Thiourea (BioDeep_00000009892)
Secondary id: BioDeep_00000415840
human metabolite BioNovoGene_Lab2019
代谢物信息卡片
Thiocarbonic acid diamide
化学式: CH4N2S (76.0095)
中文名称: 硫脲
谱图信息:
最多检出来源 Viridiplantae(general) 29.63%
分子结构信息
SMILES: C(=S)(N)N
InChI: InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
描述信息
Thiourea is an organic compound of carbon, nitrogen, sulfur and hydrogen, with the formula CSN2H4 or (NH2)2CS. It is similar to urea, except that the oxygen atom is replaced by a sulfur atom. The properties of urea and thiourea differ significantly because of the relative electronegativities of sulfur and oxygen. Thiourea is a versatile reagent in organic synthesis. "Thioureas" refers to a broad class of compounds with the general structure (R1R2N)(R3R4N)C=S. Thioureas are related to thioamides, e.g. RC(S)NR2, where R is methyl, ethyl, etc. Thiourea is prohibited from use in food. Industrial uses of thiourea include production of flame retardant resins, and vulcanization accelerators. Thiourea is used as an auxiliary agent in diazo paper (light-sensitive photocopy paper) and almost all other types of copy paper. It is also used to tone silver-gelatin photographic prints. The liquid silver cleaning product TarnX is essentially a solution of thiourea. A leaching agent for gold leaching and silver leaching can be created by selectively oxidizing thiourea, bypassing the steps of cyanide use and smelting. Another common application for use of thiourea is a common sulfur source for making semiconductor cadmium sulfide nanoparticle. Thiourea is a planar molecule. The C=S bond distance is 1.60±0.1 for a wide range of derivatives. This narrow range indicates that the C=S bond is insensitive to the nature of the substitutent. Thus, the thioamide, which is similar to an amide group, is difficult to perturb. Thiourea reduces peroxides to the corresponding diols. The intermediate of the reaction is an unstable epidioxide which can only be identified at -100 °C. Epidioxide is similar to epoxide except with two oxygen atoms. This intermediate reduces to diol by thiourea
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
Prohibited from use in food
同义名列表
38 个代谢物同义名
Thiocarbonic acid diamide; Thiocarbonate diamide; Carbonothioic diamide; Thiocarbonic diamide; beta -Thiopseudourea; Aminothiocarboxamide; beta-Thiopseudourea; Urea, thio- (8ci); 2-thio-Pseudourea; 2-Thiopseudourea; Pseudothiourea; Sulfocarbamide; Aminothioamide; Thiourea, acs; Thioharnstoff; Thiocarbamide; Thiomocovina; Thiokarbamid; Thiocarbamid; Isothiourea; 2-thio-Urea; Thiuronium; H2NC(S)NH2; 2-Thiourea; thio-Urea; Sulfourea; Sulfouren; (NH2)2CS; Tsizp 34; Sulourea; THIOUREA; Thiurea; TOU; THU; tu; Thiourea; Thiourea; Thiourea
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:36946
- KEGG: C14415
- PubChem: 2723790
- HMDB: HMDB0034155
- Metlin: METLIN24051
- ChEMBL: CHEMBL260876
- Wikipedia: Thiourea
- MeSH: Thiourea
- foodb: FDB012439
- chemspider: 2005981
- CAS: 17356-08-0
- CAS: 62-56-6
- PMhub: MS000023713
- PubChem: 17395415
- PDB-CCD: TOU
- NIKKAJI: J2.351E
- RefMet: Thiourea
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-86
- KNApSAcK: 36946
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chujian Ma, Luyang Tian, Yan-En Wang, Jingqian Huo, Zexiu An, Susu Sun, Song Kou, Wenfei Wang, Yaze Li, Jinlin Zhang, Lai Chen. Discovery of Novel Pyrazole Acyl Thiourea Skeleton Analogue as Potential Herbicide Candidates.
Journal of agricultural and food chemistry.
2024 Apr; 72(14):7727-7734. doi:
10.1021/acs.jafc.3c08863. [PMID: 38530940] - Cengiz Kaya, Sabri Akin, Ali Sarioğlu, Muhammad Ashraf, Mohammed Nasser Alyemeni, Parvaiz Ahmad. Enhancement of soybean tolerance to water stress through regulation of nitrogen and antioxidant defence mechanisms mediated by the synergistic role of salicylic acid and thiourea.
Plant physiology and biochemistry : PPB.
2024 Jan; 207(?):108320. doi:
10.1016/j.plaphy.2023.108320. [PMID: 38183901] - Changrong Wang, Caiyan Zhao, Weipeng Wang, Xiaoqing Liu, Hongzhang Deng. Biomimetic noncationic lipid nanoparticles for mRNA delivery.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Dec; 120(51):e2311276120. doi:
10.1073/pnas.2311276120. [PMID: 38079547] - Faisal K Algethami, Basant H Koraim, Ehab A Abdelrahman, Yasmeen G Abou El-Reash, Mahmoud S Rizk, Fatehy M Abdel-Haleem. Ionophore-modified polyaniline-based optode for the determination of hydrogen sulfite levels in beverages, wastewater, and soil.
Analytical methods : advancing methods and applications.
2023 11; 15(45):6275-6285. doi:
10.1039/d3ay01320k. [PMID: 37955946] - Mohammed Raed Abdullah Al Gburi, Eyup Altinoz, Hulya Elbe, Melike Ozgul Onal, Umit Yilmaz, Nesibe Yilmaz, Melike Karayakali, Mehmet Demir. Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea.
Drug and chemical toxicology.
2023 Nov; 46(5):1024-1034. doi:
10.1080/01480545.2022.2119994. [PMID: 36069203] - Hamada Abdelgawad, Pooja Negi, Gaurav Zinta, Afrah E Mohammed, Modhi O Alotaibi, Gerrit Beemster, Ahmed M Saleh, Ashish Kumar Srivastava. Nocardiopsis lucentensis and thiourea co-application mitigates arsenic stress through enhanced antioxidant metabolism and lignin accumulation in rice.
The Science of the total environment.
2023 Feb; ?(?):162295. doi:
10.1016/j.scitotenv.2023.162295. [PMID: 36801323] - Anurakti Shukla, Ankita Gupta, Sudhakar Srivastava. Bacterial consortium (Priestia endophytica NDAS01F, Bacillus licheniformis NDSA24R, and Priestia flexa NDAS28R) and thiourea mediated amelioration of arsenic stress and growth improvement of Oryza sativa L.
Plant physiology and biochemistry : PPB.
2023 Feb; 195(?):14-24. doi:
10.1016/j.plaphy.2022.12.022. [PMID: 36584629] - Jiahui Wu, Zhitian Peng, Qiyun Wu, Roy Wai Lun Tang, Tingxia Dong, Huaiyou Wang, Karl Wah Keung Tsim. The water extract of Aloe vera prevents fluoxetine-induced multiple-drug resistance of E. coli by inhibiting reactive oxygen species formation and membrane permeability.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154421. doi:
10.1016/j.phymed.2022.154421. [PMID: 36054995] - Cengiz Kaya, Ferhat Ugurlar, Shahid Farooq, Muhammed Ashraf, Mohammed Nasser Alyemeni, Parvaiz Ahmad. Combined application of asparagine and thiourea improves tolerance to lead stress in wheat by modulating AsA-GSH cycle, lead detoxification and nitrogen metabolism.
Plant physiology and biochemistry : PPB.
2022 Nov; 190(?):119-132. doi:
10.1016/j.plaphy.2022.08.014. [PMID: 36113307] - Sana Faryal, Rehman Ullah, Muhammad Nauman Khan, Baber Ali, Aqsa Hafeez, Mariusz Jaremko, Kamal Ahmad Qureshi. Thiourea-Capped Nanoapatites Amplify Osmotic Stress Tolerance in Zea mays L. by Conserving Photosynthetic Pigments, Osmolytes Biosynthesis and Antioxidant Biosystems.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185744. [PMID: 36144480] - Umar Farooq, Sara Khan, Sadia Naz, Tanveer A Wani, Syed Majid Bukhari, Abullahi Tunde Aborode, Sohail Anjum Shahzad, Seema Zargar. Three New Acrylic Acid Derivatives from Achillea mellifolium as Potential Inhibitors of Urease from Jack Bean and α-Glucosidase from Saccharomyces cerevisiae.
Molecules (Basel, Switzerland).
2022 Aug; 27(15):. doi:
10.3390/molecules27155004. [PMID: 35956953] - Tejashree Ghate, Kanchan Soneji, Vitthal Barvkar, Padma Ramakrishnan, Debasish Prusty, Sk Ramiz Islam, Soumen Kanti Manna, Ashish Kumar Srivastava. Thiourea mediated ROS-metabolites reprogramming restores root system architecture under arsenic stress in rice.
Journal of hazardous materials.
2022 08; 435(?):129020. doi:
10.1016/j.jhazmat.2022.129020. [PMID: 35650738] - Jingxuan Deng, Zhenxing Huang, Jinbo Wang, Xiaohong Shan, Wansheng Shi, Wenquan Ruan. Wild Heterotrophic Nitrifying Strain Pseudomonas BT1 Isolated from Kitchen Waste Sludge Restores Ammonia Nitrogen Removal in a Sewage Treatment Plant Shocked by Thiourea.
Applied biochemistry and biotechnology.
2022 Jul; 194(7):2901-2918. doi:
10.1007/s12010-022-03850-7. [PMID: 35294734] - Olesya V Pokidova, Nina S Emel'yanova, Alexandra Yu Kormukhina, Veronika O Novikova, Alexander V Kulikov, Alexander I Kotelnikov, Natalia A Sanina. Albumin as a prospective carrier of the nitrosyl iron complex with thiourea and thiosulfate ligands under aerobic conditions.
Dalton transactions (Cambridge, England : 2003).
2022 Apr; 51(16):6473-6485. doi:
10.1039/d2dt00291d. [PMID: 35394482] - Munish Kumar Upadhyay, Arnab Majumdar, Ashish Kumar Srivastava, Sutapa Bose, Penna Suprasanna, Sudhakar Srivastava. Antioxidant enzymes and transporter genes mediate arsenic stress reduction in rice (Oryza sativa L.) upon thiourea supplementation.
Chemosphere.
2022 Apr; 292(?):133482. doi:
10.1016/j.chemosphere.2021.133482. [PMID: 34979210] - Fangzhou Xu, Shengxin Guo, Wei Zhang, Yanyan Wang, Panpan Wei, Shunhong Chen, Jian Wu. Trifluoromethylpyridine thiourea derivatives: design, synthesis and inhibition of the self-assembly of tobacco mosaic virus particles.
Pest management science.
2022 Apr; 78(4):1417-1427. doi:
10.1002/ps.6758. [PMID: 34908221] - Elena A Golysheva, Natalya A Maslennikova, Denis S Baranov, Sergei A Dzuba. Structural properties of supercooled deep eutectic solvents: choline chloride-thiourea compared to reline.
Physical chemistry chemical physics : PCCP.
2022 Mar; 24(10):5974-5981. doi:
10.1039/d1cp05162h. [PMID: 35199802] - Gregory F Grawe, Katia M Oliveira, Celisnolia M Leite, Tamires D de Oliveira, João Honorato, Antonio G Ferreira, Eduardo E Castellano, Marcia R Cominetti, Rodrigo S Correa, Alzir A Batista. Ruthenium(II)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers.
Dalton transactions (Cambridge, England : 2003).
2022 Jan; 51(4):1489-1501. doi:
10.1039/d1dt02851k. [PMID: 34989381] - Zikai Liu, Qing Cheng, Xiaoli Ma, Mingke Song. Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells.
International journal of molecular sciences.
2022 Jan; 23(2):. doi:
10.3390/ijms23020901. [PMID: 35055084] - Nicole H Lopez, Biaoru Li, Chithra Palani, Umapathy Siddaramappa, Mayuko Takezaki, Hongyan Xu, Wenbo Zhi, Betty S Pace. Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice.
PloS one.
2022; 17(5):e0261799. doi:
10.1371/journal.pone.0261799. [PMID: 35639781] - Ilaria Fraudentali, Chiara Pedalino, Paraskevi Tavladoraki, Riccardo Angelini, Alessandra Cona. A New Player in Jasmonate-Mediated Stomatal Closure: The Arabidopsis thaliana Copper Amine Oxidase β.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123399. [PMID: 34943906] - Rachakunta Munikishore, Liang-Liang Wang, Shuqun Zhang, Qin-Shi Zhao, Zhili Zuo. An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94.
Bioorganic chemistry.
2021 11; 116(?):105317. doi:
10.1016/j.bioorg.2021.105317. [PMID: 34488126] - Laura Micheli, Mariaconcetta Durante, Elena Lucarini, Silvia Sgambellone, Laura Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini. The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4+ T Cells.
Biomolecules.
2021 10; 11(10):. doi:
10.3390/biom11101447. [PMID: 34680083] - Deepa R Parmar, Jigar Y Soni, Ramakrishna Guduru, Rahul H Rayani, Rakesh V Kusurkar, Anand G Vala, Sahista N Talukdar, Ibrahim H Eissa, Ahmed M Metwaly, Ahmed Khalil, Vishwanath Zunjar, Satyanarayana Battula. Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies.
Bioorganic chemistry.
2021 10; 115(?):105206. doi:
10.1016/j.bioorg.2021.105206. [PMID: 34339975] - Naznin Ahmed, Khussboo Rahman, Mira Rahman, Khadeja Sultana Sathi, Md Mahabub Alam, Kamrun Nahar, Md Shahidul Islam, Mirza Hasanuzzaman. Insight into the thiourea-induced drought tolerance in two chickpea varieties: Regulation of osmoprotection, reactive oxygen species metabolism and glyoxalase system.
Plant physiology and biochemistry : PPB.
2021 Oct; 167(?):449-458. doi:
10.1016/j.plaphy.2021.08.020. [PMID: 34411784] - Tianhui Yang, Ruyi He, Gongzhe Li, Jia Liang, Liang Zhao, Xing Zhao, Liyang Li, Peng Wang. Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Neuroscience letters.
2021 07; 758(?):136004. doi:
10.1016/j.neulet.2021.136004. [PMID: 34098025] - Na Gan, Qiaomei Sun, Zili Suo, Shuangshuang Zhang, Ludan Zhao, Hongzhao Xiang, Wenjing Wang, Zhiqiang Li, Xiaoxiang Liao, Hui Li. How hydrophilic group affects drug-protein binding modes: Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin.
Journal of pharmaceutical and biomedical analysis.
2021 Jul; 201(?):114121. doi:
10.1016/j.jpba.2021.114121. [PMID: 34020341] - Natasha P Murphy, Helen R Mott, Darerca Owen. Progress in the therapeutic inhibition of Cdc42 signalling.
Biochemical Society transactions.
2021 06; 49(3):1443-1456. doi:
10.1042/bst20210112. [PMID: 34100887] - Xiang-Ke Chen, Joseph Shiu-Kwong Kwan, Raymond Chuen-Chung Chang, Alvin Chun-Hang Ma. 1-phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos.
Autophagy.
2021 05; 17(5):1222-1231. doi:
10.1080/15548627.2020.1755119. [PMID: 32286915] - S J Jenepha Mary, Sayantan Pradhan, C James. Molecular structure, NBO analysis of the hydrogen-bonded interactions, spectroscopic (FT-IR, FT-Raman), drug likeness and molecular docking of the novel anti COVID-2 molecule (2E)-N-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]-hydrazinecarbothioamide (Dimer) - quantum chemical approach.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Apr; 251(?):119388. doi:
10.1016/j.saa.2020.119388. [PMID: 33503560] - Munish Kumar Upadhyay, Arnab Majumdar, Anil Barla, Sutapa Bose, Sudhakar Srivastava. Thiourea supplementation mediated reduction of grain arsenic in rice (Oryza sativa L.) cultivars: A two year field study.
Journal of hazardous materials.
2021 04; 407(?):124368. doi:
10.1016/j.jhazmat.2020.124368. [PMID: 33153787] - Nasima Arshad, Aamer Saeed, Fouzia Perveen, Rabail Ujan, Shahid I Farooqi, Pervaiz Ali Channar, Ghulam Shabir, Hesham R El-Seedi, Aneela Javed, Maham Yamin, Michael Bolte, Tuncer Hökelek. Synthesis, X-ray, Hirshfeld surface analysis, exploration of DNA binding, urease enzyme inhibition and anticancer activities of novel adamantane-naphthyl thiourea conjugate.
Bioorganic chemistry.
2021 04; 109(?):104707. doi:
10.1016/j.bioorg.2021.104707. [PMID: 33639362] - Yu Xiao, Lulu Zhang, Heting Zhang, Hongyu Feng, Zhe Li, Huiping Chen. Interaction between endogenous H2O2 and OsVPE3 in the GA-induced PCD of rice aleurone layers.
Plant cell reports.
2021 Apr; 40(4):691-705. doi:
10.1007/s00299-021-02665-w. [PMID: 33559721] - Jan Madacki, Martin Kopál, Mary Jackson, Jana Korduláková. Mycobacterial Epoxide Hydrolase EphD Is Inhibited by Urea and Thiourea Derivatives.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062884. [PMID: 33809178] - Jia-Hui Li, Yan Wang, Yun-Peng Wu, Ran-Hong Li, Shuang Liang, Jing Zhang, Yong-Gang Zhu, Bei-Jie Xie. Synthesis, herbicidal activity study and molecular docking of novel pyrimidine thiourea.
Pesticide biochemistry and physiology.
2021 Feb; 172(?):104766. doi:
10.1016/j.pestbp.2020.104766. [PMID: 33518053] - Nida Mansoora, Shameem Kausar, Syeda Fasiha Amjad, Samia Yaseen, Huma Shahid, Khadija Tul Kubra, Saad A M Alamri, Sulaiman A Alrumman, Ebrahem M Eid, Ghulam Mustafa, Saleha Ahmed Ali, Subhan Danish. Application of sewage sludge combined with thiourea improves the growth and yield attributes of wheat (Triticum aestivum L.) genotypes under arsenic-contaminated soil.
PloS one.
2021; 16(11):e0259289. doi:
10.1371/journal.pone.0259289. [PMID: 34735516] - Jie Li, Xinle Li, Daquan Liu, Shiqi Zhang, Nian Tan, Hiroki Yokota, Ping Zhang. Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner.
Cell death & disease.
2020 12; 11(12):1069. doi:
10.1038/s41419-020-03264-5. [PMID: 33318479] - Sourish Ghosh, Teegan A Dellibovi-Ragheb, Adeline Kerviel, Eowyn Pak, Qi Qiu, Matthew Fisher, Peter M Takvorian, Christopher Bleck, Victor W Hsu, Anthony R Fehr, Stanley Perlman, Sooraj R Achar, Marco R Straus, Gary R Whittaker, Cornelis A M de Haan, John Kehrl, Grégoire Altan-Bonnet, Nihal Altan-Bonnet. β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Cell.
2020 12; 183(6):1520-1535.e14. doi:
10.1016/j.cell.2020.10.039. [PMID: 33157038] - Asli Emincik, Zeynep Banu Gungor, Elif Guzel. Effects of salubrinal on ER stress in an experimental model of polycystic ovary syndrome.
Ultrastructural pathology.
2020 Nov; 44(4-6):422-435. doi:
10.1080/01913123.2020.1850963. [PMID: 33393432] - X Wang, J Zhang, J Song, M Huang, J Cai, Q Zhou, T Dai, D Jiang. Abscisic acid and hydrogen peroxide are involved in drought priming-induced drought tolerance in wheat (Triticum aestivum L.).
Plant biology (Stuttgart, Germany).
2020 Nov; 22(6):1113-1122. doi:
10.1111/plb.13143. [PMID: 32530558] - Оlesya V Pokidova, Victor B Luzhkov, Nina S Emel'yanova, Vladimir B Krapivin, Alexander I Kotelnikov, Natalia A Sanina, Sergey M Aldoshin. Effect of albumin on the transformation of dinitrosyl iron complexes with thiourea ligands.
Dalton transactions (Cambridge, England : 2003).
2020 Sep; 49(36):12674-12685. doi:
10.1039/d0dt02452j. [PMID: 32959848] - Ming-Shun Mei, Yu-Hui Wang, Qing Hu, Qing-Hua Li, Da-Yu Shi, Dingding Gao, Guangbo Ge, Guo-Qiang Lin, Ping Tian. Enantioselective [3+2] annulation of isatin-derived MBH-carbonates and 3-nitroindoles enabled by a bifunctional DMAP-thiourea.
Chemical communications (Cambridge, England).
2020 Sep; 56(73):10718-10721. doi:
10.1039/d0cc04462h. [PMID: 32789367] - Peterson Anand, Alan G S Harper. Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation.
Cell calcium.
2020 09; 90(?):102248. doi:
10.1016/j.ceca.2020.102248. [PMID: 32629299] - Stephen Shrum, Julia Tobacyk, Sorena Lo, Nirmala Parajuli, Lee Ann MacMillan-Crow. The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury.
Archives of biochemistry and biophysics.
2020 07; 688(?):108410. doi:
10.1016/j.abb.2020.108410. [PMID: 32446891] - Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta. The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.
Metallomics : integrated biometal science.
2020 06; 12(6):891-901. doi:
10.1039/d0mt00006j. [PMID: 32337526] - Heba E Hashem, Abd El-Galil E Amr, Eman S Nossier, Elsayed A Elsayed, Eman M Azmy. Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors.
Molecules (Basel, Switzerland).
2020 Jun; 25(12):. doi:
10.3390/molecules25122766. [PMID: 32549386] - Mengmeng Han, Baoyuan Wang, Guilong Song, Shengqing Shi. Comparative study of alleviation effects of DMTU and PCIB on root growth inhibition in two tall fescue varieties under cadmium stress.
Ecotoxicology and environmental safety.
2020 Jun; 196(?):110528. doi:
10.1016/j.ecoenv.2020.110528. [PMID: 32240865] - Thea Bismo Strøm, Katrine Bjune, Trond P Leren. Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional.
Human molecular genetics.
2020 05; 29(8):1229-1238. doi:
10.1093/hmg/ddz238. [PMID: 31600776] - Lijuan Liu, Lin Huang, Xianyong Lin, Chengliang Sun. Hydrogen peroxide alleviates salinity-induced damage through enhancing proline accumulation in wheat seedlings.
Plant cell reports.
2020 May; 39(5):567-575. doi:
10.1007/s00299-020-02513-3. [PMID: 32025801] - Stefan G Kathman, Julia Boshart, Hui Jing, Benjamin F Cravatt. Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells.
ACS chemical biology.
2020 04; 15(4):871-877. doi:
10.1021/acschembio.0c00086. [PMID: 32195565] - Beatriz N Cunha, Liany Luna-Dulcey, Ana M Plutin, Rafael G Silveira, João Honorato, Raúl R Cairo, Tamires D de Oliveira, Marcia R Cominetti, Eduardo E Castellano, Alzir A Batista. Selective Coordination Mode of Acylthiourea Ligands in Half-Sandwich Ru(II) Complexes and Their Cytotoxic Evaluation.
Inorganic chemistry.
2020 Apr; 59(7):5072-5085. doi:
10.1021/acs.inorgchem.0c00319. [PMID: 32208661] - Xiao Du, Shilan Zhang, Qunyan Xiang, Jingyuan Chen, Feng Tian, Jin Xu, Xin Li, Yuansheng Tan, Ling Liu. The Role of a Selective P2Y6 Receptor Antagonist, MRS2578, on the Formation of Angiotensin II-Induced Abdominal Aortic Aneurysms.
BioMed research international.
2020; 2020(?):1983940. doi:
10.1155/2020/1983940. [PMID: 32382533] - Hong-Li Guo, Shuo Zhang, Christopher North, Min Zhang, Xiao-Xia Meng, Xiu-Li Gao. Alkyl Thiourea Functionalised Silica for the Effective Removal of Heavy Metals from Acanthopanax senticosus Extract.
BioMed research international.
2020; 2020(?):9860425. doi:
10.1155/2020/9860425. [PMID: 32309445] - Stephen Shrum, Nancy J Rusch, Lee Ann MacMillan-Crow. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro.
Biomolecules.
2019 12; 9(12):. doi:
10.3390/biom9120825. [PMID: 31817165] - Mianli Bian, Jianlin He, Huanhuan Jin, Naqi Lian, Jiangjuan Shao, Qinglong Guo, Shijun Wang, Feng Zhang, Shizhong Zheng. Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress.
Apoptosis : an international journal on programmed cell death.
2019 12; 24(11-12):905-920. doi:
10.1007/s10495-019-01568-2. [PMID: 31538267] - Raja Solomon Viswas, Sheetal Pundir, Hoyun Lee. Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach.
Journal of enzyme inhibition and medicinal chemistry.
2019 Dec; 34(1):620-630. doi:
10.1080/14756366.2019.1571055. [PMID: 30727782] - Yunfei Shi, Hongyan Si, Peng Wang, Shangxing Chen, Shibin Shang, Zhanqian Song, Zongde Wang, Shengliang Liao. Derivatization of Natural Compound β-Pinene Enhances Its In Vitro Antifungal Activity against Plant Pathogens.
Molecules (Basel, Switzerland).
2019 Aug; 24(17):. doi:
10.3390/molecules24173144. [PMID: 31470567] - Maria Talmon, Silvia Rossi, Dmitry Lim, Federica Pollastro, Gioele Palattella, Federico A Ruffinatti, Patrizia Marotta, Renzo Boldorini, Armando A Genazzani, Luigia G Fresu. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event.
The Journal of biological chemistry.
2019 08; 294(33):12472-12482. doi:
10.1074/jbc.ra119.007763. [PMID: 31248983] - Hamad Ali, Fizza Iftikhar, Sarah Shafi, Hina Siddiqui, Ishtiaq Ahmad Khan, M Iqbal Choudhary, Syed Ghulam Musharraf. Thiourea derivatives induce fetal hemoglobin production in-vitro: A new class of potential therapeutic agents for β-thalassemia.
European journal of pharmacology.
2019 Jul; 855(?):285-293. doi:
10.1016/j.ejphar.2019.05.027. [PMID: 31100414] - Arleta Rifati Nixha, Adem Ergun, Nahit Gencer, Oktay Arslan, Mustafa Arslan. Development of carbazole-bearing pyridopyrimidine-substituted urea/thiourea as polyphenol oxidase inhibitors: synthesis, biochemistry, and theoretical studies.
Archives of physiology and biochemistry.
2019 Jul; 125(3):263-269. doi:
10.1080/13813455.2018.1453523. [PMID: 29569496] - Linlin Wang, Ye Wang, Zhang Lei. Chrysin ameliorates ANTU-induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs.
Journal of biochemical and molecular toxicology.
2019 Jul; 33(7):e22332. doi:
10.1002/jbt.22332. [PMID: 30974023] - Chantal Massé, Yves Berthiaume. Effect of adrenalectomy on pulmonary edema resolution.
Clinical and investigative medicine. Medecine clinique et experimentale.
2019 06; 42(2):E33-37. doi:
10.25011/cim.v42i2.32814. [PMID: 31228963] - Kazunori Aoi, Akiyoshi Nishio, Takashi Okazaki, Masahiro Takeo, Masataka Masuda, Toshiro Fukui, Kazushige Uchida, Kazuichi Okazaki. Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2019 Jun; 19(4):548-556. doi:
10.1016/j.pan.2019.04.005. [PMID: 31040063] - Nancy L Benner, Rebecca L McClellan, Christopher R Turlington, Ole A W Haabeth, Robert M Waymouth, Paul A Wender. Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery.
Journal of the American Chemical Society.
2019 05; 141(21):8416-8421. doi:
10.1021/jacs.9b03154. [PMID: 31083999] - Lesly-Anne Samedy, Gina J Ryan, Robert H Superko, Kathryn M Momary. CETP genotype and concentrations of HDL and lipoprotein subclasses in African-American men.
Future cardiology.
2019 05; 15(3):187-195. doi:
10.2217/fca-2018-0058. [PMID: 31148465] - Laura A Jowett, Angela Ricci, Xin Wu, Ethan N W Howe, Philip A Gale. Investigating the Influence of Steric Hindrance on Selective Anion Transport.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071278. [PMID: 30986928] - Xiaowei Song, Guanghai Yan, Songshi Quan, Enhao Jin, Jishan Quan, Guangyu Jin. MRI-visible liposome-polyethylenimine complexes for DNA delivery: preparation and evaluation.
Bioscience, biotechnology, and biochemistry.
2019 Apr; 83(4):622-632. doi:
10.1080/09168451.2018.1562875. [PMID: 30585119] - Yingying Zhao, Yihua Zhang, Feijie Liu, Ren Wang, Liqin Huang, Wenbiao Shen. Hydrogen peroxide is involved in methane-induced tomato lateral root formation.
Plant cell reports.
2019 Mar; 38(3):377-389. doi:
10.1007/s00299-019-02372-7. [PMID: 30617541] - Kanwal, Majid Khan, Arshia, Khalid Mohammed Khan, Shahnaz Parveen, Muniza Shaikh, Narjis Fatima, M Iqbal Choudhary. Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies.
Bioorganic chemistry.
2019 03; 83(?):595-610. doi:
10.1016/j.bioorg.2018.10.070. [PMID: 30513472] - Nino Trattnig, Patrick Mayrhofer, Renate Kunert, Lukas Mach, Ralph Pantophlet, Paul Kosma. Comparative Antigenicity of Thiourea and Adipic Amide Linked Neoglycoconjugates Containing Modified Oligomannose Epitopes for the Carbohydrate-Specific anti-HIV Antibody 2G12.
Bioconjugate chemistry.
2019 01; 30(1):70-82. doi:
10.1021/acs.bioconjchem.8b00731. [PMID: 30525492] - Muhammad Arfan, Da-Wei Zhang, Li-Juan Zou, Shi-Shuai Luo, Wen-Rong Tan, Tong Zhu, Hong-Hui Lin. Hydrogen Peroxide and Nitric Oxide Crosstalk Mediates Brassinosteroids Induced Cold Stress Tolerance in Medicago truncatula.
International journal of molecular sciences.
2019 Jan; 20(1):. doi:
10.3390/ijms20010144. [PMID: 30609774] - Jiang Bian, Ying Zhang, Yan Liu, Qun Li, Hai-Bin Tang, Qing Liu. P2Y6 Receptor-Mediated Spinal Microglial Activation in Neuropathic Pain.
Pain research & management.
2019; 2019(?):2612534. doi:
10.1155/2019/2612534. [PMID: 31281556] - Dmitry A Sibarov, Ekaterina E Poguzhelskaya, Sergei M Antonov. Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol.
BMC neuroscience.
2018 Nov; 19(1):73. doi:
10.1186/s12868-018-0475-3. [PMID: 30419823] - Sheng-Fan Wang, Chih-Hsuan Wung, Meng-Shian Chen, Chian-Feng Chen, Pen-Hui Yin, Tien-Shun Yeh, Yuh-Lih Chang, Yueh-Ching Chou, Hung-Hsu Hung, Hsin-Chen Lee. Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
International journal of molecular sciences.
2018 Oct; 19(11):. doi:
10.3390/ijms19113389. [PMID: 30380689] - Gülay Akyüz, Emre Menteşe, Mustafa Emirik, Nimet Baltaş. Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease.
Bioorganic chemistry.
2018 10; 80(?):121-128. doi:
10.1016/j.bioorg.2018.06.011. [PMID: 29894891] - Junbo Zheng, Yongbo Huang, Diana Islam, Xiao-Yan Wen, Sulong Wu, Catherine Streutker, Alice Luo, Manshu Li, Julie Khang, Bing Han, Nanshan Zhong, Yimin Li, Kaijiang Yu, Haibo Zhang. Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury.
Respiratory research.
2018 Sep; 19(1):190. doi:
10.1186/s12931-018-0869-x. [PMID: 30268129] - Shuo Li, Jiafang Li, Nan Wang, Gaixiang Hao, Jinsheng Sun. Characterization of UDP-Activated Purinergic Receptor P2Y₆ Involved in Japanese Flounder Paralichthys olivaceus Innate Immunity.
International journal of molecular sciences.
2018 Jul; 19(7):. doi:
10.3390/ijms19072095. [PMID: 30029501] - Saman Khan, Atif Zafar, Imrana Naseem. Copper-redox cycling by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated DNA damage and apoptosis: A mechanism for cancer chemoprevention.
Chemico-biological interactions.
2018 Jun; 290(?):64-76. doi:
10.1016/j.cbi.2018.05.010. [PMID: 29803612] - Bei Liu, Bin Zhang, Shiliang Huang, Lixia Yang, Carolyn M Roos, Michael A Thompson, Y S Prakash, Jie Zang, Jordan D Miller, Ruiwei Guo. Ca2+ Entry Through Reverse Mode Na+/Ca2+ Exchanger Contributes to Store Operated Channel-Mediated Neointima Formation After Arterial Injury.
The Canadian journal of cardiology.
2018 06; 34(6):791-799. doi:
10.1016/j.cjca.2018.01.012. [PMID: 29705161] - Roberto Biondi, Stefano Brancorsini, Giulia Poli, Maria Giulia Egidi, Enrico Capodicasa, Livio Bottiglieri, Sandro Gerli, Eleonora Brillo, Gian Carlo Di Renzo, Dragos Cretoiu, Romeo Micu, Nicolae Suciu. Detection and scavenging of hydroxyl radical via D-phenylalanine hydroxylation in human fluids.
Talanta.
2018 May; 181(?):172-181. doi:
10.1016/j.talanta.2017.12.084. [PMID: 29426497] - Xiaohui Wang, Xianjuan Dong, Yingying Feng, Xiao Liu, Jinling Wang, Zhongxiu Zhang, Jun Li, Yunfang Zhao, Shepo Shi, Pengfei Tu. H2O2 and NADPH oxidases involve in regulation of 2-(2-phenylethyl)chromones accumulation during salt stress in Aquilaria sinensis calli.
Plant science : an international journal of experimental plant biology.
2018 Apr; 269(?):1-11. doi:
10.1016/j.plantsci.2018.01.002. [PMID: 29606206] - Q M Chen, Y Yu, C M Lin, N Cui, J Y Zhao, T F Song, H Y Fan. Glucohexaose-induced protein phosphatase 2C regulates cell redox status of cucumber seedling.
Journal of biosciences.
2018 Mar; 43(1):117-126. doi:
10.1007/s12038-018-9738-5. [PMID: 29485120] - Tanzeela Abdul Fattah, Aamer Saeed, Pervaiz Ali Channar, Zaman Ashraf, Qamar Abbas, Mubashir Hassan, Fayaz Ali Larik. Synthesis, enzyme inhibitory kinetics, and computational studies of novel 1-(2-(4-isobutylphenyl) propanoyl)-3-arylthioureas as Jack bean urease inhibitors.
Chemical biology & drug design.
2018 02; 91(2):434-447. doi:
10.1111/cbdd.13090. [PMID: 28834266] - Elvia Mena-Avila, Ricardo Márquez-Gómez, Guillermo Aquino-Miranda, Gustavo Nieto-Alamilla, José-Antonio Arias-Montaño. Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes.
Pharmacological reports : PR.
2018 Feb; 70(1):146-155. doi:
10.1016/j.pharep.2017.08.007. [PMID: 29414147] - Mahmoud F Seleiman, Ahmed M S Kheir. Saline soil properties, quality and productivity of wheat grown with bagasse ash and thiourea in different climatic zones.
Chemosphere.
2018 Feb; 193(?):538-546. doi:
10.1016/j.chemosphere.2017.11.053. [PMID: 29169129] - Chao Ji, Bo Yang, Shu-Ying Huang, Jin-Wen Huang, Bo Cheng. Salubrinal protects human skin fibroblasts against UVB-induced cell death by blocking endoplasmic reticulum (ER) stress and regulating calcium homeostasis.
Biochemical and biophysical research communications.
2017 12; 493(4):1371-1376. doi:
10.1016/j.bbrc.2017.10.012. [PMID: 28988108] - Ji-Jun Huang, Yi-Jie Wang, Min Zhang, Peng Zhang, He Liang, Hua-Jun Bai, Xiu-Jian Yu, Huang-Tian Yang. Functional expression of the Ca2+ signaling machinery in human embryonic stem cells.
Acta pharmacologica Sinica.
2017 Dec; 38(12):1663-1672. doi:
10.1038/aps.2017.29. [PMID: 28713161] - Ziwei Huang, Min Zhou, Qian Wang, Mengjiao Zhu, Sheng Chen, Huang Li. Mechanical and hypoxia stress can cause chondrocytes apoptosis through over-activation of endoplasmic reticulum stress.
Archives of oral biology.
2017 Dec; 84(?):125-132. doi:
10.1016/j.archoralbio.2017.09.021. [PMID: 28987725] - Pradeep Sherkhane, Josef P Kapfhammer. Chronic pharmacological blockade of the Na+ /Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures.
The European journal of neuroscience.
2017 Sep; 46(5):2108-2120. doi:
10.1111/ejn.13649. [PMID: 28715135] - Daquan Liu, Yunlong Zhang, Xinle Li, Jie Li, Shuang Yang, Xiaoxue Xing, Guanwei Fan, Hiroki Yokota, Ping Zhang. eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress.
Scientific reports.
2017 07; 7(1):5062. doi:
10.1038/s41598-017-05488-6. [PMID: 28698612] - Min Zhu, Meixue Zhou, Lana Shabala, Sergey Shabala. Physiological and molecular mechanisms mediating xylem Na+ loading in barley in the context of salinity stress tolerance.
Plant, cell & environment.
2017 Jul; 40(7):1009-1020. doi:
10.1111/pce.12727. [PMID: 26881809] - Yoshiji Ohta, Koji Yashiro, Takashi Kobayashi, Kazuo Inui, Junji Yoshino. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats.
Fundamental & clinical pharmacology.
2017 Jun; 31(3):319-328. doi:
10.1111/fcp.12268. [PMID: 28107553] - Yaning Chang, Jingwei Zhang, Xiulei Chen, Zhong Li, Xiaoyong Xu. Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita.
Bioorganic & medicinal chemistry letters.
2017 06; 27(11):2641-2644. doi:
10.1016/j.bmcl.2016.12.065. [PMID: 28434762] - Lamya H Al-Wahaibi, Hanan M Hassan, Amal M Abo-Kamar, Hazem A Ghabbour, Ali A El-Emam. Adamantane-Isothiourea Hybrid Derivatives: Synthesis, Characterization, In Vitro Antimicrobial, and In Vivo Hypoglycemic Activities.
Molecules (Basel, Switzerland).
2017 Apr; 22(5):. doi:
10.3390/molecules22050710. [PMID: 28468231] - Ashish Kumar Srivastava, Gaurav Sablok, Michael Hackenberg, Uday Deshpande, Penna Suprasanna. Thiourea priming enhances salt tolerance through co-ordinated regulation of microRNAs and hormones in Brassica juncea.
Scientific reports.
2017 04; 7(?):45490. doi:
10.1038/srep45490. [PMID: 28382938] - Muhammad Ahmed Waqas, Imran Khan, Muhammad Javaid Akhter, Mehmood Ali Noor, Umair Ashraf. Exogenous application of plant growth regulators (PGRs) induces chilling tolerance in short-duration hybrid maize.
Environmental science and pollution research international.
2017 Apr; 24(12):11459-11471. doi:
10.1007/s11356-017-8768-0. [PMID: 28316047] - Wenbo Li, Randy F Lacey, Yajin Ye, Juan Lu, Kuo-Chen Yeh, Youli Xiao, Laigeng Li, Chi-Kuang Wen, Brad M Binder, Yang Zhao. Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1.
PLoS genetics.
2017 04; 13(4):e1006703. doi:
10.1371/journal.pgen.1006703. [PMID: 28388654] - Moustafa T Gabr, Nadia S El-Gohary, Eman R El-Bendary, Mohamed M El-Kerdawy, Nanting Ni. Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship.
European journal of medicinal chemistry.
2017 Mar; 128(?):36-44. doi:
10.1016/j.ejmech.2017.01.030. [PMID: 28147307] - Yue Zhang, Xiang Gao, Shuanggang Chen, Min Zhao, Jing Chen, Rui Liu, Shengyang Cheng, Mengyuan Qi, Shuo Wang, Wei Liu. Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy.
Cellular signalling.
2017 02; 31(?):31-40. doi:
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