undecylprodigiosin (BioDeep_00000009044)

   

natural product


代谢物信息卡片


(2Z,5Z)-3-methoxy-5-pyrrol-2-ylidene-2-[(5-undecyl-1H-pyrrol-2-yl)methylidene]pyrrole

化学式: C25H35N3O (393.278)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 52.12%

分子结构信息

SMILES: CCCCCCCCCCCC1=CC=C(N1)C=C2C(=CC(=N2)C3=CC=CN3)OC
InChI: InChI=1S/C25H35N3O/c1-3-4-5-6-7-8-9-10-11-13-20-15-16-21(27-20)18-24-25(29-2)19-23(28-24)22-14-12-17-26-22/h12,14-19,26-27H,3-11,13H2,1-2H3/b24-18-

描述信息

A member of the class of tripyrroles that is 1H-pyrrole substituted by (4-methoxy-1H,5H-[2,2-bipyrrol]-5-ylidene)methyl and undecyl groups at positions 2 and 5, respectively. It is a pigment produced by Stveptomyces coelicolor.
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

4 个代谢物同义名

2-((3-Methoxy-5-(1H-pyrrol-2-yl)-2H-pyrrol-2-ylidene)methyl)-5-undecyl-1H-pyrrole; undecylprodigiosin; (2Z,5Z)-3-methoxy-5-pyrrol-2-ylidene-2-[(5-undecyl-1H-pyrrol-2-yl)methylidene]pyrrole; Undecylprodigiosin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

569 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BIRC5, CAT, DYRK3, FASN, MYC, PIK3C2A, RELA, XIAP
Endoplasmic reticulum membrane 6 CD4, PIGB, PIGC, PIGH, PIGM, PIGN
Nucleus 7 BIRC5, DYRK3, MYC, PARP1, PIK3C2A, RELA, XIAP
cytosol 10 BIRC5, CAT, DYRK3, FASN, PARP1, PIGN, PIK3C2A, PRF1, RELA, XIAP
nuclear body 1 PARP1
trans-Golgi network 1 PIK3C2A
nucleoplasm 8 ATP2B1, BIRC5, DYRK3, MYC, PARP1, PIK3C2A, RELA, XIAP
Cell membrane 5 ATP2B1, CD4, CD8A, PIK3C2A, PRF1
Cytoplasmic granule 1 DYRK3
Multi-pass membrane protein 7 ATP2B1, ATP4A, PIGB, PIGC, PIGM, PIGN, PRF1
Synapse 1 ATP2B1
glutamatergic synapse 2 ATP2B1, RELA
Golgi apparatus 1 FASN
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 PARP1
plasma membrane 8 ATP2B1, ATP4A, CD4, CD8A, FASN, PIGN, PIK3C2A, PRF1
synaptic vesicle membrane 1 ATP2B1
Membrane 10 ATP2B1, ATP4A, CAT, FASN, MYC, PARP1, PIGB, PIGN, PIK3C2A, PRF1
apical plasma membrane 1 ATP4A
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ATP2B1, CAT, FASN, PIK3C2A
endoplasmic reticulum 1 PIGH
extracellular space 2 ATP4A, IL2
mitochondrion 2 CAT, PARP1
protein-containing complex 4 BIRC5, CAT, MYC, PARP1
intracellular membrane-bounded organelle 4 ATP2B1, CAT, DYRK3, PIK3C2A
Single-pass type I membrane protein 2 CD4, CD8A
Secreted 2 IL2, PRF1
extracellular region 4 CAT, CD8A, IL2, PRF1
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 CAT
transcription regulator complex 2 PARP1, RELA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DYRK3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD4, CD8A
microtubule cytoskeleton 1 BIRC5
nucleolus 2 MYC, PARP1
midbody 1 BIRC5
Early endosome 1 CD4
vesicle 1 PIK3C2A
Apical cell membrane 1 ATP4A
Membrane raft 1 CD4
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 CAT
microtubule 1 BIRC5
spindle 1 BIRC5
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
nuclear speck 1 DYRK3
interphase microtubule organizing center 1 BIRC5
receptor complex 1 CD8A
chromatin 3 MYC, PARP1, RELA
cell projection 1 ATP2B1
Chromosome 2 BIRC5, PARP1
cytoskeleton 1 DYRK3
centriole 1 BIRC5
Golgi apparatus, trans-Golgi network 1 PIK3C2A
Nucleus, nucleolus 2 MYC, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 BIRC5
Basolateral cell membrane 1 ATP2B1
site of double-strand break 1 PARP1
nuclear envelope 2 MYC, PARP1
endosome lumen 1 PRF1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Nucleus, nucleoplasm 1 MYC
Melanosome 1 FASN
cytoplasmic stress granule 1 DYRK3
Nucleus speckle 1 DYRK3
Presynaptic cell membrane 1 ATP2B1
clathrin-coated vesicle 1 PIK3C2A
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 CD4
phosphatidylinositol 3-kinase complex 1 PIK3C2A
kinetochore 1 BIRC5
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
RNA polymerase II transcription repressor complex 1 MYC
immunological synapse 2 ATP2B1, PRF1
chromosome, centromeric region 1 BIRC5
clathrin-coated endocytic vesicle membrane 1 CD4
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 PARP1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
[Isoform 1]: Cell membrane 1 CD8A
Rough endoplasmic reticulum 1 MYC
pericentriolar material 1 DYRK3
site of DNA damage 1 PARP1
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex 2 PIGC, PIGH
Myc-Max complex 1 MYC
T cell receptor complex 2 CD4, CD8A
catalase complex 1 CAT
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
photoreceptor ribbon synapse 1 ATP2B1
NF-kappaB p50/p65 complex 1 RELA
potassium:proton exchanging ATPase complex 1 ATP4A
NF-kappaB complex 1 RELA
glycogen granule 1 FASN
glycosylphosphatidylinositol-mannosyltransferase I complex 1 PIGM
nucleoplasmic reticulum 1 MYC


文献列表

  • Alejandro Cuevas, Nicolás Saavedra, Luis A Salazar, Marcela F Cavalcante, Jacqueline C Silva, Dulcineia S P Abdalla. Prodigiosin Modulates the Immune Response and Could Promote a Stable Atherosclerotic Lession in C57bl/6 Ldlr-/- Mice. International journal of molecular sciences. 2020 Sep; 21(17):. doi: 10.3390/ijms21176417. [PMID: 32899258]
  • Xiaocao Liu, Guosong Zheng, Gang Wang, Weihong Jiang, Lei Li, Yinhua Lu. Overexpression of the diguanylate cyclase CdgD blocks developmental transitions and antibiotic biosynthesis in Streptomyces coelicolor. Science China. Life sciences. 2019 Nov; 62(11):1492-1505. doi: 10.1007/s11427-019-9549-8. [PMID: 31228045]
  • Roberto Scaffaro, Francesco Lopresti, Alberto Sutera, Luigi Botta, Rosa Maria Fontana, Giuseppe Gallo. Plasma modified PLA electrospun membranes for actinorhodin production intensification in Streptomyces coelicolor immobilized-cell cultivations. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):233-241. doi: 10.1016/j.colsurfb.2017.05.060. [PMID: 28599184]
  • Saša Lazović, Andreja Leskovac, Sandra Petrović, Lidija Senerovic, Nevena Krivokapić, Tatjana Mitrović, Nikola Božović, Vesna Vasić, Jasmina Nikodinovic-Runic. Biological effects of bacterial pigment undecylprodigiosin on human blood cells treated with atmospheric gas plasma in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2017 Jan; 69(1):55-62. doi: 10.1016/j.etp.2016.11.003. [PMID: 27843060]
  • Dan Shu, Lei Chen, Weihua Wang, Zhenyu Yu, Cong Ren, Weiwen Zhang, Sheng Yang, Yinhua Lu, Weihong Jiang. afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor. Applied microbiology and biotechnology. 2009 Jan; 81(6):1149-60. doi: 10.1007/s00253-008-1738-1. [PMID: 18949475]
  • Ming Li, Tae-Jong Kim, Hyung-Jin Kwon, Joo-Won Suh. Effects of extracellular ATP on the physiology of Streptomyces coelicolor A3(2). FEMS microbiology letters. 2008 Sep; 286(1):24-31. doi: 10.1111/j.1574-6968.2008.01248.x. [PMID: 18565122]
  • Yu-Hong Wei, Wei-Chuan Chen. Enhanced production of prodigiosin-like pigment from Serratia marcescens SMdeltaR by medium improvement and oil-supplementation strategies. Journal of bioscience and bioengineering. 2005 Jun; 99(6):616-22. doi: 10.1263/jbb.99.616. [PMID: 16233840]
  • Haifeng Hu, Qin Zhang, Kozo Ochi. Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans. Journal of bacteriology. 2002 Jul; 184(14):3984-91. doi: 10.1128/jb.184.14.3984-3991.2002. [PMID: 12081971]
  • T Kataoka, J Magae, M Yamasaki, K Nagai. Prodigiosin 25-C perturbs permeation of acetate in a cultured cell line. Bioscience, biotechnology, and biochemistry. 1995 Oct; 59(10):1891-5. doi: 10.1271/bbb.59.1891. [PMID: 8534981]