Loganin (BioDeep_00000000013)

 

Secondary id: BioDeep_00000175591

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,4a,5,6,7,7a-hexahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester

化学式: C17H26O10 (390.1526)
中文名称: 马钱素, 马钱子苷
谱图信息: 最多检出来源 Viridiplantae(plant) 20.01%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Loganin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/loganin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000013). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O
InChI: InChI=1S/C17H26O10/c1-6-9(19)3-7-8(15(23)24-2)5-25-16(11(6)7)27-17-14(22)13(21)12(20)10(4-18)26-17/h5-7,9-14,16-22H,3-4H2,1-2H3

描述信息

Loganin is an iridoid monoterpenoid with formula C17H26O10 that is isolated from several plant species and exhibits neuroprotective and anti-inflammatory properties. It has a role as a plant metabolite, a neuroprotective agent, an EC 3.4.23.46 (memapsin 2) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-inflammatory agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a cyclopentapyran, a beta-D-glucoside, an enoate ester, a monosaccharide derivative, an iridoid monoterpenoid, a methyl ester and a secondary alcohol. It is functionally related to a loganetin.

Loganin is one of the best-known of the iridoid glycosides. It is named for the Loganiaceae, having first been isolated from the seeds of a member of that plant family, namely those of Strychnos nux-vomica. It also occurs in Alstonia boonei (Apocynaceae),[1] a medicinal tree of West Africa and in the medicinal/entheogenic shrub Desfontainia spinosa (Columelliaceae) native to Central America and South America.

Loganin is a natural product found in Strychnos axillaris, Lonicera japonica, and other organisms with data available.

An iridoid monoterpenoid with formula C17H26O10 that is isolated from several plant species and exhibits neuroprotective and anti-inflammatory properties.
Loganin, also known as loganoside, is a member of the class of compounds known as iridoid o-glycosides. Iridoid o-glycosides are iridoid monoterpenes containing a glycosyl (usually a pyranosyl) moiety linked to the iridoid skeleton. Thus, loganin is considered to be an isoprenoid lipid molecule. Loganin is soluble (in water) and a very weakly acidic compound (based on its pKa). Loganin can be found in a number of food items such as groundcherry, annual wild rice, muscadine grape, and broad bean, which makes loganin a potential biomarker for the consumption of these food products. Loganin is one of the best-known of the iridoid glycosides.It is named for the Loganiaceae,having first been isolated from the seeds of a member of that plant family, namely those of Strychnos nux-vomica. It also occurs in Alstonia boonei (Apocynaceae), a medicinal tree of West Africa and in the medicinal/entheogenic shrub Desfontainia spinosa (Columelliaceae) native to Central America and South America .

Loganin is formed from loganic acid by the enzyme loganic acid O-methyltransferase (LAMT). Loganin then becomes a substrate for the enzyme secologanin synthase (SLS) to form secologanin, a secoiridoid monoterpene found as part of ipecac and terpene indole alkaloids.
Loganin is the main iridoid glycoside compound in Cornus officinalis and has anti-inflammatory and anti-shock effects.
Loganin is the main iridoid glycoside compound in Cornus officinalis and has anti-inflammatory and anti-shock effects.

同义名列表

68 个代谢物同义名

(1S,4aS,6S,7R,7aS)-Methyl 6-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; (1S,4aS,6S,7R,7aS)-Methyl6-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; (1S,4aS,6S,7R,7aS)-methyl 6-hydroxy-7-methyl-1-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYL-, METHYL ESTER, (1S-(1.ALPHA.,4A.ALPHA.,6.ALPHA.,7.ALPHA.,7A.ALPHA.))-; methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, (1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha))-; methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate; METHYL (1S-(1.ALPHA.,4A.ALPHA.,6.ALPHA.,7.ALPHA.,7A.ALPHA.))-1-(.BETA.-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYLCYCLOPENTA(C)PYRAN-4-CARBOXYLATE; (1S)-1.ALPHA.-(.BETA.-D-GLUCOPYRANOSYLOXY)-1,4A.ALPHA.,5,6,7,7A.ALPHA.-HEXAHYDRO-6.ALPHA.-HYDROXY-7.ALPHA.-METHYLCYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID METHYL ESTER; Methyl (1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha))-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta(c)pyran-4-carboxylate; (1S)-1alpha-(beta-D-GLUCOPYRANOSYLOXY)-1,4Aalpha,5,6,7,7Aalpha-HEXAHYDRO-6alpha-HYDROXY-7alpha-METHYLCYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID METHYL ESTER; cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, (1S, 4aS, 6S, 7R, 7aS)-; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYL-, METHYL ESTER, (1S,4AS,6S,7R,7AS)-; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(beta-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYL-, METHYL ESTER, (1S,4AS,6S,7R,7AS)-; 6-hydroxy-7-methyl-1-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester; Cyclopenta[c]pyran-4-carboxylic acid,1-(b-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, (1S,4aS,6S,7R,7aS)-; methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta(c)pyran-4-carboxylate; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYL-, METHYL ESTER; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(beta-D-GLUCOPYRANOSYLOXY)-1,4A,5,6,7,7A-HEXAHYDRO-6-HYDROXY-7-METHYL-, METHYL ESTER; 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester; 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta(c)pyran-4-carboxylic acid methyl ester; Methyl 6-hydroxy-7-methyl-1-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5; 5A5AFFBA-93AB-4635-A071-FC87B9DC023D; 7-Hydroxy-6-desoxyverbenalin; Loganin, analytical standard; AMBQHHVBBHTQBF-UOUCRYGSSA-N; Spectrum5_000628; Spectrum3_001875; Spectrum4_001914; Spectrum2_001637; UNII-H7WJ16Q93C; 7-deoxyloganin; LOGANIN, (-)-; DivK1c_006659; MEGxp0_000723; KBio2_001983; LOGANIN [MI]; ACon1_001749; KBio2_007119; KBio2_004551; KBio3_002852; KBio1_001603; (-)-Loganin; loganoside; H7WJ16Q93C; C17H26O10; Meliatin; Loganin; (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,4a,5,6,7,7a-hexahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[d]pyran-4-carboxylate; methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[d]pyran-4-carboxylate; SDCCGMLS-0066747.P001; EINECS 242-398-0; SpecPlus_000563; Spectrum_001503; SPECTRUM1504066; KBioGR_002535; KBioSS_001983; BSPBio_003350; SPBio_001733; LMPR01020102; ZINC03978792; CHEBI:15771; 18524-94-2; Loganin



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

9 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(4)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

360 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, BCL2, BDNF, CASP1, CASP3, IL18, MAPK14, NFE2L2, NLRP3, NOS2, PIK3CA, PTGS2, STAT3, TLR4
Peripheral membrane protein 3 CYP1B1, GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, HMOX1, PTGS2
Nucleus 9 AKT1, BCL2, CASP3, HMOX1, MAPK14, NFE2L2, NLRP3, NOS2, STAT3
cytosol 12 AKT1, BCL2, CASP1, CASP3, HMOX1, IL18, MAPK14, NFE2L2, NLRP3, NOS2, PIK3CA, STAT3
dendrite 1 BDNF
centrosome 1 NFE2L2
nucleoplasm 7 AKT1, CASP3, HMOX1, MAPK14, NFE2L2, NOS2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 4 AKT1, CASP1, TLR4, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 2 GORASP1, NLRP3
cell cortex 1 AKT1
cell surface 2 TLR4, TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 GORASP1, NFE2L2
Golgi membrane 3 GORASP1, INS, NLRP3
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 4 IL18, NFE2L2, NLRP3, NOS2
plasma membrane 8 AKT1, CASP1, NFE2L2, NOS2, PIK3CA, STAT3, TLR4, TNF
Membrane 7 AKT1, BCL2, BDNF, CYP1B1, HMOX1, NLRP3, TLR4
axon 1 BDNF
caveola 1 PTGS2
endoplasmic reticulum 4 BCL2, HMOX1, NLRP3, PTGS2
extracellular space 6 BDNF, HMOX1, IL18, IL6, INS, TNF
perinuclear region of cytoplasm 5 BDNF, HMOX1, NOS2, PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CYP1B1, MAPK14, NLRP3
protein-containing complex 4 AKT1, BCL2, CASP1, PTGS2
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 5 BDNF, IL18, IL6, INS, NLRP3
extracellular region 7 BDNF, IL18, IL6, INS, MAPK14, NLRP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 CASP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
microtubule 1 CASP1
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
AIM2 inflammasome complex 1 CASP1
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
canonical inflammasome complex 1 CASP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yu Wang, Min Zhao, Jing Li, Yue Liu. Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage. Clinical and experimental pharmacology & physiology. 2024 Jun; 51(6):e13858. doi: 10.1111/1440-1681.13858. [PMID: 38636940]
  • Priya Rao, Mark A Yaroslavsky, Justin C Miller, Mary A Schuler. Catalytic Site Constraints in the P450s Mediating Loganic Acid (7DLH) and Secologanic Acid Synthesis (SLAS) in Camptotheca. Biochemistry. 2023 Sep; 62(18):2763-2774. doi: 10.1021/acs.biochem.3c00126. [PMID: 37656055]
  • Jingzi Chen, Jiaming Ge, Weisan Chen, Ying Zhao, Tianbao Song, Kun Fu, Xiankuan Li, Yanchao Zheng. UPLC-Q-TOF-MS based investigation into the bioactive compounds and molecular mechanisms of Lamiophlomis Herba against hepatic fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155085. doi: 10.1016/j.phymed.2023.155085. [PMID: 37757709]
  • Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu. Development and validation of a simple and rapid UPLC-MS/MS method for loganin and its application in pharmacokinetic and tissue distribution studies. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117130. doi: 10.1016/j.jep.2023.117130. [PMID: 37678422]
  • Wenfan Li, Pei Fan, Xiaobo Wang, Haifeng Tang. Loganin alleviates myocardial ischemia-reperfusion injury through GLP-1R/NLRP3-mediated pyroptosis pathway. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23908. [PMID: 37497884]
  • Xudong Huang, Xiao Chen, Qi Li, Bai-He Ni, Weiguo Wang. Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; ?(?):107202. doi: 10.1016/j.toxicon.2023.107202. [PMID: 37348819]
  • Yunfeng Zhou, Dongmei Luo, Junzhuo Shi, Xiaojia Yang, Wangjun Xu, Weiping Gao, Yukun Guo, Qian Zhao, Xinmei Xie, Yangyang He, Guanhua Du, Xiaobin Pang. Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin. Journal of ethnopharmacology. 2023 Apr; ?(?):116455. doi: 10.1016/j.jep.2023.116455. [PMID: 37019163]
  • Hyoju Jeon, Chang-Gun Lee, Hyesoo Jeong, Seong-Hoon Yun, Jeonghyun Kim, Laxmi Prasad Uprety, Kang-Il Oh, Shivani Singh, Jisu Yoo, Eunkuk Park, Seon-Yong Jeong. Inhibitory Effects of Loganin on Adipogenesis In Vitro and In Vivo. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054752. [PMID: 36902181]
  • Yu-Xuan Guo, Cong-Yuan Xia, Yu Yan, Yan Han, Rui Shi, Jun He, Yu-Ming Wang, Ze-Xing Wang, Wei-Ku Zhang, Jie-Kun Xu. Loganin improves chronic unpredictable mild stress-induced depressive-like behaviors and neurochemical dysfunction. Journal of ethnopharmacology. 2023 Feb; ?(?):116288. doi: 10.1016/j.jep.2023.116288. [PMID: 36809822]
  • Jiaqi Zhang, Yaoyao Wang, Xiaoran Liu, Hao Liu, Xingli Zhao, Shufang Lv, Huawei Xu, Hongxiao Zhang, Xiaogai Hou, Dianyun Hou. Expression Analysis of CoHMGS in Cornus officinalis and Subcellular Localization of the Enzyme It Encodes. DNA and cell biology. 2023 Feb; 42(2):91-96. doi: 10.1089/dna.2022.0527. [PMID: 36730809]
  • Xiaolong Hao, Can Wang, Wei Zhou, Qingyan Ruan, Chenhong Xie, Yinkai Yang, Chengyu Xiao, Yan Cai, Jingyi Wang, Yao Wang, Xuebin Zhang, Itay Maoz, Guoyin Kai. OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila. Journal of integrative plant biology. 2023 Jan; 65(1):133-149. doi: 10.1111/jipb.13377. [PMID: 36194508]
  • Fan Zhang, Yu Yan, Jia Zhang, Li Li, Yu-Wei Wang, Cong-Yuan Xia, Wen-Wen Lian, Ying Peng, Jiang Zheng, Jun He, Jie-Kun Xu, Wei-Ku Zhang. Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review. Phytotherapy research : PTR. 2022 Jun; 36(6):2272-2299. doi: 10.1002/ptr.7347. [PMID: 35583806]
  • Lianghua Chen, Qiujuan Ma, Gongye Zhang, Yongbin Lei, Weiwei Wang, Yuqi Zhang, Tingting Li, Wei Zhong, Yanlin Ming, Gang Song. Protective effect and mechanism of loganin and morroniside on acute lung injury and pulmonary fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Mar; 99(?):154030. doi: 10.1016/j.phymed.2022.154030. [PMID: 35279615]
  • Fei Huang, Xiang Wang, Guifang Xiao, Juan Xiao. Loganin exerts a protective effect on ischemia-reperfusion-induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO-1 signaling pathways. Drug development research. 2022 02; 83(1):150-157. doi: 10.1002/ddr.21853. [PMID: 34189758]
  • Yu-Chi Cheng, Yu-Min Chiu, Zen-Kong Dai, Bin-Nan Wu. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Cells. 2021 10; 10(10):. doi: 10.3390/cells10102688. [PMID: 34685668]
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