as germacrane sesquiterpenoids. Germacrane sesquiterpenoids are sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups. Germacrene d can be found in a number of food items such as peppermint, roman camomile, hyssop, and common walnut, which makes germacrene d a potential biomarker for the consumption of these food products.
Germacrone 4,5-epoxide
Germacrone 4,5-epoxide is found in turmeric. Germacrone 4,5-epoxide is a constituent of essential oil of Curcuma zedoaria (zedoary) Constituent of essential oil of Curcuma zedoaria (zedoary). Germacrone 4,5-epoxide is found in turmeric.
Germacrene B
Constituent of the peel oil of yuzu Citrus junos. Germacrene B is found in many foods, some of which are pepper (spice), lime, citrus, and common oregano. Germacrene B is found in citrus. Germacrene B is a constituent of the peel oil of yuzu Citrus junos.
Furanogermenone
Furanogermenone is found in ginger. Furanogermenone is a constituent of Curcuma zedoaria (zedoary). Constituent of Curcuma zedoaria (zedoary). Furanogermenone is found in ginger.
Preisocalamendiol
Preisocalamendiol is found in herbs and spices. Preisocalamendiol is a constituent of Acorus calamus (sweet flag) Constituent of Acorus calamus (sweet flag). Preisocalamendiol is found in herbs and spices and root vegetables.
Germacrone-13-al
Germacrone-13-al is found in herbs and spices. Germacrone-13-al is a constituent of Curcuma longa (turmeric). Constituent of Curcuma longa (turmeric). Germacrone-13-al is found in turmeric and herbs and spices.
Acoragermacrone
Acoragermacrone is found in herbs and spices. Acoragermacrone is a constituent of Acorus calamus (sweet flag). Constituent of Acorus calamus (sweet flag). Acoragermacrone is found in herbs and spices and root vegetables.
Euglobal VII
Euglobal VII is a constituent of Eucalyptus globulus (Tasmanian blue gum) Constituent of Eucalyptus globulus (Tasmanian blue gum).
7(14)-Isodaucen-10-one
7(14)-Isodaucen-10-one is found in herbs and spices. 7(14)-Isodaucen-10-one is a constituent of Clary sage oil (Salvia sclarea). Constituent of Clary sage oil (Salvia sclarea). 7(14)-Isodaucen-10-one is found in herbs and spices.
Romucosine C
Romucosine C is found in alcoholic beverages. Romucosine C is an alkaloid from Rollinia mucosa (biriba).
Oryzanol A
Oryzanol A is found in cereals and cereal products. Oryzanol A is from rice bran oil (Oryza sativa
Germacrenone
Germacrenone is found in fruits. Germacrenone is a constituent of Carissa edulis (agam) Constituent of Carissa edulis (agam). Germacrenone is found in fruits.
(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol
(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol is found in herbs and spices. (1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol is a constituent of Laurus nobilis (bay laurel). Constituent of Laurus nobilis (bay laurel). (1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol is found in tea and herbs and spices.
Tanacetol B
Tanacetol B is found in herbs and spices. Tanacetol B is a constituent of Tanacetum vulgare (tansy) Constituent of Tanacetum vulgare (tansy). Tanacetol B is found in herbs and spices.
Tanacetol A
Tanacetol A is found in herbs and spices. Tanacetol A is a constituent of Tanacetum vulgare (tansy) Constituent of Tanacetum vulgare (tansy). Tanacetol A is found in herbs and spices.
Involucrin
Germacrene A
Germacrene a is a member of the class of compounds known as germacrane sesquiterpenoids. Germacrane sesquiterpenoids are sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups. Germacrene a can be found in sweet basil, which makes germacrene a a potential biomarker for the consumption of this food product.
1-methyl-5-methylene-8-(1-methylethyl)-1,6-cyclodecadiene
Flavouring compound [Flavornet]
