Classification Term: 2130
2'-Hydroxy-dihydrochalcones (ontology term: CHEMONTID:0003473)
found 18 associated metabolites at category
metabolite taxonomy ontology rank level.
Ancestor: Chalcones and dihydrochalcones
Child Taxonomies: There is no child term of current ontology term.
Phloretin
Phloretin is the aglucone of phlorizin, a plant-derived dihydrochalcone phytochemical reported to promote potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. Phloretin, which is present in apples, pears and tomatoes, has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells. Phloretin also inhibits HT-29 cell growth by inducing apoptosis, which may be mediated through changes in mitochondrial membrane permeability and activation of the caspase pathways. Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport (PMID:18158826, 11560962, 18063724, 15671209, 12083758). Phloretin is a biomarker for the consumption of apples. Phloretin has been found to be a metabolite of Escherichia (PMID:23542617). Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2, 4 and 6. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a dihydrochalcone. Phloretin is a natural dihydrochalcone found in apples and many other fruits. Phloretin is a natural product found in Malus doumeri, Populus candicans, and other organisms with data available. A natural dihydrochalcone found in apples and many other fruits. Phloretin is a dihydrochalcone, a type of natural phenols. It is the phloroglucin ester of paraoxyhydratropic acid. It can be found in apple tree leaves. Phloretin is a biomarker for the consumption of apples. A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2, 4 and 6. IPB_RECORD: 341; CONFIDENCE confident structure Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4]. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4]. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation[4].
1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone
1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-1-propanone is isolated from Populus balsamifera (balsam poplar) oi Isolated from Populus balsamifera (balsam poplar) oil.
(-)-Catechin 3-O-gallate
(-)-catechin-3-O-gallate is a gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-catechin. It has a role as a metabolite. It is a gallate ester, a polyphenol and a member of flavans. It is functionally related to a (-)-catechin and a gallic acid. It is an enantiomer of a (+)-catechin-3-O-gallate. (-)-Catechin gallate is a natural product found in Rheum palmatum, Vitis vinifera, and other organisms with data available. A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-catechin. (-)-Catechin 3-O-gallate is a polyphenol compound found in foods of plant origin (PMID: 20428313) (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
Aspalathin
C21H24O11 (452.13185539999995)
Aspalathin is found in tea. Aspalathin is a constituent of Aspalathus linearis (rooibos) Aspalathin is a C-linked dihydrochalcone glycoside and flavonoid found in rooibos, a common herbal tea. (Aspalathus linearis). Aspalathin is a chalcone and has shown antimutagenic, and antioxidant properties
Myrigalon B
Myrigalon B is found in herbs and spices. Myrigalon B is isolated from Myrica gale (bog myrtle). Isolated from Myrica gale (bog myrtle). Myrigalon B is found in herbs and spices.
Myrigalone G
Myrigalone G is found in herbs and spices. Myrigalone G is a constituent of the fruit of Myrica gale (bog myrtle). Constituent of the fruit of Myrica gale (bog myrtle). Myrigalone G is found in herbs and spices.
Myrigalone H
Myrigalone H is found in herbs and spices. Myrigalone H is a constituent of the fruit of Myrica gale (bog myrtle). D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics Constituent of the fruit of Myrica gale (bog myrtle). Myrigalone H is found in herbs and spices. D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
1-(2,4-Dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone
1-(2,4-Dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone is found in breadfruit. 1-(2,4-Dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone is a constituent of Artocarpus communis (breadfruit) Constituent of Artocarpus communis (breadfruit). 1-(2,4-Dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone is found in breadfruit and fruits.
(R)-Kanzonol Y
(R)-Kanzonol Y is found in herbs and spices. (R)-Kanzonol Y is a constituent of Glycyrrhiza glabra (licorice)
2-Geranyl-2',3,4,4'-tetrahydroxydihydrochalcone
2-Geranyl-2,3,4,4-tetrahydroxydihydrochalcone is found in fruits. 2-Geranyl-2,3,4,4-tetrahydroxydihydrochalcone is a constituent of Artocarpus communis (breadfruit) Constituent of Artocarpus communis (breadfruit). 2-Geranyl-2,3,4,4-tetrahydroxydihydrochalcone is found in fruits.
Myrigalone E
Myrigalone E is found in herbs and spices. Myrigalone E is a constituent of Myrica gale (bog myrtle)
3-Hydroxyphloretin
3-Hydroxyphloretin is a polyphenol compound found in foods of plant origin (PMID: 20428313)
alpha,beta-Dihydroxanthohumol
alpha,beta-Dihydroxanthohumol is found in alcoholic beverages. alpha,beta-Dihydroxanthohumol is a constituent of hops (Humulus lupulus) Constituent of hops (Humulus lupulus). alpha,beta-Dihydroxanthohumol is found in alcoholic beverages.
Dihydronaringenin-O-sulphate
Dihydronaringenin-O-sulphate is a conjugate of dihydronaringenin and sulphate. Dihydronaringenin, also known as phloretin, is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves. (Wikipedia)
Chamaechromone
Nothofagin
C21H24O10 (436.13694039999996)
1-Propanone, 1-(3-beta-D-glucopyranosyl-2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-
C21H24O10 (436.13694039999996)