Nocodazole (BioDeep_00000009530)
Secondary id: BioDeep_00000858503
human metabolite blood metabolite
代谢物信息卡片
(5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester
化学式: C14H11N3O3S (301.0521)
中文名称: 诺考达唑
谱图信息:
最多检出来源 Homo sapiens(blood) 5.86%
分子结构信息
SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
InChI: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
Same as: D05197
同义名列表
19 个代谢物同义名
(5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester; methyl N-[6-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl]carbamate; (5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate methyl ester; Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamic acid; N-(5-(2-Thienoyl)-2-benzimidazolyl)carbamic acid methyl ester; Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate; N-(5-(2-Thenoyl)-2-benzimidazolyl)carbamic acid methyl ester; N-(5-(2-Thienoyl)-2-benzimidazolyl)carbamate methyl ester; N-(5-(2-Thenoyl)-2-benzimidazolyl)carbamate methyl ester; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamic acid; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate; Nocodazolum; Oncodazole; nocodazole; Nocodazol; R-17934; R17,934; R 17934; Nocodazole
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:34892
- KEGG: C13719
- PubChem: 4122
- HMDB: HMDB0255688
- Metlin: METLIN69657
- DrugBank: DB08313
- ChEMBL: CHEMBL9514
- Wikipedia: Nocodazole
- MeSH: Nocodazole
- chemspider: 3979
- CAS: 31430-18-9
- PMhub: MS000023323
- PubChem: 586308
- PDB-CCD: NW6
- PDB-CCD: NZO
- NIKKAJI: J20.370J
- KNApSAcK: 34892
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoshiyuki Ozono, Atsushi Tamura, Shogo Nakayama, Elisa Herawati, Yukiko Hanada, Kazuya Ohata, Maki Takagishi, Masahide Takahashi, Takao Imai, Yumi Ohta, Kazuo Oshima, Takashi Sato, Hidenori Inohara, Sachiko Tsukita. Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules.
Scientific reports.
2021 10; 11(1):20224. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2013 Feb; 110(7):2546-51. doi:
10.1073/pnas.1216182110. [PMID: 23359699] - Stefano Coppola, Francesco Cardarelli, Daniela Pozzi, Laura C Estrada, Michelle A Digman, Enrico Gratton, Angelo Bifone, Carlotta Marianecci, Giulio Caracciolo. The role of cytoskeleton networks on lipid-mediated delivery of DNA.
Therapeutic delivery.
2013 Feb; 4(2):191-202. doi:
10.4155/tde.12.151. [PMID: 23343159] - Mallikarjun Patil, Navjotsingh Pabla, Shuang Huang, Zheng Dong. Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.
Cell cycle (Georgetown, Tex.).
2013 Jan; 12(1):166-71. doi:
10.4161/cc.23053. [PMID: 23255108] - Cody Kelley, Yongzheng Zhang, Ajit Parhi, Malvika Kaul, Daniel S Pilch, Edmond J LaVoie. 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
Bioorganic & medicinal chemistry.
2012 Dec; 20(24):7012-29. doi:
10.1016/j.bmc.2012.10.009. [PMID: 23127490] - Krishna P Kota, Jacqueline G Benko, Rajini Mudhasani, Cary Retterer, Julie P Tran, Sina Bavari, Rekha G Panchal. High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection.
Viruses.
2012 Sep; 4(10):1865-77. doi:
10.3390/v4101865. [PMID: 23202445] - Noriaki Satoh, Yumiko Toyohira, Hideaki Itoh, Han Zhang, Susumu Ueno, Masato Tsutsui, Kojiro Takahashi, Nobuyuki Yanagihara. Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2012 Sep; 385(9):921-31. doi:
10.1007/s00210-012-0773-8. [PMID: 22752240] - Aurora Irene Idilli, Elisabetta Onelli, Alessandra Moscatelli. Low concentration of LatB dramatically changes the microtubule organization and the timing of vegetative nucleus/generative cell entrance in tobacco pollen tubes.
Plant signaling & behavior.
2012 Aug; 7(8):947-50. doi:
10.4161/psb.20907. [PMID: 22827942] - Verena Schwartz, Alexander Krüttgen, Joachim Weis, Christian Weber, Tammo Ostendorf, Hongqi Lue, Jürgen Bernhagen. Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF.
European journal of cell biology.
2012 Jun; 91(6-7):435-49. doi:
10.1016/j.ejcb.2011.08.006. [PMID: 22014447] - Tiffany M Scharadin, Haibing Jiang, Stuart Martin, Richard L Eckert. TIG3 interaction at the centrosome alters microtubule distribution and centrosome function.
Journal of cell science.
2012 Jun; 125(Pt 11):2604-14. doi:
10.1242/jcs.096495. [PMID: 22427689] - Anna-Leena Salmela, Jeroen Pouwels, Anu Kukkonen-Macchi, Sinikka Waris, Pauliina Toivonen, Kimmo Jaakkola, Jenni Mäki-Jouppila, Lila Kallio, Marko J Kallio. The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.
Experimental cell research.
2012 Mar; 318(5):578-92. doi:
10.1016/j.yexcr.2011.12.014. [PMID: 22227008] - Irina Akopova, Sabina Tatur, Mariusz Grygorczyk, Rafał Luchowski, Ignacy Gryczynski, Zygmunt Gryczynski, Julian Borejdo, Ryszard Grygorczyk. Imaging exocytosis of ATP-containing vesicles with TIRF microscopy in lung epithelial A549 cells.
Purinergic signalling.
2012 Mar; 8(1):59-70. doi:
10.1007/s11302-011-9259-2. [PMID: 21881960] - Eleonora Fridman, David Lichtstein, Haim Rosen. Formation of new high density glycogen-microtubule structures is induced by cardiac steroids.
The Journal of biological chemistry.
2012 Feb; 287(9):6518-29. doi:
10.1074/jbc.m111.273698. [PMID: 22228762] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, Susanna R Keller, John J Gildea, Robert M Carey. Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):437-45. doi:
10.1161/hypertensionaha.111.184788. [PMID: 22203736] - Kyu-Sang Park, Andreas Wiederkehr, Claes B Wollheim. Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Feb; 16(1):71-7. doi:
10.4196/kjpp.2012.16.1.71. [PMID: 22416223] - Cho Rong Han, Do Youn Jun, Hyun Ju Woo, Su-Yang Jeong, Mi-Hee Woo, Young Ho Kim. Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus.
Bioorganic & medicinal chemistry letters.
2012 Jan; 22(2):945-53. doi:
10.1016/j.bmcl.2011.12.023. [PMID: 22197393] - Takeshi Terabayashi, Masaji Sakaguchi, Kaori Shinmyozu, Toshio Ohshima, Ai Johjima, Teru Ogura, Hiroaki Miki, Ryuichi Nishinakamura. Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
PloS one.
2012; 7(6):e39714. doi:
10.1371/journal.pone.0039714. [PMID: 22768111] - Fawaz G Haj, Ola Sabet, Ali Kinkhabwala, Sabine Wimmer-Kleikamp, Vassilis Roukos, Hong-Mei Han, Markus Grabenbauer, Martin Bierbaum, Claude Antony, Benjamin G Neel, Philippe I Bastiaens. Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
PloS one.
2012; 7(5):e36633. doi:
10.1371/journal.pone.0036633. [PMID: 22655028] - Kelly E Coller, Nicholas S Heaton, Kristi L Berger, Jacob D Cooper, Jessica L Saunders, Glenn Randall. Molecular determinants and dynamics of hepatitis C virus secretion.
PLoS pathogens.
2012 Jan; 8(1):e1002466. doi:
10.1371/journal.ppat.1002466. [PMID: 22241992] - Weiming Yang, Malcolm A McCrae. The rotavirus enterotoxin (NSP4) promotes re-modeling of the intracellular microtubule network.
Virus research.
2012 Jan; 163(1):269-74. doi:
10.1016/j.virusres.2011.10.011. [PMID: 22036730] - Wei Liu, Lucy X Fan, Xia Zhou, William E Sweeney, Ellis D Avner, Xiaogang Li. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.
PloS one.
2012; 7(11):e49418. doi:
10.1371/journal.pone.0049418. [PMID: 23152903] - Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager. Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation.
PloS one.
2012; 7(4):e34945. doi:
10.1371/journal.pone.0034945. [PMID: 22536341] - Ana Guzman-Aranguez, Ashley M Woodward, Jesús Pintor, Pablo Argüeso. Targeted disruption of core 1 β1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes.
PloS one.
2012; 7(5):e36628. doi:
10.1371/journal.pone.0036628. [PMID: 22574202] - Flora De Conto, Enrica Di Lonardo, Maria Cristina Arcangeletti, Carlo Chezzi, Maria Cristina Medici, Adriana Calderaro. Highly dynamic microtubules improve the effectiveness of early stages of human influenza A/NWS/33 virus infection in LLC-MK2 cells.
PloS one.
2012; 7(7):e41207. doi:
10.1371/journal.pone.0041207. [PMID: 22911759] - Mario Schelhaas, Bhavin Shah, Michael Holzer, Peter Blattmann, Lena Kühling, Patricia M Day, John T Schiller, Ari Helenius. Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis.
PLoS pathogens.
2012; 8(4):e1002657. doi:
10.1371/journal.ppat.1002657. [PMID: 22536154] - William L Rice, Yan Zhang, Ying Chen, Toshiyuki Matsuzaki, Dennis Brown, Hua A Jenny Lu. Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells.
PloS one.
2012; 7(2):e32843. doi:
10.1371/journal.pone.0032843. [PMID: 22403603] - Stanton B Gelvin. Traversing the Cell: Agrobacterium T-DNA's Journey to the Host Genome.
Frontiers in plant science.
2012; 3(?):52. doi:
10.3389/fpls.2012.00052. [PMID: 22645590] - Dominik Filipp, Ondrej Ballek, Jasper Manning. Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement.
Frontiers in immunology.
2012; 3(?):155. doi:
10.3389/fimmu.2012.00155. [PMID: 22701458] - Shilin Cheung, Laura J Fick, Denise D Belsham, David A Lovejoy, Michael Thompson. Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation.
The Analyst.
2011 Nov; 136(21):4412-21. doi:
10.1039/c1an15534b. [PMID: 21866285] - Stephen Vadia, Eusondia Arnett, Anne-Cécile Haghighat, Elisabeth M Wilson-Kubalek, Rodney K Tweten, Stephanie Seveau. The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.
PLoS pathogens.
2011 Nov; 7(11):e1002356. doi:
10.1371/journal.ppat.1002356. [PMID: 22072970] - Elena Piccoli, Matteo Nadai, Carla Mucignat Caretta, Valeria Bergonzini, Claudia Del Vecchio, Huy Riem Ha, Laurent Bigler, Daniele Dal Zoppo, Elisabetta Faggin, Andrea Pettenazzo, Rocco Orlando, Cristiano Salata, Arianna Calistri, Giorgio Palù, Aldo Baritussio. Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Biochemical pharmacology.
2011 Nov; 82(9):1234-49. doi:
10.1016/j.bcp.2011.07.090. [PMID: 21878321] - Olivier Reynard, Kirill Nemirov, Audrey Page, Mathieu Mateo, Hervé Raoul, Winfried Weissenhorn, Viktor E Volchkov. Conserved proline-rich region of Ebola virus matrix protein VP40 is essential for plasma membrane targeting and virus-like particle release.
The Journal of infectious diseases.
2011 Nov; 204 Suppl 3(?):S884-91. doi:
10.1093/infdis/jir359. [PMID: 21987765] - Lin Sun, Dongshan Zhang, Fuyou Liu, Xudong Xiang, Guanghui Ling, Li Xiao, Yinghong Liu, Xuejing Zhu, Ming Zhan, Yeyi Yang, Vinay K Kondeti, Yashpal S Kanwar. Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192.
The Journal of pathology.
2011 Nov; 225(3):364-77. doi:
10.1002/path.2961. [PMID: 21984124] - Marina N Semenova, Alex S Kiselyov, Dmitry V Tsyganov, Leonid D Konyushkin, Sergei I Firgang, Roman V Semenov, Oleg R Malyshev, Mikhail M Raihstat, Fabian Fuchs, Anne Stielow, Margareta Lantow, Alex A Philchenkov, Michael P Zavelevich, Nikolay S Zefirov, Sergei A Kuznetsov, Victor V Semenov. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.
Journal of medicinal chemistry.
2011 Oct; 54(20):7138-49. doi:
10.1021/jm200737s. [PMID: 21916509] - Ying-Che Lu, Hong-Chen Chen. Involvement of lipid rafts in adhesion-induced activation of Met and EGFR.
Journal of biomedical science.
2011 Oct; 18(?):78. doi:
10.1186/1423-0127-18-78. [PMID: 22032640] - William J Chirico. Protein release through nonlethal oncotic pores as an alternative nonclassical secretory pathway.
BMC cell biology.
2011 Oct; 12(?):46. doi:
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The Journal of biological chemistry.
2011 Oct; 286(40):34761-9. doi:
10.1074/jbc.m111.219378. [PMID: 21693704] - Claudia Borrmann, Rolf Stricker, Georg Reiser. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1).
Cell and tissue research.
2011 Oct; 346(1):89-98. doi:
10.1007/s00441-011-1245-z. [PMID: 21972134] - Natalie A Counihan, Stephen M Rawlinson, Brett D Lindenbach. Trafficking of hepatitis C virus core protein during virus particle assembly.
PLoS pathogens.
2011 Oct; 7(10):e1002302. doi:
10.1371/journal.ppat.1002302. [PMID: 22028650] - T Zampolla, E Spikings, D Rawson, T Zhang. Cytoskeleton proteins F-actin and tubulin distribution and interaction with mitochondria in the granulosa cells surrounding stage III zebrafish (Danio rerio) oocytes.
Theriogenology.
2011 Oct; 76(6):1110-9. doi:
10.1016/j.theriogenology.2011.05.018. [PMID: 21752457] - Bénédicte Desforges, Philippe Savarin, Ouissame Bounedjah, Stéphanie Delga, Loïc Hamon, Patrick A Curmi, David Pastré. Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity.
American journal of physiology. Cell physiology.
2011 Sep; 301(3):C705-16. doi:
10.1152/ajpcell.00128.2011. [PMID: 21677260] - Cherilyn A Elwell, Shaobo Jiang, Jung Hwa Kim, Albert Lee, Torsten Wittmann, Kentaro Hanada, Paul Melancon, Joanne N Engel. Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.
PLoS pathogens.
2011 Sep; 7(9):e1002198. doi:
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