Tyrocidine (BioDeep_00000009056)
natural product
代谢物信息卡片
化学式: C66H87N13O13 (1269.6546)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
InChI: InChI=1S/C66H87N13O13/c1-38(2)32-47-59(85)77-52(36-42-20-12-7-13-21-42)66(92)79-31-15-23-53(79)64(90)76-49(34-41-18-10-6-11-19-41)61(87)74-48(33-40-16-8-5-9-17-40)60(86)75-51(37-55(69)82)62(88)70-46(28-29-54(68)81)58(84)73-50(35-43-24-26-44(80)27-25-43)63(89)78-56(39(3)4)65(91)71-45(22-14-30-67)57(83)72-47/h5-13,16-21,24-27,38-39,45-53,56,80H,14-15,22-23,28-37,67H2,1-4H3,(H2,68,81)(H2,69,82)(H,70,88)(H,71,91)(H,72,83)(H,73,84)(H,74,87)(H,75,86)(H,76,90)(H,77,85)(H,78,89)/t45-,46-,47-,48+,49-,50-,51-,52+,53-,56-/m0/s1
描述信息
A homodetic cyclic decapeptide consisting of D-Phe, L-Pro, L-Phe, D-Phe, L-Asn, L-Gln, L-Tyr, L-Val, L-Orn, and L-Leu residues coupled in sequence and cyclised head-to-tail.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
4 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:71947
- ChEBI: CHEBI:29701
- KEGG: C12041
- PubChem: 16129635
- PubChem: 16160721
- Metlin: METLIN69271
- ChEMBL: CHEMBL408504
- MeSH: Tyrocidine
- CAS: 8011-61-8
- CAS: 1481-70-5
- PMhub: MS000022793
- MetaboLights: MTBLC29701
- PubChem: 14196
- 3DMET: B04412
- NIKKAJI: J14.834B
- KNApSAcK: 29701
- LOTUS: LTS0228758
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 91061 - Bacilli: LTS0228758
- 2 - Bacteria: LTS0228758
- 55080 - Brevibacillus: LTS0228758
- 1393 - Brevibacillus brevis:
- 1393 - Brevibacillus brevis: 10.1007/S11274-018-2437-4
- 1393 - Brevibacillus brevis: 10.1021/JA01632A015
- 1393 - Brevibacillus brevis: LTS0228758
- 186822 - Paenibacillaceae: LTS0228758
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juan Li, Zhengcai Ma, Zhipeng Yang, Maochun Yang, Changsheng Li, Mengmeng Li, Xiaoduo Li, Xiantao Chen, Hang Ma, Wanqun Chen, Xiaoli Ye, Xuegang Li. Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Journal of ethnopharmacology.
2024 Mar; 322(?):117600. doi:
10.1016/j.jep.2023.117600. [PMID: 38103844] - Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He. Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy.
Journal of diabetes research.
2024; 2024(?):6942156. doi:
10.1155/2024/6942156. [PMID: 38282657] - Jibao Zhu, Chengfei Hu, Zizhen Zeng, Xiaoyu Deng, Lingbing Zeng, Saisai Xie, Yuanying Fang, Yi Jin, Valérie Alezra, Yang Wan. Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism.
European journal of medicinal chemistry.
2021 Oct; 221(?):113488. doi:
10.1016/j.ejmech.2021.113488. [PMID: 33991963] - Michaela Wenzel, Marina Rautenbach, J Arnold Vosloo, Tjalling Siersma, Christopher H M Aisenbrey, Ekaterina Zaitseva, Wikus E Laubscher, Wilma van Rensburg, Jan C Behrends, Burkhard Bechinger, Leendert W Hamoen. The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S.
mBio.
2018 10; 9(5):. doi:
10.1128/mbio.00802-18. [PMID: 30301848] - Xu Yang, Ahmed E Yousef. Antimicrobial peptides produced by Brevibacillus spp.: structure, classification and bioactivity: a mini review.
World journal of microbiology & biotechnology.
2018 Mar; 34(4):57. doi:
10.1007/s11274-018-2437-4. [PMID: 29594558] - Marina Rautenbach, Anscha M Troskie, Johan A Vosloo, Margitta E Dathe. Antifungal membranolytic activity of the tyrocidines against filamentous plant fungi.
Biochimie.
2016 Nov; 130(?):122-131. doi:
10.1016/j.biochi.2016.06.008. [PMID: 27328781] - Anscha Mari Troskie, Marina Rautenbach, Nicolas Delattin, Johan Arnold Vosloo, Margitta Dathe, Bruno P A Cammue, Karin Thevissen. Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms.
Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):3697-707. doi:
10.1128/aac.02381-14. [PMID: 24752256] - R Zuo, D Ornek, B C Syrett, R M Green, C-H Hsu, F B Mansfeld, T K Wood. Inhibiting mild steel corrosion from sulfate-reducing bacteria using antimicrobial-producing biofilms in Three-Mile-Island process water.
Applied microbiology and biotechnology.
2004 Apr; 64(2):275-83. doi:
10.1007/s00253-003-1403-7. [PMID: 12898064] - F J Aranda, B de Kruijff. Interrelationships between tyrocidine and gramicidin A' in their interaction with phospholipids in model membranes.
Biochimica et biophysica acta.
1988 Jan; 937(1):195-203. doi:
10.1016/0005-2736(88)90241-6. [PMID: 2446665]
