Phloretin (BioDeep_00000000335)

 

Secondary id: BioDeep_00000270635, BioDeep_00000860723

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one

化学式: C15H14O5 (274.0841)
中文名称: 根皮素
谱图信息: 最多检出来源 Viridiplantae(plant) 19.93%

Reviewed

Last reviewed on 2024-07-29.

Cite this Page

Phloretin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/phloretin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000335). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(O)C=C(O)C(C(=O)CCC2C=CC(O)=CC=2)=C(O)C=1
InChI: InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

描述信息

Phloretin is the aglucone of phlorizin, a plant-derived dihydrochalcone phytochemical reported to promote potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. Phloretin, which is present in apples, pears and tomatoes, has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells. Phloretin also inhibits HT-29 cell growth by inducing apoptosis, which may be mediated through changes in mitochondrial membrane permeability and activation of the caspase pathways. Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport (PMID:18158826, 11560962, 18063724, 15671209, 12083758). Phloretin is a biomarker for the consumption of apples. Phloretin has been found to be a metabolite of Escherichia (PMID:23542617).
Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2, 4 and 6. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a dihydrochalcone.
Phloretin is a natural dihydrochalcone found in apples and many other fruits.
Phloretin is a natural product found in Malus doumeri, Populus candicans, and other organisms with data available.
A natural dihydrochalcone found in apples and many other fruits.
Phloretin is a dihydrochalcone, a type of natural phenols. It is the phloroglucin ester of paraoxyhydratropic acid. It can be found in apple tree leaves. Phloretin is a biomarker for the consumption of apples.
A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2, 4 and 6.
IPB_RECORD: 341; CONFIDENCE confident structure
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4].
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4].
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4].

同义名列表

60 个代谢物同义名

InChI=1/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H; 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)-PROPAN-1-ONE [FHFI]; 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; 1-(2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanon; .beta.-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; beta-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; .beta.-(p-Hydroxyphenyl)-2,6-trihydroxypropiophenone; Propiophenone, 2,4,6-trihydroxy-3-(p-hydroxyphenyl)-; 2,4,6-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone; Propiophenone,4,6-trihydroxy-3-(p-hydroxyphenyl)-; 2,4,6-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; 2,4,6-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2,6-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; .beta.-(p-Hydroxyphenyl)phloropropiophenone; beta-(p-Hydroxyphenyl)phloropropiophenone; Phloretin, analytical reference material; 2,4,4,6-Tetrahydroxy-Dihydrochalcone; 2,6-Dihydroxy-4-methoxyacetophenone; 4,2,4,6-Tetrahydroxydihydrochalcone; 2,4,4,6-Tetrahydroxydihydrochalcone; 4-O-Methylphloracetophenone; Phloretin - CAS 60-82-2; Dihydronaringenin; Phloretin, >=99\\%; Spectrum2_000681; BCBcMAP01_000040; PHLORETIN [INCI]; Spectrum3_001036; Spectrum5_001698; Spectrum4_001172; UNII-S5J5OE47MK; PHLORETIN [MI]; Oprea1_824722; Lopac0_001012; DivK1c_006429; KBio3_002071; Tox21_501012; KBio1_001373; KBio2_006911; Tox21_202854; KBio2_004343; KBio2_001775; CAS-60-82-2; SMP1_000238; S5J5OE47MK; Asebogenol; Phloretol; Phloretin; C15H14O5; BP_35; 2uxi; G50; NSC 407292; RJC 02792; Phloretin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

160 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(158)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADIG, BCL2, CASP3, CAT, FABP4, MAPK14, MTOR, PIK3CA, PRKAA2, PTGS2, SLC2A2, TP53, TYR
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 9 ADIG, BCL2, CASP3, FABP4, HMOX1, MAPK14, MTOR, PRKAA2, TP53
cytosol 13 BCL2, CASP3, CAT, FABP4, HMOX1, MAPK14, MTOR, PIK3CA, PRKAA2, PRKCQ, SLC2A1, SLC2A4, TP53
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
trans-Golgi network 1 SLC2A4
centrosome 1 TP53
nucleoplasm 6 CASP3, HMOX1, MAPK14, MTOR, PRKAA2, TP53
Cell membrane 4 SLC2A1, SLC2A2, SLC2A4, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 3 SLC2A1, SLC2A2, SLC2A4
Golgi apparatus membrane 1 MTOR
cell surface 1 TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 1 PRKAA2
Golgi membrane 3 INS, MTOR, SLC2A1
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
sarcolemma 2 SLC2A1, SLC2A4
Lysosome 2 MTOR, TYR
Presynapse 2 SLC2A1, SLC2A4
plasma membrane 6 PIK3CA, PRKCQ, SLC2A1, SLC2A2, SLC2A4, TNF
Membrane 10 ADIG, BCL2, CAT, HMOX1, MTOR, PRKAA2, SLC2A1, SLC2A2, SLC2A4, TP53
apical plasma membrane 2 SLC2A1, SLC2A2
axon 1 PRKAA2
basolateral plasma membrane 1 SLC2A1
brush border 1 SLC2A2
caveola 2 PTGS2, SLC2A1
extracellular exosome 4 CAT, FABP4, SLC2A1, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, TP53
extracellular space 4 HMOX1, IL6, INS, TNF
perinuclear region of cytoplasm 4 HMOX1, PIK3CA, SLC2A4, TYR
intercalated disc 2 PIK3CA, SLC2A1
mitochondrion 4 BCL2, CAT, MAPK14, TP53
protein-containing complex 4 BCL2, CAT, PTGS2, TP53
intracellular membrane-bounded organelle 2 CAT, TYR
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TYR
Secreted 3 ADIG, IL6, INS
extracellular region 6 ADIG, CAT, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 1 TP53
centriolar satellite 1 PRKCQ
photoreceptor inner segment 1 SLC2A1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 SLC2A4, TNF
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
Z disc 1 SLC2A1
nucleolus 1 TP53
Melanosome membrane 1 TYR
midbody 1 SLC2A1
cell-cell junction 1 SLC2A2
clathrin-coated pit 1 SLC2A4
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 SLC2A4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
Peroxisome 1 CAT
sarcoplasmic reticulum 1 SLC2A4
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 1 TP53
phagocytic cup 1 TNF
spindle pole 1 MAPK14
blood microparticle 1 SLC2A1
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
Lipid droplet 2 ADIG, FABP4
female germ cell nucleus 1 SLC2A1
Cytoplasmic vesicle membrane 1 SLC2A4
Melanosome 2 SLC2A1, TYR
cytoplasmic stress granule 1 PRKAA2
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
cortical actin cytoskeleton 1 SLC2A1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 SLC2A4
[Isoform 1]: Nucleus 1 TP53
death-inducing signaling complex 1 CASP3
female pronucleus 1 SLC2A1
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
glucose transporter complex 1 SLC2A1
insulin-responsive compartment 1 SLC2A4
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yanzhi Yang, Linlan Tao, Yunyun Li, Ying Wu, Qianqian Ran, Dan Li, Shu-Ming Li, Xia Yu, Chun-Mao Yuan, Kang Zhou. Fungal Prenyltransferase AnaPT and Its F265 Mutants Catalyze the Dimethylallylation at the Nonaromatic Carbon of Phloretin. Journal of agricultural and food chemistry. 2024 Apr; 72(14):8018-8026. doi: 10.1021/acs.jafc.4c00928. [PMID: 38557039]
  • Virgile Neyman, Maude Quicray, Frédéric Francis, Catherine Michaux. Toxicological, biochemical, and in silico investigations of three trehalase inhibitors for new ways to control aphids. Archives of insect biochemistry and physiology. 2024 Apr; 115(4):e22112. doi: 10.1002/arch.22112. [PMID: 38605672]
  • Shizi Zhang, Yunfeng Xu, Fang Wang, Liyun Yang, Lijuan Luo, Lingyan Jiang. Transcriptomic and Physiological Analysis of the Effects of Exogenous Phloretin and Pterostilbene on Resistance Responses of Stylosanthes against Anthracnose. International journal of molecular sciences. 2024 Feb; 25(5):. doi: 10.3390/ijms25052701. [PMID: 38473948]
  • Roberta Cassano, Federica Curcio, Roberta Sole, Silvia Mellace, Sonia Trombino. Gallic Acid-Based Hydrogels for Phloretin Intestinal Release: A Promising Strategy to Reduce Oxidative Stress in Chronic Diabetes. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050929. [PMID: 38474441]
  • Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu. Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity. Molecules (Basel, Switzerland). 2023 Dec; 29(1):. doi: 10.3390/molecules29010066. [PMID: 38202649]
  • Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao. Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2023 Nov; 78(11-12):383-387. doi: 10.1515/znc-2023-0046. [PMID: 37608519]
  • Jiawen Wang, Yuanyuan Zhao, Bingtao Zhai, Jiangxue Cheng, Jing Sun, Xiaofei Zhang, Dongyan Guo. Phloretin Transfersomes for Transdermal Delivery: Design, Optimization, and In Vivo Evaluation. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196790. [PMID: 37836633]
  • Jyoti Chhimwal, Rakesh Kumar Dhritlahre, Prince Anand, Ruchika, Vikram Patial, Ankit Saneja, Yogendra S Padwad. Amorphous solid dispersion augments the bioavailability of phloretin and its therapeutic efficacy via targeting mTOR/SREBP-1c axis in NAFLD mice. Biomaterials advances. 2023 Sep; 154(?):213627. doi: 10.1016/j.bioadv.2023.213627. [PMID: 37748276]
  • Yule Wang, Yuduan Ding, Qian Zhao, Chen Wu, Cecilia H Deng, Jingru Wang, Yufan Wang, Yanfang Yan, Rui Zhai, Yar-Khing Yauk, Fengwang Ma, Ross G Atkinson, Pengmin Li. Dihydrochalcone glycoside biosynthesis in Malus is regulated by two MYB-like transcription factors and is required for seed development. The Plant journal : for cell and molecular biology. 2023 Aug; ?(?):. doi: 10.1111/tpj.16444. [PMID: 37648286]
  • Richmond Djorgbenoo, Weixin Wang, Yingdong Zhu, Shengmin Sang. Detoxification of the Lipid Peroxidation Aldehyde, 4-Hydroxynonenal, by Apple Phloretin In Vitro and in Mice. Journal of agricultural and food chemistry. 2023 Jul; ?(?):. doi: 10.1021/acs.jafc.3c01038. [PMID: 37418694]
  • Shiv Kumar, Jyoti Chhimwal, Suresh Kumar, Rahul Singh, Vikram Patial, Rituraj Purohit, Yogendra S Padwad. Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice. Life sciences. 2023 Apr; ?(?):121668. doi: 10.1016/j.lfs.2023.121668. [PMID: 37023949]
  • Su-Min Woo, Ngoc Anh Nguyen, Jeong-Eun Seon, Jin Jang, Su-Min Yee, Ngoc Tan Cao, Harim Choi, Chul-Ho Yun, Hyung-Sik Kang. 3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041851. [PMID: 36838843]
  • Heqin Yan, Wei Zheng, Zhouchen Ye, Jing Yu, Yougen Wu. Comparison of the Main Metabolites in Different Maturation Stages of Camelliavietnamensis Huang Seeds. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206817. [PMID: 36296410]
  • Jinqian Chen, Hao Zhang, Xia Hu, Mengyuan Xu, Yanjun Su, Chunze Zhang, Yuan Yue, Xiaomin Zhang, Xinyu Wang, Wei Cui, Zhenyu Zhao, Xichuan Li. Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Oct; 84(?):105447. doi: 10.1016/j.tiv.2022.105447. [PMID: 35868516]
  • Fernanda Sayuri Itou da Silva, Paulo Francisco Veiga Bizerra, Márcio Shigueaki Mito, Renato Polimeni Constantin, Eduardo Makiyama Klosowski, Byanca Thais Lima de Souza, Paulo Vinicius Moreira da Costa Menezes, Paulo Sérgio Alves Bueno, Letícia Fernanda Nanami, Rogério Marchiosi, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho, Emy Luiza Ishii-Iwamoto, Rodrigo Polimeni Constantin. The metabolic and toxic acute effects of phloretin in the rat liver. Chemico-biological interactions. 2022 Sep; 364(?):110054. doi: 10.1016/j.cbi.2022.110054. [PMID: 35872042]
  • Jyoti Chhimwal, Abhishek Goel, Mahesh Sukapaka, Vikram Patial, Yogendra Padwad. Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD. The Journal of nutritional biochemistry. 2022 09; 107(?):109062. doi: 10.1016/j.jnutbio.2022.109062. [PMID: 35609858]
  • Swapnil Tripathi, Dharati Parmar, Shabrin Fathima, Samir Raval, Gyanendra Singh. Coenzyme Q10, Biochanin A and Phloretin Attenuate Cr(VI)-Induced Oxidative Stress and DNA Damage by Stimulating Nrf2/HO-1 Pathway in the Experimental Model. Biological trace element research. 2022 Aug; ?(?):. doi: 10.1007/s12011-022-03358-5. [PMID: 35953644]
  • Alexander M Firsov, Ljudmila S Khailova, Tatyana I Rokitskaya, Elena A Kotova, Yuri N Antonenko. Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler. Biochemistry. Biokhimiia. 2022 Aug; 87(8):812-822. doi: 10.1134/s0006297922080120. [PMID: 36171648]
  • Yingdong Zhu, Weixin Wang, Qiju Huang, Changlin Hu, Shengmin Sang. Metabolic Investigation on the Interaction Mechanism between Dietary Dihydrochalcone Intake and Lipid Peroxidation Product Acrolein Reduction. Molecular nutrition & food research. 2022 05; 66(9):e2101107. doi: 10.1002/mnfr.202101107. [PMID: 35194934]
  • Swapnil Tripathi, Shabrin Fhatima, Dharati Parmar, Dhirendra Pratap Singh, SukhDev Mishra, Rajeev Mishra, Gyanendra Singh. Therapeutic effects of CoenzymeQ10, Biochanin A and Phloretin against arsenic and chromium induced oxidative stress in mouse (Mus musculus) brain. 3 Biotech. 2022 May; 12(5):116. doi: 10.1007/s13205-022-03171-w. [PMID: 35547012]
  • Wenbo Mao, Yujuan Fan, Xu Wang, Guize Feng, Yan You, Haidong Li, Yongyan Chen, Jialin Yang, Hongbo Weng, Xiaoyan Shen. Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway. Pharmacological research. 2022 05; 179(?):106205. doi: 10.1016/j.phrs.2022.106205. [PMID: 35381340]
  • Liyuan Gu, Rui Sun, Wenjuan Wang, Qiang Xia. Nanostructured lipid carriers for the encapsulation of phloretin: preparation and in vitro characterization studies. Chemistry and physics of lipids. 2022 01; 242(?):105150. doi: 10.1016/j.chemphyslip.2021.105150. [PMID: 34673008]
  • Bolin Lian, Yuanyuan Li, Qilei Yang, Lanlan Xie, Qian Zhang, Yanjie Liu, Xiuhua Zhao, Shujun Li. Phloretin loaded porous starch (Ph-PS): Preparation, characterization, in vitro release and protective effect against oxidative stress in vivo zebrafish model. International journal of biological macromolecules. 2021 Dec; 193(Pt B):2047-2053. doi: 10.1016/j.ijbiomac.2021.11.036. [PMID: 34774597]
  • Samer Al-Samir, Maximilian Prill, Claudiu T Supuran, Gerolf Gros, Volker Endeward. CO2 permeability of the rat erythrocyte membrane and its inhibition. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):1602-1606. doi: 10.1080/14756366.2021.1952194. [PMID: 34261373]
  • Antonio Casado-Díaz, Ángel Rodríguez-Ramos, Bárbara Torrecillas-Baena, Gabriel Dorado, José Manuel Quesada-Gómez, María Ángeles Gálvez-Moreno. Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114185. [PMID: 34836440]
  • Jie Ren, Puze Li, Dong Yan, Min Li, Jinsong Qi, Mingyong Wang, Genshen Zhong, Minna Wu. Interplay between the Gut Microbiome and Metabolism in Ulcerative Colitis Mice Treated with the Dietary Ingredient Phloretin. Journal of microbiology and biotechnology. 2021 Oct; 31(10):1409-1419. doi: 10.4014/jmb.2104.04038. [PMID: 34373435]
  • Hong Hu, Xi Bai, Kexing Xu, Cheng Zhang, Liang Chen. Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers. Poultry science. 2021 Aug; 100(8):101217. doi: 10.1016/j.psj.2021.101217. [PMID: 34161850]
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